Bioconductor Affymetrix Probe Listing

Probe	Symbol	Description	Chromosome	Chromosome Location	GenBank	Gene	PubMed	Gene Ontology	Pathway
TC1100000681.mm.2	Gm12250	predicted gene 12250	11	58183842	NM_001135115	631323	9
TC0500002755.mm.2	Cxcl9	chemokine (C-X-C motif) ligand 9	5	-92321330	NM_008599, BC003343 NM_008599, BC003343	17329	118	cytokine activity extracellular region extracellular space extracellular space chemotaxis defense response inflammatory response immune response chemokine activity response to bacterium external side of plasma membrane neutrophil chemotaxis CXCR chemokine receptor binding positive regulation of myoblast differentiation defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of myoblast fusion	04060 04062 04620
TC1000001994.mm.2	Calhm6	calcium homeostasis modulator family member 6	10	-34126066	NM_175449, BC095946 NM_175449, BC095946	215900	16	cation channel activity integral component of plasma membrane ion transport membrane integral component of membrane
TC0300001444.mm.2					NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990			nucleotide binding immune system process GTPase activity protein binding GTP binding extracellular region cytoplasm Golgi apparatus Golgi apparatus cytosol plasma membrane inflammatory response response to bacterium membrane hydrolase activity GMP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle interleukin-1 beta production interleukin-1 beta production interleukin-18 production protein localization to Golgi apparatus cellular response to interferon-beta identical protein binding protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host positive regulation of innate immune response perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium protein homotetramerization defense response to virus cellular response to interferon-gamma cellular response to interferon-gamma positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly
TC0500003731.mm.2	Gbp4	guanylate binding protein 4	5	-105115766	NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434	17472	11	negative regulation of transcription by RNA polymerase II negative regulation of protein phosphorylation GTPase activity protein binding GTP binding negative regulation of protein ubiquitination cytoplasmic vesicle negative regulation of interferon-alpha production negative regulation of protein import into nucleus defense response to protozoan regulation of defense response to virus defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma
TC1400001182.mm.2	Acod1	aconitate decarboxylase 1	14	103047011	NM_008392	16365	38	immune system process positive regulation of antimicrobial humoral response positive regulation of antimicrobial humoral response mitochondrion mitochondrion defense response defense response defense response inflammatory response embryo implantation response to bacterium lyase activity negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production response to lipopolysaccharide negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway cellular response to interferon-beta innate immune response negative regulation of innate immune response aconitate decarboxylase activity aconitate decarboxylase activity aconitate decarboxylase activity aconitate decarboxylase activity negative regulation of inflammatory response defense response to virus cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to progesterone stimulus tolerance induction to lipopolysaccharide tolerance induction to lipopolysaccharide positive regulation of reactive oxygen species metabolic process
TC1700000077.mm.2	Tagap	T cell activation Rho GTPase activating protein	17	7925999	NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728	72536	28	guanyl-nucleotide exchange factor activity GTPase activator activity signal transduction defense response to virus
TC1500001728.mm.2	Ly6a	lymphocyte antigen 6 complex, locus A	15	-74994876	NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070	110454	177	protein binding intracellular anatomical structure plasma membrane response to bacterium external side of plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway
TC1800000610.mm.2	Iigp1	interferon inducible GTPase 1	18	60376028, 60373615	NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649	60440	44	nucleotide binding immune system process GTPase activity GTPase activity GTPase activity protein binding GTP binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus defense response response to bacterium regulation of autophagy membrane hydrolase activity GDP binding cytokine-mediated signaling pathway symbiont-containing vacuole membrane cellular response to interferon-beta cellular response to interferon-beta identical protein binding identical protein binding defense response to protozoan innate immune response defense response to Gram-negative bacterium
TC1900000102.mm.2	Batf2	basic leucine zipper transcription factor, ATF-like 2	19	6164438	NM_028967, BC024521 NM_028967, BC024521	74481	28	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cell differentiation defense response to protozoan myeloid dendritic cell differentiation
TC0200002544.mm.2	Cd40	CD40 antigen	2	165055635	NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40	21939	573	positive regulation of protein phosphorylation immune system process regulation of immunoglobulin production immune response-regulating cell surface receptor signaling pathway immune response-regulating cell surface receptor signaling pathway antigen binding antigen binding protein binding extracellular region extracellular space cytoplasm plasma membrane cellular calcium ion homeostasis cellular calcium ion homeostasis inflammatory response inflammatory response external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane enzyme binding protein domain specific binding CD40 signaling pathway CD40 signaling pathway positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of B cell proliferation ubiquitin protein ligase binding positive regulation of interleukin-12 production positive regulation of interleukin-12 production response to interferon-gamma CD40 receptor complex CD40 receptor complex TRIF-dependent toll-like receptor signaling pathway signaling receptor activity B cell activation B cell activation B cell activation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein defense response to protozoan defense response to protozoan neuronal cell body positive regulation of I-kappaB kinase/NF-kappaB signaling varicosity intracellular membrane-bounded organelle positive regulation of MAP kinase activity protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of blood vessel endothelial cell migration positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of isotype switching to IgG isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of protein kinase C signaling positive regulation of endothelial cell apoptotic process positive regulation of endothelial cell apoptotic process	04060 04514 04620 04672 05144 05145 05310 05320 05322 05330 05340 05416
TC0600003229.mm.2	Cd69	CD69 antigen	6	-129267323	NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69	12515	114	calcium ion binding external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane carbohydrate binding protein-containing complex cellular response to drug identical protein binding
TC0500002623.mm.2	Kdr	kinase insert domain protein receptor	5	-75957364, -75932826	NM_010612, BC020530 NM_010612, BC020530	16542	1021	nucleotide binding angiogenesis ovarian follicle development branching involved in blood vessel morphogenesis vasculogenesis response to hypoxia positive regulation of protein phosphorylation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lymph vessel development cell migration involved in sprouting angiogenesis positive regulation of mesenchymal cell proliferation hematopoietic progenitor cell differentiation endocardium development endothelium development endochondral bone growth protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding extracellular region nucleus cytoplasm cytoplasm endosome early endosome endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cytosolic calcium ion concentration multicellular organism development positive regulation of cell population proliferation regulation of cell shape male gonad development external side of plasma membrane cell surface positive regulation of endothelial cell migration positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane positive regulation of macroautophagy kinase activity phosphorylation cell migration cell migration transferase activity peptidyl-tyrosine phosphorylation growth factor binding growth factor binding cell junction hemopoiesis cell differentiation lung development positive regulation of cell migration positive regulation of BMP signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway cytoplasmic vesicle positive regulation of TOR signaling positive regulation of kinase activity embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation vascular endothelial growth factor signaling pathway vascular endothelial growth factor binding response to drug identical protein binding neuron projection neuronal cell body negative regulation of apoptotic process surfactant homeostasis receptor complex positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration membrane raft cell fate commitment cadherin binding endothelial cell differentiation endothelial cell differentiation endothelial cell differentiation endothelial cell differentiation positive regulation of angiogenesis positive regulation of angiogenesis positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation post-embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of calcium-mediated signaling positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization calcium ion homeostasis blood vessel endothelial cell differentiation vascular wound healing ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cell periphery positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission sorting endosome regulation of hematopoietic progenitor cell differentiation regulation of bone development cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis	04060 04144 04370 04510
TC1700001596.mm.2	Mmp25	matrix metallopeptidase 25	17	-23629175	NM_001033339, BC112379 NM_001033339, BC112379	240047	20	metalloendopeptidase activity plasma membrane plasma membrane proteolysis inflammatory response peptidase activity metallopeptidase activity zinc ion binding cell surface membrane integral component of membrane peptidase activator activity hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix anchored component of membrane metal ion binding hard palate development
TC1700002781.mm.2	H2-Ab1	histocompatibility 2, class II antigen A, beta 1	17	34263226	NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998	14961	780	adaptive immune response B cell affinity maturation immune system process immunoglobulin production involved in immunoglobulin-mediated immune response humoral immune response mediated by circulating immunoglobulin antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of antigen processing and presentation positive regulation of T-helper 1 type immune response protein binding intracellular anatomical structure early endosome multivesicular body Golgi apparatus plasma membrane immune response transcription factor binding external side of plasma membrane cell surface toxic substance binding membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II ubiquitin protein ligase binding negative regulation of T cell proliferation peptide antigen binding MHC class II protein complex protein-containing complex binding positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell activation antigen processing and presentation of peptide antigen T cell receptor signaling pathway cellular response to interferon-gamma protein antigen binding	04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416
TC1100002643.mm.2					NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522			GTPase activity GTPase activity GTP binding endoplasmic reticulum membrane defense response immune response response to virus response to bacterium response to interferon-gamma response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta
TC1600002148.mm.2	Mx1	MX dynamin-like GTPase 1	16	-97447036, -97447034	NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113	17857	108	mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission GTPase activity nucleus cytoplasm plasma membrane microtubule binding postsynaptic density microtubule cytoskeleton membrane synaptic vesicle budding from presynaptic endocytic zone membrane axon cytoplasmic vesicle receptor internalization mitochondrial membrane dendritic spine head regulation of synapse structure or activity membrane fusion postsynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization
TC1200002525.mm.2	Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	12	104236146, 104214453	NM_009251	20715	30	adaptive immune response immune system process serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm apoptotic process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone
TC1100002649.mm.2					NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522			GTPase activity GTPase activity GTP binding endoplasmic reticulum membrane defense response immune response response to virus response to bacterium response to interferon-gamma response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta
TC0500000171.mm.2	Fgl2	fibrinogen-like protein 2	5	21372672	NM_008013, BC028893 NM_008013, BC028893	14190	70	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell immunoglobulin production involved in immunoglobulin-mediated immune response negative regulation of dendritic cell antigen processing and presentation negative regulation of macrophage antigen processing and presentation signaling receptor binding extracellular region extracellular space peptidase activity cytolysis negative regulation of memory T cell differentiation negative regulation of defense response to virus collagen-containing extracellular matrix
TC0100003591.mm.2	Ifi213	interferon activated gene 213	1	-173591956, -173580356, -173573955, -173566282	NM_001177349, NM_001177350 NM_001177349, NM_001177350	623121	10	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding
TC0300001447.mm.2	Gbp2	guanylate binding protein 2	3	142620662	NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882	14469	54	nucleotide binding GTPase activity GTPase activity GTP binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol response to bacterium membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle protein localization to nucleus cellular response to interferon-beta protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interferon-gamma
TC0700001841.mm.2	Itgal	integrin alpha L	7	127296259	NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802	16408	202	immunological synapse T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell plasma membrane cell-cell junction phagocytosis cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion cell surface receptor signaling pathway integrin-mediated signaling pathway integrin complex external side of plasma membrane cell surface membrane integral component of membrane regulation of cell-cell adhesion positive regulation of cell-cell adhesion ICAM-3 receptor activity integrin alphaL-beta2 complex memory T cell extravasation positive regulation of T cell proliferation receptor clustering protein-containing complex binding metal ion binding activated T cell proliferation cell adhesion molecule binding positive regulation of calcium-mediated signaling cell-cell adhesion cell-cell adhesion	04514 04650 04670 04810 05144 05150 05323 05416
TC0300003133.mm.2	Ifi44	interferon-induced protein 44	3	-151730922	NM_133871, BC111882 NM_133871, BC111882	99899	16	molecular_function cytoplasm immune response response to bacterium
TC0200002374.mm.2	Procr	protein C receptor, endothelial	2	155751216	NM_011171, BC028755 NM_011171, BC028755	19124	78	extracellular space extracellular space centrosome blood coagulation hemostasis protein C-terminus binding membrane integral component of membrane signaling receptor activity perinuclear region of cytoplasm negative regulation of coagulation negative regulation of coagulation negative regulation of coagulation
TC1100001222.mm.2	Ccl12	chemokine (C-C motif) ligand 12	11	82101844	NM_011331, BC027520 NM_011331, BC027520	20293	33	MAPK cascade angiogenesis monocyte chemotaxis monocyte chemotaxis monocyte chemotaxis positive regulation of leukocyte migration cytokine activity extracellular region extracellular space chemotaxis inflammatory response inflammatory response inflammatory response immune response cytoskeleton organization G protein-coupled receptor signaling pathway chemokine activity regulation of cell shape cytokine-mediated signaling pathway neutrophil chemotaxis lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding negative regulation of glial cell apoptotic process protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration CCR chemokine receptor binding eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of calcium ion import negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process negative regulation of natural killer cell chemotaxis	04060 04062
TC0200000551.mm.2					NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556			urea cycle urea cycle citrulline metabolic process argininosuccinate metabolic process argininosuccinate metabolic process nucleotide binding argininosuccinate synthase activity argininosuccinate synthase activity protein binding ATP binding nucleus cytoplasm cytoplasm mitochondrion mitochondrial outer membrane lysosome endoplasmic reticulum cytosol arginine biosynthetic process arginine biosynthetic process aspartate metabolic process circadian rhythm circadian rhythm cellular amino acid biosynthetic process response to zinc ion response to mycotoxin toxic substance binding amino acid binding ligase activity identical protein binding neuron projection neuronal cell body perikaryon myelin sheath positive regulation of nitric oxide biosynthetic process response to glucocorticoid cell body fiber cellular response to laminar fluid shear stress negative regulation of leukocyte cell-cell adhesion
TC0200001854.mm.2					NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633			molecular_function cytochrome-c oxidase activity cellular_component nucleus mitochondrion mitochondrial respiratory chain complex IV response to bacterium BMP signaling pathway negative regulation of inflammatory response cellular response to lipopolysaccharide
TC0500002895.mm.2					NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768			GTPase activity GTP binding response to bacterium symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle cellular response to interferon-beta defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma
TC1200002524.mm.2	Serpina3f	serine (or cysteine) peptidase inhibitor, clade A, member 3F	12	104214543, 104214632	NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133	238393	19	serine-type endopeptidase inhibitor activity extracellular space response to bacterium negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone
TC0200004599.mm.2	Il1a	interleukin 1 alpha	2	-129299609	NM_010554, BC003727 NM_010554, BC003727	16175	389	fever generation positive regulation of cytokine production connective tissue replacement involved in inflammatory response wound healing cytokine activity cytokine activity interleukin-1 receptor binding copper ion binding extracellular region extracellular space extracellular space extracellular space cytoplasm cytosol plasma membrane cellular sodium ion homeostasis inflammatory response inflammatory response immune response negative regulation of cell population proliferation cell surface positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of steroid biosynthetic process cytokine-mediated signaling pathway cytokine-mediated signaling pathway keratinization positive regulation of prostaglandin secretion positive regulation of interleukin-2 production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade regulation of actin cytoskeleton organization positive regulation of immature T cell proliferation in thymus cellular response to heat ectopic germ cell programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade response to copper ion positive regulation of protein secretion regulation of nitric-oxide synthase activity positive regulation of cell division regulation of sensory perception of pain positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of monocyte chemotactic protein-1 production extrinsic apoptotic signaling pathway in absence of ligand positive regulation of neutrophil migration negative regulation of establishment of Sertoli cell barrier positive regulation of neutrophil extravasation	04010 04060 04210 04380 04640 04940 05020 05140 05323 05332
TC1700002352.mm.2	C3	complement component 3	17	-57203966	NM_009778, BC043338 NM_009778, BC043338	12266	585	positive regulation of type IIa hypersensitivity positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex immune system process endopeptidase inhibitor activity protein binding extracellular region extracellular space extracellular space extracellular space extracellular space lipid metabolic process fatty acid metabolic process inflammatory response complement activation complement activation complement activation complement activation complement activation, alternative pathway complement activation, classical pathway blood coagulation lipid binding response to bacterium cell surface positive regulation of vascular endothelial growth factor production positive regulation of glucose transmembrane transport regulation of triglyceride biosynthetic process positive regulation of lipid storage neuron remodeling C5L2 anaphylatoxin chemotactic receptor binding protein-containing complex oviduct epithelium development vascular associated smooth muscle cell differentiation innate immune response positive regulation of G protein-coupled receptor signaling pathway positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of receptor-mediated endocytosis positive regulation of developmental growth positive regulation of phagocytosis retina development in camera-type eye positive regulation of phagocytosis, engulfment positive regulation of phagocytosis, engulfment positive regulation of ERK1 and ERK2 cascade amyloid-beta clearance amyloid-beta clearance complement-dependent cytotoxicity complement-mediated synapse pruning vertebrate eye-specific patterning cell surface receptor signaling pathway involved in cell-cell signaling positive regulation of apoptotic cell clearance	04145 04610 05140 05142 05150 05322
TC1400002162.mm.2	Phf11b	PHD finger protein 11B	14	-59320963	NM_001164327	236451	3	molecular_function nucleus nucleoplasm biological_process nuclear membrane
TC0300001446.mm.2	Gbp3	guanylate binding protein 3	3	142560355, 142560043	NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195	55932	23	nucleotide binding GTPase activity GTPase activity GTP binding nucleus cytoplasm Golgi apparatus cytosol cytosol plasma membrane membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle cellular response to interferon-beta protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma
TC1100001223.mm.2	Ccl8	chemokine (C-C motif) ligand 8	11	82115184	NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103	20307	40	monocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space chemotaxis inflammatory response immune response G protein-coupled receptor signaling pathway chemokine activity heparin binding neutrophil chemotaxis positive regulation of GTPase activity positive regulation of myoblast differentiation CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of myoblast fusion	04060 04062
TC0500002757.mm.2	Cxcl11	chemokine (C-X-C motif) ligand 11	5	-92359544, -92359544	NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903	56066	38	extracellular space inflammatory response chemokine activity neutrophil chemotaxis CXCR chemokine receptor binding antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide	04060 04062 04620
TC0100003575.mm.2	Slamf8	SLAM family member 8	1	-172581376	NM_029084, BC024587 NM_029084, BC024587	74748	14	leukocyte chemotaxis involved in inflammatory response B-1 B cell lineage commitment negative regulation of macrophage chemotaxis membrane integral component of membrane regulation of NAD(P)H oxidase activity cellular response to drug signaling receptor activity defense response to bacterium identical protein binding regulation of kinase activity regulation of B cell differentiation negative regulation of respiratory burst involved in inflammatory response negative regulation of monocyte chemotaxis phagosome acidification negative regulation of neutrophil migration negative regulation of dendritic cell chemotaxis
TC0500002896.mm.2	Gbp11	guanylate binding protein 11	5	-105323025, -105323025	NM_001039647, BC111039 NM_001039647, BC111039	634650	3	GTPase activity GTP binding cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma
TC0300001445.mm.2	Gbp7	guanylate binding protein 7	3	142530335	NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229	229900	15	GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle defense response to protozoan defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma
TC0500002756.mm.2	Cxcl10	chemokine (C-X-C motif) ligand 10	5	-92346638	NM_021274, BC030067 NM_021274, BC030067	15945	278	positive regulation of leukocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space extracellular space chemotaxis defense response inflammatory response immune response G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway chemokine activity chemokine activity heparin binding positive regulation of cell population proliferation response to bacterium external side of plasma membrane T cell chemotaxis regulation of T cell chemotaxis negative regulation of angiogenesis positive regulation of cell migration neutrophil chemotaxis killing of cells of other organism chemoattractant activity endothelial cell activation regulation of cell population proliferation regulation of apoptotic process CXCR chemokine receptor binding negative regulation of myoblast differentiation CXCR3 chemokine receptor binding positive regulation of release of sequestered calcium ion into cytosol defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis regulation of endothelial tube morphogenesis negative regulation of myoblast fusion positive regulation of T cell migration	04060 04062 04620 04622 04623
TC1800000606.mm.2	Gm4951	predicted gene 4951	18	60212076	NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147	240327	12	GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta cellular response to interferon-beta
TC1700000835.mm.2	Pla2g7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	17	43568450	NM_013737, BC010726 NM_013737, BC010726	27226	49	1-alkyl-2-acetylglycerophosphocholine esterase activity 1-alkyl-2-acetylglycerophosphocholine esterase activity phospholipid binding extracellular region extracellular space cytoplasm lipid metabolic process inflammatory response phospholipid catabolic process lipid catabolic process hydrolase activity low-density lipoprotein particle high-density lipoprotein particle low-density lipoprotein particle remodeling lipid oxidation plasma lipoprotein particle oxidation phosphatidylcholine catabolic process platelet activating factor metabolic process calcium-independent phospholipase A2 activity platelet activating factor catabolic process positive regulation of monocyte chemotaxis	00565 01100
human-RPTR-AJ510163-1_st
TC0200004396.mm.2	Rasgrp1	RAS guanyl releasing protein 1	2	-117279983	NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341	19419	77	cytokine production positive regulation of protein phosphorylation inflammatory response to antigenic stimulus guanyl-nucleotide exchange factor activity calcium ion binding intracellular anatomical structure cytoplasm endoplasmic reticulum Golgi apparatus cytosol cytosol plasma membrane plasma membrane small GTPase mediated signal transduction zinc ion binding regulation of phosphatidylinositol 3-kinase signaling membrane diacylglycerol binding natural killer cell activation cell differentiation phosphatidylcholine binding secretory granule localization positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell differentiation positive regulation of T cell differentiation in thymus intracellular signal transduction T cell proliferation B cell proliferation T cell activation B cell activation identical protein binding mast cell degranulation positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of natural killer cell mediated cytotoxicity positive regulation of JNK cascade positive regulation of Ras protein signal transduction metal ion binding vesicle transport along microtubule regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade activation of GTPase activity activation of GTPase activity	04010 04660
TC0200003355.mm.2	Traf1	TNF receptor-associated factor 1	2	-34941749	NM_009421, BC096595 NM_009421, BC096595	22029	63	tumor necrosis factor receptor binding tumor necrosis factor receptor binding protein binding cytoplasm apoptotic process signal transduction zinc ion binding cytoplasmic side of plasma membrane ubiquitin protein ligase binding ubiquitin protein ligase binding thioesterase binding tumor necrosis factor-mediated signaling pathway identical protein binding regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade positive regulation of NF-kappaB transcription factor activity protein K63-linked ubiquitination plasma membrane signaling receptor complex regulation of extrinsic apoptotic signaling pathway	05200 05222
TC1400002160.mm.2	Phf11	PHD finger protein 11	14		NM_001164329	628693	3
TC0700002128.mm.2	Tarm1	T cell-interacting, activating receptor on myeloid cells 1	7	-3486499, -3489068	NM_177363	245126	10	adaptive immune response immune system process plasma membrane plasma membrane membrane integral component of membrane immunoglobulin receptor binding innate immune response positive regulation of cytokine production involved in inflammatory response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation
TC0400001543.mm.2	Fabp3	fatty acid binding protein 3, muscle and heart	4	130308737	NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542	14077	90	long-chain fatty acid transporter activity fatty acid binding extracellular space extracellular space cytoplasm cytosol cytosol cytoskeletal protein binding lipid binding long-chain fatty acid transport long-chain fatty acid transport long-chain fatty acid transport sarcoplasm intracellular lipid transport long-chain fatty acid binding cholesterol homeostasis regulation of fatty acid oxidation icosatetraenoic acid binding brown fat cell differentiation phospholipid homeostasis oleic acid binding positive regulation of phospholipid biosynthetic process positive regulation of long-chain fatty acid import into cell positive regulation of long-chain fatty acid import into cell regulation of phosphatidylcholine biosynthetic process	03320
TC1100001241.mm.2	Slfn4	schlafen 4	11	83175185	NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770	20558	22	molecular_function cellular_component response to bacterium
TC0100001634.mm.2	Ifi208	interferon activated gene 208	1	173673664, 173673664	NM_001162938	100033459	63	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding
TC1700002816.mm.2	Cfb	complement factor B	17	-34856373	NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451	14962	166	immune system process serine-type endopeptidase activity extracellular region extracellular space proteolysis complement activation complement activation, alternative pathway complement activation, alternative pathway complement activation, alternative pathway peptidase activity serine-type peptidase activity cell population proliferation hydrolase activity innate immune response response to thyroid hormone	04610 05150
TC1100001239.mm.2	Slfn1	schlafen 1	11	83116819	NM_011407, BC052869 NM_011407, BC052869	20555	22	negative regulation of transcription by RNA polymerase II negative regulation of protein phosphorylation protein binding nucleus cytoplasm cell cycle arrest negative regulation of cell population proliferation negative regulation of T cell proliferation negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter negative regulation of G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle
TC0100001604.mm.2	Slamf6	SLAM family member 6	1	171917461, 171917461	NM_030710, BC030031 NM_030710, BC030031	30925	44	natural killer cell differentiation natural killer cell proliferation adaptive immune response immune system process plasma membrane integral component of plasma membrane membrane integral component of membrane positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity T-helper 17 cell lineage commitment
TC1400002161.mm.2	Phf11a	PHD finger protein 11A	14	-59276912	NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760	219131	13	molecular_function nucleus nucleoplasm nuclear membrane metal ion binding regulation of immune response
TC1400002869.mm.2	Phf11d	PHD finger protein 11D	14	-59347406	NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673	219132	18	molecular_function nucleus nucleoplasm biological_process nuclear membrane metal ion binding
rat-RPTR-AJ510163-1_st
TC0200003209.mm.2	Slc2a6	solute carrier family 2 (facilitated glucose transporter), member 6	2	-27021364, -27021366	NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946	227659	20	transporter activity lysosome lysosomal membrane regulation of glycolytic process regulation of glycolytic process carbohydrate transport membrane integral component of membrane transmembrane transporter activity transmembrane transport
human-RPTR-U57609-2_st
TC1100003115.mm.2	Scimp	SLP adaptor and CSK interacting membrane protein	11	-70790931	NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178	327957	16	ruffle immunological synapse immunological synapse cytokine production involved in immune response positive regulation of dendritic cell cytokine production protein binding plasma membrane membrane integral component of membrane filopodium leading edge membrane uropod membrane cytoplasmic vesicle positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of stress-activated MAPK cascade toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor TLR1:TLR2 signaling pathway cell projection receptor complex phagocytic vesicle molecular adaptor activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin tetraspanin-enriched microdomain
TC0700004530.mm.2	Irf7	interferon regulatory factor 7	7	-141263182	NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799	54123	230	transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding immune system process regulation of adaptive immune response DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of gene expression immunoglobulin mediated immune response positive regulation of type I interferon production type I interferon production interferon-alpha production interferon-beta production positive regulation of interferon-alpha production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production regulation of MyD88-dependent toll-like receptor signaling pathway regulation of MyD88-independent toll-like receptor signaling pathway innate immune response regulation of innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II defense response to virus defense response to virus type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway sequence-specific double-stranded DNA binding	04620 04622 04623 05160
TC0200000868.mm.2	Gpd2	glycerol phosphate dehydrogenase 2, mitochondrial	2	57237677, 57238381	NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359	14571	55	glycerol-3-phosphate dehydrogenase [NAD+] activity glycerol-3-phosphate dehydrogenase (quinone) activity calcium ion binding mitochondrion mitochondrion mitochondrion mitochondrial inner membrane glycerol-3-phosphate metabolic process glycerol-3-phosphate metabolic process gluconeogenesis NADH metabolic process glycerol-3-phosphate dehydrogenase complex membrane oxidoreductase activity multicellular organism growth camera-type eye development metal ion binding sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	00564
TC0600003237.mm.2	Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	6	-129485247, -129485246	NM_138648	108078	104	immune system process low-density lipoprotein particle receptor activity low-density lipoprotein particle receptor activity extracellular region nucleoplasm plasma membrane plasma membrane inflammatory response inflammatory response cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell death cell death negative regulation of gene expression membrane integral component of membrane extrinsic component of plasma membrane carbohydrate binding lipoprotein metabolic process lipoprotein metabolic process identical protein binding intracellular membrane-bounded organelle receptor complex receptor complex	03320 04145
TC1900001253.mm.2	Gda	guanine deaminase	19	-21391306	NM_010266, BC076583 NM_010266, BC076583	14544	33	protein binding cytosol cytosol guanine catabolic process zinc ion binding guanine deaminase activity guanine deaminase activity guanine deaminase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds deaminase activity positive regulation of microtubule polymerization GMP catabolic process dGMP catabolic process guanine metabolic process metal ion binding	00230 01100
TC0600003169.mm.2	Ccnd2	cyclin D2	6	-127125708	NM_009829, BC049086 NM_009829, BC049086	12444	357	regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex cyclin-dependent protein kinase holoenzyme complex chromatin positive regulation of protein phosphorylation protein binding nucleus nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cell cycle long-term memory positive regulation of cell population proliferation adult locomotory behavior membrane cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding nuclear membrane negative regulation of apoptotic process mitotic cell cycle phase transition positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of epithelial cell proliferation cell division regulation of cell cycle cellular response to X-ray cyclin D2-CDK4 complex positive regulation of G1/S transition of mitotic cell cycle positive regulation of G1/S transition of mitotic cell cycle	04110 04115 04310 04510 04630
TC1100003097.mm.2	Cxcl16	chemokine (C-X-C motif) ligand 16	11	-70455188, -70454388	NM_023158, BC019961 NM_023158, BC019961	66102	81	low-density lipoprotein particle receptor activity low-density lipoprotein particle receptor activity scavenger receptor activity scavenger receptor activity cytokine activity extracellular space extracellular space extracellular space extracellular space receptor-mediated endocytosis chemotaxis chemokine activity chemokine activity chemokine activity T cell chemotaxis T cell chemotaxis membrane integral component of membrane positive regulation of cell growth positive regulation of cell migration positive regulation of cell migration response to cytokine response to interferon-gamma response to tumor necrosis factor chemokine receptor binding lymphocyte chemotaxis cellular response to lipopolysaccharide	04060 04062
TC1900001418.mm.2	Ch25h	cholesterol 25-hydroxylase	19	-34473783	NM_009890, BC039919 NM_009890, BC039919	12642	45	C-4 methylsterol oxidase activity cholesterol 25-hydroxylase activity monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process cholesterol metabolic process steroid hydroxylase activity steroid hydroxylase activity lipid biosynthetic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity B cell chemotaxis metal ion binding	00120
TC0500002753.mm.2	Naaa	N-acylethanolamine acid amidase	5	-92257659	NM_001163687, NM_025972, BC004572 NM_001163687, NM_025972, BC004572 NM_001163687, NM_025972, BC004572	67111	24	cytoplasm lysosome lysosome lipid metabolic process fatty acid metabolic process sphingosine metabolic process transcription factor binding membrane lipid catabolic process hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds N-acylsphingosine amidohydrolase activity fatty acid amide hydrolase activity extrinsic component of membrane N-(long-chain-acyl)ethanolamine deacylase activity N-acylethanolamine metabolic process N-acylphosphatidylethanolamine metabolic process
TC0600003606.mm.2	Klrb1b	killer cell lectin-like receptor subfamily B member 1B	6	-128813705, -128813705	NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389	80782	31	protein binding plasma membrane integral component of plasma membrane external side of plasma membrane membrane integral component of membrane carbohydrate binding signaling receptor activity identical protein binding negative regulation of natural killer cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity
TC1700001905.mm.2	H2-Aa	histocompatibility 2, class II antigen A, alpha	17	-34282743	NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925	14960	115	adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosome plasma membrane immune response external side of plasma membrane membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II response to interferon-gamma negative regulation of T cell proliferation peptide antigen binding MHC class II protein complex protein-containing complex binding positive regulation of T cell differentiation antigen processing and presentation of peptide antigen	04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416
TC1800000617.mm.2					NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated)			activation of MAPK activity prostaglandin biosynthetic process amyloid-beta binding positive regulation of protein phosphorylation positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway adaptive immune response T cell activation involved in immune response immune system process positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process cytokine receptor activity cytokine receptor activity cytokine receptor activity protein binding extracellular space nucleus cytoplasm cytoplasm lysosome endosome late endosome multivesicular body vacuole endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane plasma membrane integral component of plasma membrane intracellular protein transport intracellular protein transport defense response immune response cell population proliferation external side of plasma membrane cell surface cell surface positive regulation of gene expression membrane integral component of membrane immunoglobulin mediated immune response antigen processing and presentation antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II cytokine binding cytokine binding MHC class II protein complex binding negative regulation of cell migration positive regulation of B cell proliferation positive regulation of prostaglandin biosynthetic process positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-8 production protein-containing complex positive regulation of kinase activity positive regulation of kinase activity response to interferon-gamma response to interferon-gamma macrophage migration inhibitory factor signaling pathway macrophage migration inhibitory factor receptor complex macrophage migration inhibitory factor receptor complex NOS2-CD74 complex macrophage migration inhibitory factor binding macrophage migration inhibitory factor binding MHC class II protein binding MHC class II protein binding CD4 receptor binding MHC class II protein complex MHC class II protein complex MHC class II protein binding, via antigen binding groove negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator protein folding chaperone positive thymic T cell selection negative thymic T cell selection positive regulation of innate immune response negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated negative regulation of viral entry into host cell positive regulation of viral entry into host cell positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation protein stabilization nitric-oxide synthase binding chaperone cofactor-dependent protein refolding chaperone cofactor-dependent protein refolding positive regulation of macrophage cytokine production positive regulation of macrophage cytokine production protein-containing complex assembly protein trimerization positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of macrophage migration inhibitory factor signaling pathway
TC0200005290.mm.2	Zbp1	Z-DNA binding protein 1	2	-173206611, -173213735	NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033	58203	62	activation of innate immune response immune system process DNA binding DNA binding DNA binding left-handed Z-DNA binding RNA binding double-stranded RNA binding protein binding nucleus nucleus nucleus cytoplasm cytoplasm cytosol cytosol apoptotic process programmed cell death viral process identical protein binding positive regulation of apoptotic process positive regulation of apoptotic process innate immune response regulation of inflammatory response positive regulation of inflammatory response defense response to virus defense response to virus defense response to virus positive regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway positive regulation of necroptotic process positive regulation of necroptotic process positive regulation of necroptotic process pyroptosis regulation of interleukin-1-mediated signaling pathway	04623
TC0500001240.mm.2	Oasl1	2'-5' oligoadenylate synthetase-like 1	5	114923239	NM_145209, BC032152 NM_145209, BC032152	231655	23	immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytosol cytosol immune response response to virus membrane transferase activity negative regulation of viral genome replication negative regulation of viral genome replication innate immune response defense response to virus defense response to virus regulation of ribonuclease activity
mouse-RPTR-AJ510163-1_st
TC0600003537.mm.2	Clec9a	C-type lectin domain family 9, member a	6	129408861	NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955	232414	47	positive regulation of cytokine production receptor-mediated endocytosis receptor-mediated endocytosis receptor-mediated endocytosis cell surface cell surface cell surface membrane integral component of membrane carbohydrate binding
TC1600000116.mm.2	Ciita	class II transactivator	16	10480071, 10489780, 10488177	NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699	12265	178	negative regulation of transcription by RNA polymerase II nucleotide binding transcription regulatory region sequence-specific DNA binding ATP binding GTP binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated inflammatory response protein C-terminus binding cell surface kinase activity phosphorylation PML body transferase activity transferase activity, transferring acyl groups activating transcription factor binding activating transcription factor binding response to interferon-gamma response to interferon-gamma protein-containing complex binding positive regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of viral entry into host cell response to antibiotic	04612 05145 05340
TC0200005438.mm.2	Helz2	helicase with zinc finger 2, transcriptional coactivator	2	-181227614	NM_183162	229003	19	nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay DNA binding RNA binding RNA helicase activity helicase activity ribonuclease activity ATP binding nucleus nucleoplasm cytoplasm hydrolase activity nuclear receptor coactivator activity positive regulation of transcription by RNA polymerase II metal ion binding
TC1800001396.mm.2	Gm4841	predicted gene 4841	18	-60268300	NM_001034859, BC150900 NM_001034859, BC150900	225594	9	GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta
TC0600002425.mm.2	Il23r	interleukin 23 receptor	6	-67422931	NM_144548, BC112425 NM_144548, BC112425	209590	93	positive regulation of defense response to virus by host immune system process leukocyte mediated immunity positive regulation of T-helper 1 type immune response cytokine receptor activity interleukin-12 receptor binding interleukin-12 receptor binding plasma membrane plasma membrane integral component of plasma membrane inflammatory response receptor signaling pathway via JAK-STAT external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine binding response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of interferon-gamma production positive regulation of interleukin-12 production response to interferon-gamma interleukin-23 binding interleukin-23 binding interleukin-23 receptor activity receptor complex receptor complex innate immune response interleukin-23 receptor complex interleukin-23 receptor complex	04060 04630
TC1500001727.mm.2	Ly6i	lymphocyte antigen 6 complex, locus I	15	-74979533	NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087	57248	13	plasma membrane plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway
TC1100002641.mm.2	Irgm1	immunity-related GTPase family M member 1	11	-48865244	NM_008326, BC145957 NM_008326, BC145957	15944	77	autophagosome assembly nucleotide binding immune system process GTPase activity GTP binding lysosome endosome late endosome autophagosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane autophagy defense response defense response response to bacterium membrane hydrolase activity cytoplasmic vesicle cellular response to interferon-beta cell projection autolysosome innate immune response phagocytic vesicle positive regulation of interferon-gamma-mediated signaling pathway cellular response to interferon-gamma positive regulation by symbiont of host autophagy positive regulation of autophagosome maturation
mouse-RPTR-U57609-2_st
TC1700002782.mm.2	H2-Eb1	histocompatibility 2, class II antigen E beta	17	34305866	NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638	14969	80	adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosomal membrane immune response membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II late endosome membrane response to interferon-gamma MHC class II protein complex	04145 04514 04612 04640 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416
TC1700000618.mm.2	H2-DMa	histocompatibility 2, class II, locus DMa	17	34122831, 34125517	NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992	14998	91	adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of germinal center formation positive regulation of humoral immune response protein binding intracellular anatomical structure lysosome lysosomal membrane lysosomal membrane endosome late endosome multivesicular body immune response cell surface endosome membrane protein transport membrane integral component of membrane immunoglobulin mediated immune response antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle positive thymic T cell selection positive regulation of T cell differentiation inner ear development positive regulation of immune response chaperone cofactor-dependent protein refolding chaperone cofactor-dependent protein refolding protein-containing complex assembly	04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416
TC1300000157.mm.2	Aoah	acyloxyacyl hydrolase	13	20794112, 20794112	NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767	27052	35	calcium ion binding calcium ion binding calcium ion binding extracellular region lipid metabolic process fatty acid metabolic process lipopolysaccharide metabolic process lipopolysaccharide catabolic process lipopolysaccharide catabolic process hydrolase activity hydrolase activity, acting on ester bonds cytoplasmic vesicle intracellular membrane-bounded organelle metal ion binding acyloxyacyl hydrolase activity acyloxyacyl hydrolase activity acyloxyacyl hydrolase activity negative regulation of inflammatory response negative regulation of inflammatory response
TC0600001369.mm.2	Usp18	ubiquitin specific peptidase 18	6	121245905	NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577	24110	69	cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleus cytosol cytosol ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity response to bacterium protein deubiquitination hydrolase activity ISG15-specific protease activity response to stilbenoid intracellular membrane-bounded organelle regulation of inflammatory response
TC0600003329.mm.2	Plbd1	phospholipase B domain containing 1	6	-136612070	NM_025806, BC019793 NM_025806, BC019793	66857	16	phospholipase activity extracellular region extracellular space lysosome lipid metabolic process phospholipid catabolic process lipid catabolic process hydrolase activity
rat-RPTR-U57609-2_st
TC1600001580.mm.2	Cd86	CD86 antigen	16	-36603868	NM_019388, BC013807, CD86 NM_019388, BC013807, CD86 NM_019388, BC013807, CD86	12524	335	toll-like receptor signaling pathway adaptive immune response immune system process immunoglobulin production negative regulation of T cell anergy signaling receptor binding protein binding plasma membrane immune response cell surface receptor signaling pathway activation of phospholipase C activity external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane CD40 signaling pathway T cell costimulation toll-like receptor 3 signaling pathway centriolar satellite positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation B cell activation negative regulation of T cell proliferation intracellular membrane-bounded organelle defense response to virus extracellular exosome cellular response to lipopolysaccharide cellular response to lipopolysaccharide positive regulation of NIK/NF-kappaB signaling activation of protein kinase C activity	04514 04620 04672 04940 05320 05322 05323 05330 05332 05416
TC1300000498.mm.2	Cd83	CD83 antigen	13	43785111	NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83	12522	58	external side of plasma membrane response to organic cyclic compound membrane integral component of membrane negative regulation of interleukin-4 production positive regulation of interleukin-10 production positive regulation of interleukin-2 production positive regulation of CD4-positive, alpha-beta T cell differentiation
TC0900000184.mm.2	Icam1	intercellular adhesion molecule 1	9	21015939	NM_010493, BC008626 NM_010493, BC008626	15894	567	immunological synapse T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation integrin binding integrin binding extracellular space plasma membrane integral component of plasma membrane cell adhesion cell adhesion cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion sensory perception of sound regulation of cell shape external side of plasma membrane cell surface membrane integral component of membrane positive regulation of actin filament polymerization cell adhesion mediated by integrin positive regulation of GTPase activity adhesion of symbiont to host protein-containing complex binding membrane raft positive regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity negative regulation of calcium ion transport establishment of endothelial barrier extracellular exosome positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus T cell extravasation establishment of endothelial intestinal barrier establishment of Sertoli cell barrier cell-cell adhesion regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cellular response to amyloid-beta positive regulation of leukocyte adhesion to vascular endothelial cell cellular response to leukemia inhibitory factor negative regulation of endothelial cell apoptotic process	04514 04650 04670 05143 05144 05150 05323 05416
TSUnmapped00000047.mm.2	Cd83	CD83 antigen	13	43785111	NM_001289915	12522	58	external side of plasma membrane response to organic cyclic compound membrane integral component of membrane negative regulation of interleukin-4 production positive regulation of interleukin-10 production positive regulation of interleukin-2 production positive regulation of CD4-positive, alpha-beta T cell differentiation
TC1100003396.mm.2	Ccl5	chemokine (C-C motif) ligand 5	11	-83525778	NM_013653, BC033508 NM_013653, BC033508	20304	216	MAPK cascade positive regulation of defense response to virus by host monocyte chemotaxis phosphatidylinositol phospholipase C activity protein kinase activity cytokine activity protein binding extracellular region extracellular space extracellular space extracellular space cytoplasm calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response inflammatory response inflammatory response immune response leukocyte cell-cell adhesion G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling chemokine activity chemokine activity heparin binding response to toxic substance positive regulation of gene expression positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis positive regulation of T cell chemotaxis positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration phospholipase activator activity receptor signaling protein tyrosine kinase activator activity positive regulation of cell migration neutrophil chemotaxis pseudopodium assembly positive regulation of cellular biosynthetic process activation of phospholipase D activity positive regulation of fever generation lipopolysaccharide-mediated signaling pathway CCR1 chemokine receptor binding CCR1 chemokine receptor binding CCR5 chemokine receptor binding positive regulation of cell-cell adhesion mediated by integrin response to cytokine positive regulation of homotypic cell-cell adhesion response to interferon-gamma response to tumor necrosis factor T-helper 1 cell diapedesis chemoattractant activity positive regulation of T cell proliferation neutrophil activation positive regulation of phosphorylation chemokine receptor binding positive regulation of tyrosine phosphorylation of STAT protein identical protein binding protein homodimerization activity protein kinase B signaling positive regulation of GTPase activity protein self-association negative regulation by host of viral transcription negative regulation of viral genome replication positive regulation of neuron differentiation positive regulation of osteoclast differentiation negative regulation of G protein-coupled receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion chemokine receptor antagonist activity CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis lymphocyte chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation regulation of insulin secretion regulation of T cell activation positive regulation of calcium ion transport negative regulation of cell death positive regulation of mast cell chemotaxis chemokine-mediated signaling pathway chemokine-mediated signaling pathway negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of monocyte chemotaxis positive regulation of monocyte chemotaxis regulation of neuron death negative regulation of neuron death negative regulation of macrophage apoptotic process positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of T cell migration positive regulation of natural killer cell chemotaxis	04060 04062 04620 04621 04623 05020 05142 05323
TC1400000745.mm.2	Mmp14	matrix metallopeptidase 14 (membrane-inserted)	14	54431597	NM_008608, BC076638 NM_008608, BC076638	17387	211	skeletal system development ossification endochondral ossification endopeptidase activity metalloendopeptidase activity metalloendopeptidase activity metalloendopeptidase activity integrin binding extracellular space nucleus cytoplasm cytosol plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding response to hormone positive regulation of myotube differentiation positive regulation of protein processing membrane integral component of membrane cell migration hydrolase activity extracellular matrix organization positive regulation of cell growth lung development positive regulation of cell migration collagen catabolic process collagen catabolic process extracellular matrix cytoplasmic vesicle zymogen activation zymogen activation zymogen activation chondrocyte proliferation macropinosome intermediate filament cytoskeleton positive regulation of B cell differentiation negative regulation of Notch signaling pathway metal ion binding embryonic cranial skeleton morphogenesis branching morphogenesis of an epithelial tube tissue remodeling negative regulation of focal adhesion assembly head development bone development metalloaminopeptidase activity craniofacial suture morphogenesis regulation of protein localization to plasma membrane positive regulation of macrophage migration	04912
TC1900001123.mm.2	AW112010	expressed sequence AW112010	19	-11047611	NR_102366, NM_001177351 NR_102366, NM_001177351	107350	10	molecular_function cellular_component biological_process
TC0300002051.mm.2					NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558			G protein-coupled receptor activity plasma membrane immune response signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity hematopoietic stem cell homeostasis
TC1900000504.mm.2	Ifit1	interferon-induced protein with tetratricopeptide repeats 1	19	34640888	NM_008331, BC003768 NM_008331, BC003768	15957	59	immune system process RNA binding protein binding cytoplasm cytosol response to virus response to bacterium cellular response to interferon-alpha cellular response to interferon-beta innate immune response defense response to virus	05160
TC0300000096.mm.2	Car2	carbonic anhydrase 2	3	14886268, 14886287	NM_009801, BC055291 NM_009801, BC055291	12349	152	morphogenesis of an epithelium arylesterase activity carbonate dehydratase activity carbonate dehydratase activity carbonate dehydratase activity carbonate dehydratase activity extracellular space cytoplasm cytoplasm cytosol plasma membrane plasma membrane microvillus one-carbon metabolic process regulation of pH zinc ion binding carbon dioxide transport carbon dioxide transport carbon dioxide transport membrane basolateral plasma membrane lyase activity hydro-lyase activity axon positive regulation of synaptic transmission, GABAergic positive regulation of cellular pH reduction positive regulation of cellular pH reduction angiotensin-activated signaling pathway myelin sheath myelin sheath regulation of anion transport apical part of cell apical part of cell positive regulation of osteoclast differentiation positive regulation of bone resorption metal ion binding secretion regulation of intracellular pH regulation of intracellular pH positive regulation of dipeptide transmembrane transport regulation of chloride transport	00910 04966 04971 04972 04976
TC0900003250.mm.2	Csrnp1	cysteine-serine-rich nuclear protein 1	9	-119971162, -119971162, -119971162, -119971162	NM_153287, BC050066 NM_153287, BC050066	215418	24	DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process post-embryonic development sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis roof of mouth development face morphogenesis
TC0X00002999.mm.2	Armcx6	armadillo repeat containing, X-linked 6	X	-134748454	NM_001007578, BC027264 NM_001007578, BC027264	278097	14	molecular_function mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane
TC0700002644.mm.2	Axl	AXL receptor tyrosine kinase	7	-25756499	NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230	26362	152	nucleotide binding virus receptor activity neuron migration neuron migration natural killer cell differentiation natural killer cell differentiation phosphatidylserine binding negative regulation of cytokine production positive regulation of cytokine-mediated signaling pathway blood vessel remodeling immune system process protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding ATP binding extracellular space plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis phagocytosis phagocytosis inflammatory response enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development spermatogenesis nervous system development cell surface actin cytoskeleton membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity forebrain cell migration cell differentiation platelet activation platelet activation cellular response to extracellular stimulus myosin heavy chain binding negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of natural killer cell differentiation secretion by cell positive regulation of kinase activity erythrocyte homeostasis erythrocyte homeostasis substrate adhesion-dependent cell spreading cellular response to interferon-alpha ovulation cycle negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle receptor complex apoptotic cell clearance apoptotic cell clearance protein kinase B signaling protein kinase B signaling negative regulation of neuron apoptotic process negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding innate immune response viral entry into host cell positive regulation of pinocytosis negative regulation of lymphocyte activation positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling vagina development cellular response to hydrogen peroxide cellular response to lipopolysaccharide neutrophil clearance positive regulation of viral life cycle negative regulation of dendritic cell apoptotic process
TC0400001047.mm.2	Pde4b	phosphodiesterase 4B, cAMP specific	4	102589842, 102254938, 102254741, 102570059, 102587557, 102421554	NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259	18578	65	gamma-tubulin complex neutrophil homeostasis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleus nucleus cytoplasm centrosome cytosol cytosol cytosol voltage-gated calcium channel complex signal transduction synaptic vesicle response to heat postsynaptic density membrane Z disc cAMP binding neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of interleukin-2 production cellular response to drug gamma-tubulin binding dendritic spine ion channel binding ion channel binding perinuclear region of cytoplasm perinuclear region of cytoplasm T cell receptor signaling pathway leukocyte migration excitatory synapse cellular response to lipopolysaccharide cellular response to epinephrine stimulus cell periphery regulation of cardiac muscle cell contraction negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process regulation of high voltage-gated calcium channel activity negative regulation of relaxation of cardiac muscle	00230
TC1600001198.mm.2	Socs1	suppressor of cytokine signaling 1	16	-10783808	NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368	12703	310	regulation of cytokine production regulation of protein phosphorylation insulin-like growth factor receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol phosphatidylinositol 3-kinase complex receptor signaling pathway via JAK-STAT negative regulation of signal transduction regulation of activation of Janus kinase activity kinase inhibitor activity cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein kinase binding cytoplasmic vesicle intracellular signal transduction cytoplasmic ribonucleoprotein granule regulation of growth regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein positive regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation fat cell differentiation positive regulation of regulatory T cell differentiation regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity regulation of interferon-gamma-mediated signaling pathway cellular response to amino acid stimulus cellular response to cytokine stimulus cellular response to organic cyclic compound	04120 04380 04630 04910 04930 05145
TC1900000441.mm.2	Cd274	CD274 antigen	19	29367437	NM_021893, BC066841, CD274 NM_021893, BC066841, CD274 NM_021893, BC066841, CD274	60533	389	adaptive immune response immune system process positive regulation of tolerance induction to tumor cell protein binding nucleoplasm endosome plasma membrane immune response immune response signal transduction cell surface receptor signaling pathway cell surface receptor signaling pathway external side of plasma membrane external side of plasma membrane cell surface actin cytoskeleton membrane integral component of membrane positive regulation of cell migration T cell costimulation T cell costimulation early endosome membrane negative regulation of interferon-gamma production negative regulation of interleukin-10 production positive regulation of interleukin-10 production response to cytokine positive regulation of T cell proliferation positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of activated T cell proliferation recycling endosome membrane extracellular exosome cellular response to lipopolysaccharide toxin transport negative regulation of tumor necrosis factor superfamily cytokine production positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD8-positive, alpha-beta T cell activation	04514
TC1700000864.mm.2	Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon	17	45555699	NM_008690, BC030923 NM_008690, BC030923	18037	38	fibrillar center protein binding nucleoplasm cytoplasm Golgi apparatus cytosol D-serine transport negative regulation of transcription, DNA-templated perinuclear region of cytoplasm	04660 04662 04722 04920
TC1400000574.mm.2	Pnp	purine-nucleoside phosphorylase	14	50944302	NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679	18950	86	nucleoside binding positive regulation of T cell mediated cytotoxicity purine nucleobase binding catalytic activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity extracellular region nucleus cytoplasm cytoplasm cytosol cytosol cytoskeleton nucleobase-containing compound metabolic process inosine catabolic process inosine catabolic process inosine catabolic process deoxyinosine catabolic process adenosine catabolic process adenosine catabolic process deoxyguanosine catabolic process GTP biosynthetic process AMP catabolic process AMP catabolic process IMP catabolic process IMP catabolic process intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes nucleoside metabolic process response to gamma radiation transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups urate biosynthetic process urate biosynthetic process positive regulation of T cell proliferation positive regulation of T cell proliferation purine nucleoside metabolic process purine nucleoside metabolic process purine nucleoside metabolic process phosphate ion binding identical protein binding positive regulation of B cell differentiation positive regulation of DNA repair GMP catabolic process GMP catabolic process dGMP catabolic process dGMP catabolic process dAMP catabolic process dAMP catabolic process dGTP metabolic process guanosine catabolic process positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell differentiation negative regulation of T cell apoptotic process	00230 00240 00760 01100
TC0100003589.mm.2					XM_136331
TC1900000502.mm.2	Ifit3b	interferon-induced protein with tetratricopeptide repeats 3B	19	34607956	NM_001005858	667370	10	RNA binding cytoplasm mitochondrion cytosol cytosol identical protein binding defense response to virus
TC0400002737.mm.2	Lpar1	lysophosphatidic acid receptor 1	4	-58435251, -58435251, -58435251	NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425	14745	150	activation of MAPK activity G-protein alpha-subunit binding G protein-coupled receptor activity protein binding phospholipid binding cytoplasm cytoplasm endosome plasma membrane plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activation of phospholipase C activity activation of phospholipase C activity regulation of cell shape regulation of cell shape cell surface positive regulation of cell death negative regulation of neuron projection development negative regulation of neuron projection development negative regulation of neuron projection development membrane integral component of membrane regulation of metabolic process neurogenesis endocytic vesicle PDZ domain binding bleb assembly positive regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction lysophosphatidic acid binding neuron projection neuronal cell body positive regulation of apoptotic process dendritic spine dendritic shaft positive regulation of MAPK cascade negative regulation of cAMP-mediated signaling positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of stress fiber assembly cell chemotaxis positive regulation of dendritic spine development lysophosphatidic acid receptor activity lysophosphatidic acid receptor activity lysophosphatidic acid receptor activity positive regulation of smooth muscle cell chemotaxis cellular response to 1-oleoyl-sn-glycerol 3-phosphate	04080 04540
TC0700004288.mm.2	Nupr1	nuclear protein transcription regulator 1	7	-126623245	NM_019738, BC002109 NM_019738, BC002109	56312	64	acute inflammatory response DNA binding chromatin binding transcription coactivator activity protein binding nucleus nucleus nucleoplasm cytoplasm protein acetylation negative regulation of cell population proliferation male gonad development response to toxic substance negative regulation of autophagy negative regulation of autophagy negative regulation of cardiac muscle cell apoptotic process acetyltransferase activator activity positive regulation of protein modification process protein-DNA complex skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity intercellular bridge negative regulation of cell cycle negative regulation of cell cycle negative regulation of cell cycle positive regulation of cell cycle negative regulation of glycolytic process negative regulation of fibroblast proliferation perinuclear region of cytoplasm negative regulation of epithelial cell proliferation negative regulation of programmed necrotic cell death protein-containing complex assembly positive regulation of neuroinflammatory response positive regulation of proteasomal protein catabolic process negative regulation of autophagosome assembly positive regulation of oxidative phosphorylation negative regulation of epithelial cell apoptotic process negative regulation of type B pancreatic cell proliferation regulation of response to endoplasmic reticulum stress regulation of female gonad development positive regulation of intrinsic apoptotic signaling pathway
TC1700001902.mm.2	Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	17	-34182098	NM_013585, BC116364 NM_013585, BC116364	16912	91	proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol cytosol proteasome core complex proteasome core complex proteolysis peptidase activity response to bacterium proteasomal ubiquitin-independent protein catabolic process hydrolase activity antigen processing and presentation antigen processing and presentation proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process proteasome binding spermatoproteasome complex regulation of cysteine-type endopeptidase activity	03050
TC1400000071.mm.2	Flnb	filamin, beta	14	7817956	NM_134080	286940	65	stress fiber keratinocyte development epithelial cell morphogenesis actin binding protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane brush border focal adhesion skeletal muscle tissue development actin cytoskeleton organization cell differentiation identical protein binding neuron projection neuronal cell body phagocytic vesicle cellular response to interferon-gamma	04010 04510
TC0200000486.mm.2	Ralgds	ral guanine nucleotide dissociation stimulator	2	28533463, 28513166	NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225	19730	32	guanyl-nucleotide exchange factor activity protein binding intracellular anatomical structure nucleus cytoplasm cytosol brush border signal transduction small GTPase mediated signal transduction GTPase regulator activity	05200 05210 05212
TC1900000501.mm.2	Ifit3	interferon-induced protein with tetratricopeptide repeats 3	19	34583528	NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563	15959	31	immune system process RNA binding protein binding cytoplasm mitochondrion cytosol cytosol response to bacterium cellular response to interferon-alpha cellular response to interferon-beta response to stilbenoid identical protein binding innate immune response defense response to virus
TC0400004171.mm.2	Isg15	ISG15 ubiquitin-like modifier	4	-156199423	NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346	100038882	94	integrin binding protein binding extracellular region nucleus cytoplasm integrin-mediated signaling pathway response to bacterium modification-dependent protein catabolic process modification-dependent protein catabolic process cytosolic small ribosomal subunit positive regulation of bone mineralization protein tag protein tag negative regulation of protein ubiquitination ubiquitin protein ligase binding ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation interferon-gamma production interleukin-10 production regulation of interferon-gamma production response to type I interferon defense response to bacterium defense response to bacterium negative regulation of viral genome replication positive regulation of erythrocyte differentiation defense response to virus defense response to virus	04622
TC0300001109.mm.2	Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	3	107036161	NM_008418, BC132349, BC137667 NM_008418, BC132349, BC137667 NM_008418, BC132349, BC137667	16491	82	ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex outward rectifier potassium channel activity membrane integral component of membrane axon axon regulation of ion transmembrane transport calyx of Held membrane raft protein homooligomerization transmembrane transport potassium ion transmembrane transport potassium ion transmembrane transport glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane
TC1100001236.mm.2	Slfn5	schlafen 5	11	82952101	NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910	327978	19	nucleotide binding ATP binding nucleus cell differentiation
TC0500000466.mm.2	Bst1	bone marrow stromal cell antigen 1	5	43818892	NM_009763	12182	37	uropod regulation of cell-matrix adhesion NAD+ nucleosidase activity plasma membrane positive regulation of cell population proliferation membrane transferase activity hydrolase activity phosphorus-oxygen lyase activity extrinsic component of membrane positive regulation of B cell proliferation anchored component of membrane regulation of actin cytoskeleton organization NAD(P)+ nucleosidase activity regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling NAD+ nucleotidase, cyclic ADP-ribose generating ADP-ribosyl cyclase activity cyclic ADP-ribose hydrolase regulation of neutrophil chemotaxis	00760 01100 04020 04970 04972
TC1100004150.mm.2	Socs3	suppressor of cytokine signaling 3	11	-117966086	NM_007707, BC052031 NM_007707, BC052031	12702	427	phosphotyrosine residue binding regulation of protein phosphorylation protein binding cytoplasm cytosol phosphatidylinositol 3-kinase complex signal transduction receptor signaling pathway via JAK-STAT negative regulation of signal transduction intracellular signal transduction regulation of growth negative regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process regulation of cell differentiation regulation of cell differentiation positive regulation of cell differentiation positive regulation of cell differentiation negative regulation of receptor signaling pathway via JAK-STAT negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity negative regulation of inflammatory response branching involved in labyrinthine layer morphogenesis placenta blood vessel development trophoblast giant cell differentiation trophoblast giant cell differentiation spongiotrophoblast differentiation spongiotrophoblast differentiation cellular response to leukemia inhibitory factor	04120 04380 04630 04910 04920 04930 05160
TC1600001092.mm.2	Mx2	MX dynamin-like GTPase 2	16	97536080, 97536082	NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127	17858	25	mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission GTPase activity nucleus cytoplasm plasma membrane microtubule binding postsynaptic density microtubule cytoskeleton membrane synaptic vesicle budding from presynaptic endocytic zone membrane axon cytoplasmic vesicle receptor internalization mitochondrial membrane dendritic spine head regulation of synapse structure or activity membrane fusion postsynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization
TC1900000500.mm.2	Ifit2	interferon-induced protein with tetratricopeptide repeats 2	19	34551087, 34550693	NM_008332, BC050835 NM_008332, BC050835	15958	39	immune system process RNA binding cytoplasm endoplasmic reticulum cytosol apoptotic process response to virus response to virus negative regulation of protein binding cellular response to interferon-alpha positive regulation of apoptotic process innate immune response defense response to virus
TC0300002802.mm.2	Vcam1	vascular cell adhesion molecule 1	3	-116110019	NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823	22329	334	podosome integrin binding integrin binding extracellular space early endosome endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane microvillus cell adhesion cell adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion heart development primary amine oxidase activity amine metabolic process external side of plasma membrane cell surface membrane integral component of membrane viral process filopodium anchored component of membrane heterotypic cell-cell adhesion calcium-mediated signaling using intracellular calcium source positive regulation of T cell proliferation sarcolemma apical part of cell cell adhesion molecule binding leukocyte tethering or rolling cell chemotaxis innervation embryonic placenta morphogenesis chorio-allantoic fusion cardiac neuron differentiation visceral serous pericardium development alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex cellular response to glucose stimulus cell periphery cell-cell adhesion cell-cell adhesion in response to extracellular stimulus cellular response to amyloid-beta	04514 04670 05143 05144
TC0900001339.mm.2	Tlr9	toll-like receptor 9	9	106222597	NM_031178, BC172644 NM_031178, BC172644	81897	855	microglial cell activation regulation of cytokine production positive regulation of cytokine production regulation of protein phosphorylation activation of innate immune response toll-like receptor signaling pathway toll-like receptor signaling pathway response to molecule of bacterial origin immune system process positive regulation of immunoglobulin production regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity interleukin-1 receptor binding protein binding cytoplasm lysosome endosome endoplasmic reticulum plasma membrane plasma membrane plasma membrane plasma membrane inflammatory response immune response immune response signal transduction I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation response to virus positive regulation of autophagy positive regulation of gene expression membrane integral component of membrane basolateral plasma membrane apical plasma membrane maintenance of gastrointestinal epithelium positive regulation of B cell proliferation cytoplasmic vesicle early phagosome negative regulation of NF-kappaB transcription factor activity tumor necrosis factor production tumor necrosis factor production negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 9 signaling pathway siRNA binding endolysosome endolysosome endolysosome pattern recognition receptor activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of JUN kinase activity innate immune response unmethylated CpG binding phagocytic vesicle regulation of B cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus defense response to virus positive regulation of nitric-oxide synthase biosynthetic process positive regulation of NIK/NF-kappaB signaling negative regulation of ATPase-coupled calcium transmembrane transporter activity cellular response to chloroquine	04620 05142 05143 05144
TC1900000105.mm.2	Majin	membrane anchored junction protein	19	6184344	NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092	622554	13	chromosome, telomeric region molecular_function DNA binding nucleus integral component of nuclear inner membrane integral component of nuclear inner membrane chromosome homologous chromosome pairing at meiosis homologous chromosome pairing at meiosis membrane integral component of membrane meiotic telomere clustering meiotic cell cycle meiotic attachment of telomere to nuclear envelope meiotic attachment of telomere to nuclear envelope
TC0900003125.mm.2	Ccrl2	chemokine (C-C motif) receptor-like 2	9	-111054833, -111054833, -111054833	NM_017466, BC038631 NM_017466, BC038631	54199	35	G protein-coupled receptor activity chemokine receptor activity cytoplasm plasma membrane integral component of plasma membrane chemotaxis inflammatory response inflammatory response immune response signal transduction G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity C-C chemokine receptor activity calcium-mediated signaling C-C chemokine binding chemokine receptor binding chemokine receptor binding CCR chemokine receptor binding cell chemotaxis
TC1800001181.mm.2	Sting1	stimulator of interferon response cGAMP interactor 1	18	-35733677	NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640	72512	348	autophagosome assembly autophagosome assembly autophagosome assembly nucleotide binding activation of innate immune response activation of innate immune response activation of innate immune response positive regulation of defense response to virus by host immune system process protein binding nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane endosome autophagosome autophagosome autophagosome peroxisome endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane autophagy transcription factor binding regulation of gene expression membrane integral component of membrane positive regulation of macroautophagy positive regulation of macroautophagy positive regulation of macroautophagy protein kinase binding integral component of endoplasmic reticulum membrane regulation of cellular metabolic process cytoplasmic vesicle ubiquitin protein ligase binding positive regulation of protein binding positive regulation of type I interferon production positive regulation of type I interferon production positive regulation of type I interferon production interferon-beta production interferon-beta production cyclic-di-GMP binding cyclic-di-GMP binding cyclic-di-GMP binding cellular response to interferon-beta identical protein binding protein homodimerization activity innate immune response innate immune response innate immune response positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II perinuclear region of cytoplasm regulation of inflammatory response positive regulation of DNA-binding transcription factor activity protein complex oligomerization defense response to virus defense response to virus defense response to virus cyclic-GMP-AMP binding cyclic-GMP-AMP binding cyclic-GMP-AMP binding reticulophagy reticulophagy cellular response to exogenous dsRNA cellular response to organic cyclic compound cellular response to organic cyclic compound integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	04622 04623
TC0100001632.mm.2	Ifi209	interferon activated gene 209	1	173630858	NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379	236312	17	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta cellular response to interferon-beta identical protein binding
TC1100004265.mm.2	Igtp	interferon gamma induced GTPase	11	58199555	NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607	16145	50	GTPase activity GTPase activity endoplasmic reticulum membrane cytosol defense response cellular response to interferon-beta cellular response to interferon-beta	05145
TC0600002663.mm.2	Rab43	RAB43, member RAS oncogene family	6	-87788852, -87788852, -87788852, -87788852	NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248	69834	23	autophagosome assembly nucleotide binding GTPase activity GTPase activity GTP binding Golgi apparatus intracellular protein transport Golgi organization endomembrane system membrane virion assembly cytoplasmic vesicle retrograde transport, plasma membrane to Golgi phagocytic vesicle phagocytic vesicle cellular response to interferon-gamma phagosome maturation toxin transport
TC0600002641.mm.2	Mxd1	MAX dimerization protein 1	6	-86647044	NM_010751, BC034860 NM_010751, BC034860	17119	48	negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding protein binding nucleus nucleoplasm mitochondrion cytosol regulation of transcription by RNA polymerase II protein dimerization activity
TC0300001110.mm.2	AI504432	expressed sequence AI504432	3	107039503	NR_033498	229694	11
TC1700002780.mm.2	H2-DMb1	histocompatibility 2, class II, locus Mb1	17	34153190	NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718	14999	23	adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II lysosome lysosomal membrane endosome immune response membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle chaperone cofactor-dependent protein refolding	04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416
TC1100000119.mm.2	Upp1	uridine phosphorylase 1	11	9118007, 9118102, 9118506	NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559	22271	43	catalytic activity uridine phosphorylase activity uridine phosphorylase activity nucleoplasm cytoplasm cytosol uridine catabolic process uridine catabolic process pyrimidine nucleotide metabolic process CMP catabolic process dCMP catabolic process dCMP catabolic process thymidine phosphorylase activity nucleoside metabolic process nucleotide catabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups identical protein binding UMP catabolic process dTMP catabolic process dUMP catabolic process uridine metabolic process deoxyuridine phosphorylase activity	00240 00983 01100
TC1600001556.mm.2	Parp14	poly (ADP-ribose) polymerase family, member 14	16	-35832877	NM_001039530, BC138874 NM_001039530, BC138874	547253	32	immune system process transcription corepressor activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity protein binding nucleus cytoplasm cytoplasm cytoplasm cytosol plasma membrane protein ADP-ribosylation negative regulation of gene expression negative regulation of gene expression transferase activity transferase activity, transferring glycosyl groups enzyme binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein innate immune response negative regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway protein poly-ADP-ribosylation protein poly-ADP-ribosylation NAD+ binding protein mono-ADP-ribosylation protein mono-ADP-ribosylation positive regulation of interleukin-4-mediated signaling pathway positive regulation of interleukin-4-mediated signaling pathway protein ADP-ribosylase activity protein ADP-ribosylase activity
TC0200003689.mm.2	Stk39	serine/threonine kinase 39	2	-68210446	NM_016866, BC051964, BC064443 NM_016866, BC051964, BC064443 NM_016866, BC051964, BC064443	53416	90	nucleotide binding activation of MAPK activity activation of MAPK activity negative regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol cytosol cytoskeleton protein phosphorylation protein phosphorylation signal transduction regulation of blood pressure positive regulation of T cell chemotaxis membrane kinase activity kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation extrinsic component of membrane protein kinase binding positive regulation of ion transmembrane transporter activity intracellular signal transduction intracellular signal transduction maintenance of lens transparency chemokine (C-X-C motif) ligand 12 signaling pathway intracellular membrane-bounded organelle positive regulation of potassium ion transport protein autophosphorylation protein autophosphorylation protein autophosphorylation regulation of inflammatory response ion homeostasis cellular hypotonic response negative regulation of pancreatic juice secretion negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport negative regulation of creatine transmembrane transporter activity cellular response to chemokine negative regulation of sodium ion transmembrane transporter activity
TC0500002840.mm.2	Plac8	placenta-specific 8	5	-100553725, -100553725	NM_139198, BC010789 NM_139198, BC010789	231507	35	chromatin binding protein binding nucleus positive regulation of cell population proliferation response to cold negative regulation of multicellular organism growth defense response to bacterium negative regulation of apoptotic process negative regulation of apoptotic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II brown fat cell differentiation positive regulation of cold-induced thermogenesis
TC0600002323.mm.2	Nod1	nucleotide-binding oligomerization domain containing 1	6	-54923941, -54923941	NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670	107607	170	nucleotide binding pattern recognition receptor signaling pathway immune system process positive regulation of dendritic cell antigen processing and presentation protein binding ATP binding cytoplasm cytosol plasma membrane apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response positive regulation of cell death membrane detection of bacterium basolateral plasma membrane positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade intracellular signal transduction intracellular signal transduction pattern recognition receptor activity defense response to bacterium identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein-containing complex binding innate immune response phagocytic vesicle positive regulation of JNK cascade anchored component of plasma membrane CARD domain binding defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade cellular response to muramyl dipeptide positive regulation of NIK/NF-kappaB signaling positive regulation of xenophagy	04621
TC0500003243.mm.2	Hcar2	hydroxycarboxylic acid receptor 2	5	-123863569	NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296	80885	66	purinergic nucleotide receptor activity neutrophil apoptotic process G protein-coupled receptor activity GTP binding plasma membrane apoptotic process signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway membrane integral component of membrane cell junction positive regulation of neutrophil apoptotic process negative regulation of lipid catabolic process positive regulation of adiponectin secretion nicotinic acid receptor activity
TC0800000482.mm.2	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	8	40862366	NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082	11988	62	L-ornithine transmembrane transporter activity L-ornithine transmembrane transporter activity nitric oxide production involved in inflammatory response high-affinity arginine transmembrane transporter activity high-affinity lysine transmembrane transporter activity plasma membrane plasma membrane nitric oxide biosynthetic process amino acid transport amino acid transmembrane transporter activity amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity arginine transmembrane transporter activity arginine transmembrane transporter activity arginine transmembrane transporter activity L-lysine transmembrane transporter activity L-lysine transmembrane transporter activity L-amino acid transport arginine transport membrane integral component of membrane transmembrane transporter activity cell junction macrophage activation regulation of macrophage activation regulation of inflammatory response transmembrane transport L-arginine transmembrane transporter activity L-arginine transmembrane transporter activity amino acid import across plasma membrane low-affinity L-arginine transmembrane transporter activity high-affinity L-ornithine transmembrane transporter activity L-arginine import across plasma membrane L-arginine import across plasma membrane L-arginine import across plasma membrane L-lysine import across plasma membrane L-ornithine import across plasma membrane L-arginine transport L-alpha-amino acid transmembrane transport L-ornithine transmembrane transport L-ornithine transmembrane transport
TC0600000459.mm.2	Zyx	zyxin	6	42349827, 42349827	NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775	22793	63	stress fiber stress fiber protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane adherens junction focal adhesion focal adhesion focal adhesion cell adhesion cell-matrix adhesion signal transduction transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway actin cytoskeleton cell junction stress fiber assembly phagocytic vesicle metal ion binding cellular response to interferon-gamma	04510
TC0300001232.mm.2	Cnn3	calponin 3, acidic	3	121426540	NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268	71994	43	actin binding protein binding calmodulin binding cytosol microtubule binding postsynaptic density actin cytoskeleton dendrite actomyosin structure organization negative regulation of ATPase activity neuronal cell body dendritic spine
TC0500000468.mm.2	Cd38	CD38 antigen	5	43868808	NM_007646, BC046312, CD38 NM_007646, BC046312, CD38 NM_007646, BC046312, CD38	12494	193	response to hypoxia NAD+ nucleosidase activity NAD+ nucleosidase activity nucleus plasma membrane plasma membrane positive regulation of cytosolic calcium ion concentration positive regulation of cell population proliferation response to hormone cell surface negative regulation of neuron projection development artery smooth muscle contraction membrane integral component of membrane basolateral plasma membrane transferase activity hydrolase activity hydrolase activity, acting on glycosyl bonds phosphorus-oxygen lyase activity phosphorus-oxygen lyase activity positive regulation of cell growth secretory granule membrane positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of insulin secretion response to hydroperoxide response to drug identical protein binding negative regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of bone resorption negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasoconstriction NAD(P)+ nucleosidase activity B cell receptor signaling pathway long-term synaptic depression NAD+ nucleotidase, cyclic ADP-ribose generating	00760 01100 04020 04640 04970 04972
TC0500003730.mm.2	Gbp9	guanylate-binding protein 9	5	-105076465	NM_172777, BC057170 NM_172777, BC057170	236573	13	GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma
TC0500000283.mm.2	Il6	interleukin 6	5	30013113	NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766	16193	2037	neutrophil apoptotic process neutrophil apoptotic process neutrophil apoptotic process myeloid cell homeostasis germinal center B cell differentiation immunoglobulin production hepatic immune response positive regulation of immunoglobulin production positive regulation of acute inflammatory response signaling receptor binding cytokine activity cytokine activity interleukin-6 receptor binding interleukin-6 receptor binding protein binding extracellular region extracellular space extracellular space cytoplasm interleukin-6 receptor complex interleukin-6 receptor complex negative regulation of protein kinase activity acute-phase response inflammatory response immune response growth factor activity positive regulation of cell population proliferation negative regulation of cell population proliferation regulation of cell shape response to wounding external side of plasma membrane gene expression vascular endothelial growth factor production regulation of vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of neuron projection development positive regulation of gliogenesis response to activity cytokine-mediated signaling pathway endocrine pancreas development neuron projection development interleukin-21 production negative regulation of chemokine production negative regulation of chemokine production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation cellular response to hepatocyte growth factor stimulus positive regulation of T cell proliferation T cell activation regulation of cell population proliferation positive regulation of protein import into nucleus positive regulation of tyrosine phosphorylation of STAT protein glucose homeostasis glucose homeostasis glucose homeostasis defense response to protozoan regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of nitric oxide biosynthetic process cell redox homeostasis positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of gluconeogenesis positive regulation of translation positive regulation of DNA replication negative regulation of bone resorption negative regulation of bone resorption negative regulation of membrane potential positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of receptor signaling pathway via JAK-STAT muscle cell cellular homeostasis negative regulation of hormone secretion negative regulation of muscle organ development positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of insulin secretion regulation of insulin secretion positive regulation of B cell activation positive regulation of DNA-binding transcription factor activity response to glucocorticoid defense response to virus positive regulation of protein kinase B signaling positive regulation of transmission of nerve impulse positive regulation of glial cell proliferation branching involved in salivary gland morphogenesis branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis T follicular helper cell differentiation glucagon secretion regulation of glucagon secretion regulation of glucagon secretion interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of cell proliferation in bone marrow T-helper 17 cell lineage commitment T-helper 17 cell lineage commitment hepatocyte proliferation positive regulation of extracellular matrix disassembly liver regeneration cellular response to virus positive regulation of cytokine production involved in inflammatory response negative regulation of neuron death positive regulation of apoptotic DNA fragmentation positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of T-helper 2 cell cytokine production negative regulation of primary miRNA processing negative regulation of interleukin-1-mediated signaling pathway	04060 04620 04621 04623 04630 04640 04672 05020 05142 05143 05144 05146 05200 05323 05332 05410
TC1700000684.mm.2	H2-Q4	histocompatibility 2, Q region locus 4	17	35379616	NM_001143689, BC010602 NM_001143689, BC010602	15015	32	positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site
TC1800000609.mm.2	F830016B08Rik	RIKEN cDNA F830016B08 gene	18	60293379	NM_001101475	240328	9	GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta
TC0500003176.mm.2	Oas3	2'-5' oligoadenylate synthetase 3	5	-120753097	NM_145226, BC141055 NM_145226, BC141055	246727	19	nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol plasma membrane immune response response to virus membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus defense response to virus regulation of ribonuclease activity regulation of ribonuclease activity	05160
TC0200000933.mm.2	Gca	grancalcin	2	62664326	NM_145523, BC021450 NM_145523, BC021450	227960	17	calcium ion binding cytoplasm cytosol cytosol plasma membrane membrane protein homodimerization activity metal ion binding protein heterodimerization activity
TC0100000039.mm.2	Adhfe1	alcohol dehydrogenase, iron containing, 1	1	9547947	NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584	76187	17	alcohol dehydrogenase (NAD+) activity mitochondrion mitochondrion glutamate catabolic process via 2-oxoglutarate oxidoreductase activity metal ion binding hydroxyacid-oxoacid transhydrogenase activity
TC0700002034.mm.2	Ifitm1	interferon induced transmembrane protein 1	7	140967428, 140968075, 140968027	NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972	68713	35	ossification somitogenesis immune system process molecular_function early endosome plasma membrane response to virus anterior/posterior pattern specification membrane integral component of membrane protein-containing complex response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response negative regulation of viral entry into host cell negative regulation of viral entry into host cell defense response to virus defense response to virus type I interferon signaling pathway	04662
TC1000002794.mm.2	Tmtc2	transmembrane and tetratricopeptide repeat containing 2	10	-105187663	NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363	278279	12	mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane transferase activity protein O-linked mannosylation calcium ion homeostasis
TC1700001952.mm.2	Aif1	allograft inflammatory factor 1	17	-35170985	NM_019467, BC021539 NM_019467, BC021539	11629	177	ruffle microglial cell activation phagocytic cup positive regulation of protein phosphorylation actin binding calcium ion binding calcium ion binding protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytoskeleton actin filament actin filament actin filament plasma membrane phagocytosis, engulfment positive regulation of cell population proliferation negative regulation of gene expression positive regulation of muscle hyperplasia membrane Rac protein signal transduction lamellipodium lamellipodium actin filament polymerization parallel actin filament bundle assembly positive regulation of cell migration ruffle membrane ruffle membrane ruffle membrane positive regulation of chemokine production positive regulation of interleukin-6 production cellular response to oxidative stress positive regulation of T cell proliferation cell projection negative regulation of apoptotic process perikaryon positive regulation of nitric oxide biosynthetic process metal ion binding perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation positive regulation of chemotaxis actin filament binding actin filament binding actin filament binding actin filament bundle assembly actin filament bundle assembly actin filament bundle assembly actin crosslink formation negative regulation of smooth muscle cell chemotaxis positive regulation of smooth muscle cell chemotaxis positive regulation of mononuclear cell migration positive regulation of monocyte chemotaxis positive regulation of fibroblast growth factor production ruffle assembly ruffle assembly ruffle assembly positive regulation of G1/S transition of mitotic cell cycle positive regulation of T cell migration
TC1700002823.mm.2	H2-T10	histocompatibility 2, T region locus 10	17	-36115875, -36115870	NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760	15024	23	positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding	04144 04145 04514 04612 04940 05320 05330 05332 05416
TC0600003084.mm.2	Clec4e	C-type lectin domain family 4, member e	6	-123281788	NM_019948, BC003218 NM_019948, BC003218	56619	84	positive regulation of cytokine production pattern recognition receptor signaling pathway T cell differentiation involved in immune response immune system process calcium ion binding protein binding immune response membrane integral component of membrane carbohydrate binding signaling receptor activity Fc-gamma receptor signaling pathway pattern recognition receptor activity defense response to bacterium innate immune response metal ion binding
TC0200004602.mm.2	Il1b	interleukin 1 beta	2	-129364577	NM_008361, BC011437 NM_008361, BC011437	16176	1139	negative regulation of transcription by RNA polymerase II MAPK cascade activation of MAPK activity fever generation positive regulation of protein phosphorylation cytokine activity cytokine activity interleukin-1 receptor binding integrin binding extracellular region extracellular space extracellular space extracellular space cytoplasm lysosome inflammatory response inflammatory response immune response positive regulation of cytosolic calcium ion concentration memory positive regulation of cell population proliferation negative regulation of cell population proliferation response to carbohydrate vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of glucose transmembrane transport positive regulation of cell death negative regulation of glutamate secretion cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein domain specific binding secretory granule hyaluronan biosynthetic process positive regulation of cell migration neutrophil chemotaxis sequestering of triglyceride positive regulation of prostaglandin biosynthetic process cytoplasmic vesicle positive regulation of fever generation lipopolysaccharide-mediated signaling pathway vesicle positive regulation of prostaglandin secretion response to lipopolysaccharide response to lipopolysaccharide response to lipopolysaccharide interleukin-1 beta production interleukin-6 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of stress-activated MAPK cascade positive regulation of immature T cell proliferation in thymus positive regulation of immature T cell proliferation in thymus response to ATP response to ATP positive regulation of heterotypic cell-cell adhesion social behavior ectopic germ cell programmed cell death positive regulation of myosin light chain kinase activity cellular response to drug positive regulation of T cell proliferation positive regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of angiogenesis positive regulation of angiogenesis negative regulation of lipid metabolic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of complement activation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of JNK cascade positive regulation of JNK cascade negative regulation of insulin receptor signaling pathway astrocyte activation positive regulation of astrocyte differentiation regulation of defense response to virus by host positive regulation of inflammatory response positive regulation of phagocytosis regulation of neurogenesis negative regulation of neurogenesis regulation of insulin secretion negative regulation of synaptic transmission leukocyte migration negative regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of nitric-oxide synthase activity regulation of nitric-oxide synthase activity regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of cell division positive regulation of glial cell proliferation positive regulation of calcidiol 1-monooxygenase activity negative regulation of adiponectin secretion regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade monocyte aggregation interleukin-1-mediated signaling pathway response to interleukin-1 cellular response to lipopolysaccharide cellular response to organic substance cellular response to organic cyclic compound positive regulation of monocyte chemotactic protein-1 production positive regulation of neutrophil chemotaxis extrinsic apoptotic signaling pathway in absence of ligand positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling positive regulation of RNA biosynthetic process regulation of establishment of endothelial barrier negative regulation of gap junction assembly negative regulation of branching morphogenesis of a nerve negative regulation of neural precursor cell proliferation positive regulation of T-helper 1 cell cytokine production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	04010 04060 04210 04380 04620 04621 04623 04640 04940 05010 05020 05140 05142 05143 05144 05146 05323 05332
TC0200001866.mm.2	Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	2	124089968, 124610295, 124653580	NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680	214968	53	neural crest cell migration protein binding extracellular space cytoplasm Golgi apparatus plasma membrane integral component of plasma membrane multicellular organism development nervous system development axon guidance cell surface positive regulation of smooth muscle cell migration negative regulation of smooth muscle cell migration membrane integral component of membrane ventricular system development ventricular system development cell differentiation semaphorin receptor binding semaphorin receptor binding positive regulation of cell migration negative regulation of axon extension chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis collagen-containing extracellular matrix semaphorin-plexin signaling pathway	04360
TC1100000496.mm.2					NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437			GTPase activity G protein-coupled receptor activity olfactory receptor activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane defense response defense response signal transduction G protein-coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane cellular response to interferon-beta response to stimulus
TC0800000115.mm.2	F10	coagulation factor X	8	13037307	NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219	14058	49	serine-type endopeptidase activity calcium ion binding phospholipid binding extracellular region extracellular space endoplasmic reticulum proteolysis blood coagulation blood coagulation hemostasis peptidase activity serine-type peptidase activity membrane hydrolase activity intracellular membrane-bounded organelle positive regulation of protein kinase B signaling	04610
TC0800001078.mm.2	Lpcat2	lysophosphatidylcholine acyltransferase 2	8	92855332	NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287	270084	21	1-acylglycerol-3-phosphate O-acyltransferase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Golgi stack lipid droplet plasma membrane lipid metabolic process platelet activating factor biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups phosphatidylcholine acyl-chain remodeling metal ion binding 1-acylglycerophosphocholine O-acyltransferase activity 1-acylglycerophosphocholine O-acyltransferase activity 1-alkylglycerophosphocholine O-acetyltransferase activity plasmalogen synthase activity membrane organization	00564 00565 01100
TC1900001422.mm.2	Ifit1bl1	interferon induced protein with tetratricpeptide repeats 1B like 1	19	-34592887, -34592887	NM_001101605, NM_001110517 NM_001101605, NM_001110517	667373	13	RNA binding RNA binding cytoplasm cytosol cytosol defense response to virus	05160
TC1700000621.mm.2	Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	17	34187555	NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897	21354	256	nucleotide binding adaptive immune response immune system process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ATP binding mitochondrion endoplasmic reticulum defense response protein transport ABC-type peptide antigen transporter activity ABC-type peptide antigen transporter activity ABC-type peptide antigen transporter activity ABC-type peptide transporter activity peptide transport peptide transport membrane integral component of membrane integral component of membrane ATPase activity antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I MHC class Ib protein binding integral component of endoplasmic reticulum membrane phagocytic vesicle membrane centriolar satellite protection from natural killer cell mediated cytotoxicity MHC protein binding MHC class I protein binding MHC class I protein binding peptide antigen binding ATPase-coupled transmembrane transporter activity protein homodimerization activity MHC class I peptide loading complex MHC class I peptide loading complex TAP complex intracellular membrane-bounded organelle ADP binding protein-containing complex binding cytosol to endoplasmic reticulum transport TAP1 binding TAP1 binding TAP2 binding tapasin binding transmembrane transport peptide transmembrane transporter activity	02010 04145 04612 05340
TC0700000693.mm.2	1600014C10Rik	RIKEN cDNA 1600014C10 gene	7	38183786, 38183216	NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099	72244	15	molecular_function cytoplasm mitochondrion endoplasmic reticulum cytosol autophagy apoptotic process response to oxidative stress membrane integral component of membrane mitochondrial membrane mitochondrial calcium ion homeostasis
TC1300000691.mm.2	Tgfbi	transforming growth factor, beta induced	13	56609585	NM_009369, BC129900, BC129901 NM_009369, BC129900, BC129901 NM_009369, BC129900, BC129901	21810	77	integrin binding extracellular matrix structural constituent collagen binding extracellular region basement membrane extracellular space extracellular space extracellular space extracellular space trans-Golgi network cell adhesion cell adhesion cell population proliferation extracellular matrix organization extracellular matrix organization extracellular matrix extracellular matrix identical protein binding cell adhesion molecule binding extracellular matrix binding collagen-containing extracellular matrix
TC0800001110.mm.2					NM_001033207, NR_106040 NM_001033207, NR_106040			nucleotide binding RNA polymerase II cis-regulatory region sequence-specific DNA binding immune system process ATP binding nucleus nucleus nucleus cytoplasm centrosome cytosol cytosol response to bacterium negative regulation of NF-kappaB transcription factor activity negative regulation of NF-kappaB transcription factor activity intracellular signal transduction regulation of kinase activity innate immune response innate immune response positive regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway
TC1000001596.mm.2	Stat2	signal transducer and activator of transcription 2	10	128270497	NM_019963, BC167243 NM_019963, BC167243	20847	120	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific regulation of protein phosphorylation DNA binding DNA-binding transcription factor activity protein binding nucleus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II defense response signal transduction receptor signaling pathway via JAK-STAT cytokine-mediated signaling pathway regulation of cell population proliferation identical protein binding response to peptide hormone ubiquitin-like protein ligase binding defense response to virus type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway regulation of mitochondrial fission	04062 04380 04630 05160
TC0500001239.mm.2	Oasl2	2'-5' oligoadenylate synthetase-like 2	5	114896933	NM_011854, BC034361 NM_011854, BC034361	23962	21	nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytosol purine nucleotide biosynthetic process immune response response to virus membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding defense response to virus regulation of ribonuclease activity
TC0200002223.mm.2	Cst7	cystatin F (leukocystatin)	2	150570414	NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049	13011	25	cysteine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular region extracellular space extracellular space extracellular space cytoplasm lysosome lysosome lysosome endosome late endosome late endosome multivesicular body endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus Golgi apparatus negative regulation of peptidase activity negative regulation of peptidase activity peptidase inhibitor activity peptidase inhibitor activity cytoplasmic vesicle cytoplasmic vesicle positive regulation of myelination positive regulation of myelination protein homodimerization activity inhibition of cysteine-type endopeptidase activity inhibition of cysteine-type endopeptidase activity negative regulation of microglial cell activation negative regulation of microglial cell activation
TC0100000375.mm.2	Stat1	signal transducer and activator of transcription 1	1	52119437, 52119621	NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808	20846	857	chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific negative regulation of endothelial cell proliferation positive regulation of defense response to virus by host DNA binding double-stranded DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity tumor necrosis factor receptor binding protein binding nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cytosol transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II activation of cysteine-type endopeptidase activity involved in apoptotic process defense response signal transduction receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT response to nutrient blood circulation positive regulation of cell population proliferation response to mechanical stimulus response to bacterium macrophage derived foam cell differentiation negative regulation of angiogenesis cytokine-mediated signaling pathway cytokine-mediated signaling pathway enzyme binding axon dendrite lipopolysaccharide-mediated signaling pathway CCR5 chemokine receptor binding response to lipopolysaccharide positive regulation of interferon-alpha production cellular response to insulin stimulus protein-containing complex tumor necrosis factor-mediated signaling pathway response to cytokine negative regulation of macrophage fusion response to type I interferon histone acetyltransferase binding nuclear hormone receptor binding response to interferon-beta cellular response to interferon-beta regulation of cell population proliferation histone binding response to drug identical protein binding protein homodimerization activity negative regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to peptide hormone response to peptide hormone sequence-specific DNA binding ubiquitin-like protein ligase binding positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation by virus of viral protein levels in host cell perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation response to cAMP defense response to virus protein phosphatase 2A binding positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway renal tubule development repressing transcription factor binding cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interferon-gamma cellular response to organic cyclic compound promoter-specific chromatin binding	04062 04380 04620 04630 05140 05145 05160 05200 05212
TC0700002499.mm.2	Nectin2	nectin cell adhesion molecule 2	7	-19724160, -19716643	NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941	19294	73	acrosome assembly acrosome assembly positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of immunoglobulin mediated immune response positive regulation of immunoglobulin mediated immune response protein binding plasma membrane plasma membrane cell-cell junction cell-cell junction zonula adherens cytoskeleton organization cytoskeleton organization cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules spermatid development spermatid nucleus differentiation fertilization cell surface membrane integral component of membrane integral component of membrane virion attachment to host cell fusion of virus membrane with host plasma membrane fusion of virus membrane with host plasma membrane sperm mitochondrion organization cell part morphogenesis positive regulation of mast cell activation positive regulation of mast cell activation susceptibility to natural killer cell mediated cytotoxicity susceptibility to natural killer cell mediated cytotoxicity identical protein binding identical protein binding protein homodimerization activity protein homodimerization activity apical junction complex apical junction complex cell-cell contact zone adhesion of symbiont to host cilium organization positive regulation of natural killer cell mediated cytotoxicity regulation of viral entry into host cell regulation of viral entry into host cell coreceptor-mediated virion attachment to host cell coreceptor-mediated virion attachment to host cell cell adhesion molecule binding cell adhesion molecule binding cell adhesion molecule binding positive regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway establishment of mitochondrion localization establishment of mitochondrion localization susceptibility to T cell mediated cytotoxicity susceptibility to T cell mediated cytotoxicity	04514 04520
TC0700001258.mm.2	Ctsc	cathepsin C	7	88278084, 88278084	NM_009982, BC067063 NM_009982, BC067063	13032	77	T cell mediated cytotoxicity cysteine-type endopeptidase activity serine-type endopeptidase activity extracellular space nucleoplasm cytoplasm lysosome lysosome endoplasmic reticulum Golgi apparatus centrosome proteolysis proteolysis peptidase activity cysteine-type peptidase activity cysteine-type peptidase activity response to organic substance peptidase activator activity involved in apoptotic process hydrolase activity phosphatase binding chloride ion binding negative regulation of myelination negative regulation of myelination identical protein binding intracellular membrane-bounded organelle protein self-association chaperone binding proteolysis involved in cellular protein catabolic process collagen-containing extracellular matrix positive regulation of proteolysis involved in cellular protein catabolic process positive regulation of microglial cell activation positive regulation of apoptotic signaling pathway	04142
TC1700000464.mm.2	Pacsin1	protein kinase C and casein kinase substrate in neurons 1	17	27685238, 27655590	NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698	23969	44	protein binding phospholipid binding phospholipid binding phospholipid binding cytoplasm cytoplasm cytoplasm endosome cytoskeleton plasma membrane plasma membrane endocytosis cytoskeleton organization cytoskeleton organization actin filament organization signal transduction cytoskeletal protein binding lipid binding membrane cell junction regulation of endocytosis COPI-coated vesicle cytoplasmic vesicle ruffle membrane identical protein binding cell projection neuron projection myelin sheath axon terminus synapse negative regulation of endocytosis perinuclear region of cytoplasm synaptic vesicle endocytosis synaptic vesicle endocytosis neuron development neuron projection morphogenesis neuron projection morphogenesis protein localization to membrane protein localization to plasma membrane plasma membrane tubulation plasma membrane tubulation plasma membrane tubulation photoreceptor ribbon synapse presynaptic endocytic zone postsynaptic density membrane glutamatergic synapse regulation of postsynaptic neurotransmitter receptor internalization positive regulation of dendrite development positive regulation of dendrite development
TC0400001425.mm.2					NM_008385, NR_030480, BC028864 NM_008385, NR_030480, BC028864 NM_008385, NR_030480, BC028864			in utero embryonic development phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity cytoplasm endosome cytosol cytosol cytosol signal transduction spermatogenesis membrane membrane integral component of membrane hydrolase activity flagellated sperm motility cytoplasmic vesicle inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol dephosphorylation metal ion binding inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol phosphate phosphatase activity regulation of protein processing
TC1100004266.mm.2	Irgm2	immunity-related GTPase family M member 2	11	58214976	NM_019440	54396	22	autophagosome assembly Golgi membrane positive regulation of protein phosphorylation GTPase activity GTPase activity mitochondrion endoplasmic reticulum membrane Golgi apparatus Golgi apparatus cytosol defense response response to bacterium positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation protein kinase binding symbiont-containing vacuole protein destabilization positive regulation of peptidyl-serine phosphorylation response to interferon-gamma response to interferon-gamma cellular response to interferon-beta defense response to bacterium defense response to bacterium defense response to protozoan regulation of protein-containing complex assembly protein serine/threonine kinase activator activity innate immune response CARD domain binding protein stabilization defense response to Gram-negative bacterium BH3 domain binding positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide positive regulation of protein serine/threonine kinase activity positive regulation by symbiont of host autophagy cellular response to virus positive regulation of autophagosome maturation
TC1100000989.mm.2	Xaf1	XIAP associated factor 1	11	72301628	NM_001037713, BC153050 NM_001037713, BC153050	327959	16	nucleus nucleoplasm cytoplasm mitochondrion apoptotic process negative regulation of protein-containing complex assembly response to interferon-beta metal ion binding
TC0900001722.mm.2	Birc3	baculoviral IAP repeat-containing 3	9	-7848700	NM_007464, BC011338 NM_007464, BC011338	11796	101	ubiquitin-protein transferase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol apoptotic process transferase activity positive regulation of protein ubiquitination positive regulation of protein ubiquitination protein-containing complex negative regulation of phosphorylation regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process protein-containing complex binding membrane raft metal ion binding regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity necroptotic process cellular response to tumor necrosis factor regulation of NIK/NF-kappaB signaling positive regulation of protein polyubiquitination negative regulation of reactive oxygen species metabolic process	04120 04210 04510 04621 05145 05200 05222
TC1700002779.mm.2	H2-DMb2	histocompatibility 2, class II, locus Mb2	17	34145248, 34143228	NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960	15000	23	protein binding lysosome lysosomal membrane lysosomal membrane late endosome multivesicular body endosome membrane integral component of membrane antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle chaperone cofactor-dependent protein refolding	04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416
TC1700000148.mm.2	Sod2	superoxide dismutase 2, mitochondrial	17	13007838	NM_013671, BC010548 NM_013671, BC010548	20656	394	response to reactive oxygen species response to superoxide response to superoxide age-dependent response to oxidative stress age-dependent response to reactive oxygen species release of cytochrome c from mitochondria liver development detection of oxygen acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure DNA binding superoxide dismutase activity superoxide dismutase activity superoxide dismutase activity superoxide dismutase activity protein binding cytoplasm mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial inner membrane mitochondrial matrix regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II glutathione metabolic process superoxide metabolic process superoxide metabolic process response to oxidative stress response to oxidative stress mitochondrion organization heart development locomotory behavior regulation of blood pressure negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes post-embryonic development response to gamma radiation positive regulation of hydrogen peroxide biosynthetic process response to activity oxidoreductase activity removal of superoxide radicals removal of superoxide radicals oxygen binding enzyme binding respiratory electron transport chain hemopoiesis manganese ion binding manganese ion binding positive regulation of cell migration response to nutrient levels oxygen homeostasis vasodilation response to drug response to hydrogen peroxide superoxide anion generation mitochondrial nucleoid hydrogen peroxide metabolic process identical protein binding negative regulation of apoptotic process myelin sheath negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation metal ion binding negative regulation of fibroblast proliferation neuron development response to axon injury erythrophore differentiation hydrogen peroxide biosynthetic process regulation of catalytic activity protein homotetramerization regulation of mitochondrial membrane potential iron ion homeostasis response to hyperoxia negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of membrane hyperpolarization negative regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	04146 05016
TC0700004011.mm.2	Gvin3	GTPase, very large interferon inducible, family member 3	7	-106595548	NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982	434223	8	molecular_function cellular_component biological_process
TC1100003382.mm.2	Slfn8	schlafen 8	11	-83002157, -83002157	NM_001167743, NM_181545 NM_001167743, NM_181545	276950	15	tRNA binding nucleotide binding immune system process nuclease activity endonuclease activity endoribonuclease activity endoribonuclease activity ATP binding cytoplasm zinc ion binding rRNA catabolic process tRNA catabolic process hydrolase activity metal ion binding defense response to virus
TC0900000032.mm.2	Casp4	caspase 4, apoptosis-related cysteine peptidase	9	5308848, 5308859	NM_007609, BC061255 NM_007609, BC061255	12363	223	immune system process cysteine-type endopeptidase activity cysteine-type endopeptidase activity protein binding extracellular region cytoplasm mitochondrion endoplasmic reticulum cytosol plasma membrane proteolysis inflammatory response actin filament organization peptidase activity cysteine-type peptidase activity programmed cell death membrane protein autoprocessing protein autoprocessing hydrolase activity positive regulation of interleukin-1 beta production protein-containing complex ectopic germ cell programmed cell death ectopic germ cell programmed cell death regulation of apoptotic process neuron projection neuronal cell body innate immune response CARD domain binding regulation of inflammatory response regulation of inflammatory response regulation of inflammatory response inflammasome complex intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pyroptosis pyroptosis pyroptosis IPAF inflammasome complex NLRP3 inflammasome complex scaffold protein binding AIM2 inflammasome complex intrinsic apoptotic signaling pathway cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway cellular response to amyloid-beta
TC0500003729.mm.2	Gbp8	guanylate-binding protein 8	5	-105014152	NM_029509, BC031475 NM_029509, BC031475	76074	11	GTPase activity GTP binding cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma
TC1700002822.mm.2					NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819			positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding
TC0200005013.mm.2	Samhd1	SAM domain and HD domain, 1	2	-157119560, -157097533	NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198	56045	46	nucleotide binding double-strand break repair via homologous recombination immune system process nucleic acid binding single-stranded DNA binding RNA binding catalytic activity GTP binding nucleus nucleus nucleoplasm chromosome plasma membrane dGTP catabolic process dGTP catabolic process DNA replication DNA repair cellular response to DNA damage stimulus metabolic process zinc ion binding dGTPase activity dGTPase activity dGTPase activity deoxyribonucleotide catabolic process somatic hypermutation of immunoglobulin genes hydrolase activity triphosphoric monoester hydrolase activity triphosphoric monoester hydrolase activity dGTP binding site of double-strand break identical protein binding innate immune response regulation of innate immune response regulation of innate immune response dATP catabolic process dATP catabolic process metal ion binding protein homotetramerization protein homotetramerization defense response to virus defense response to virus negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway tetraspanin-enriched microdomain DNA strand resection involved in replication fork processing
TC1700000935.mm.2	Treml2	triggering receptor expressed on myeloid cells-like 2	17	48300037	NM_001033405, BC160362 NM_001033405, BC160362	328833	17	plasma membrane cell surface cell surface membrane integral component of membrane signaling receptor activity signaling receptor activity T cell activation T cell activation
TC0800001952.mm.2	Rab11fip1	RAB11 family interacting protein 1 (class I)	8	-27138772	NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094	75767	17	endosome cytosol protein transport membrane small GTPase binding cytoplasmic vesicle intracellular membrane-bounded organelle intracellular membrane-bounded organelle regulated exocytosis negative regulation of adiponectin secretion	04144
TC0200003630.mm.2	Ifih1	interferon induced with helicase C domain 1	2	-62595792	NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200	71586	136	nucleotide binding immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding nucleus cytoplasm zinc ion binding zinc ion binding response to virus response to virus hydrolase activity protein sumoylation positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production MDA-5 signaling pathway identical protein binding ribonucleoprotein complex binding innate immune response innate immune response metal ion binding defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA	04622
TC0200003624.mm.2	Dpp4	dipeptidylpeptidase 4	2	-62330072, -62333222	NM_001159543, NM_010074, BC022183 NM_001159543, NM_010074, BC022183 NM_001159543, NM_010074, BC022183	13482	183	virus receptor activity behavioral fear response response to hypoxia protease binding regulation of T cell mediated immunity aminopeptidase activity serine-type endopeptidase activity signaling receptor binding collagen binding extracellular region endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane proteolysis proteolysis cell adhesion peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity dipeptidyl-peptidase activity positive regulation of cell population proliferation cell surface negative regulation of extracellular matrix disassembly membrane integral component of membrane apical plasma membrane hydrolase activity lamellipodium cell junction endocytic vesicle T cell costimulation regulation of cell-cell adhesion mediated by integrin locomotory exploration behavior psychomotor behavior T cell activation peptide binding identical protein binding protein homodimerization activity cell projection endothelial cell migration chemorepellent activity intercellular canaliculus establishment of localization negative regulation of neutrophil chemotaxis	04974
TC0200001729.mm.2	Thbs1	thrombospondin 1	2	118111875	NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917	21825	301	activation of MAPK activity phosphatidylserine binding negative regulation of endothelial cell proliferation negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion fibronectin binding sprouting angiogenesis negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation outflow tract morphogenesis endocardial cushion development growth plate cartilage development growth plate cartilage development integrin binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region fibrinogen complex extracellular space extracellular space extracellular space cytoplasm endoplasmic reticulum inflammatory response inflammatory response response to unfolded protein cell cycle arrest cell adhesion heparin binding positive regulation of cell population proliferation response to mechanical stimulus response to glucose external side of plasma membrane cell surface positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of long-chain fatty acid import across plasma membrane negative regulation of nitric oxide mediated signal transduction negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of macrophage chemotaxis positive regulation of fibroblast migration positive regulation of cell-substrate adhesion cell migration negative regulation of angiogenesis negative regulation of angiogenesis negative regulation of angiogenesis negative regulation of angiogenesis sarcoplasmic reticulum fibroblast growth factor binding peptide cross-linking secretory granule low-density lipoprotein particle binding positive regulation of blood coagulation positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway extracellular matrix platelet alpha granule response to magnesium ion negative regulation of interleukin-12 production positive regulation of tumor necrosis factor production response to endoplasmic reticulum stress negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process laminin binding positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis behavioral response to pain blood vessel morphogenesis positive regulation of smooth muscle cell proliferation transforming growth factor beta binding extracellular matrix binding positive regulation of chemotaxis response to calcium ion positive regulation of protein kinase B signaling negative regulation of fibrinolysis collagen-containing extracellular matrix collagen-containing extracellular matrix fibrinogen binding collagen V binding monocyte aggregation positive regulation of transforming growth factor beta production cellular response to nitric oxide negative regulation of cell migration involved in sprouting angiogenesis positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of sprouting angiogenesis positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis	04115 04145 04350 04510 04512 05144 05219
TC0300002312.mm.2					NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800			angiogenesis neural crest cell migration adaptive immune response T cell differentiation involved in immune response immune system process extracellular space plasma membrane integral component of plasma membrane multicellular organism development nervous system development axonogenesis axon guidance regulation of cell shape regulation of endothelial cell migration membrane integral component of membrane negative regulation of angiogenesis cell differentiation semaphorin receptor binding positive regulation of cell migration T-helper 1 cell differentiation chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway positive regulation of excitatory synapse assembly positive regulation of inhibitory synapse assembly
TC0700001116.mm.2	Isg20	interferon-stimulated protein	7	78913423, 78913764, 78914234	NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751	57444	17	3'-5'-exoribonuclease activity DNA catabolic process, exonucleolytic DNA catabolic process, exonucleolytic immune system process nucleic acid binding RNA binding nuclease activity exonuclease activity exonuclease activity nucleus nucleus nucleolus cytoplasm rRNA processing RNA catabolic process RNA catabolic process single-stranded DNA 3'-5' exodeoxyribonuclease activity exoribonuclease II activity response to virus Cajal body PML body hydrolase activity U1 snRNA binding U2 snRNA binding U3 snoRNA binding negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus defense response to virus
TC0500000488.mm.2	Lap3	leucine aminopeptidase 3	5	45493373	NM_024434, BC016536 NM_024434, BC016536	66988	31	aminopeptidase activity intracellular anatomical structure nucleoplasm cytoplasm mitochondrion trans-Golgi network cytosol proteolysis peptidase activity metalloexopeptidase activity hydrolase activity protein metabolic process manganese ion binding midbody metal ion binding	00330 00480 01100
TC0600001193.mm.2	Itpr1	inositol 1,4,5-trisphosphate receptor 1	6	108213095	NM_010585, BC172648 NM_010585, BC172648	16438	282	response to hypoxia response to hypoxia ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding nuclear envelope nuclear envelope nuclear inner membrane nucleolus cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane plasma membrane plasma membrane calcineurin complex ion transport calcium ion transport apoptotic process positive regulation of cytosolic calcium ion concentration protein C-terminus binding post-embryonic development positive regulation of neuron projection development postsynaptic density postsynaptic density calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum calcium channel inhibitor activity protein phosphatase binding integral component of endoplasmic reticulum membrane dendrite cytoplasmic vesicle membrane secretory granule membrane secretory granule membrane smooth endoplasmic reticulum membrane platelet dense granule membrane platelet dense tubular network cytoplasmic vesicle endoplasmic reticulum calcium ion homeostasis protein-containing complex protein-containing complex phosphatidylinositol binding phosphatidylinositol binding epithelial fluid transport identical protein binding neuronal cell body positive regulation of apoptotic process intracellular membrane-bounded organelle ion channel binding protein-containing complex binding membrane raft perinuclear region of cytoplasm negative regulation of calcium-mediated signaling voluntary musculoskeletal movement release of sequestered calcium ion into cytosol release of sequestered calcium ion into cytosol release of sequestered calcium ion into cytosol positive regulation of calcium ion transport transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding cellular response to cAMP synaptic membrane liver regeneration Schaffer collateral - CA1 synapse Schaffer collateral - CA1 synapse inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels presynapse postsynapse GABA-ergic synapse negative regulation of neuron death positive regulation of hepatocyte proliferation	04020 04070 04114 04270 04540 04720 04730 04912 04970 04971 04972 05010 05016
TC0300001937.mm.2	Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	3	-50364935	NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408	26570	91	amino acid transmembrane transport rough endoplasmic reticulum cytoskeleton plasma membrane plasma membrane glutathione metabolic process amino acid transport brain development visual learning response to toxic substance cell surface response to organic cyclic compound L-amino acid transmembrane transporter activity membrane integral component of membrane ventricular system development striatum development transmembrane transporter activity adult behavior brush border membrane regulation of neutrophil apoptotic process cellular response to stress cellular response to oxidative stress glutathione transmembrane transport regulation of cell population proliferation intracellular membrane-bounded organelle apical part of cell regulation of melanin biosynthetic process lung alveolus development modulation of chemical synaptic transmission regulation of synapse organization regulation of protein transport response to redox state transmembrane transport limb development platelet aggregation organic substance transport glutamate homeostasis glutamate homeostasis astrocyte projection L-glutamate import across plasma membrane dipeptide import across plasma membrane regulation of cellular response to oxidative stress regulation of cysteine metabolic process negative regulation of oxidative stress-induced neuron death negative regulation of oxidative stress-induced neuron death regulation of glutathione biosynthetic process regulation of AMPA glutamate receptor clustering regulation of glutamate metabolic process
TC0400001392.mm.2	Nt5c1a	5'-nucleotidase, cytosolic IA	4	123201484	NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733	230718	9	nucleotide binding magnesium ion binding cytoplasm cytosol cytosol 5'-nucleotidase activity 5'-nucleotidase activity nucleotide metabolic process purine nucleoside monophosphate catabolic process hydrolase activity dAMP catabolic process adenosine metabolic process adenosine metabolic process	00230 00240 00760 01100
TC0400001510.mm.2	Rnf19b	ring finger protein 19B	4	129058143	NM_029219	75234	19	ubiquitin ligase complex protein polyubiquitination adaptive immune response immune system process ubiquitin-protein transferase activity cytoplasm endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process interferon-gamma production natural killer cell mediated cytotoxicity ubiquitin binding cytolytic granule cytolytic granule metal ion binding protein autoubiquitination ubiquitin protein ligase activity ubiquitin protein ligase activity
TC0100003890.mm.2	Mndal	myeloid nuclear differentiation antigen like	1	-173857219, -173857221	NM_001170853	100040462	12	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleus nucleoplasm nucleolus nucleolus cytosol transcription factor binding response to bacterium negative regulation of cell growth positive regulation of interleukin-1 beta production cellular response to interferon-beta regulation of growth identical protein binding
TC0700003943.mm.2	Trim30a	tripartite motif-containing 30A	7	-104409025, -104409025	NM_009099, BC005447 NM_009099, BC005447	20128	34	protein polyubiquitination DNA binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytoplasm cytosol autophagy zinc ion binding response to bacterium regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production regulation of protein localization negative regulation of toll-like receptor signaling pathway protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of protein catabolic process regulation of viral entry into host cell positive regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus protein autoubiquitination ubiquitin protein ligase activity negative regulation of NLRP3 inflammasome complex assembly negative regulation of reactive oxygen species metabolic process
TC1200001552.mm.2	Rsad2	radical S-adenosyl methionine domain containing 2	12	-26442742	NM_021384, BC057868 NM_021384, BC057868	58185	39	ossification fibrillar center immune system process catalytic activity protein binding mitochondrion mitochondrion mitochondrial outer membrane mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane lipid droplet response to virus response to virus membrane regulation of ossification positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation protein self-association negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding negative regulation of protein secretion positive regulation of immune response iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding defense response to virus defense response to virus defense response to virus positive regulation of T-helper 2 cell cytokine production
TC0700003039.mm.2	Saa3	serum amyloid A 3	7	-46711997	NM_011315, BC055885 NM_011315, BC055885	20210	76	extracellular region extracellular space acute-phase response I-kappaB phosphorylation response to bacterium high-density lipoprotein particle response to stilbenoid Toll-like receptor 4 binding chemoattractant activity cell chemotaxis cellular response to interleukin-1
TC0100001574.mm.2	Fcgr4	Fc receptor, IgG, low affinity IV	1	171018925	NM_144559, BC027310 NM_144559, BC027310	246256	54	transmembrane signaling receptor activity plasma membrane integral component of plasma membrane cell surface receptor signaling pathway external side of plasma membrane cell surface cell surface membrane integral component of membrane IgE receptor activity IgG receptor activity IgE binding IgG binding neutrophil activation positive regulation of bone resorption regulation of immune response regulation of sensory perception of pain cellular response to lipopolysaccharide	04145 04380 04650 05140 05150 05322
TC1100001171.mm.2	Nos2	nitric oxide synthase 2, inducible	11	78925290, 78920786, 78924739	NM_010927, BC062378 NM_010927, BC062378	18126	1387	response to hypoxia actin binding nitric-oxide synthase activity nitric-oxide synthase activity nitric-oxide synthase activity protein binding calmodulin binding extracellular space nucleus nucleus cytoplasm cytoplasm peroxisome cytosol cytosol cytosol plasma membrane arginine catabolic process arginine catabolic process arginine catabolic process superoxide metabolic process nitric oxide biosynthetic process nitric oxide biosynthetic process nitric oxide biosynthetic process inflammatory response inflammatory response nitric oxide mediated signal transduction circadian rhythm beta-catenin binding cAMP-dependent protein kinase regulator activity response to bacterium response to hormone FMN binding FMN binding negative regulation of gene expression negative regulation of gene expression vesicle membrane vesicle membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen peptidyl-cysteine S-nitrosylation protein kinase binding heme binding cortical cytoskeleton positive regulation of guanylate cyclase activity prostaglandin secretion response to lipopolysaccharide response to lipopolysaccharide interleukin-6 production interleukin-8 production tetrahydrobiopterin binding arginine binding cellular response to drug regulation of cell population proliferation negative regulation of protein catabolic process defense response to bacterium defense response to bacterium defense response to bacterium identical protein binding protein homodimerization activity cadherin binding negative regulation of blood pressure metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm flavin adenine dinucleotide binding flavin adenine dinucleotide binding NADP binding regulation of insulin secretion nitric-oxide synthase binding positive regulation of killing of cells of other organism Hsp90 protein binding cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interferon-gamma cellular response to organic cyclic compound regulation of cytokine production involved in inflammatory response	00330 01100 04020 04146 05140 05142 05145 05146 05200 05222
TC0800001118.mm.2	Ccl22	chemokine (C-C motif) ligand 22	8	94745683	NM_009137, BC012658 NM_009137, BC012658	20299	54	monocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space chemotaxis inflammatory response immune response G protein-coupled receptor signaling pathway chemokine activity neutrophil chemotaxis killing of cells of other organism positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor	04060 04062
TC1500002316.mm.2	Gpr84	G protein-coupled receptor 84	15	-103308234	NM_030720, BC023249 NM_030720, BC023249	80910	22	urotensin II receptor activity G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway neuropeptide signaling pathway G protein-coupled peptide receptor activity membrane integral component of membrane receptor complex
TC1400002744.mm.2	Gpr18	G protein-coupled receptor 18	14	-121911433	NM_182806, BC034872 NM_182806, BC034872	110168	23	CD8-positive, alpha-beta intraepithelial T cell differentiation CD8-positive, alpha-beta intraepithelial T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation negative regulation of leukocyte chemotaxis G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane cytoplasmic vesicle negative regulation of tumor necrosis factor production positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
TC0800001037.mm.2	Nod2	nucleotide-binding oligomerization domain containing 2	8	88647346	NM_145857, BC168407 NM_145857, BC168407	257632	337	nucleotide binding pattern recognition receptor signaling pathway innate immune response in mucosa activation of immune response cytokine production involved in immune response immune system process immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of dendritic cell antigen processing and presentation negative regulation of T cell mediated immunity positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin actin binding protein binding ATP binding cytoplasm cytoplasm Golgi apparatus cytosol cytosol cytosol cytoskeleton plasma membrane defense response inflammatory response positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria signal transduction positive regulation of cell population proliferation detection of biotic stimulus cell surface membrane detection of bacterium basolateral plasma membrane endodeoxyribonuclease activity, producing 5'-phosphomonoesters enzyme binding protein kinase binding maintenance of gastrointestinal epithelium Hsp70 protein binding positive regulation of protein ubiquitination vesicle negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to peptidoglycan response to muramyl dipeptide response to muramyl dipeptide response to muramyl dipeptide response to muramyl dipeptide response to lipopolysaccharide detection of muramyl dipeptide muramyl dipeptide binding muramyl dipeptide binding negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-2 production negative regulation of tumor necrosis factor production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade positive regulation of stress-activated MAPK cascade protein-containing complex negative regulation of toll-like receptor 2 signaling pathway intracellular signal transduction intracellular signal transduction pattern recognition receptor activity defense response to bacterium defense response to bacterium peptidoglycan binding peptidoglycan binding regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity protein-containing complex binding innate immune response positive regulation of innate immune response positive regulation of innate immune response phagocytic vesicle positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of JNK cascade anchored component of plasma membrane positive regulation of epithelial cell proliferation CARD domain binding regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase biosynthetic process Hsp90 protein binding positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to muramyl dipeptide macrophage inflammatory protein-1 alpha production positive regulation of monocyte chemotactic protein-1 production regulation of neutrophil chemotaxis positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination positive regulation of xenophagy negative regulation of macrophage apoptotic process positive regulation of prostaglandin-E synthase activity	04621
TC0200004511.mm.2	Gatm	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	2	-122594472	NM_025961, BC003879 NM_025961, BC003879	67092	37	mitochondrion mitochondrion mitochondrion mitochondrial inner membrane mitochondrial intermembrane space creatine metabolic process creatine biosynthetic process creatine biosynthetic process multicellular organism development response to nutrient learning or memory response to organic substance muscle atrophy amidinotransferase activity amidinotransferase activity glycine amidinotransferase activity membrane transferase activity response to peptide hormone response to mercury ion positive regulation of cold-induced thermogenesis	00260 00330 01100
TC0500003181.mm.2	Oas1a	2'-5' oligoadenylate synthetase 1A	5	-120896256	NM_145211, BC013715, BC057878 NM_145211, BC013715, BC057878 NM_145211, BC013715, BC057878	246730	33	2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol purine nucleotide biosynthetic process response to virus membrane negative regulation of viral genome replication negative regulation of viral process defense response to virus regulation of ribonuclease activity	05160
TC1500000688.mm.2	Apobec3	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3	15	79895022, 79892407	NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314	80287	101	P-body hematopoietic progenitor cell differentiation immune system process RNA binding catalytic activity cytidine deaminase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm zinc ion binding negative regulation of transposition negative regulation of transposition negative regulation of transposition cytidine to uridine editing hydrolase activity negative regulation of viral genome replication innate immune response negative regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding deoxycytidine deaminase activity deoxycytidine deaminase activity regulation of defense response to virus defense response to virus defense response to virus DNA cytosine deamination DNA demethylation regulation of viral life cycle
TC1200001729.mm.2	Gpr33	G protein-coupled receptor 33	12	-52023003	NM_008159, BC064084 NM_008159, BC064084	14762	10	complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity plasma membrane inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane
TC1900000439.mm.2	Jak2	Janus kinase 2	19	29251802	NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834	16452	481	nucleotide binding activation of MAPKK activity euchromatin microglial cell activation adaptive immune response immune system process protein kinase activity protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signaling receptor binding growth hormone receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cytosol cytoskeleton plasma membrane caveola focal adhesion chromatin organization protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process response to oxidative stress signal transduction enzyme linked receptor protein signaling pathway G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein protein C-terminus binding positive regulation of cell population proliferation negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to oxidative stress hormone-mediated signaling pathway negative regulation of cardiac muscle cell apoptotic process positive regulation of cell-substrate adhesion positive regulation of phosphatidylinositol 3-kinase signaling membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein kinase binding heme binding negative regulation of cell-cell adhesion myeloid cell differentiation cell differentiation erythrocyte differentiation erythrocyte differentiation positive regulation of cell migration axon regeneration type 1 angiotensin receptor binding mineralocorticoid receptor signaling pathway positive regulation of insulin secretion response to lipopolysaccharide positive regulation of phosphoprotein phosphatase activity positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production acetylcholine receptor binding response to hydroperoxide tumor necrosis factor-mediated signaling pathway programmed cell death induced by symbiont response to tumor necrosis factor post-embryonic hemopoiesis histone kinase activity (H3-Y41 specific) histone kinase activity (H3-Y41 specific) histone H3-Y41 phosphorylation histone H3-Y41 phosphorylation intracellular signal transduction interleukin-12-mediated signaling pathway cellular response to interleukin-3 SH2 domain binding positive regulation of protein import into nucleus histone binding positive regulation of tyrosine phosphorylation of STAT protein identical protein binding activation of Janus kinase activity regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of DNA binding negative regulation of DNA binding negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding insulin receptor substrate binding innate immune response membrane raft positive regulation of MHC class II biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of heart contraction positive regulation of transcription by RNA polymerase II response to antibiotic protein autophosphorylation protein autophosphorylation metal ion binding platelet-derived growth factor receptor signaling pathway regulation of inflammatory response positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation modulation of chemical synaptic transmission positive regulation of cell activation positive regulation of DNA-binding transcription factor activity peptide hormone receptor binding positive regulation of nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway positive regulation of SMAD protein signal transduction growth hormone receptor signaling pathway growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT positive regulation of growth hormone receptor signaling pathway negative regulation of cell death mammary gland epithelium development response to interleukin-12 cellular response to lipopolysaccharide cellular response to dexamethasone stimulus response to granulocyte macrophage colony-stimulating factor extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway postsynapse glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of cold-induced thermogenesis positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of epithelial cell apoptotic process positive regulation of vascular associated smooth muscle cell proliferation positive regulation of signaling receptor activity positive regulation of apoptotic signaling pathway	04062 04630 04920 05140 05145
TC1300002725.mm.2	Parp8	poly (ADP-ribose) polymerase family, member 8	13	-116850843	NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881	52552	20	NAD+ ADP-ribosyltransferase activity intracellular anatomical structure protein ADP-ribosylation transferase activity transferase activity, transferring glycosyl groups protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity
TC1900000217.mm.2	Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	19	11407660	NM_029499, BC027496 NM_029499, BC027496	64380	12	molecular_function cellular_component biological_process
TC0100001338.mm.2	Ptgs2	prostaglandin-endoperoxide synthase 2	1	150100030	NM_011198, BC052900 NM_011198, BC052900	19225	998	prostaglandin biosynthetic process prostaglandin biosynthetic process angiogenesis peroxidase activity prostaglandin-endoperoxide synthase activity prostaglandin-endoperoxide synthase activity protein binding nuclear inner membrane nuclear inner membrane nuclear outer membrane nuclear outer membrane cytoplasm cytoplasm cytoplasm endoplasmic reticulum caveola lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process inflammatory response response to oxidative stress embryo implantation embryo implantation learning memory regulation of blood pressure positive regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of vascular endothelial growth factor production positive regulation of cell death membrane oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen sensory perception of pain cyclooxygenase pathway cyclooxygenase pathway enzyme binding heme binding keratinocyte differentiation bone mineralization ovulation positive regulation of prostaglandin biosynthetic process positive regulation of fever generation positive regulation of fever generation positive regulation of synaptic plasticity negative regulation of synaptic transmission, dopaminergic response to lipopolysaccharide protein-containing complex positive regulation of peptidyl-serine phosphorylation response to cytokine maintenance of blood-brain barrier regulation of cell population proliferation positive regulation of protein import into nucleus anagen protein homodimerization activity neuron projection neuron projection positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle positive regulation of nitric oxide biosynthetic process negative regulation of cell cycle positive regulation of vasoconstriction negative regulation of smooth muscle contraction positive regulation of smooth muscle contraction decidualization decidualization metal ion binding positive regulation of smooth muscle cell proliferation brown fat cell differentiation dioxygenase activity negative regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic cellular response to non-ionic osmotic stress cellular response to fluid shear stress positive regulation of transforming growth factor beta production positive regulation of cell migration involved in sprouting angiogenesis positive regulation of fibroblast growth factor production positive regulation of brown fat cell differentiation positive regulation of platelet-derived growth factor production regulation of neuroinflammatory response negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	00590 01100 04370 05140 05200 05222
TC0700003946.mm.2	Trim30d	tripartite motif-containing 30D	7	-104470013	NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631	209387	13	protein polyubiquitination nucleoplasm cytoplasm cytosol regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity
TC1100002003.mm.2					XM_001477846
TC0800000538.mm.2	Acsl1	acyl-CoA synthetase long-chain family member 1	8	46490965, 46471036	NM_007981, BC056644 NM_007981, BC056644	14081	64	very long-chain fatty acid metabolic process very long-chain fatty acid metabolic process nucleotide binding long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding mitochondrion mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane endoplasmic reticulum endoplasmic reticulum plasma membrane lipid metabolic process fatty acid metabolic process lipid biosynthetic process lipid biosynthetic process response to organic substance positive regulation of long-chain fatty acid import across plasma membrane fatty acid transport membrane integral component of membrane ligase activity triglyceride biosynthetic process adiponectin-activated signaling pathway long-chain fatty-acyl-CoA biosynthetic process long-chain fatty-acyl-CoA biosynthetic process xenobiotic catabolic process intracellular membrane-bounded organelle acetate-CoA ligase (ADP-forming) activity long-chain fatty acid import into cell arachidonate-CoA ligase activity arachidonate-CoA ligase activity phytanate-CoA ligase activity positive regulation of protein serine/threonine kinase activity oleoyl-CoA ligase activity decanoate-CoA ligase activity positive regulation of cold-induced thermogenesis	00071 01100 03320 04146 04920
TC0700004002.mm.2					NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717			molecular_function cellular_component biological_process
TC1700001954.mm.2	Tnf	tumor necrosis factor	17	-35199366	NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720	21926	2923	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II MAPK cascade activation of MAPKKK activity activation of MAPK activity transcription regulatory region sequence-specific DNA binding microglial cell activation microglial cell activation cell activation positive regulation of cytokine production phagocytic cup regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation protease binding protease binding negative regulation of L-glutamate import across plasma membrane leukocyte activation involved in inflammatory response chronic inflammatory response to antigenic stimulus regulation of immunoglobulin production negative regulation of cytokine production involved in immune response positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of systemic arterial blood pressure cytokine activity cytokine activity cytokine activity tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding protein binding extracellular region extracellular space extracellular space extracellular space intracellular anatomical structure cytoplasm plasma membrane integral component of plasma membrane integral component of plasma membrane glucose metabolic process regulation of transcription by RNA polymerase II apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response inflammatory response inflammatory response inflammatory response immune response humoral immune response signal transduction JNK cascade multicellular organism development positive regulation of cell population proliferation negative regulation of cell population proliferation extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage response to virus animal organ morphogenesis external side of plasma membrane external side of plasma membrane cell surface cell surface response to organic substance negative regulation of heart rate vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of gene expression negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane calcium-mediated signaling secretory granule extracellular matrix organization osteoclast differentiation sequestering of triglyceride cortical actin cytoskeleton organization positive regulation of protein-containing complex assembly positive regulation of fever generation negative regulation of myelination lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide negative regulation of interleukin-6 production positive regulation of chemokine production positive regulation of fractalkine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of peptidyl-serine phosphorylation tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway positive regulation of heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion toll-like receptor 3 signaling pathway negative regulation of myosin-light-chain-phosphatase activity regulation of cell population proliferation regulation of cell population proliferation vasodilation positive regulation of tyrosine phosphorylation of STAT protein defense response to bacterium identical protein binding neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of protein-containing complex disassembly positive regulation of protein-containing complex disassembly positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration negative regulation of viral genome replication membrane raft membrane raft cellular extravasation positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of osteoclast differentiation positive regulation of protein catabolic process positive regulation of action potential positive regulation of cell adhesion positive regulation of mitotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of translational initiation by iron negative regulation of glucose import negative regulation of glucose import positive regulation of JNK cascade positive regulation of JNK cascade positive regulation of receptor signaling pathway via JAK-STAT positive regulation of smooth muscle cell proliferation regulation of protein secretion regulation of inflammatory response positive regulation of inflammatory response positive regulation of phagocytosis regulation of insulin secretion positive regulation of synaptic transmission positive regulation of synaptic transmission regulation of synapse organization defense response to Gram-positive bacterium leukocyte migration leukocyte tethering or rolling detection of mechanical stimulus involved in sensory perception of pain negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of nitrogen compound metabolic process positive regulation of protein transport response to glucocorticoid positive regulation of hair follicle development positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling recycling endosome positive regulation of glial cell proliferation positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity epithelial cell proliferation involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of vascular wound healing negative regulation of branching involved in lung morphogenesis positive regulation of calcineurin-NFAT signaling cascade cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to nicotine cellular response to organic cyclic compound positive regulation of podosome assembly endothelial cell apoptotic process protein localization to plasma membrane negative regulation of oxidative phosphorylation apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway necroptotic signaling pathway necroptotic signaling pathway negative regulation of bile acid secretion positive regulation of interleukin-33 production positive regulation of cytokine production involved in inflammatory response negative regulation of amyloid-beta clearance positive regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of synoviocyte proliferation positive regulation of superoxide dismutase activity positive regulation of amyloid-beta formation positive regulation of neutrophil activation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of protein localization to plasma membrane positive regulation of protein localization to plasma membrane regulation of establishment of endothelial barrier positive regulation of oxidative stress-induced neuron death negative regulation of bicellular tight junction assembly positive regulation of I-kappaB phosphorylation negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of vascular associated smooth muscle cell proliferation positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell positive regulation of protein localization to cell surface negative regulation of signaling receptor activity positive regulation of blood microparticle formation positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of hepatocyte proliferation regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process negative regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	04010 04060 04210 04350 04380 04612 04620 04621 04622 04640 04650 04660 04664 04920 04930 04940 05010 05014 05140 05142 05143 05144 05145 05146 05160 05310 05322 05323 05330 05332 05410 05414
TC0400003681.mm.2	Themis2	thymocyte selection associated family member 2	4	-132782356	NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126	230787	18	immune system process protein binding nucleus nucleus cytoplasm cytoplasm inflammatory response T cell receptor signaling pathway T cell receptor signaling pathway
TC1800000924.mm.2	Crem	cAMP responsive element modulator	18	-3294165, -3266353, -3266353, -3266353, -3266353, -3266353	NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193	12916	153	negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus transcription regulator complex transcription regulator complex cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II glycosphingolipid metabolic process spermatogenesis spermatogenesis circadian rhythm circadian regulation of gene expression negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II rhythmic process response to cAMP ATF4-CREB1 transcription factor complex sequence-specific double-stranded DNA binding
TC1500002183.mm.2	Rnd1	Rho family GTPase 1	15	-98669204	NM_172612, BC048531 NM_172612, BC048531	223881	18	nucleotide binding GTPase activity signaling receptor binding GTP binding intracellular anatomical structure cytoplasm cytosol cytoskeleton plasma membrane plasma membrane adherens junction cell cortex actin filament organization actin filament organization negative regulation of cell adhesion establishment or maintenance of cell polarity small GTPase mediated signal transduction regulation of cell shape actin cytoskeleton membrane neuron remodeling cell migration protein kinase binding cortical cytoskeleton organization cytoplasmic vesicle regulation of actin cytoskeleton organization cell projection intracellular membrane-bounded organelle intracellular membrane-bounded organelle	04360
TC1400000580.mm.2	Rnase6	ribonuclease, RNase A family, 6	14	51123907, 51129036, 51129063	NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634	78416	15	nucleic acid binding nuclease activity endonuclease activity ribonuclease activity ribonuclease activity extracellular region extracellular space extracellular space extracellular space lysosome hydrolase activity antibacterial humoral response antibacterial humoral response antibacterial humoral response cytoplasmic vesicle defense response to bacterium innate immune response innate immune response innate immune response defense response to Gram-negative bacterium defense response to Gram-negative bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide RNA phosphodiester bond hydrolysis
TC0900002197.mm.2	Il10ra	interleukin 10 receptor, alpha	9	-45253836	NM_008348, BC146496 NM_008348, BC146496	16154	73	cytokine receptor activity interleukin-10 receptor activity cytoplasm cytosol plasma membrane plasma membrane negative regulation of autophagy membrane integral component of membrane cytokine-mediated signaling pathway interleukin-10 binding positive regulation of receptor signaling pathway via JAK-STAT regulation of synapse organization ubiquitin-dependent endocytosis	04060 04630 05145
TC0900001768.mm.2	Endod1	endonuclease domain containing 1	9	-14353989	NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490	71946	19	nucleic acid binding nuclease activity endonuclease activity extracellular region biological_process hydrolase activity metal ion binding	04210
TC0700004003.mm.2					NR_040453, NR_040456 NR_040453, NR_040456
TC0700001793.mm.2	Il4ra	interleukin 4 receptor, alpha	7	125552270	NM_001008700, BC112911 NM_001008700, BC112911	16190	384	immune system process production of molecular mediator involved in inflammatory response positive regulation of immunoglobulin production cytokine receptor activity protein binding extracellular region extracellular space nucleoplasm plasma membrane membrane integral component of membrane immunoglobulin mediated immune response positive regulation of chemokine production centriolar satellite regulation of cell population proliferation defense response to protozoan positive regulation of macrophage activation receptor complex positive regulation of mast cell degranulation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of cold-induced thermogenesis positive regulation of myoblast fusion	04060 04630 04640
TC1300000624.mm.2	Hrh2	histamine receptor H2	13	54192128, 54192132	NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958	15466	62	gastric acid secretion histamine-induced gastric acid secretion gastrin-induced gastric acid secretion epithelial cell morphogenesis G protein-coupled receptor activity histamine receptor activity G protein-coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission memory visual learning membrane integral component of membrane dendrite neurotransmitter receptor activity positive regulation of vasoconstriction regulation of synaptic plasticity digestive tract development gland development negative regulation of arachidonic acid secretion heterocyclic compound binding toxin transport	04020 04080 04971
TC0500001896.mm.2	Fzd1	frizzled class receptor 1	5	-4753838	NM_021457, BC053010 NM_021457, BC053010	14362	86	positive regulation of protein phosphorylation membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis transmembrane signaling receptor activity G protein-coupled receptor activity signaling receptor binding frizzled binding plasma membrane plasma membrane signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling cell-cell signaling multicellular organism development cell surface positive regulation of neuron projection development membrane integral component of membrane Wnt signaling pathway Wnt-protein binding Wnt-protein binding Wnt-protein binding PDZ domain binding negative regulation of BMP signaling pathway epithelial cell differentiation epithelial cell differentiation autocrine signaling non-canonical Wnt signaling pathway astrocyte-dopaminergic neuron signaling response to drug identical protein binding protein homodimerization activity Wnt-activated receptor activity Wnt-activated receptor activity neuron projection canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein heterodimerization activity positive regulation of DNA-binding transcription factor activity hard palate development canonical Wnt signaling pathway canonical Wnt signaling pathway canonical Wnt signaling pathway canonical Wnt signaling pathway ventricular septum morphogenesis negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure negative regulation of oxidative stress-induced neuron death regulation of presynapse assembly regulation of presynapse assembly	04310 04916 05200 05217
TC1100003779.mm.2	Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	11	-100694883	NM_030150, BC029209 NM_030150, BC029209	80861	36	nucleotide binding immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity ATP binding cytoplasm cytoplasm zinc ion binding zinc ion binding response to virus response to virus response to bacterium hydrolase activity negative regulation of type I interferon production negative regulation of type I interferon production positive regulation of type I interferon production positive regulation of interferon-beta production negative regulation of MDA-5 signaling pathway negative regulation of RIG-I signaling pathway negative regulation of RIG-I signaling pathway innate immune response regulation of innate immune response negative regulation of innate immune response negative regulation of innate immune response metal ion binding defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway	04622
TC0600003305.mm.2	Mansc1	MANSC domain containing 1	6	-134609206	NM_026345, BC039930 NM_026345, BC039930	67729	14	molecular_function cellular_component biological_process membrane integral component of membrane
TC0200000222.mm.2	Il15ra	interleukin 15 receptor, alpha chain	2	11705711, 11705292	NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192	16169	143	extracellular region nucleus plasma membrane plasma membrane plasma membrane receptor signaling pathway via JAK-STAT cell surface negative regulation of neuron projection development membrane integral component of membrane protein kinase binding cytoplasmic vesicle positive regulation of natural killer cell differentiation interleukin-15-mediated signaling pathway interleukin-15-mediated signaling pathway interleukin-15 receptor activity interleukin-15 receptor activity positive regulation of phagocytosis	04060 04630 04672
TC0600002114.mm.2	Parp12	poly (ADP-ribose) polymerase family, member 12	6	-39086411	NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645	243771	25	NAD+ ADP-ribosyltransferase activity cellular_component nucleus protein ADP-ribosylation transferase activity protein phosphopantetheinylation metal ion binding protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity
TC1200000279.mm.2	Nampt	nicotinamide phosphoribosyltransferase	12	32820334	NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358	59027	155	nucleotide binding microglial cell activation catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity cytokine activity extracellular region extracellular space nucleus cytoplasm cytoplasm cytosol plasma membrane circadian rhythm NAD biosynthetic process negative regulation of autophagy regulation of lung blood pressure nuclear speck transferase activity transferase activity, transferring glycosyl groups pyridine nucleotide biosynthetic process cell junction circadian regulation of gene expression identical protein binding identical protein binding positive regulation of transcription by RNA polymerase II nicotinamide phosphoribosyltransferase activity nicotinamide phosphoribosyltransferase activity rhythmic process positive regulation of smooth muscle cell proliferation positive regulation of nitric-oxide synthase biosynthetic process negative regulation of cellular senescence	00760
TC1700000505.mm.2	Pim1	proviral integration site 1	17	29493084, 29490784	NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316	18712	186	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding ATP binding nucleus nucleolus cytoplasm cytoplasm cytosol plasma membrane protein phosphorylation protein phosphorylation apoptotic process cell cycle transcription factor binding membrane kinase activity phosphorylation transferase activity regulation of transmembrane transporter activity manganese ion binding manganese ion binding ribosomal small subunit binding negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity protein serine/threonine kinase activator activity positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated protein autophosphorylation protein autophosphorylation metal ion binding protein stabilization positive regulation of cardiac muscle cell proliferation vitamin D receptor signaling pathway positive regulation of protein serine/threonine kinase activity positive regulation of brown fat cell differentiation regulation of hematopoietic stem cell proliferation positive regulation of cardioblast proliferation cellular detoxification	04630 05221
TC1800000834.mm.2	Pstpip2	proline-serine-threonine phosphatase-interacting protein 2	18	77794549	NM_013831, BC002123, BC057654 NM_013831, BC002123, BC057654 NM_013831, BC002123, BC057654	19201	37	actin binding protein binding cytoplasm cytosol cytoskeleton cytoskeleton actin filament plasma membrane cytoskeleton organization membrane cell migration actin filament polymerization actin filament binding
TC1500002347.mm.2	Parp10	poly (ADP-ribose) polymerase family, member 10	15	-76232994	NM_001163575, NM_001163576 NM_001163575, NM_001163576	671535	16	transcription corepressor activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity nucleus nucleus nucleolus cytoplasm cytoplasm Golgi apparatus cytosol DNA repair protein ADP-ribosylation cellular response to DNA damage stimulus negative regulation of gene expression negative regulation of gene expression regulation of chromatin assembly transferase activity transferase activity, transferring glycosyl groups translesion synthesis negative regulation of NF-kappaB transcription factor activity negative regulation of viral genome replication negative regulation of fibroblast proliferation protein poly-ADP-ribosylation protein poly-ADP-ribosylation protein auto-ADP-ribosylation K63-linked polyubiquitin modification-dependent protein binding protein mono-ADP-ribosylation protein mono-ADP-ribosylation negative regulation of protein K63-linked ubiquitination protein ADP-ribosylase activity protein ADP-ribosylase activity
TC1100000792.mm.2	Adora2b	adenosine A2b receptor	11	62248983	NM_007413, BC116415, BC116416 NM_007413, BC116415, BC116416 NM_007413, BC116415, BC116416	11541	178	G protein-coupled adenosine receptor activity positive regulation of endothelial cell proliferation G protein-coupled adenosine receptor signaling pathway positive regulation of chronic inflammatory response to non-antigenic stimulus G protein-coupled receptor activity plasma membrane plasma membrane signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cell population proliferation negative regulation of cell population proliferation cell surface positive regulation of vascular endothelial growth factor production positive regulation of endothelial cell migration positive regulation of norepinephrine secretion positive regulation of cGMP-mediated signaling positive regulation of steroid biosynthetic process regulation of glucose metabolic process membrane integral component of membrane positive regulation of guanylate cyclase activity cellular response to extracellular stimulus positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-6 production negative regulation of collagen biosynthetic process positive regulation of catecholamine secretion positive regulation of mast cell degranulation positive regulation of cAMP-mediated signaling synapse relaxation of vascular associated smooth muscle Schaffer collateral - CA1 synapse Schaffer collateral - CA1 synapse glutamatergic synapse glutamatergic synapse glutamatergic synapse glutamatergic synapse response to angiotensin regulation of synaptic vesicle exocytosis regulation of synaptic vesicle exocytosis	04020 04080 04270
TC0300002659.mm.2	Mov10	Mov10 RISC complex RNA helicase	3	-104794833, -104794833	NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743	17454	39	nucleotide binding P-body RNA binding RNA binding helicase activity protein binding ATP binding nucleus cytoplasm cytosol cytosol cytosol negative regulation of transposition, RNA-mediated negative regulation of transposition, RNA-mediated hydrolase activity gene silencing by RNA 5'-3' RNA helicase activity post-transcriptional gene silencing by RNA gene silencing by miRNA mRNA cleavage involved in gene silencing by miRNA cytoplasmic ribonucleoprotein granule P granule defense response to virus positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization regulation of neuron projection arborization
TC1100003663.mm.2	Arl5c	ADP-ribosylation factor-like 5C	11	-97989579	NM_207231, BC065791 NM_207231, BC065791	217151	11	nucleotide binding GTP binding cytoplasm trans-Golgi network intracellular protein transport vesicle-mediated transport protein localization to Golgi membrane
TC0700003862.mm.2	Trim21	tripartite motif-containing 21	7	-102557919	NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580	20821	59	protein polyubiquitination protein polyubiquitination DNA binding transcription coactivator activity RNA binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytoplasm cytosol protein monoubiquitination cell cycle zinc ion binding regulation of gene expression positive regulation of autophagy positive regulation of autophagy protein ubiquitination protein ubiquitination transferase activity SCF ubiquitin ligase complex protein kinase binding cytoplasmic vesicle protein destabilization negative regulation of NF-kappaB transcription factor activity positive regulation of protein binding regulation of protein localization negative regulation of viral transcription response to interferon-gamma identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response innate immune response positive regulation of cell cycle negative regulation of innate immune response regulation of viral entry into host cell positive regulation of viral entry into host cell metal ion binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination ubiquitin protein ligase activity ubiquitin protein ligase activity protein K63-linked ubiquitination negative regulation of protein deubiquitination negative regulation of viral release from host cell	05322
TC0800002330.mm.2	Tma16	translation machinery associated 16	8	-66476342	NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844	66282	15	molecular_function nucleus nucleoplasm nucleolus biological_process
TC0500000816.mm.2	Dck	deoxycytidine kinase	5	88765012	NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062	13178	28	nucleotide binding magnesium ion binding deoxyadenosine kinase activity deoxycytidine kinase activity deoxycytidine kinase activity deoxyguanosine kinase activity ATP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol nucleobase-containing compound metabolic process pyrimidine nucleotide metabolic process drug binding kinase activity transferase activity deoxynucleoside kinase activity nucleoside kinase activity pyrimidine deoxyribonucleoside binding protein homodimerization activity deoxycytidine metabolic process nucleotide phosphorylation	00230 00240 01100
TC0500003180.mm.2	Oas1g	2'-5' oligoadenylate synthetase 1G	5	-120876141	NM_011852, BC018470, BC043339 NM_011852, BC018470, BC043339 NM_011852, BC018470, BC043339	23960	17	2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol membrane negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity
TC0700003996.mm.2					NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717			molecular_function cellular_component biological_process
TC0100002711.mm.2					XR_140448
TC1000001813.mm.2	Tnfaip3	tumor necrosis factor, alpha-induced protein 3	10	-19000909, -19000909	NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221	21929	188	B-1 B cell homeostasis protease binding response to molecule of bacterial origin response to molecule of bacterial origin marginal zone B cell differentiation negative regulation of granuloma formation regulation of germinal center formation regulation of immunoglobulin production negative regulation of chronic inflammatory response DNA binding catalytic activity ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleus cytoplasm cytoplasm lysosome proteolysis apoptotic process inflammatory response cytoskeleton organization protein C-terminus binding metabolic process peptidase activity cysteine-type peptidase activity zinc ion binding response to wounding negative regulation of autophagy cell migration protein ubiquitination protein deubiquitination transferase activity hydrolase activity kinase binding positive regulation of Wnt signaling pathway negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of heterotypic cell-cell adhesion negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K29-linked deubiquitination protein K11-linked deubiquitination identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding protein self-association regulation of innate immune response positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of innate immune response metal ion binding negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of B cell activation negative regulation of cell death Lys63-specific deubiquitinase activity cellular response to hydrogen peroxide negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway K63-linked polyubiquitin modification-dependent protein binding protein K63-linked deubiquitination protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process protein K33-linked deubiquitination positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process	04621
TC0700003517.mm.2	Slco3a1	solute carrier organic anion transporter family, member 3a1	7	-74275417, -74281915	NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059	108116	23	positive regulation of protein phosphorylation transporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane ion transport oligopeptide transport organic anion transmembrane transporter activity basal plasma membrane cell surface sodium-independent organic anion transmembrane transporter activity organic anion transport prostaglandin transport prostaglandin transport membrane integral component of membrane apical plasma membrane oligopeptide transmembrane transporter activity sodium-independent organic anion transport positive regulation of NF-kappaB transcription factor activity transmembrane transport
TC1400000851.mm.2	Spata13	spermatogenesis associated 13	14	60634704, 60732903	NM_001033272, BC138455, BC145285 NM_001033272, BC138455, BC145285 NM_001033272, BC138455, BC145285	219140	30	guanyl-nucleotide exchange factor activity nucleoplasm cytoplasm cytosol plasma membrane membrane cell migration lamellipodium lamellipodium assembly filopodium regulation of cell migration ruffle membrane regulation of Rho protein signal transduction intracellular signal transduction identical protein binding cell projection filopodium assembly
TC0300002188.mm.2	Rapgef2	Rap guanine nucleotide exchange factor (GEF) 2	3	-79062510, -79062510	NM_001099624	76089	38	blood vessel development neuron migration guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity GTPase activator activity intracellular anatomical structure cytoplasm endosome late endosome cytosol plasma membrane bicellular tight junction signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide signaling pathway small GTPase mediated signal transduction multicellular organism development nervous system development negative regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of neuron projection development membrane apical plasma membrane protein kinase binding cAMP-mediated signaling cAMP-mediated signaling ventricular system development forebrain neuron development microvillus assembly cell junction endocytic vesicle cell differentiation PDZ domain binding neuron projection development neuron projection development brain-derived neurotrophic factor receptor signaling pathway beta-1 adrenergic receptor binding positive regulation of protein binding Rap protein signal transduction protein-containing complex nerve growth factor signaling pathway regulation of cell population proliferation neuron projection neuronal cell body positive regulation of GTPase activity positive regulation of GTPase activity positive regulation of GTPase activity positive regulation of cAMP-mediated signaling synapse positive regulation of protein kinase activity positive regulation of protein kinase activity negative regulation of melanin biosynthetic process regulation of synaptic plasticity perinuclear region of cytoplasm WW domain binding negative regulation of dendrite morphogenesis negative regulation of dendrite morphogenesis establishment of endothelial barrier phosphatidic acid binding positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to cAMP cellular response to cAMP cellular response to cGMP adenylate cyclase-activating adrenergic receptor signaling pathway protein localization to plasma membrane establishment of endothelial intestinal barrier regulation of cell junction assembly cellular response to nerve growth factor stimulus positive regulation of cAMP-dependent protein kinase activity positive regulation of cAMP-dependent protein kinase activity positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell apoptotic process positive regulation of vasculogenesis positive regulation of neuron migration	04010
TC1900001019.mm.2	Prdx5	peroxiredoxin 5	19	-6906696	NM_012021, BC008174 NM_012021, BC008174	54683	60	RNA polymerase III transcription regulatory region sequence-specific DNA binding peroxidase activity signaling receptor binding signaling receptor binding protein binding nucleus cytoplasm cytoplasm cytoplasm mitochondrion mitochondrion mitochondrion peroxisome peroxisome peroxisomal matrix peroxisomal matrix cytosol response to oxidative stress response to oxidative stress thioredoxin peroxidase activity thioredoxin peroxidase activity antioxidant activity antioxidant activity negative regulation of transcription by RNA polymerase III oxidoreductase activity cytoplasmic vesicle positive regulation of collagen biosynthetic process cellular response to oxidative stress cellular response to reactive oxygen species hydrogen peroxide catabolic process hydrogen peroxide catabolic process hydrogen peroxide catabolic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle cell redox homeostasis perinuclear region of cytoplasm negative regulation of oxidoreductase activity peroxiredoxin activity regulation of apoptosis involved in tissue homeostasis NADPH oxidation peroxynitrite reductase activity reactive nitrogen species metabolic process	04146
TC0300002506.mm.2	Fcgr1	Fc receptor, IgG, high affinity I	3	-96282908	NM_010186, BC160240 NM_010186, BC160240	14129	186	antibody-dependent cellular cytotoxicity positive regulation of type IIa hypersensitivity positive regulation of type III hypersensitivity immune system process transmembrane signaling receptor activity plasma membrane integral component of plasma membrane receptor-mediated endocytosis phagocytosis, recognition phagocytosis, engulfment cell surface receptor signaling pathway cell surface receptor signaling pathway response to bacterium external side of plasma membrane membrane integral component of membrane IgG receptor activity IgG binding IgG binding antigen processing and presentation of exogenous antigen leukotriene receptor binding antigen processing and presentation of exogenous peptide antigen via MHC class I defense response to bacterium innate immune response membrane raft positive regulation of phagocytosis regulation of immune response regulation of immune response positive regulation of phagocytosis, engulfment positive regulation of protein tyrosine kinase activity	04145 04380 04640 04666 05140 05150 05322
TC1600001557.mm.2	Dtx3l	deltex 3-like, E3 ubiquitin ligase	16	-35926514	NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694	209200	18	positive regulation of defense response to virus by host immune system process ubiquitin-protein transferase activity enzyme inhibitor activity nucleus nucleoplasm nucleoplasm cytoplasm lysosome endosome early endosome cytosol DNA repair double-strand break repair chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus Notch signaling pathway enzyme activator activity endosome to lysosome transport histone monoubiquitination protein transport membrane protein ubiquitination transferase activity enzyme binding positive regulation of protein binding protein-containing complex histone H2A ubiquitination histone H2B ubiquitination positive regulation of chromatin binding histone binding ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated metal ion binding negative regulation of ubiquitin-protein transferase activity defense response to virus protein autoubiquitination ubiquitin protein ligase activity protein K48-linked ubiquitination STAT family protein binding positive regulation of protein localization to nucleus positive regulation of NAD+ ADP-ribosyltransferase activity positive regulation of protein localization to early endosome positive regulation of receptor catabolic process positive regulation of double-strand break repair via nonhomologous end joining	04330
TC1400001086.mm.2	Epsti1	epithelial stromal interaction 1 (breast)	14	77904238, 77904238	NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821	108670	13	molecular_function cellular_component biological_process
TC0200004636.mm.2	Slc4a11	solute carrier family 4, sodium bicarbonate transporter-like, member 11	2	-130684107	NM_001081162, BC111884 NM_001081162, BC111884	269356	26	sodium channel activity inorganic anion exchanger activity plasma membrane plasma membrane ion transport sodium ion transport anion transport vesicle membrane bicarbonate transmembrane transporter activity proton channel activity symporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane basolateral plasma membrane basolateral plasma membrane apical plasma membrane transmembrane transporter activity cellular cation homeostasis fluid transport borate transport active borate transmembrane transporter activity protein dimerization activity ion homeostasis ion homeostasis transmembrane transport proton transmembrane transport
TC1200000225.mm.2	Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	12	26469214	NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565	22169	17	nucleotide binding cytidylate kinase activity cytidylate kinase activity nucleoside diphosphate kinase activity nucleoside diphosphate kinase activity thymidylate kinase activity thymidylate kinase activity ATP binding nucleoplasm cytoplasm mitochondrion mitochondrion nucleoside diphosphate phosphorylation pyrimidine nucleotide biosynthetic process dUDP biosynthetic process dUDP biosynthetic process dTDP biosynthetic process dTDP biosynthetic process dTTP biosynthetic process uridylate kinase activity uridylate kinase activity nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity UMP kinase activity nucleoside monophosphate kinase activity cellular response to lipopolysaccharide	00240 01100
TC0300000161.mm.2	Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	3	27317076	NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808	22035	189	cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space plasma membrane apoptotic process immune response zinc ion binding membrane integral component of membrane tumor necrosis factor receptor superfamily binding identical protein binding positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process TRAIL binding metal ion binding positive regulation of release of cytochrome c from mitochondria positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway	04060 04210 04650
TC1300001526.mm.2	Gpr141	G protein-coupled receptor 141	13	-19749681	NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587	353346	13	G protein-coupled receptor activity cellular_component plasma membrane signal transduction membrane integral component of membrane
TC1400000575.mm.2	Pnp2	purine-nucleoside phosphorylase 2	14	50956140	NM_001123371	667034	10	nucleoside binding purine nucleobase binding purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity extracellular region nucleus cytoplasm cytoplasm cytosol phosphate ion binding identical protein binding	00230 00240 00760 01100
TC0600000637.mm.2	Creb5	cAMP responsive element binding protein 5	6	53573373, 53287302	NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487	231991	23	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cAMP response element binding identical protein binding fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II adipose tissue development sequence-specific double-stranded DNA binding	04962 05016 05215
TC0200003560.mm.2	Nr4a2	nuclear receptor subfamily 4, group A, member 2	2	-57107225, -57107225	NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715	18227	310	negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific response to hypoxia neuron migration response to amphetamine DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleus nucleoplasm transcription regulator complex cytoplasm transcription, DNA-templated transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II nervous system development zinc ion binding adult locomotory behavior post-embryonic development response to inorganic substance gene expression regulation of gene expression nuclear speck response to insecticide central nervous system projection neuron axonogenesis central nervous system neuron differentiation central nervous system neuron differentiation habenula development neuron differentiation cellular response to extracellular stimulus cellular response to extracellular stimulus cellular response to oxidative stress glucocorticoid receptor binding glucocorticoid receptor binding regulation of dopamine metabolic process dopamine biosynthetic process dopamine metabolic process neuron maturation positive regulation of catalytic activity negative regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding regulation of respiratory gaseous exchange fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding protein heterodimerization activity general adaptation syndrome cellular response to corticotropin-releasing hormone stimulus cellular response to corticotropin-releasing hormone stimulus dopaminergic neuron differentiation dopaminergic neuron differentiation dopaminergic neuron differentiation sequence-specific double-stranded DNA binding negative regulation of apoptotic signaling pathway
TC1700000685.mm.2	H2-Q5	histocompatibility 2, Q region locus 5	17	35394098	NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944	15016	29
TC0600001481.mm.2	Parp11	poly (ADP-ribose) polymerase family, member 11	6	127453626, 127446839	NM_181402, BC040269 NM_181402, BC040269	101187	18	NAD+ ADP-ribosyltransferase activity nucleus nuclear envelope nuclear pore nucleoplasm cytosol protein ADP-ribosylation nuclear envelope organization spermatogenesis protein transport nuclear body transferase activity transferase activity, transferring glycosyl groups protein phosphopantetheinylation cell differentiation mRNA transport protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity
TC1700000622.mm.2	Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	17	34198194	NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450	16913	114	proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity protein binding nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteasome core complex proteolysis peptidase activity proteasomal ubiquitin-independent protein catabolic process hydrolase activity antigen processing and presentation cell differentiation proteasome-mediated ubiquitin-dependent protein catabolic process fat cell differentiation fat cell differentiation proteolysis involved in cellular protein catabolic process regulation of endopeptidase activity spermatoproteasome complex	03050
TC0100000758.mm.2					XM_979370
TC1700000600.mm.2	Daxx	Fas death domain-associated protein	17	33909497, 33909600, 33909444	NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373	13163	100	negative regulation of transcription by RNA polymerase II mitotic cytokinesis chromosome, centromeric region heterochromatin XY body positive regulation of protein phosphorylation p53 binding transcription coactivator activity transcription coactivator activity transcription corepressor activity transcription corepressor activity transcription corepressor activity protein binding nucleus nucleus nucleoplasm chromosome cytoplasm cytosol microtubule cell cortex chromatin organization nucleosome assembly nucleosome assembly nucleosome assembly chromatin remodeling regulation of transcription, DNA-templated apoptotic process transcription factor binding transcription factor binding JUN kinase binding negative regulation of myotube differentiation nuclear body PML body PML body PML body kinesin binding enzyme binding protein kinase binding protein kinase activator activity androgen receptor signaling pathway PML body organization regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of histone phosphorylation cellular response to heat cellular response to unfolded protein regulation of multicellular organism growth histone binding histone binding histone binding protein homodimerization activity regulation of apoptotic process neuron projection positive regulation of apoptotic process negative regulation of apoptotic process cell body positive regulation of protein kinase activity negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein N-terminus binding androgen receptor binding protein localization to chromatin cellular response to cadmium ion cellular response to copper ion cellular response to diamide apoptotic signaling pathway sumo-dependent protein binding transcription regulator inhibitor activity positive regulation of neuron death cellular response to sodium arsenite positive regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway	04010 05014
TC0100003889.mm.2	Ifi211	interferon activated gene 211	1	-173896340	NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397	381308	19	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus nucleolus cytosol transcription factor binding response to bacterium nuclear speck positive regulation of interleukin-1 beta production nuclear periphery cellular response to interferon-beta identical protein binding
TC0800001698.mm.2	Rab20	RAB20, member RAS oncogene family	8	-11453389	NM_011227, BC089570 NM_011227, BC089570	19332	33	nucleotide binding GTPase activity GTP binding Golgi apparatus intracellular protein transport endomembrane system protein transport membrane cytoplasmic vesicle intracellular membrane-bounded organelle phagocytic vesicle phagocytic vesicle cellular response to interferon-gamma phagosome acidification phagosome-lysosome fusion
TC0700003942.mm.2					XM_485980
TC0200004109.mm.2	Nr1h3	nuclear receptor subfamily 1, group H, member 3	2	-91184060, -91184060	NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646	22259	438	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II chromatin transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity nuclear receptor activity nuclear receptor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol regulation of transcription, DNA-templated fatty acid biosynthetic process zinc ion binding positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of cholesterol efflux negative regulation of cholesterol storage negative regulation of cholesterol storage cell differentiation positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone sterol response element binding positive regulation of toll-like receptor 4 signaling pathway phosphatidylcholine acyl-chain remodeling cholesterol homeostasis cholesterol homeostasis cholesterol homeostasis negative regulation of macrophage activation receptor complex apoptotic cell clearance sequence-specific DNA binding cellular lipid metabolic process protein-containing complex binding positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding retinoid X receptor binding negative regulation of pinocytosis negative regulation of inflammatory response negative regulation of inflammatory response positive regulation of lipoprotein lipase activity lipid homeostasis lipid homeostasis sterol homeostasis triglyceride homeostasis triglyceride homeostasis cellular response to lipopolysaccharide cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes RNA polymerase II transcription regulator complex RNA polymerase II transcription regulator complex negative regulation of cold-induced thermogenesis negative regulation of response to endoplasmic reticulum stress	03320 05160
TC0800001451.mm.2	Irf8	interferon regulatory factor 8	8	120736357, 120738638	NM_008320, BC005450 NM_008320, BC005450	15900	289	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific plasmacytoid dendritic cell differentiation immune system process DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II phagocytosis autophagy immune response response to bacterium myeloid cell differentiation regulation of type I interferon production positive regulation of interferon-gamma production positive regulation of interleukin-12 production defense response to bacterium defense response to protozoan positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription initiation from RNA polymerase II promoter cellular response to lipopolysaccharide cellular response to interferon-gamma dendritic cell differentiation sequence-specific double-stranded DNA binding
TC1100002642.mm.2	Gm5431	predicted gene 5431	11	-48887421	NM_001024230	432555	9	GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta
TC0700003941.mm.2	Trim30b	tripartite motif-containing 30B	7	-104355397	NM_175648	244183	14	protein polyubiquitination nucleoplasm cytoplasm cytosol regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity
TC0600003503.mm.2	Herc6	hect domain and RLD 6	6	57580991	NM_025992	67138	17	hematopoietic progenitor cell differentiation immune system process ubiquitin-protein transferase activity nucleoplasm cytoplasm cytosol response to bacterium protein ubiquitination transferase activity protein phosphopantetheinylation cyclin binding innate immune response ubiquitin protein ligase activity
TC0300002053.mm.2	P2ry13	purinergic receptor P2Y, G-protein coupled 13	3	-59207893	NM_028808, BC119043 NM_028808, BC119043	74191	40	G protein-coupled receptor activity endoplasmic reticulum plasma membrane signal transduction G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity G protein-coupled purinergic nucleotide receptor activity cellular response to organic cyclic compound	04080
TC1_GL456212_random00000013.mm.2	Sp110	Sp110 nuclear body protein	1	-85576898, -85576898	BC039938	109032	29	DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding nucleus nucleoplasm regulation of transcription by RNA polymerase II apoptotic process response to bacterium response to bacterium positive regulation of apoptotic process innate immune response
TC1600001742.mm.2	Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	16	-55811376, -55811376	NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188	80859	64	protein binding nucleus nucleus inflammatory response regulation of gene expression nuclear speck cytoplasmic ribonucleoprotein granule positive regulation of inflammatory response T cell receptor signaling pathway positive regulation of T-helper 17 cell differentiation
TC1700001993.mm.2	H2-T24	histocompatibility 2, T region locus 24	17	-36005694	NM_008207, BC156693 NM_008207, BC156693	15042	11	positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding	04144 04145 04514 04612 04940 05320 05330 05332 05416
TC0100003888.mm.2	Ifi204	interferon activated gene 204	1	-173747293	NM_008329	15951	60	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding double-stranded DNA binding transcription coregulator activity protein binding nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytosol regulation of transcription by RNA polymerase II multicellular organism development transcription factor binding response to bacterium response to bacterium nuclear speck positive regulation of interleukin-1 beta production cellular response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta nuclear inclusion body intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding positive regulation of osteoblast differentiation inner ear development
TC0200005175.mm.2	Prex1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	2	-166566344	NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940	277360	42	guanyl-nucleotide exchange factor activity phospholipid binding cytoplasm cytosol plasma membrane plasma membrane G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway membrane T cell differentiation positive regulation of cell migration growth cone neutrophil chemotaxis regulation of actin filament polymerization regulation of Rho protein signal transduction intracellular signal transduction dendritic shaft positive regulation of GTPase activity positive regulation of cell adhesion perinuclear region of cytoplasm regulation of dendrite development reactive oxygen species metabolic process positive regulation of substrate adhesion-dependent cell spreading	04062
TC0600003108.mm.2	C1s1	complement component 1, s subcomponent 1	6	-124530343, -124530343	NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880	50908	16	immune system process serine-type endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular region extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity identical protein binding innate immune response metal ion binding	04610 05150 05322
TC0600001258.mm.2	Irak2	interleukin-1 receptor-associated kinase 2	6	113638466	NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324	108960	42	nucleotide binding regulation of cytokine-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway protein kinase activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm plasma membrane protein phosphorylation inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity intracellular signal transduction protein homodimerization activity regulation of apoptotic process negative regulation of DNA-binding transcription factor activity protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1	04210 04722
TC0700004538.mm.2	Slc25a22	solute carrier family 25 (mitochondrial carrier, glutamate), member 22	7	-141429748, -141429748, -141429748	NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949	68267	35	L-glutamate transmembrane transporter activity L-glutamate transmembrane transporter activity mitochondrion mitochondrial inner membrane transport L-aspartate transmembrane transporter activity symporter activity aspartate transmembrane transport L-glutamate transmembrane transport L-glutamate transmembrane transport membrane integral component of membrane transmembrane transporter activity malate-aspartate shuttle transmembrane transport
TC0600003307.mm.2	Dusp16	dual specificity phosphatase 16	6	-134715467	NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232	70686	39	inactivation of MAPK activity inactivation of MAPK activity phosphoprotein phosphatase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol protein dephosphorylation protein tyrosine/threonine phosphatase activity dephosphorylation phosphatase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation negative regulation of MAPK cascade mitogen-activated protein kinase binding	04010
TC0200002410.mm.2	Src	Rous sarcoma oncogene	2	157424292	NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953	20779	555	nucleotide binding primary ovarian follicle growth positive regulation of cytokine production podosome immune system process protein kinase activity protein kinase activity protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding signaling receptor binding signaling receptor binding insulin receptor binding integrin binding protein binding ATP binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm mitochondrion mitochondrion mitochondrial inner membrane mitochondrial inner membrane lysosome late endosome cytosol cytosol cytoskeleton actin filament plasma membrane plasma membrane plasma membrane caveola caveola focal adhesion protein phosphorylation cell cycle cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway protein C-terminus binding cell population proliferation positive regulation of gene expression regulation of epithelial cell migration positive regulation of epithelial cell migration positive regulation of glucose metabolic process positive regulation of protein processing postsynaptic density positive regulation of smooth muscle cell migration membrane membrane kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation enzyme binding kinase binding protein kinase binding protein domain specific binding heme binding regulation of cell-cell adhesion cell junction cell differentiation estrogen receptor binding forebrain development extrinsic component of cytoplasmic side of plasma membrane negative regulation of protein-containing complex assembly ubiquitin protein ligase binding protein destabilization positive regulation of protein autophosphorylation activation of protein kinase B activity negative regulation of telomere maintenance via telomerase ruffle membrane regulation of intracellular estrogen receptor signaling pathway substrate adhesion-dependent cell spreading cellular response to reactive oxygen species positive regulation of dephosphorylation intracellular signal transduction intracellular signal transduction osteoclast development osteoclast development cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation SH2 domain binding odontogenesis neuron projection positive regulation of apoptotic process negative regulation of apoptotic process stress fiber assembly negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of protein binding positive regulation of MAP kinase activity positive regulation of phosphatidylinositol 3-kinase activity ion channel binding protein-containing complex binding transcytosis innate immune response bone resorption bone resorption positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of insulin receptor signaling pathway protein autophosphorylation ephrin receptor binding ephrin receptor binding neurotrophin TRK receptor signaling pathway focal adhesion assembly perinuclear region of cytoplasm perinuclear region of cytoplasm oogenesis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding progesterone receptor signaling pathway progesterone receptor signaling pathway positive regulation of small GTPase mediated signal transduction phosphoprotein binding positive regulation of protein transport negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization negative regulation of telomerase activity uterus development branching involved in mammary gland duct morphogenesis regulation of cell projection assembly intestinal epithelial cell development intestinal epithelial cell development interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade response to interleukin-1 BMP receptor binding growth factor receptor binding growth factor receptor binding connexin binding cellular response to peptide hormone stimulus cellular response to progesterone stimulus cellular response to fluid shear stress cellular response to transforming growth factor beta stimulus positive regulation of podosome assembly positive regulation of podosome assembly positive regulation of protein serine/threonine kinase activity angiotensin-activated signaling pathway involved in heart process positive regulation of canonical Wnt signaling pathway scaffold protein binding scaffold protein binding regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse postsynaptic specialization, intracellular component positive regulation of protein localization to nucleus positive regulation of intracellular signal transduction positive regulation of ovarian follicle development positive regulation of lamellipodium morphogenesis positive regulation of DNA biosynthetic process positive regulation of platelet-derived growth factor receptor-beta signaling pathway regulation of early endosome to late endosome transport negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway regulation of caveolin-mediated endocytosis	04012 04144 04370 04510 04520 04530 04540 04912 05100
TC1500001155.mm.2	Ptger4	prostaglandin E receptor 4 (subtype EP4)	15	-5233398	NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193	19219	209	negative regulation of cytokine production positive regulation of cytokine production positive regulation of protein phosphorylation negative regulation of peptide secretion G protein-coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity prostaglandin E receptor activity prostaglandin E receptor activity plasma membrane plasma membrane inflammatory response signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration JNK cascade positive regulation of cell population proliferation positive regulation of gene expression negative regulation of hydrogen peroxide metabolic process regulation of circadian sleep/wake cycle, wakefulness positive regulation of smooth muscle cell migration membrane integral component of membrane regulation of ossification nuclear membrane response to lipopolysaccharide negative regulation of interleukin-1 alpha production negative regulation of tumor necrosis factor production positive regulation of interleukin-10 production positive regulation of interleukin-8 production negative regulation of integrin activation positive regulation of urine volume positive regulation of renal sodium excretion T-helper cell differentiation negative regulation of circadian sleep/wake cycle, REM sleep chemokinesis positive regulation of tyrosine phosphorylation of STAT protein neuronal cell body positive regulation of cAMP-mediated signaling neuron projection terminus positive regulation of osteoblast differentiation positive regulation of ossification positive regulation of bone resorption positive regulation of cell adhesion positive regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of protein secretion negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of inflammatory response positive regulation of inflammatory response regulation of stress fiber assembly negative regulation of nitric-oxide synthase biosynthetic process bone development positive regulation of mucus secretion ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to prostaglandin E stimulus positive regulation of wound healing ductus arteriosus closure positive regulation of hyaluronan biosynthetic process negative regulation of ductus arteriosus closure negative regulation of small intestine smooth muscle contraction positive regulation of calcitonin secretion positive regulation of chemokinesis positive regulation of substance P secretion positive regulation of matrix metallopeptidase secretion negative regulation of endothelin production positive regulation of substance P secretion, neurotransmission positive regulation of ovarian follicle development positive regulation of antral ovarian follicle growth positive regulation of neutrophil extravasation negative regulation of eosinophil extravasation	04080
TC0300002680.mm.2	I830077J02Rik	RIKEN cDNA I830077J02 gene	3	-105925890	NM_001033780, BC147821, BC147828 NM_001033780, BC147821, BC147828 NM_001033780, BC147821, BC147828	433638	10	molecular_function cellular_component biological_process membrane integral component of membrane
TC1200000280.mm.2	Gdap10	ganglioside-induced differentiation-associated-protein 10	12	32824115	NR_045032, BC052902 NR_045032, BC052902	100504486	5	molecular_function cellular_component response to bacterium
TC1000000778.mm.2	Icosl	icos ligand	10	78069367	NM_015790, BC029227 NM_015790, BC029227	50723	107	regulation of cytokine production adaptive immune response immune system process signaling receptor binding signaling receptor binding protein binding plasma membrane integral component of plasma membrane signal transduction external side of plasma membrane external side of plasma membrane membrane integral component of membrane positive regulation of interleukin-4 production cytoplasmic ribonucleoprotein granule positive regulation of activated T cell proliferation T cell activation B cell activation identical protein binding isotype switching T cell receptor signaling pathway	04514 04672
TC0200001158.mm.2	Itga4	integrin alpha 4	2	79255425	NM_010576, BC068313 NM_010576, BC068313	16401	250	fibronectin binding fibronectin binding blood vessel remodeling positive regulation of leukocyte migration cell-matrix adhesion involved in ameboidal cell migration antigen binding plasma membrane cell-cell junction cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion cell-matrix adhesion integrin-mediated signaling pathway heart development integrin complex external side of plasma membrane cell surface cell surface membrane integral component of membrane cell migration C-X3-C chemokine binding growth cone cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading integrin alpha4-beta7 complex neuronal cell body receptor clustering metal ion binding cell adhesion molecule binding leukocyte tethering or rolling diapedesis face development axonogenesis involved in innervation mesenchyme development chorio-allantoic fusion visceral serous pericardium development extracellular exosome T cell migration negative regulation of protein homodimerization activity cell-cell adhesion import into cell cell-cell adhesion in response to extracellular stimulus positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte tethering or rolling cellular response to amyloid-beta positive regulation of vascular endothelial cell proliferation neuron projection extension protein antigen binding clathrin-dependent extracellular exosome endocytosis positive regulation of endothelial cell apoptotic process positive regulation of T cell migration	04510 04512 04514 04640 04670 04672 04810 05140 05410 05412 05414
TC1100002567.mm.2	Pttg1	pituitary tumor-transforming gene 1	11	-43420243, -43420243	NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324	30939	83	regulation of cell growth cysteine-type endopeptidase inhibitor activity nucleus nucleus nucleus cytoplasm cytosol DNA repair cellular response to DNA damage stimulus cell cycle chromosome segregation mitotic sister chromatid cohesion negative regulation of cell population proliferation cellular process SH3 domain binding heat shock protein binding ribosome binding homologous chromosome segregation homologous chromosome segregation chromosome organization cell division negative regulation of mitotic sister chromatid separation	04110 04114
TC0400003917.mm.2	Pdpn	podoplanin	4	-143267408	NM_010329, BC026551 NM_010329, BC026551	14726	331	cell morphogenesis cell morphogenesis ruffle lymphangiogenesis signaling receptor binding signaling receptor binding protein binding mitochondrion cytosol plasma membrane plasma membrane prostaglandin metabolic process movement of cell or subcellular component cell adhesion signal transduction Rho protein signal transduction Rho protein signal transduction multicellular organism development cell population proliferation negative regulation of cell population proliferation regulation of cell shape external side of plasma membrane positive regulation of platelet activation positive regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition membrane integral component of membrane basolateral plasma membrane basolateral plasma membrane apical plasma membrane apical plasma membrane chemokine binding chemokine binding lamellipodium lamellipodium cell junction regulation of cell adhesion filopodium filopodium lung development lung development positive regulation of cell migration positive regulation of cell migration lamellipodium membrane cytoplasmic vesicle filopodium membrane microvillus membrane ruffle membrane tube morphogenesis tube morphogenesis cell projection negative regulation of apoptotic process wound healing, spreading of cells membrane raft lung alveolus development lymph node development chaperone binding chaperone binding positive regulation of cellular component movement response to hyperoxia lymphatic endothelial cell fate commitment visceral serous pericardium development leading edge of lamellipodium actin-mediated cell contraction actin-mediated cell contraction positive regulation of extracellular matrix disassembly positive regulation of extracellular matrix disassembly tetraspanin-enriched microdomain cell-cell adhesion cell-cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of substrate adhesion-dependent cell spreading positive regulation of platelet aggregation positive regulation of platelet aggregation positive regulation of platelet aggregation positive regulation of platelet aggregation regulation of myofibroblast contraction regulation of myofibroblast contraction regulation of G1/S transition of mitotic cell cycle regulation of lamellipodium morphogenesis regulation of lamellipodium morphogenesis
TC0900001511.mm.2	Bcl2a1c	B cell leukemia/lymphoma 2 related protein A1c	9	114330134	NM_007535, BC120720 NM_007535, BC120720	12046	4	mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity protein heterodimerization activity extrinsic apoptotic signaling pathway in absence of ligand
TC0400000495.mm.2	Aldh1b1	aldehyde dehydrogenase 1 family, member B1	4	45799021	NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768	72535	32	aldehyde dehydrogenase (NAD+) activity nucleoplasm mitochondrion mitochondrion cytosol oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor intracellular membrane-bounded organelle	00010 00040 00053 00071 00280 00310 00330 00340 00380 00410 00561 00620 00640 01100
TC0800002431.mm.2	Bst2	bone marrow stromal cell antigen 2	8	-71534255	NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949	69550	43	immune system process cytoplasm endosome Golgi apparatus plasma membrane metalloendopeptidase inhibitor activity response to virus cell surface cell surface cell surface membrane integral component of membrane apical plasma membrane anchored component of membrane regulation of actin cytoskeleton organization response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response innate immune response defense response to virus negative regulation of intracellular transport of viral material negative regulation of intracellular transport of viral material
TC0500002818.mm.2	Rasgef1b	RasGEF domain family, member 1B	5	-99217419	NM_145839, NM_181318, BC050858, BC052726 NM_145839, NM_181318, BC050858, BC052726 NM_145839, NM_181318, BC050858, BC052726 NM_145839, NM_181318, BC050858, BC052726	320292	21	guanyl-nucleotide exchange factor activity regulation of catalytic activity
TC1700002071.mm.2	H2-M2	histocompatibility 2, M region locus 2	17	-37480850	NM_008204, BC150676 NM_008204, BC150676	14990	17	positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane cell surface peptide antigen binding	04144 04145 04514 04612 04940 05320 05330 05332 05416
TC0100000697.mm.2	Nyap2	neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2	1	81077406, 81077307, 81077203, 81076949	NM_172849, BC082310 NM_172849, BC082310	241134	15	protein binding phosphatidylinositol 3-kinase signaling neuron projection morphogenesis
TC1500000549.mm.2	Ly6e	lymphocyte antigen 6 complex, locus E	15	74955024	NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711	17069	39	in utero embryonic development plasma membrane membrane adrenal gland development acetylcholine receptor inhibitor activity acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding organ growth norepinephrine metabolic process negative regulation of viral entry into host cell negative regulation of viral entry into host cell epinephrine secretion ventricular cardiac muscle tissue morphogenesis acetylcholine receptor signaling pathway
TC1200001902.mm.2	Rtn1	reticulon 1	12	-72211748, -72211748, -72211748	NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579	104001	42	Golgi membrane endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane smooth endoplasmic reticulum Golgi apparatus membrane integral component of membrane negative regulation of amyloid-beta formation
TC0500003175.mm.2	Oas2	2'-5' oligoadenylate synthetase 2	5	-120730332	NM_145227	246728	27	nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytoplasm cytosol RNA catabolic process immune response response to virus response to bacterium membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding perinuclear region of cytoplasm defense response to virus defense response to virus type I interferon signaling pathway regulation of ribonuclease activity regulation of lactation	05160
TC0200003574.mm.2	Cytip	cytohesin 1 interacting protein	2	-58129138	NM_139200, BC007144 NM_139200, BC007144	227929	22	nucleoplasm cytoplasm endosome cytosol cell cortex cell cortex regulation of cell adhesion regulation of cell adhesion
TC0100001018.mm.2	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	1	106171868	NM_133821, BC059254 NM_133821, BC059254	98432	54	regulation of protein phosphorylation regulation of T cell anergy catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein serine/threonine phosphatase activity nucleus nucleoplasm cytoplasm cytoplasm plasma membrane protein dephosphorylation apoptotic process signal transduction entrainment of circadian clock membrane hydrolase activity nuclear membrane regulation of apoptotic process intracellular membrane-bounded organelle regulation of MAPK cascade regulation of JNK cascade metal ion binding positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade positive regulation of protein kinase C signaling negative regulation of protein kinase C signaling regulation of p38MAPK cascade
TC0600000131.mm.2	Met	met proto-oncogene	6	17463956	NM_008591	17295	399	negative regulation of transcription by RNA polymerase II nucleotide binding activation of MAPK activity neuron migration endothelial cell morphogenesis liver development liver development placenta development protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity hepatocyte growth factor-activated receptor activity hepatocyte growth factor-activated receptor activity hepatocyte growth factor-activated receptor activity protein binding ATP binding extracellular space cytoplasm plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway chemical synaptic transmission multicellular organism development nervous system development brain development muscle organ development muscle organ development skeletal muscle tissue development beta-catenin binding basal plasma membrane basal plasma membrane positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation positive regulation of glucose transmembrane transport positive regulation of neuron projection development postsynaptic density muscle cell migration myotube differentiation membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity semaphorin receptor activity protein phosphatase binding neuron differentiation flagellated sperm motility dendrite adult behavior pancreas development positive regulation of microtubule polymerization regulation of interleukin-6 production positive regulation of peptidyl-serine phosphorylation positive regulation of kinase activity negative regulation of Rho protein signal transduction sperm flagellum glucose homeostasis identical protein binding neuron projection neuronal cell body receptor complex phospholipase binding phosphatidylinositol 3-kinase binding protein-containing complex binding postsynaptic membrane positive regulation of DNA replication positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II protein autophosphorylation protein autophosphorylation hepatocyte growth factor receptor signaling pathway branching morphogenesis of an epithelial tube positive regulation of dendrite morphogenesis modulation of chemical synaptic transmission positive chemotaxis positive chemotaxis myoblast proliferation negative regulation of stress fiber assembly positive regulation of protein kinase B signaling cardiac muscle cell development cardiac muscle contraction excitatory synapse excitatory postsynaptic potential regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling establishment of skin barrier negative regulation of thrombin-activated receptor signaling pathway semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway negative regulation of transforming growth factor beta production reactive oxygen species metabolic process regulation of cellular response to oxidative stress positive regulation of p38MAPK cascade negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of guanyl-nucleotide exchange factor activity positive regulation of endothelial cell chemotaxis	04060 04144 04360 04510 04520 05100 05144 05200 05211 05218
TC1500000776.mm.2	Tspo	translocator protein	15	83563572	NM_009775, BC002055 NM_009775, BC002055	12257	111	androgen binding mitochondrion mitochondrion mitochondrion mitochondrial outer membrane endoplasmic reticulum cytosol steroid biosynthetic process ion transport chloride transport lipid transport glial cell migration benzodiazepine receptor activity negative regulation of mitochondrion organization positive regulation of necrotic cell death cholesterol binding membrane integral component of membrane negative regulation of protein ubiquitination negative regulation of tumor necrosis factor production positive regulation of apoptotic process intracellular membrane-bounded organelle ion channel binding negative regulation of nitric oxide biosynthetic process behavioral response to pain regulation of steroid biosynthetic process positive regulation of mitochondrial depolarization positive regulation of calcium ion transport contact inhibition positive regulation of glial cell proliferation negative regulation of glial cell proliferation establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion negative regulation of autophagy of mitochondrion negative regulation of ATP metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process	04080
TC1800000590.mm.2	Isoc1	isochorismatase domain containing 1	18	58659481	NM_025478, BC016576 NM_025478, BC016576	66307	21	molecular_function catalytic activity cytoplasm peroxisome peroxisome biological_process
TC0200003278.mm.2	Ptges	prostaglandin E synthase	2	-30889470	NM_022415, BC024960 NM_022415, BC024960	64292	186	prostaglandin biosynthetic process prostaglandin biosynthetic process prostaglandin biosynthetic process glutathione transferase activity glutathione peroxidase activity prostaglandin-D synthase activity prostaglandin-D synthase activity prostaglandin-D synthase activity nuclear envelope lumen cytoplasm lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process negative regulation of cell population proliferation membrane integral component of membrane integral component of membrane oxidoreductase activity transferase activity isomerase activity sensory perception of pain regulation of fever generation positive regulation of prostaglandin secretion intracellular membrane-bounded organelle glutathione binding perinuclear region of cytoplasm prostaglandin-E synthase activity prostaglandin-E synthase activity regulation of inflammatory response	00590 01100
TC0200000781.mm.2	Acvr2a	activin receptor IIA	2	48814108	NM_007396, BC138823 NM_007396, BC138823	11480	112	nucleotide binding gastrulation with mouth forming second positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein binding ATP binding cytoplasm plasma membrane plasma membrane protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway spermatogenesis determination of left/right symmetry mesoderm development male gonad development anterior/posterior pattern specification regulation of signal transduction cell surface positive regulation of pathway-restricted SMAD protein phosphorylation coreceptor activity membrane integral component of membrane kinase activity phosphorylation transferase activity activin-activated receptor activity activin-activated receptor activity growth factor binding growth factor binding PDZ domain binding positive regulation of bone mineralization BMP signaling pathway BMP signaling pathway activin receptor signaling pathway activin receptor signaling pathway positive regulation of activin receptor signaling pathway inhibin-betaglycan-ActRII complex inhibin binding inhibin binding sperm ejaculation penile erection receptor complex receptor complex protein self-association positive regulation of erythrocyte differentiation positive regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of follicle-stimulating hormone secretion activin receptor complex activin binding activin binding activin binding embryonic skeletal system development regulation of nitric-oxide synthase activity Sertoli cell proliferation cellular response to growth factor stimulus cellular response to BMP stimulus BMP receptor activity	04060 04350
TC0600001403.mm.2	Clec4n	C-type lectin domain family 4, member n	6	123229842	NM_001190320, NM_001190321, NM_020001, BC023008 NM_001190320, NM_001190321, NM_020001, BC023008 NM_001190320, NM_001190321, NM_020001, BC023008 NM_001190320, NM_001190321, NM_020001, BC023008	56620	78	positive regulation of cytokine production adaptive immune response immune system process calcium ion binding protein binding mannose binding plasma membrane membrane integral component of membrane carbohydrate binding carbohydrate binding positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response metal ion binding defense response to fungus
TC1700001395.mm.2	Tagap1	T cell activation GTPase activating protein 1	17	-6954964	NM_147155, BC165956 NM_147155, BC165956	380608	14	GTPase activator activity cellular_component
TC1700002788.mm.2					NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754			positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface phagocytic vesicle membrane beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site integral component of lumenal side of endoplasmic reticulum membrane
TC1200001041.mm.2	Serpina3i	serine (or cysteine) peptidase inhibitor, clade A, member 3I	12	104263121	NM_001199940	628900	12	serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity response to cytokine response to peptide hormone
TC1000003161.mm.2	Dgka	diacylglycerol kinase, alpha	10	-128720135, -128720135, -128720135, -128720135	NM_016811, BC006713 NM_016811, BC006713	13139	57	nucleotide binding NAD+ kinase activity diacylglycerol kinase activity diacylglycerol kinase activity diacylglycerol kinase activity calcium ion binding ATP binding phospholipid binding cytoplasm cytosol cytosol plasma membrane plasma membrane lipid metabolic process phosphatidic acid biosynthetic process signal transduction protein kinase C-activating G protein-coupled receptor signaling pathway lipid binding kinase activity phosphorylation transferase activity intracellular signal transduction diacylglycerol metabolic process diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation lipid phosphorylation metal ion binding	00561 00564 01100 04070
TC1400001052.mm.2	Rubcnl	RUN and cysteine rich domain containing beclin 1 interacting protein like	14	75016026, 75016035	NM_198642, BC052668 NM_198642, BC052668	271221	11	autophagosome membrane autophagosome membrane lipid metabolic process autophagy lipid binding phosphatidylinositol-5-phosphate binding membrane regulation of lipid metabolic process cytoplasmic vesicle phosphatidylinositol-3-phosphate binding intracellular membrane-bounded organelle autophagosome-lysosome fusion autophagosome-lysosome fusion autophagosome-endosome fusion autophagosome-endosome fusion phosphatidylinositol-4-phosphate binding regulation of glycogen metabolic process autophagosome maturation autophagosome maturation autophagosome maturation phosphatidylinositol phosphate binding
TC1700002778.mm.2	Tapbp	TAP binding protein	17	33919477	NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074	21356	69	Golgi membrane MHC class Ib protein complex assembly antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent protein binding endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane defense response regulation of gene expression membrane integral component of membrane antigen processing and presentation of endogenous peptide antigen via MHC class I phagocytic vesicle membrane MHC class I peptide loading complex TAP1 binding TAP2 binding peptide antigen stabilization regulation of protein complex stability TAP complex binding protein-containing complex assembly	04612
TC0100000300.mm.2	Il18rap	interleukin 18 receptor accessory protein	1	40515361	NM_010553, BC120598, BC120600 NM_010553, BC120598, BC120600 NM_010553, BC120598, BC120600	16174	16	interleukin-1 receptor activity plasma membrane inflammatory response signal transduction cell population proliferation membrane integral component of membrane hydrolase activity interferon-gamma production interleukin-6 production interleukin-18-mediated signaling pathway interleukin-18-mediated signaling pathway interleukin-18-mediated signaling pathway T-helper 1 cell cytokine production interleukin-18 receptor activity interleukin-18 receptor activity neutrophil activation interleukin-18 receptor complex positive regulation of natural killer cell mediated cytotoxicity NAD(P)+ nucleosidase activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity NAD+ nucleotidase, cyclic ADP-ribose generating cellular response to interleukin-18	04060
TC1300000113.mm.2	Inhba	inhibin beta-A	13	16011850	NM_008380, BC053527 NM_008380, BC053527	16323	200	G1/S transition of mitotic cell cycle ovarian follicle development mesoderm formation hair follicle development hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation signaling receptor binding cytokine activity cytokine activity hormone activity extracellular region extracellular region extracellular space extracellular space extracellular space regulation of transcription by RNA polymerase II cell cycle arrest growth factor activity negative regulation of cell population proliferation male gonad development positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation peptide hormone binding striatal medium spiny neuron differentiation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway inhibin binding endodermal cell differentiation odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion identical protein binding activin A complex inhibin A complex protein-containing complex binding positive regulation of erythrocyte differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of follicle-stimulating hormone secretion mesodermal cell differentiation perinuclear region of cytoplasm negative regulation of hair follicle development roof of mouth development positive regulation of ovulation SMAD protein signal transduction eyelid development in camera-type eye type II activin receptor binding cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol GABAergic neuron differentiation extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	04060 04350
TC0800001079.mm.2	Capns2	calpain, small subunit 2	8	92901394	NM_027112	69543	8	calcium ion binding protein binding cytoplasm plasma membrane plasma membrane membrane metal ion binding
TC0400001924.mm.2	Mthfr	methylenetetrahydrofolate reductase	4	148039076, 148041188	NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466	17769	98	neural tube closure catalytic activity methylenetetrahydrofolate reductase (NAD(P)H) activity methylenetetrahydrofolate reductase (NAD(P)H) activity methylenetetrahydrofolate reductase (NAD(P)H) activity cytosol cytosol methionine metabolic process metabolic process methionine biosynthetic process methionine biosynthetic process oxidoreductase activity regulation of histone methylation tetrahydrofolate interconversion tetrahydrofolate interconversion protein-containing complex binding synapse tetrahydrofolate metabolic process flavin adenine dinucleotide binding NADP binding homocysteine metabolic process heterochromatin maintenance FAD binding modified amino acid binding	00670 01100
TC1200002440.mm.2	Gpr132	G protein-coupled receptor 132	12	-112850875	NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524	56696	46	G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway negative regulation of G2/M transition of mitotic cell cycle negative regulation of G2/M transition of mitotic cell cycle membrane integral component of membrane
TC1200000715.mm.2	Arg2	arginase type II	12	79130787	NM_009705, BC023349 NM_009705, BC023349	11847	105	urea cycle ureteric bud development adaptive immune response immune system process negative regulation of type 2 immune response arginase activity arginase activity cytoplasm mitochondrion mitochondrion mitochondrion mitochondrion arginine metabolic process striated muscle contraction regulation of L-arginine import hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines arginine catabolic process to ornithine arginine catabolic process to ornithine manganese ion binding regulation of interleukin-1 beta production negative regulation of interleukin-13 production negative regulation of interleukin-17 production negative regulation of tumor necrosis factor production negative regulation of tumor necrosis factor production innate immune response negative regulation of striated muscle contraction metal ion binding nitric-oxide synthase binding negative regulation of nitric-oxide synthase activity negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of chemokine (C-C motif) ligand 4 production negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of defense response to bacterium regulation of reactive oxygen species biosynthetic process negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of cellular senescence	00330 01100 05146
TC0900003335.mm.2	Uba7	ubiquitin-like modifier activating enzyme 7	9	107975566	NM_023738, BC138843 NM_023738, BC138843	74153	30	ubiquitin-protein transferase activity nucleus cytoplasm cellular protein modification process cellular response to DNA damage stimulus ISG15 activating enzyme activity ISG15 activating enzyme activity ISG15 activating enzyme activity modification-dependent protein catabolic process ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation protein modification by small protein conjugation	04120 05012
TC1000000529.mm.2	Sowahc	sosondowah ankyrin repeat domain family member C	10	59221921	NM_172939	268301	13	molecular_function cellular_component biological_process
TC0900003331.mm.2					NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241			B cell homeostasis negative regulation of B cell apoptotic process protein binding cytoplasm mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein-containing complex binding protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand
TC1000001761.mm.2	Stx11	syntaxin 11	10	-12939982	NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516	74732	21	SNARE binding T cell mediated cytotoxicity SNAP receptor activity Golgi apparatus plasma membrane intracellular protein transport exocytosis vesicle fusion synaptic vesicle endomembrane system protein transport membrane integral component of membrane vesicle-mediated transport SNARE complex synaptic vesicle fusion to presynaptic active zone membrane natural killer cell mediated cytotoxicity neutrophil degranulation cytotoxic T cell degranulation natural killer cell degranulation phagocytic vesicle vesicle docking presynaptic active zone membrane cellular response to interferon-gamma	04130
TC0900001365.mm.2	Cish	cytokine inducible SH2-containing protein	9	107296658	NM_009895, BC003783, BC022178 NM_009895, BC003783, BC022178 NM_009895, BC003783, BC022178	12700	61	protein binding plasma membrane phosphatidylinositol 3-kinase complex protein kinase C-activating G protein-coupled receptor signaling pathway negative regulation of signal transduction intracellular signal transduction regulation of growth phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity	04630
TC1100001016.mm.2	P2rx5	purinergic receptor P2X, ligand-gated ion channel, 5	11	73160387	NM_033321, BC138189, BC145181 NM_033321, BC138189, BC145181 NM_033321, BC138189, BC145181	94045	24	extracellularly ATP-gated cation channel activity extracellularly ATP-gated cation channel activity extracellularly ATP-gated cation channel activity integral component of nuclear inner membrane cytosol plasma membrane integral component of plasma membrane cell surface receptor signaling pathway identical protein binding regulation of skeletal muscle tissue regeneration positive regulation of calcium ion import across plasma membrane	04020 04080
TC1900000111.mm.2	Ehd1	EH-domain containing 1	19	6276895	NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828	13660	48	nucleotide binding calcium ion binding protein binding ATP binding GTP binding cytoplasm endosome early endosome early endosome lipid droplet plasma membrane plasma membrane cilium intracellular protein transport endocytosis endocytosis endocytosis endosome membrane positive regulation of cholesterol storage positive regulation of neuron projection development protein transport membrane endosomal transport endosomal transport ciliary pocket membrane cell projection organization endocytic vesicle endocytic vesicle platelet dense tubular network membrane neuron projection development small GTPase binding cytoplasmic vesicle early endosome membrane endocytic recycling endocytic recycling low-density lipoprotein particle clearance cholesterol homeostasis identical protein binding cell projection myelin sheath intracellular membrane-bounded organelle metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm protein homooligomerization recycling endosome membrane recycling endosome membrane cilium assembly cilium assembly cilium assembly protein localization to cilium protein localization to plasma membrane positive regulation of myoblast fusion cellular response to nerve growth factor stimulus positive regulation of endocytic recycling	04144
TC1200001237.mm.2	Tnfaip2	tumor necrosis factor, alpha-induced protein 2	12	111442660	NM_009396, BC138106, BC138107 NM_009396, BC138106, BC138107 NM_009396, BC138106, BC138107	21928	26	exocyst SNARE binding angiogenesis exocytosis multicellular organism development cell differentiation exocyst localization
TC0400003794.mm.2	C1qa	complement component 1, q subcomponent, alpha polypeptide	4	-136895915	NM_007572, BC002086 NM_007572, BC002086	12259	212	microglial cell activation immune system process protein binding extracellular region collagen trimer extracellular space complement activation, classical pathway aging aging neuron remodeling innate immune response synapse synapse synapse astrocyte activation synapse organization postsynapse synapse pruning complement-mediated synapse pruning vertebrate eye-specific patterning positive regulation of neuron death	04610 05020 05142 05150 05322
TC0100003320.mm.2	Tor3a	torsin family 3, member A	1	-156653616	NM_023141, BC071216 NM_023141, BC071216	30935	24	nucleotide binding protein binding ATP binding nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum lumen endoplasmic reticulum lumen ATPase activity ATPase activity
TC0X00002637.mm.2	Pdk3	pyruvate dehydrogenase kinase, isoenzyme 3	X	-93764615	NM_145630, BC008126 NM_145630, BC008126	236900	29	nucleotide binding protein kinase activity protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity ATP binding nucleolus mitochondrion mitochondrion mitochondrion carbohydrate metabolic process glucose metabolic process protein phosphorylation regulation of acetyl-CoA biosynthetic process from pyruvate regulation of glucose metabolic process regulation of glucose metabolic process kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peroxisome proliferator activated receptor signaling pathway cellular response to glucose stimulus cellular response to fatty acid hypoxia-inducible factor-1alpha signaling pathway regulation of reactive oxygen species metabolic process
TC0100003891.mm.2	Ifi203	interferon activated gene 203	1	-173920400, -173920400	BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328	15950	26	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta cellular response to interferon-beta identical protein binding
TC1300001270.mm.2	Plpp1	phospholipid phosphatase 1	13	112800776	NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161	19012	35	diacylglycerol diphosphate phosphatase activity diacylglycerol diphosphate phosphatase activity diacylglycerol diphosphate phosphatase activity plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane integral component of plasma membrane caveola lipid metabolic process phospholipid metabolic process phospholipid metabolic process phospholipid metabolic process diacylglycerol biosynthetic process sphingosine metabolic process sphingosine metabolic process sphingosine metabolic process ceramide metabolic process ceramide metabolic process ceramide metabolic process signal transduction signal transduction signal transduction phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity sphingosine-1-phosphate phosphatase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity lipid phosphatase activity phospholipid dephosphorylation phospholipid dephosphorylation phospholipid dephosphorylation phospholipid dephosphorylation ceramide-1-phosphate phosphatase activity ceramide-1-phosphate phosphatase activity	00561 00564 00565 00600 01100 04666 04975
TC1200000838.mm.2	Batf	basic leucine zipper transcription factor, ATF-like	12	85686719	NM_016767, BC132410, BC132412 NM_016767, BC132410, BC132412 NM_016767, BC132410, BC132412	53314	75	RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production lymphoid progenitor cell differentiation DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cellular response to DNA damage stimulus cell differentiation DNA damage response, signal transduction by p53 class mediator defense response to protozoan myeloid dendritic cell differentiation sequence-specific DNA binding T-helper 2 cell differentiation isotype switching positive regulation of transcription by RNA polymerase II hematopoietic stem cell differentiation T-helper 17 cell differentiation T-helper 17 cell lineage commitment sequence-specific double-stranded DNA binding
TC1900001423.mm.2	Ifit1bl2	interferon induced protein with tetratricopeptide repeats 1B like 2	19	-34617048, -34617048	NM_053217, BC138202 NM_053217, BC138202	112419	14	RNA binding RNA binding cytoplasm cytosol cytosol defense response to virus
TC1300001395.mm.2	Pfkp	phosphofructokinase, platelet	13	-6579873	NM_019703, BC006926 NM_019703, BC006926	56421	58	nucleotide binding catalytic activity 6-phosphofructokinase activity 6-phosphofructokinase activity 6-phosphofructokinase activity ATP binding ATP binding cytoplasm cytosol 6-phosphofructokinase complex 6-phosphofructokinase complex fructose 6-phosphate metabolic process fructose 6-phosphate metabolic process glycolytic process metabolic process membrane AMP binding kinase activity phosphorylation transferase activity fructose 1,6-bisphosphate metabolic process fructose 1,6-bisphosphate metabolic process identical protein binding identical protein binding protein-containing complex binding metal ion binding monosaccharide binding glycolytic process through fructose-6-phosphate canonical glycolysis fructose-6-phosphate binding fructose-6-phosphate binding cellular response to leukemia inhibitory factor	00010 00030 00051 00052 01100
TC0800002822.mm.2	Tppp3	tubulin polymerization-promoting protein family member 3	8	-105467491	NM_026481, BC010788 NM_026481, BC010788	67971	32	microtubule bundle formation microtubule bundle formation cytoplasm cytoskeleton microtubule embryo implantation tubulin binding tubulin binding positive regulation of protein polymerization decidualization microtubule polymerization perinuclear region of cytoplasm microtubule bundle
TC1300002392.mm.2	Vcan	versican	13	-89655309, -89709947	NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955	13003	200	skeletal system development ureteric bud development calcium ion binding hyaluronic acid binding extracellular region cell adhesion central nervous system development heart development glial cell migration cell surface protein phosphatase binding extracellular matrix structural constituent conferring compression resistance carbohydrate binding extracellular matrix extracellular matrix cell projection regulation of phosphoprotein phosphatase activity synapse collagen-containing extracellular matrix collagen-containing extracellular matrix perineuronal net	04514
TC0500003043.mm.2	Cmklr1	chemokine-like receptor 1	5	-113612354, -113612354	NM_008153, BC100612 NM_008153, BC100612	14747	65	complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity plasma membrane plasma membrane chemotaxis chemotaxis inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of macrophage chemotaxis positive regulation of macrophage chemotaxis membrane integral component of membrane negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-12 production positive regulation of fat cell differentiation regulation of calcium-mediated signaling regulation of calcium-mediated signaling positive regulation of cold-induced thermogenesis
TC1300000364.mm.2	Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	13	33004540	NM_009256, BC029900 NM_009256, BC029900	20723	40	T cell mediated cytotoxicity protease binding acute inflammatory response to antigenic stimulus serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding extracellular space extracellular space nucleus nucleoplasm cytoplasm cytoplasm cytoplasm Golgi apparatus cytosol immune response response to bacterium positive regulation of gene expression negative regulation of endopeptidase activity negative regulation of endopeptidase activity negative regulation by symbiont of host apoptotic process protection from natural killer cell mediated cytotoxicity defense response to bacterium cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process collagen-containing extracellular matrix negative regulation of T cell apoptotic process	05146
TC1700000214.mm.2					NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849			amyloid-beta binding amyloid-beta binding microglial cell activation positive regulation of protein phosphorylation complement receptor mediated signaling pathway immune response-regulating cell surface receptor signaling pathway complement receptor activity G protein-coupled receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane plasma membrane receptor-mediated endocytosis chemotaxis chemotaxis inflammatory response signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane calcium-mediated signaling positive regulation of superoxide anion generation signaling receptor activity signaling receptor activity cargo receptor activity defense response to bacterium negative regulation of neuron apoptotic process positive regulation of innate immune response positive regulation of G protein-coupled receptor signaling pathway astrocyte activation negative regulation of inflammatory response positive regulation of phagocytosis RAGE receptor binding positive chemotaxis positive regulation of protein kinase B signaling positive regulation of 1-phosphatidylinositol-3-kinase activity positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotaxis cellular response to amyloid-beta cellular response to amyloid-beta
TC0400001599.mm.2	Fgr	FGR proto-oncogene, Src family tyrosine kinase	4	132974094	NM_010208, BC057863 NM_010208, BC057863	14191	111	nucleotide binding phosphotyrosine residue binding phosphotyrosine residue binding positive regulation of cytokine production immune system process protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signaling receptor binding protein binding ATP binding cytoplasm mitochondrion mitochondrial inner membrane cytosol cytoskeleton plasma membrane plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway regulation of cell shape positive regulation of phosphatidylinositol 3-kinase signaling actin cytoskeleton membrane aggresome kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation protein kinase binding protein kinase binding cell differentiation bone mineralization positive regulation of cell migration extrinsic component of cytoplasmic side of plasma membrane ruffle membrane negative regulation of natural killer cell activation regulation of actin cytoskeleton organization immunoglobulin receptor binding Fc-gamma receptor I complex binding cell projection positive regulation of mast cell degranulation positive regulation of phosphatidylinositol 3-kinase activity innate immune response regulation of innate immune response regulation of protein kinase activity protein autophosphorylation skeletal system morphogenesis regulation of phagocytosis defense response to Gram-positive bacterium defense response to Gram-positive bacterium	04062
TC0600001968.mm.2	Lrrc4	leucine rich repeat containing 4	6	-28828125	NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834	192198	30	protein binding plasma membrane membrane integral component of membrane cell junction dendritic spine neuron spine synapse postsynaptic membrane modulation of chemical synaptic transmission synapse organization excitatory synapse postsynaptic density protein 95 clustering Schaffer collateral - CA1 synapse glutamatergic synapse glutamatergic synapse integral component of postsynaptic density membrane integral component of postsynaptic density membrane synaptic membrane adhesion excitatory synapse assembly
TC1000000171.mm.2	Sgk1	serum/glucocorticoid regulated kinase 1	10	21993889, 21992222, 21882183, 21978671, 21986103, 21994665	NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401	20393	198	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus nucleus cytoplasm cytoplasm mitochondrion endoplasmic reticulum cytosol cytosol plasma membrane protein phosphorylation cellular sodium ion homeostasis apoptotic process cellular response to DNA damage stimulus microtubule depolymerization long-term memory visual learning positive regulation of sodium ion transport potassium channel regulator activity membrane kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation peptidyl-serine phosphorylation positive regulation of cell growth negative regulation of microtubule polymerization cellular response to insulin stimulus regulation of protein localization intracellular signal transduction neuron projection negative regulation of apoptotic process glucocorticoid mediated signaling pathway 3-phosphoinositide-dependent protein kinase binding tau protein binding perinuclear region of cytoplasm neuron projection morphogenesis neuron projection morphogenesis positive regulation of dendrite morphogenesis regulation of cell cycle cellular response to aldosterone	04960
TC0700001520.mm.2					NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966			protein polyubiquitination nucleoplasm cytoplasm cytosol zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity
TC1100004291.mm.2	Psme2b	protease (prosome, macropain) activator subunit 2B	11	-48945351	NM_001281472	621823	13	molecular_function cellular_component biological_process
TC0400002434.mm.2	Ddx58	DEAD/H box helicase 58	4	-40203776	NM_172689, BC167209 NM_172689, BC167209	230073	157	nucleotide binding positive regulation of defense response to virus by host immune system process positive regulation of myeloid dendritic cell cytokine production DNA binding double-stranded DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding cytoplasm cytoplasm cytosol cytosol cytoskeleton plasma membrane bicellular tight junction zinc ion binding zinc ion binding detection of virus response to virus response to virus positive regulation of gene expression actin cytoskeleton membrane hydrolase activity cell junction regulation of cell migration ubiquitin protein ligase binding ruffle membrane positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production RIG-I signaling pathway identical protein binding cell projection response to exogenous dsRNA innate immune response innate immune response innate immune response positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of DNA-binding transcription factor activity defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA antiviral innate immune response ribonucleoprotein complex	04622 04623 05160
TC1700000948.mm.2	Mocs1	molybdenum cofactor synthesis 1	17	49428363	NM_020042, NM_028464 NM_020042, NM_028464	56738	18	nucleotide binding catalytic activity GTP binding Mo-molybdopterin cofactor biosynthetic process lyase activity molybdopterin synthase complex molybdopterin cofactor biosynthetic process metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding GTP 3',8'-cyclase activity GTP 3',8'-cyclase activity cyclic pyranopterin monophosphate synthase activity cyclic pyranopterin monophosphate synthase activity	04122
TC1700000703.mm.2	Ier3	immediate early response 3	17	35821712	NM_133662, BC006950 NM_133662, BC006950	15937	42	response to protozoan negative regulation of systemic arterial blood pressure protein binding nucleus nucleus nucleus regulation of DNA repair mitotic G2 DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage membrane integral component of membrane negative regulation of apoptotic process positive regulation of protein catabolic process negative regulation of glycolytic process regulation of nucleocytoplasmic transport negative regulation of inflammatory response negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of reactive oxygen species metabolic process regulation of response to DNA damage stimulus regulation of response to DNA damage stimulus regulation of response to DNA damage stimulus
TC1200000278.mm.2	Ccdc71l	coiled-coil domain containing 71 like	12	32378788	NM_001162903	72123	9	molecular_function cellular_component biological_process
TC1500000673.mm.2	Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	15	79347519, 79348060, 79346620, 79348401	NM_010755, BC022952 NM_010755, BC022952	17133	36	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific in utero embryonic development DNA binding DNA-binding transcription factor activity nucleus nucleoplasm nucleoplasm mitochondrion regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II skeletal muscle cell differentiation sequence-specific DNA binding regulation of epidermal cell differentiation regulation of epidermal cell differentiation positive regulation of transcription by RNA polymerase II sequence-specific double-stranded DNA binding
TC0400003680.mm.2	Smpdl3b	sphingomyelin phosphodiesterase, acid-like 3B	4	-132732965	NM_133888, BC009087 NM_133888, BC009087	100340	25	immune system process sphingomyelin phosphodiesterase activity protein binding extracellular region extracellular space plasma membrane lipid metabolic process sphingomyelin catabolic process inflammatory response phosphoric diester hydrolase activity phosphoric diester hydrolase activity phosphoric diester hydrolase activity phosphoric diester hydrolase activity metabolic process zinc ion binding membrane lipid catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds anchored component of membrane negative regulation of toll-like receptor signaling pathway innate immune response negative regulation of innate immune response membrane lipid catabolic process metal ion binding negative regulation of inflammatory response
TC0300000210.mm.2	Skil	SKI-like	3	31095057	NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934	20482	57	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific acrosomal vesicle blastocyst formation lymphocyte homeostasis chromatin binding protein binding nucleus nucleus nucleus transcription regulator complex cytoplasm cell cycle arrest transforming growth factor beta receptor signaling pathway skeletal muscle tissue development PML body protein domain specific binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway protein-containing complex identical protein binding protein-containing complex binding negative regulation of cell differentiation SMAD binding SMAD binding positive regulation of axonogenesis lens fiber cell differentiation response to growth factor positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
TC1900000497.mm.2	Fas	Fas (TNF receptor superfamily member 6)	19	34290658, 34290658	NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160	14102	1558	positive regulation of protein phosphorylation protease binding immunoglobulin production transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity tumor necrosis factor-activated receptor activity protein binding calmodulin binding extracellular region extracellular space cytoplasm cytosol plasma membrane apoptotic process apoptotic process activation-induced cell death of T cells activation-induced cell death of T cells activation-induced cell death of T cells inflammatory cell apoptotic process inflammatory cell apoptotic process immune response signal transduction circadian rhythm extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors response to toxic substance external side of plasma membrane external side of plasma membrane cell surface cell surface gene expression regulation of gene expression negative regulation of Schwann cell proliferation positive regulation of cell death membrane integral component of membrane apical plasma membrane nuclear body B cell mediated immunity kinase binding secretory granule dendrite regeneration death-inducing signaling complex CD95 death-inducing signaling complex CD95 death-inducing signaling complex CD95 death-inducing signaling complex positive regulation of protein-containing complex assembly regulation of stress-activated MAPK cascade regulation of stress-activated MAPK cascade cellular response to amino acid starvation Fas signaling pathway regulation of cell population proliferation sarcolemma identical protein binding identical protein binding regulation of apoptotic process neuron projection neuronal cell body T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process protein-containing complex binding negative thymic T cell selection membrane raft membrane raft regulation of lymphocyte differentiation regulation of myeloid cell differentiation perinuclear region of cytoplasm spleen development negative regulation of B cell activation response to glucocorticoid neuron apoptotic process lymphocyte apoptotic process cellular response to lithium ion cellular response to hyperoxia positive regulation of release of cytochrome c from mitochondria motor neuron apoptotic process motor neuron apoptotic process apoptotic signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process apical dendrite necroptotic signaling pathway necroptotic signaling pathway necroptotic signaling pathway negative regulation of Schwann cell migration positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	04010 04060 04115 04210 04650 04940 05010 05142 05143 05200 05320 05330 05332
TC0200001222.mm.2	Ube2l6	ubiquitin-conjugating enzyme E2L 6	2	84798827	NM_019949, BC008238 NM_019949, BC008238	56791	22	ubiquitin ligase complex nucleotide binding protein polyubiquitination protein binding ATP binding nucleus ubiquitin-dependent protein catabolic process transferase activity ubiquitin-like protein transferase activity modification-dependent protein catabolic process ubiquitin protein ligase binding ISG15-protein conjugation ISG15-protein conjugation ISG15 transferase activity ISG15 transferase activity ubiquitin binding ubiquitin conjugating enzyme activity	04120 05012
TC0100000374.mm.2	Stat4	signal transducer and activator of transcription 4	1	51987147, 52008239	NM_011487, BC098499 NM_011487, BC098499	20849	318	RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein phosphorylation defense response signal transduction receptor signaling pathway via JAK-STAT cell population proliferation positive regulation of gene expression cytokine-mediated signaling pathway cytokine-mediated signaling pathway regulation of cell population proliferation identical protein binding response to peptide hormone sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II hematopoietic stem cell homeostasis cellular response to organic substance	04630
TC0800002947.mm.2	Mlkl	mixed lineage kinase domain-like	8	-111311797	NM_029005, BC023755 NM_029005, BC023755	74568	139	nucleotide binding JUN kinase kinase kinase activity protein binding ATP binding ATP binding nucleus cytoplasm cytoplasm cytosol plasma membrane plasma membrane cell surface receptor signaling pathway activation of JUN kinase activity programmed cell death membrane protein kinase binding cell junction identical protein binding protein-containing complex binding defense response to virus defense response to virus protein homotrimerization necroptotic process necroptotic process necroptotic signaling pathway necroptotic signaling pathway execution phase of necroptosis execution phase of necroptosis
TC1100001238.mm.2	Slfn2	schlafen 2	11	83065111	NM_011408, BC138749, BC138750 NM_011408, BC138749, BC138750 NM_011408, BC138749, BC138750	20556	19	negative regulation of cell population proliferation response to bacterium
TC1700002789.mm.2					NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554			positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response embryo implantation external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane phagocytic vesicle membrane beta-2-microglobulin binding MHC class Ib protein complex positive regulation of interferon-gamma production peptide binding peptide antigen binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding defense response to virus TAP complex binding endoplasmic reticulum exit site cellular response to interferon-gamma integral component of lumenal side of endoplasmic reticulum membrane
TC0X00000072.mm.2	Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	X	7823758	NM_008423, BC139325, BC139327 NM_008423, BC139325, BC139327 NM_008423, BC139325, BC139327	16506	38	ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity A-type (transient outward) potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex postsynaptic density membrane integral component of membrane regulation of ion transmembrane transport cell projection neuronal cell body dendritic spine postsynaptic membrane metal ion binding protein homooligomerization transmembrane transport potassium ion transmembrane transport
TC0100000765.mm.2	Sp140	Sp140 nuclear body protein	1	85600702	NM_001013817, BC069971 NM_001013817, BC069971	434484	5	fibrillar center mitochondrion
TC1600001607.mm.2	Poglut1	protein O-glucosyltransferase 1	16	-38525057	NM_172380, BC026809 NM_172380, BC026809	224143	26	somitogenesis protein binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum lumen protein O-linked glycosylation protein O-linked glycosylation protein O-linked glycosylation multicellular organism development gastrulation regulation of Notch signaling pathway regulation of gastrulation endomembrane system transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via serine UDP-glucosyltransferase activity UDP-glucosyltransferase activity UDP-glucosyltransferase activity UDP-glucosyltransferase activity UDP-xylosyltransferase activity UDP-xylosyltransferase activity UDP-xylosyltransferase activity UDP-xylosyltransferase activity positive regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of Notch signaling pathway glucosyltransferase activity glucosyltransferase activity glucosyltransferase activity axial mesoderm development paraxial mesoderm development muscle tissue development circulatory system development	00514
TC1700001953.mm.2	Lst1	leukocyte specific transcript 1	17	-35185094	NM_010734, BC086881 NM_010734, BC086881	16988	21	cell morphogenesis immune system process immune response regulation of cell shape membrane integral component of membrane dendrite development dendrite development
TC1900000995.mm.2	Capn1	calpain 1	19	-5988544, -5988544	NM_001110504, NM_007600, BC026138, BC050276 NM_001110504, NM_007600, BC026138, BC050276 NM_001110504, NM_007600, BC026138, BC050276 NM_001110504, NM_007600, BC026138, BC050276	12333	173	calcium-dependent cysteine-type endopeptidase activity calcium-dependent cysteine-type endopeptidase activity calcium-dependent cysteine-type endopeptidase activity calcium-dependent cysteine-type endopeptidase activity calcium ion binding protein binding intracellular anatomical structure cytoplasm mitochondrion mitochondrion lysosome cytosol cytosol plasma membrane plasma membrane proteolysis proteolysis proteolysis cytoskeletal protein binding peptidase activity cysteine-type peptidase activity positive regulation of cardiac muscle cell apoptotic process membrane protein autoprocessing hydrolase activity enzyme binding negative regulation of actin filament polymerization receptor catabolic process positive regulation of vascular permeability metal ion binding regulation of catalytic activity mammary gland involution cellular response to hydrogen peroxide self proteolysis negative regulation of NIK/NF-kappaB signaling positive regulation of leukocyte tethering or rolling response to angiotensin	04141 04210 05010
TC1500002318.mm.2	Itga5	integrin alpha 5 (fibronectin receptor alpha)	15	-103344285	NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829	16402	224	epidermal growth factor receptor binding integrin binding integrin binding protein binding cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane cell-cell junction focal adhesion cell-substrate junction assembly cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion integrin-mediated signaling pathway memory integrin complex external side of plasma membrane cell surface cell surface positive regulation of cell-substrate adhesion membrane integral component of membrane CD40 signaling pathway cell junction positive regulation of cell migration cytoplasmic vesicle cell-substrate adhesion ruffle membrane cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion integrin alpha5-beta1 complex endodermal cell differentiation synapse regulation of angiogenesis metal ion binding positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding positive regulation of sprouting angiogenesis negative regulation of anoikis	04145 04510 04512 04640 04810 05100 05410 05412 05414
TC1900000443.mm.2	Ric1	RAB6A GEF complex partner 1	19	29522281	NM_001081319	226089	17	Golgi membrane regulation of extracellular matrix constituent secretion guanyl-nucleotide exchange factor activity cytoplasm cytosol cytosol intracellular protein transport membrane small GTPase binding protein-containing complex Ric1-Rgp1 guanyl-nucleotide exchange factor complex Ric1-Rgp1 guanyl-nucleotide exchange factor complex retrograde transport, endosome to Golgi retrograde transport, endosome to Golgi positive regulation of GTPase activity negative regulation of cellular protein catabolic process cranial skeletal system development
TC0600003231.mm.2	Klrk1	killer cell lectin-like receptor subfamily K, member 1	6	-129610322, -129610322	NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147	27007	199	stimulatory C-type lectin receptor signaling pathway adaptive immune response immune system process positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target protein binding plasma membrane plasma membrane external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane kinase binding natural killer cell activation natural killer cell activation cell differentiation carbohydrate binding positive regulation of myeloid dendritic cell activation MHC class Ib receptor activity positive regulation of interferon-gamma production signaling receptor activity MHC class I protein binding identical protein binding positive regulation of apoptotic process innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity defense response to Gram-positive bacterium cellular response to lipopolysaccharide	04650
TC1700001463.mm.2	Gpr31b	G protein-coupled receptor 31, D17Leh66b region	17	-13051320	NM_001013832, BC160363 NM_001013832, BC160363	436440	11	response to molecule of bacterial origin response to ischemia G protein-coupled receptor activity plasma membrane signal transduction G protein-coupled receptor signaling pathway response to acidic pH membrane integral component of membrane bioactive lipid receptor activity arachidonic acid binding negative regulation of inflammatory response positive regulation of immune response
TC0500003024.mm.2	Grk3	G protein-coupled receptor kinase 3	5	-112910477	NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531	320129	40	nucleotide binding positive regulation of protein phosphorylation desensitization of G protein-coupled receptor signaling pathway protein kinase activity protein serine/threonine kinase activity G protein-coupled receptor kinase activity G protein-coupled receptor kinase activity ATP binding nucleus cytosol cilium protein phosphorylation intracellular protein transport signal transduction membrane kinase activity phosphorylation transferase activity Z disc axon receptor internalization D1 dopamine receptor binding dendritic spine dendritic shaft inositol phosphate metabolic process dendrite terminus membrane raft synapse rhodopsin metabolic process beta-adrenergic receptor kinase activity perinuclear region of cytoplasm sperm midpiece	04740
TC1900000991.mm.2	Cdc42ep2	CDC42 effector protein (Rho GTPase binding) 2	19	-5917555	NM_026772, BC034884 NM_026772, BC034884	104252	20	opioid peptide activity GTPase activator activity cytoplasm cytoplasm cytosol cytoskeleton plasma membrane plasma membrane Rho protein signal transduction regulation of cell shape regulation of cell shape microtubule cytoskeleton membrane actin cytoskeleton organization positive regulation of actin filament polymerization positive regulation of actin filament polymerization small GTPase binding positive regulation of pseudopodium assembly positive regulation of pseudopodium assembly phagocytic vesicle cellular response to interferon-gamma
TC1700001032.mm.2	Trip10	thyroid hormone receptor interactor 10	17	57249450	NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249	106628	30	epithelial to mesenchymal transition protein binding nucleoplasm cytoplasm lysosome Golgi apparatus cytoskeleton microtubule plasma membrane endocytosis signal transduction lipid binding negative regulation of cardiac muscle cell apoptotic process membrane actin cytoskeleton organization hyperosmotic salinity response identical protein binding cell projection intracellular membrane-bounded organelle positive regulation of cell growth involved in cardiac muscle cell development	04910
TC1300000586.mm.2	Fbxw17	F-box and WD-40 domain protein 17	13	50417863	NM_175401, BC040428 NM_175401, BC040428	109082	14	molecular_function cellular_component
TC0500001724.mm.2	Fscn1	fascin actin-bundling protein 1	5	142960354	NM_007984, BC052408 NM_007984, BC052408	14086	66	stress fiber ruffle ruffle podosome actin binding protein binding cytoplasm cytoplasm cytosol cytoskeleton plasma membrane microvillus microvillus cell-cell junction actin filament organization cell-cell junction assembly establishment or maintenance of cell polarity drug binding drug binding positive regulation of lamellipodium assembly actin cytoskeleton actin cytoskeleton cell migration cell migration cell migration lamellipodium lamellipodium lamellipodium microspike assembly actin cytoskeleton organization parallel actin filament bundle assembly cell junction filopodium filopodium filopodium dendrite growth cone growth cone growth cone protein-macromolecule adaptor activity cell projection membrane cell projection membrane regulation of microvillus assembly regulation of actin cytoskeleton organization establishment of apical/basal cell polarity cell projection myelin sheath microspike cell motility actin filament binding actin filament binding actin filament binding actin filament bundle assembly actin filament bundle assembly actin filament bundle assembly positive regulation of filopodium assembly positive regulation of filopodium assembly positive regulation of podosome assembly positive regulation of extracellular matrix disassembly
TC0100003550.mm.2	Slamf7	SLAM family member 7	1	-171632404, -171632402	NM_144539, BC011154 NM_144539, BC011154	75345	25	adaptive immune response immune system process protein binding plasma membrane external side of plasma membrane membrane integral component of membrane regulation of natural killer cell activation identical protein binding innate immune response
TC0400001327.mm.2	Svbp	small vasohibin binding protein	4	119195309, 119195524	NM_001038998, NM_024462, BC002274 NM_001038998, NM_024462, BC002274 NM_001038998, NM_024462, BC002274	69216	16	protein binding extracellular region cytoplasm cytoskeleton proteolysis proteolysis microtubule binding protein secretion protein secretion negative regulation of endothelial cell migration negative regulation of protein ubiquitination negative regulation of protein ubiquitination apical part of cell apical part of cell axon development axon development regulation of metallopeptidase activity
TC1100000464.mm.2	Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	11	46054501, 46055983, 46127903	NM_009616	11492	57	metalloendopeptidase activity metalloendopeptidase activity protein binding nucleus Golgi apparatus membrane protein ectodomain proteolysis membrane protein ectodomain proteolysis membrane protein ectodomain proteolysis heart development peptidase activity metallopeptidase activity positive regulation of gene expression membrane integral component of membrane protein processing hydrolase activity SH3 domain binding amyloid precursor protein catabolic process metal ion binding collagen-containing extracellular matrix metalloendopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of cell-cell adhesion mediated by cadherin
TC0100000216.mm.2	Dst	dystonin	1	34160259, 33908224, 34011594	NM_001276764, NM_010081, NM_133833, NM_134448 NM_001276764, NM_010081, NM_133833, NM_134448 NM_001276764, NM_010081, NM_133833, NM_134448 NM_001276764, NM_010081, NM_133833, NM_134448	13518	135	stress fiber actin binding structural molecule activity calcium ion binding protein binding nucleus nuclear envelope cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytoskeleton microtubule intermediate filament plasma membrane focal adhesion focal adhesion cytoskeleton organization cell adhesion axonogenesis microtubule binding microtubule binding retrograde axonal transport cytoskeletal protein binding cytoplasmic side of plasma membrane postsynaptic density intercalated disc actin cytoskeleton microtubule cytoskeleton membrane membrane integral component of membrane Z disc cell junction hemidesmosome hemidesmosome axon regulation of microtubule polymerization or depolymerization cytoplasmic microtubule organization cytoplasmic microtubule organization cytoplasmic vesicle hemidesmosome assembly H zone wound healing sarcolemma protein homodimerization activity cell projection intermediate filament cytoskeleton organization metal ion binding intracellular transport perinuclear region of cytoplasm neurofilament cytoskeleton perinuclear endoplasmic reticulum
TC0500001615.mm.2					NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734			in utero embryonic development endothelial cell morphogenesis catalytic activity iron ion binding extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum Golgi apparatus trans-Golgi network protein O-linked glycosylation protein localization metabolic process procollagen-lysine 5-dioxygenase activity procollagen-lysine 5-dioxygenase activity procollagen-lysine 5-dioxygenase activity negative regulation of gene expression membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen transferase activity transferase activity, transferring glycosyl groups peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation neural tube development collagen fibril organization L-ascorbic acid binding collagen metabolic process procollagen glucosyltransferase activity procollagen glucosyltransferase activity procollagen glucosyltransferase activity vasodilation metal ion binding hydroxylysine biosynthetic process epidermis morphogenesis procollagen galactosyltransferase activity dioxygenase activity lung morphogenesis collagen-containing extracellular matrix collagen-containing extracellular matrix basement membrane assembly positive regulation of stem cell proliferation
TC0100000743.mm.2	Gm7609	predicted pseudogene 7609	1	85199610	NM_001081746	665378	10
TC0800001984.mm.2	Nrg1	neuregulin 1	8	-31814550, -31820775, -31814550, -31820775, -31837204, -31837204	NM_178591, BC151113, BC160344 NM_178591, BC151113, BC160344 NM_178591, BC151113, BC160344	211323	368	MAPK cascade cell morphogenesis startle response cardiac conduction system development transcription coregulator activity signaling receptor binding ErbB-2 class receptor binding ErbB-2 class receptor binding protein binding extracellular region extracellular space nucleus cytoplasm plasma membrane integral component of plasma membrane activation of transmembrane receptor protein tyrosine kinase activity nervous system development nervous system development synapse assembly synapse assembly brain development peripheral nervous system development heart development muscle organ development locomotory behavior axon ensheathment external side of plasma membrane glial cell differentiation positive regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling cell migration glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex neurogenesis neurogenesis myelination in peripheral nervous system cell differentiation protein tyrosine kinase activator activity axon dendrite axolemma receptor tyrosine kinase binding neuromuscular junction positive regulation of myelination intracellular signal transduction negative regulation of protein catabolic process cellular protein complex disassembly cell body synapse neurotransmitter receptor metabolic process chemorepellent activity chemorepellent activity regulation of cell differentiation positive regulation of axon extension positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of Ras protein signal transduction animal organ development neuron fate commitment oligodendrocyte differentiation cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation positive regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cardiac muscle cell differentiation positive regulation of dendritic spine development positive regulation of calcineurin-NFAT signaling cascade glutamatergic synapse glutamatergic synapse GABA-ergic synapse GABA-ergic synapse postsynapse to nucleus signaling pathway postsynapse to nucleus signaling pathway positive regulation of protein localization to cell surface positive regulation of cardiac muscle cell differentiation negative regulation of neuron migration	04012
TC0600001579.mm.2	Etv6	ets variant 6	6	134035699	NM_007961, BC052163 NM_007961, BC052163	14011	83	negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus nucleolus cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II vitellogenesis protein domain specific binding neurogenesis cell differentiation cell differentiation sequence-specific DNA binding positive regulation of transcription by RNA polymerase II hematopoietic stem cell proliferation mesenchymal cell apoptotic process	04320
TC1000002164.mm.2	Cep85l	centrosomal protein 85-like	10	-53273442	NM_001204983	100038725	10	molecular_function centrosome biological_process
TC1700000528.mm.2	Abcg1	ATP binding cassette subfamily G member 1	17	31057693	NM_009593, BC119471 NM_009593, BC119471	11307	166	nucleotide binding ATP binding mitochondrion endosome endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane lipid transport cholesterol metabolic process external side of plasma membrane external side of plasma membrane negative regulation of macrophage derived foam cell differentiation regulation of cholesterol esterification positive regulation of cholesterol efflux negative regulation of lipid storage membrane integral component of membrane ATPase activity toxin transmembrane transporter activity cholesterol transport intracellular cholesterol transport cholesterol efflux cholesterol efflux cholesterol efflux phospholipid efflux response to lipid ABC-type sterol transporter activity ABC-type sterol transporter activity low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling glycoprotein transport cholesterol homeostasis cholesterol homeostasis protein homodimerization activity amyloid precursor protein catabolic process ADP binding reverse cholesterol transport positive regulation of cholesterol biosynthetic process protein heterodimerization activity positive regulation of protein secretion recycling endosome transmembrane transport phospholipid homeostasis cellular response to high density lipoprotein particle stimulus phosphatidylcholine floppase activity cholesterol transfer activity floppase activity positive regulation of amyloid-beta formation	02010
TC0700000501.mm.2	Gmfg	glia maturation factor, gamma	7	28437468, 28440936, 28440990	NM_001039192, NM_022024, BC011488 NM_001039192, NM_022024, BC011488 NM_001039192, NM_022024, BC011488	63986	24	actin binding intracellular anatomical structure growth factor activity negative regulation of Arp2/3 complex-mediated actin nucleation negative regulation of Arp2/3 complex-mediated actin nucleation actin filament debranching actin filament debranching Arp2/3 complex binding Arp2/3 complex binding regulation of actin cytoskeleton reorganization
TC0100001496.mm.2	Sell	selectin, lymphocyte	1	164062075	NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681	20343	263	protease binding calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion external side of plasma membrane cell surface cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding response to ATP regulation of apoptotic process metal ion binding cell adhesion molecule binding leukocyte migration leukocyte tethering or rolling glycolipid binding oligosaccharide binding positive regulation of neutrophil chemotaxis	04514
TC0900003310.mm.2	Lztfl1	leucine zipper transcription factor-like 1	9	-123694405	NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224	93730	31	protein binding cytoplasm cytosol identical protein binding protein-containing complex binding protein-containing complex binding negative regulation of protein localization to cilium negative regulation of protein localization to cilium negative regulation of protein localization to ciliary membrane
TC0800001833.mm.2	Gm15056	predicted gene 15056	8	-20900605	NM_001177471	100504014	2
TC0700001519.mm.2	Trim6	tripartite motif-containing 6	7	104218794	NM_001013616, BC138965 NM_001013616, BC138965	94088	25	protein polyubiquitination protein polyubiquitination positive regulation of defense response to virus by host positive regulation of cytokine production involved in immune response protein binding nucleus nucleoplasm cytoplasm cytoplasm cytoplasm cytosol cytosol transcription factor binding zinc ion binding regulation of gene expression positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation free ubiquitin chain polymerization protein ubiquitination transferase activity protein kinase binding protein kinase binding protein kinase binding protein-macromolecule adaptor activity response to lipopolysaccharide regulation of protein localization positive regulation of peptidyl-serine phosphorylation cellular response to interferon-beta identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of viral genome replication negative regulation of viral genome replication innate immune response negative regulation of transcription, DNA-templated regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity positive regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to virus protein tyrosine kinase binding positive regulation of transcription regulatory region DNA binding negative regulation of stem cell differentiation
TC1300000522.mm.2	Mylip	myosin regulatory light chain interacting protein	13	45389741	NM_153789, BC010206, NM_181043 NM_153789, BC010206, NM_181043 NM_153789, BC010206, NM_181043	218203	32	ubiquitin-protein transferase activity ubiquitin-protein transferase activity ubiquitin-protein transferase activity cytoplasm cytoskeleton plasma membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process nervous system development cytoskeletal protein binding negative regulation of neuron projection development negative regulation of low-density lipoprotein particle clearance membrane protein ubiquitination transferase activity protein destabilization regulation of low-density lipoprotein particle receptor catabolic process cholesterol homeostasis positive regulation of protein catabolic process metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to low-density lipoprotein particle stimulus
TC0100003882.mm.2	Chpf	chondroitin polymerizing factor	1	-75474568	NM_001001565, NM_001001566, BC071273 NM_001001565, NM_001001566, BC071273 NM_001001565, NM_001001566, BC071273	74241	29	protein binding cellular_component cytoplasm mitochondrion Golgi apparatus acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups chondroitin sulfate biosynthetic process chondroitin sulfate biosynthetic process chondroitin sulfate biosynthetic process chondroitin sulfate biosynthetic process Golgi cisterna membrane metal ion binding glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	00532 01100
TC1600001479.mm.2	Apod	apolipoprotein D	16	-31296191	NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909	11815	59	response to reactive oxygen species response to reactive oxygen species response to reactive oxygen species extracellular region extracellular space intracellular anatomical structure cytoplasm cytoplasm endoplasmic reticulum glucose metabolic process lipid metabolic process lipid metabolic process lipid transport aging lipid binding negative regulation of platelet-derived growth factor receptor signaling pathway cholesterol binding cholesterol binding cytosolic ribosome dendrite negative regulation of protein import into nucleus neuronal cell body perinuclear region of cytoplasm negative regulation of smooth muscle cell proliferation negative regulation of focal adhesion assembly negative regulation of lipoprotein lipid oxidation negative regulation of lipoprotein lipid oxidation negative regulation of monocyte chemotactic protein-1 production negative regulation of cytokine production involved in inflammatory response negative regulation of smooth muscle cell-matrix adhesion negative regulation of T cell migration
TC0300002237.mm.2	Tmem131l	transmembrane 131 like	3	-83898286	NM_172681, BC062940 NM_172681, BC062940	229473	21	molecular_function cytoplasm endoplasmic reticulum plasma membrane plasma membrane membrane integral component of membrane Wnt signaling pathway negative regulation of immature T cell proliferation in thymus negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway
TC0500000170.mm.2	Gsap	gamma-secretase activating protein	5	21176278, 21186266, 21186266	NM_175437	212167	14	amyloid-beta binding Golgi apparatus trans-Golgi network trans-Golgi network regulation of proteolysis positive regulation of amyloid-beta formation positive regulation of amyloid-beta formation positive regulation of amyloid-beta formation
TC0500000602.mm.2	Fam114a1	family with sequence similarity 114, member A1	5	64970074	NM_026667, BC027235, BC110359 NM_026667, BC027235, BC110359 NM_026667, BC027235, BC110359	68303	17	molecular_function nucleoplasm cytoplasm Golgi apparatus cytosol biological_process
TC1900001118.mm.2	Ccdc86	coiled-coil domain containing 86	19	-10941480	NM_023731, BC043326 NM_023731, BC043326	108673	21	nucleus nucleoplasm chromosome nucleolus nucleolus
TC0200004204.mm.2	Prr5l	proline rich 5 like	2	-101714284, -101714284, -101714284	NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132	72446	19	negative regulation of protein phosphorylation positive regulation of protein phosphorylation mitochondrion negative regulation of signal transduction regulation of fibroblast migration regulation of fibroblast migration positive regulation of phosphatidylinositol 3-kinase signaling ubiquitin protein ligase binding TORC2 complex TORC2 complex cellular response to oxidative stress TORC2 signaling TORC2 signaling TORC2 signaling positive regulation of mRNA catabolic process positive regulation of intracellular protein transport
TC0200003528.mm.2	Nmi	N-myc (and STAT) interactor	2	-51948498	NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019	64685	23	macrophage activation involved in immune response transcription coregulator activity protein binding extracellular space extracellular space nucleus nucleoplasm cytoplasm cytoplasm cytosol transcription by RNA polymerase II negative regulation of cell population proliferation response to virus membrane negative regulation of type I interferon production negative regulation of interferon-alpha production negative regulation of interferon-beta production toll-like receptor 4 signaling pathway identical protein binding positive regulation of innate immune response negative regulation of innate immune response negative regulation of innate immune response positive regulation of inflammatory response interferon-gamma-mediated signaling pathway negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of protein K48-linked ubiquitination
TC1700000932.mm.2	Trem1	triggering receptor expressed on myeloid cells 1	17	48232738	NM_021406, BC148731 NM_021406, BC148731	58217	89	cytokine production cytokine production involved in immune response acute inflammatory response membrane integral component of membrane cell migration neutrophil chemotaxis chemokine production signaling receptor activity neutrophil-mediated killing of gram-negative bacterium neutrophil extravasation scaffold protein binding
TC0800000659.mm.2	Ddx60	DExD/H box helicase 60	8	61928086	NM_001081215	234311	16	double-stranded DNA binding RNA binding double-stranded RNA binding single-stranded RNA binding protein binding cytoplasm cytoplasm cytosol response to virus intermediate filament cytoskeleton defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway
TC1800001512.mm.2	Ptpn2	protein tyrosine phosphatase, non-receptor type 2	18	-67665500	NM_001127177, NM_008977, BC008269 NM_001127177, NM_008977, BC008269 NM_001127177, NM_008977, BC008269	19255	111	negative regulation of transcription by RNA polymerase II phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein tyrosine phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity integrin binding protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment cytosol plasma membrane protein dephosphorylation protein dephosphorylation protein dephosphorylation negative regulation of cell population proliferation insulin receptor signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage membrane dephosphorylation hydrolase activity phosphatase activity protein kinase binding syntaxin binding B cell differentiation T cell differentiation erythrocyte differentiation receptor tyrosine kinase binding peptidyl-tyrosine dephosphorylation peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis negative regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of protein tyrosine kinase activity negative regulation of interleukin-6-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade STAT family protein binding regulation of hepatocyte growth factor receptor signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway
TC1700002819.mm.2	H2-T23	histocompatibility 2, T region locus 23	17	-36029976	NM_010398, BC099472 NM_010398, BC099472	15040	74	positive regulation of antibody-dependent cellular cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity adaptive immune response immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent natural killer cell tolerance induction positive regulation of immunoglobulin production regulation of natural killer cell mediated immunity positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell cytokine production signaling receptor binding signaling receptor binding extracellular space plasma membrane immune response external side of plasma membrane cell surface membrane integral component of membrane antibacterial humoral response phagocytic vesicle membrane beta-2-microglobulin binding MHC class Ib protein complex positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of TRAIL production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation CD8-positive, alpha-beta T cell activation protection from natural killer cell mediated cytotoxicity MHC class I protein binding peptide antigen binding peptide antigen binding T cell receptor binding MHC class I protein complex negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity natural killer cell lectin-like receptor binding inner ear development defense response to Gram-positive bacterium integral component of lumenal side of endoplasmic reticulum membrane positive regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation	04144 04145 04514 04612 04650 04940 05320 05330 05332 05416
TC1500001729.mm.2	Ly6c1	lymphocyte antigen 6 complex, locus C1	15	-75045472, -75045014, -75045472, -75044017	NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764	17067	61	plasma membrane external side of plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway
TC0800002658.mm.2	Snx20	sorting nexin 20	8	-88626827	NM_027840, BC039809 NM_027840, BC039809	71607	10	phosphatidylinositol-4,5-bisphosphate binding nucleus nucleoplasm cytoplasm endosome plasma membrane lipid binding protein transport membrane early endosome membrane phosphatidylinositol-3-phosphate binding phosphatidylinositol binding
TC1300002697.mm.2	Snx18	sorting nexin 18	13	-113592178	NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951	170625	21	mitotic cell cycle mitotic cytokinesis protein binding phosphatidylinositol-4,5-bisphosphate binding endosome plasma membrane endocytosis cell cycle lipid binding protein transport membrane endosomal transport clathrin-coated vesicle growth cone extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle phosphatidylinositol binding cleavage furrow formation neuronal cell body positive regulation of GTPase activity cell division extracellular exosome
TC0500001349.mm.2	Oas1b	2'-5' oligoadenylate synthetase 1B	5	120812634, 120812637	NM_001083925, NR_003507, BC012877 NM_001083925, NR_003507, BC012877 NM_001083925, NR_003507, BC012877	23961	46	2'-5'-oligoadenylate synthetase activity double-stranded RNA binding nucleoplasm cytosol membrane negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity	05160
TC0600002324.mm.2	Ggct	gamma-glutamyl cyclotransferase	6	-54985094	NM_026637, BC080818 NM_026637, BC080818	110175	34	release of cytochrome c from mitochondria gamma-glutamylcyclotransferase activity gamma-glutamylcyclotransferase activity cytosol lyase activity protein homodimerization activity	00480
TC0600001657.mm.2	Aebp2	AE binding protein 2	6	140622662, 140626884, 140623501, 140623501, 140624908	NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681	11569	39	negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding DNA binding nucleus nucleoplasm chromatin organization regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II ESC/E(Z) complex ESC/E(Z) complex ESC/E(Z) complex metal ion binding
TC0800000800.mm.2					NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647			nucleotide binding oocyte maturation G protein-coupled receptor binding G protein-coupled receptor binding in utero embryonic development protease binding adaptive immune response immune system process negative regulation of dendritic cell cytokine production protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity hormone activity protein binding ATP binding extracellular region extracellular space extracellular space cytoplasm cytosol cytoskeleton protein phosphorylation enzyme linked receptor protein signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tyrosine phosphorylation of STAT protein positive regulation of cell population proliferation negative regulation of cell population proliferation male gonad development male gonad development positive regulation of epithelial cell migration membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein phosphatase binding B cell differentiation B cell differentiation erythrocyte differentiation negative regulation of interleukin-10 production negative regulation of interleukin-12 production intracellular signal transduction interleukin-4-mediated signaling pathway positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of apoptotic process T cell homeostasis T cell homeostasis negative regulation of apoptotic process positive regulation of cAMP-mediated signaling innate immune response negative regulation of FasL production negative regulation of T-helper 1 cell differentiation positive regulation of transcription by RNA polymerase II perinuclear region of cytoplasm lymph node development negative regulation of T cell activation positive regulation of nitric-oxide synthase biosynthetic process positive regulation of calcium ion transport regulation of T cell apoptotic process negative regulation of thymocyte apoptotic process response to interleukin-2 response to interleukin-4 response to interleukin-4 response to interleukin-15 response to interleukin-9 cellular response to cytokine stimulus positive regulation of wound healing regulation of male gonad development positive regulation of dendritic cell apoptotic process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
TC1000001149.mm.2	Tmcc3	transmembrane and coiled coil domains 3	10	94575256, 94576262, 94550919, 94311948, 94550871, 94514856	NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951	319880	20	endoplasmic reticulum biological_process endomembrane system membrane integral component of membrane identical protein binding 14-3-3 protein binding
TC1900000225.mm.2	Ms4a6b	membrane-spanning 4-domains, subfamily A, member 6B	19	11518558	NM_027209, BC027425 NM_027209, BC027425	69774	14	molecular_function cellular_component biological_process membrane integral component of membrane
TC0700002414.mm.2	Selenow	selenoprotein W	7	-15917207	NM_009156, BC052719 NM_009156, BC052719	20364	32	cytoplasm cytosol plasma membrane response to selenium ion antioxidant activity oxidoreductase activity
TC0700002632.mm.2	Lipe	lipase, hormone sensitive	7	-25379526, -25379526	NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825	16890	153	sterol esterase activity sterol esterase activity triglyceride lipase activity triglyceride lipase activity triglyceride lipase activity protein binding extracellular space nucleus cytoplasm cytoplasm mitochondrion lipid droplet cytosol cytosol plasma membrane caveola transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription lipid metabolic process steroid metabolic process cholesterol metabolic process membrane lipid catabolic process lipase activity hydrolase activity hydrolase activity, acting on ester bonds serine hydrolase activity triglyceride catabolic process triglyceride catabolic process triglyceride catabolic process protein kinase binding hormone-sensitive lipase activity rRNA primary transcript binding long-chain fatty acid catabolic process diacylglycerol catabolic process diacylglycerol catabolic process ether lipid metabolic process acylglycerol lipase activity acylglycerol lipase activity retinyl-palmitate esterase activity retinyl-palmitate esterase activity 1,3-diacylglycerol acylhydrolase activity 1,2-diacylglycerol acylhydrolase activity	04910
TC0500001597.mm.2					NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460			GTPase activator activity phospholipid binding cytoplasm cytosol plasma membrane signal transduction membrane negative regulation of GTPase activity intracellular signal transduction regulation of GTPase activity negative regulation of Ras protein signal transduction metal ion binding cellular response to calcium ion
TC1700000362.mm.2	Clcn7	chloride channel, voltage-sensitive 7	17	25136630, 25133390	NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799	26373	53	nucleotide binding voltage-gated chloride channel activity protein binding ATP binding nucleoplasm lysosome ion transport chloride transport response to pH chloride transmembrane transporter activity antiporter activity membrane integral component of membrane cytoplasmic vesicle intracellular membrane-bounded organelle transmembrane transport
TC0800002146.mm.2	Tlr3	toll-like receptor 3	8	-45395664, -45395664	NM_126166, BC099937 NM_126166, BC099937	142980	523	microglial cell activation positive regulation of cytokine production toll-like receptor signaling pathway toll-like receptor signaling pathway immune system process regulation of dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway RNA binding double-stranded RNA binding transmembrane signaling receptor activity protein binding cytoplasm endosome endoplasmic reticulum integral component of plasma membrane defense response inflammatory response signal transduction I-kappaB phosphorylation response to virus cell surface positive regulation of gene expression membrane integral component of membrane positive regulation of type I interferon production positive regulation of chemokine production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway positive regulation of type III interferon production signaling receptor activity identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to exogenous dsRNA response to dsRNA innate immune response positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus cellular response to exogenous dsRNA extrinsic apoptotic signaling pathway necroptotic signaling pathway positive regulation of NIK/NF-kappaB signaling	04620 05160
TC0600001422.mm.2	C1ra	complement component 1, r subcomponent A	6	124512620	NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078	50909	19	immune system process serine-type endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular space extracellular space complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation identical protein binding innate immune response blood microparticle	04145 04610 05150 05322
TC0100002204.mm.2	Mgat4a	mannoside acetylglucosaminyltransferase 4, isoenzyme A	1	-37439339, -37439339	NM_173870, BC165942 NM_173870, BC165942	269181	19	extracellular region endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi stack protein N-linked glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups metal ion binding	00510 01100
TC1000003226.mm.2	Gstt3	glutathione S-transferase, theta 3	10	-75774121, -75774116	NM_133994, BC003903, BC057964, BC062201 NM_133994, BC003903, BC057964, BC062201 NM_133994, BC003903, BC057964, BC062201 NM_133994, BC003903, BC057964, BC062201	103140	15	glutathione transferase activity glutathione transferase activity cytoplasm glutathione metabolic process glutathione metabolic process transferase activity
TC0600000841.mm.2	St3gal5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	6	72097607	NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559	20454	59	Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups lactosylceramide alpha-2,3-sialyltransferase activity lactosylceramide alpha-2,3-sialyltransferase activity	00604 01100
TC0900002764.mm.2	Hmgn3	high mobility group nucleosomal binding domain 3	9	-83109941	NM_026122, NM_175074, BC005693 NM_026122, NM_175074, BC005693 NM_026122, NM_175074, BC005693	94353	32	chromatin DNA binding chromatin binding chromatin binding chromatin binding nucleus nucleus nucleus chromatin organization regulation of transcription by RNA polymerase II nucleosomal DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity regulation of insulin secretion involved in cellular response to glucose stimulus
TC0900002389.mm.2	Pml	promyelocytic leukemia	9	-58217179	NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990	18854	204	chromosome, telomeric region chromatin heterochromatin response to hypoxia response to hypoxia regulation of protein phosphorylation positive regulation of defense response to virus by host immune system process DNA binding transcription coactivator activity transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm endosome endoplasmic reticulum cytosol regulation of transcription, DNA-templated regulation of transcription, DNA-templated protein targeting protein import into nucleus apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell cycle arrest cell cycle arrest cell cycle arrest transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation cell aging zinc ion binding negative regulation of cell population proliferation negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress response to UV response to gamma radiation regulation of calcium ion transport into cytosol fibroblast migration membrane viral process nuclear matrix nuclear matrix negative regulation of angiogenesis negative regulation of angiogenesis PML body PML body PML body PML body myeloid cell differentiation regulation of cell adhesion negative regulation of cell growth PML body organization PML body organization PML body organization positive regulation of histone deacetylation ubiquitin protein ligase binding nuclear membrane SUMO binding positive regulation of telomere maintenance negative regulation of telomere maintenance via telomerase endoplasmic reticulum calcium ion homeostasis negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production circadian regulation of gene expression negative regulation of translation in response to oxidative stress response to cytokine extrinsic component of endoplasmic reticulum membrane regulation of circadian rhythm intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding protein homodimerization activity entrainment of circadian clock by photoperiod proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response innate immune response cell fate commitment regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription by RNA polymerase II SMAD binding metal ion binding protein heterodimerization activity positive regulation of fibroblast proliferation retinoic acid receptor signaling pathway rhythmic process protein stabilization cobalt ion binding maintenance of protein location in nucleus defense response to virus negative regulation of telomerase activity positive regulation of apoptotic process involved in mammary gland involution branching involved in mammary gland duct morphogenesis protein-containing complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to interleukin-4 intrinsic apoptotic signaling pathway by p53 class mediator cellular senescence extrinsic apoptotic signaling pathway sumo-dependent protein binding negative regulation of viral release from host cell negative regulation of viral release from host cell positive regulation of protein localization to chromosome, telomeric region cellular response to leukemia inhibitory factor negative regulation of ubiquitin-dependent protein catabolic process regulation of double-strand break repair positive regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway	04120 04144 05200 05221
TC1400002487.mm.2	Rgcc	regulator of cell cycle	14	-79288749	NM_025427, BC049580, BC050935 NM_025427, BC049580, BC050935 NM_025427, BC049580, BC050935	66214	37	G1/S transition of mitotic cell cycle negative regulation of exit from mitosis negative regulation of cytokine production positive regulation of cytokine production negative regulation of endothelial cell proliferation positive regulation of extracellular matrix constituent secretion protein binding nucleus nucleoplasm nucleolus cytoplasm cytoplasm centrosome cytoskeleton complement activation cell cycle negative regulation of cell population proliferation positive regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of angiogenesis protein kinase binding protein kinase binding protein kinase activator activity protein kinase activator activity positive regulation of collagen biosynthetic process negative regulation of blood vessel endothelial cell migration positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity positive regulation of stress fiber assembly regulation of cell cycle R-SMAD binding positive regulation of cell cycle arrest cellular response to hypoxia mitotic cell cycle arrest fibroblast activation negative regulation of fibroblast growth factor production positive regulation of G1/S transition of mitotic cell cycle positive regulation of extracellular matrix assembly negative regulation of mitotic cell cycle phase transition negative regulation of cell-cell adhesion mediated by cadherin positive regulation of endothelial cell apoptotic process
TC1100003664.mm.2	Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	11	-98004924, -98004924, -98001507	NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713	12295	64	voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated calcium channel activity voltage-gated calcium channel activity calcium channel activity protein binding plasma membrane plasma membrane voltage-gated calcium channel complex voltage-gated calcium channel complex protein targeting to membrane ion transport calcium ion transport chemical synaptic transmission neuromuscular junction development high voltage-gated calcium channel activity high voltage-gated calcium channel activity membrane sarcoplasmic reticulum T-tubule regulation of ion transmembrane transport calcium ion transmembrane transport presynapse presynapse regulation of voltage-gated calcium channel activity regulation of calcium ion transmembrane transport via high voltage-gated calcium channel cellular response to amyloid-beta	04010 04260 05410 05412 05414
TC0700002503.mm.2	Bcl3	B cell leukemia/lymphoma 3	7	-19808461	NM_033601, BC156806 NM_033601, BC156806	12051	84	follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling transcription factor binding response to virus response to UV-C antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator midbody negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production protein-containing complex Bcl3-Bcl10 complex Bcl3/NF-kappaB2 complex T-helper 1 type immune response defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle T-helper 2 cell differentiation positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of receptor signaling pathway via JAK-STAT spleen development
TC0400003383.mm.2	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	4	-117932152	NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710	20441	29	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Golgi apparatus protein glycosylation protein glycosylation N-acetyllactosaminide alpha-2,3-sialyltransferase activity sialyltransferase activity ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups	00514 00533 00601 01100
TC1200001768.mm.2	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	12	-55489408	NM_010907, BC046754 NM_010907, BC046754	18035	242	protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytosol plasma membrane protein import into nucleus I-kappaB kinase/NF-kappaB signaling cytoplasmic sequestering of NF-kappaB nuclear localization sequence binding regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux negative regulation of lipid storage enzyme binding heat shock protein binding ubiquitin protein ligase binding lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to muramyl dipeptide response to lipopolysaccharide protein-containing complex tumor necrosis factor-mediated signaling pathway toll-like receptor 4 signaling pathway response to muscle stretch regulation of cell population proliferation identical protein binding cytoplasmic sequestering of transcription factor response to exogenous dsRNA protein-containing complex binding negative regulation of myeloid cell differentiation negative regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of inflammatory response NF-kappaB binding nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to biotic stimulus cellular response to cytokine stimulus cellular response to tumor necrosis factor cellular response to organic cyclic compound	04062 04210 04380 04620 04621 04622 04623 04660 04662 04722 04920 05140 05142 05145 05160 05200 05215 05220 05222
TC0100000916.mm.2	Gpc1	glypican 1	1	92831644	NM_016696, BC062902 NM_016696, BC062902	14733	55	copper ion binding nucleoplasm endosome Golgi lumen cytosol plasma membrane regulation of signal transduction cell surface Schwann cell differentiation membrane cell migration fibroblast growth factor binding fibroblast growth factor binding heparan sulfate proteoglycan catabolic process extracellular matrix anchored component of membrane myelin assembly negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway neuronal cell body laminin binding membrane raft membrane raft synapse synapse synapse anchored component of plasma membrane collagen-containing extracellular matrix collagen V binding regulation of protein localization to membrane positive regulation of skeletal muscle cell differentiation
TC0500001359.mm.2	Naa25	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	5	121397994	NM_172722, BC132172, BC138093 NM_172722, BC132172, BC138093 NM_172722, BC132172, BC138093	231713	22	peptide alpha-N-acetyltransferase activity cytoplasm cytoplasm Golgi apparatus cytosol N-terminal peptidyl-methionine acetylation NatB complex
TC1700001522.mm.2	Fpr1	formyl peptide receptor 1	17	-17876470	NM_013521, BC148696 NM_013521, BC148696	14293	76	G protein-coupled receptor binding complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane plasma membrane chemotaxis inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane RAGE receptor binding	04080 05150
TC1600000760.mm.2	Dcbld2	discoidin, CUB and LCCL domain containing 2	16	58408534	NM_028523, BC066097 NM_028523, BC066097	73379	21	integral component of plasma membrane cell surface membrane integral component of membrane negative regulation of cell growth wound healing
TC1600001203.mm.2	Prm1	protamine 1	16	-10796331	NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733	19118	110	nucleosome DNA binding nucleus nucleus nucleus chromosome nucleus organization multicellular organism development spermatogenesis spermatid development cell differentiation chromosome condensation
TC0300003067.mm.2	Lmo4	LIM domain only 4	3	-144188529, -144188529, -144188529	NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382	16911	153	neural tube closure ventricular septum development protein binding nucleus regulation of transcription by RNA polymerase II transcription factor binding ventral spinal cord interneuron differentiation spinal cord motor neuron differentiation spinal cord association neuron differentiation regulation of cell migration cell leading edge negative regulation of protein-containing complex assembly positive regulation of kinase activity regulation of cell fate specification positive regulation of transcription by RNA polymerase II metal ion binding thymus development regulation of cell activation RNA polymerase II transcription regulator complex
TC0700002507.mm.2	Pvr	poliovirus receptor	7	-19903577	NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220	52118	70	virus receptor activity protein binding plasma membrane adherens junction homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell surface cell migration dynein light chain binding cell-cell adhesion
TC1900001085.mm.2	Stxbp3-ps	syntaxin-binding protein 3, pseudogene	19	-9557605	NR_073559	619371	3
TC0900003241.mm.2	Myd88	myeloid differentiation primary response gene 88	9	-119335933	NM_010851, BC005591, BC058787 NM_010851, BC005591, BC058787 NM_010851, BC005591, BC058787	17874	2155	response to molecule of fungal origin leukocyte activation involved in inflammatory response neutrophil activation involved in immune response immune system process MyD88-dependent toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway signaling receptor binding Toll binding interleukin-1 receptor binding interleukin-1 receptor binding protein binding nucleus cytoplasm cytoplasm cytosol plasma membrane plasma membrane phagocytosis phagocytosis apoptotic process inflammatory response immune response signal transduction cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway JNK cascade Toll signaling pathway Toll signaling pathway response to virus induced systemic resistance regulation of gene expression positive regulation of gene expression positive regulation of gene expression postsynaptic density immunoglobulin mediated immune response cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to peptidoglycan response to lipopolysaccharide response to lipopolysaccharide type I interferon production regulation of interleukin-6 production regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interleukin-17 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production protein-containing complex Toll-like receptor binding Toll-like receptor binding regulation of cell population proliferation defense response to bacterium identical protein binding defense response to protozoan positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling protein self-association innate immune response positive regulation of JNK cascade positive regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation regulation of inflammatory response defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity type I interferon signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 3'-UTR-mediated mRNA stabilization neutrophil-mediated killing of bacterium TIR domain binding cellular response to lipopolysaccharide establishment of endothelial intestinal barrier cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response regulation of neutrophil migration regulation of chemokine (C-X-C motif) ligand 1 production regulation of chemokine (C-X-C motif) ligand 2 production	04210 04620 05140 05142 05143 05144 05145
MG-1-pos-10338280_st
TC0100002707.mm.2					NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247			DNA-binding transcription factor activity, RNA polymerase II-specific nucleus regulation of transcription by RNA polymerase II
TC0400001651.mm.2	Runx3	runt related transcription factor 3	4	135120644, 135152544	NM_019732, BC168396 NM_019732, BC168396	12399	229	negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific ossification chondrocyte differentiation chondrocyte differentiation DNA binding DNA-binding transcription factor activity protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein phosphorylation axon guidance core-binding factor complex hemopoiesis neuron differentiation hair follicle morphogenesis neuron projection development interferon-gamma production histone deacetylase binding intracellular membrane-bounded organelle negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation regulation of cell differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II SMAD binding cell maturation negative regulation of epithelial cell proliferation response to transforming growth factor beta sequence-specific double-stranded DNA binding positive regulation of extrinsic apoptotic signaling pathway
TC0800002842.mm.2	Psmb10	proteasome (prosome, macropain) subunit, beta type 10	8	-105935727	NM_013640, BC004730 NM_013640, BC004730	19171	66	proteasome complex cell morphogenesis immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteasome core complex proteolysis peptidase activity proteasomal ubiquitin-independent protein catabolic process hydrolase activity T cell proliferation proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process spermatoproteasome complex	03050
TC0900003011.mm.2	Parp3	poly (ADP-ribose) polymerase family, member 3	9	-106470321	NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754	235587	19	telomere maintenance NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity nucleus nucleoplasm nucleolus cytoplasm DNA repair double-strand break repair double-strand break repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus nuclear body transferase activity transferase activity, transferring glycosyl groups DNA ADP-ribosylation site of double-strand break site of double-strand break site of double-strand break intercellular bridge negative regulation of isotype switching positive regulation of DNA ligation regulation of mitotic spindle organization protein poly-ADP-ribosylation protein auto-ADP-ribosylation protein mono-ADP-ribosylation NAD DNA ADP-ribosyltransferase activity negative regulation of telomerase RNA reverse transcriptase activity protein localization to site of double-strand break protein ADP-ribosylase activity protein ADP-ribosylase activity positive regulation of double-strand break repair via nonhomologous end joining	03410
TC0700002696.mm.2	Zfp36	zinc finger protein 36	7	-28376783	NM_011756, BC021391 NM_011756, BC021391	22695	173	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II MAPK cascade MAPK cascade MAPK cascade exosome (RNase complex) nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA poly(A) tail shortening P-body DNA binding mRNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytosol regulation of transcription by RNA polymerase II mRNA catabolic process multicellular organism development response to wounding response to wounding cytoplasmic stress granule regulation of keratinocyte proliferation enzyme binding protein kinase binding C-C chemokine binding CCR4-NOT complex heat shock protein binding nuclear-transcribed mRNA catabolic process, deadenylation-independent decay regulation of tumor necrosis factor production negative regulation of interleukin-2 production negative regulation of viral transcription miRNA mediated inhibition of translation intracellular signal transduction mRNA 3'-UTR AU-rich region binding mRNA 3'-UTR AU-rich region binding p38MAPK cascade response to starvation regulation of mRNA stability regulation of mRNA stability regulation of mRNA stability cellular response to fibroblast growth factor stimulus cellular response to fibroblast growth factor stimulus protein-containing complex binding positive regulation of fat cell differentiation regulation of keratinocyte differentiation negative regulation of myeloid cell differentiation negative regulation of erythrocyte differentiation metal ion binding negative regulation of inflammatory response RNA destabilization mRNA transport positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA destabilization RNA polymerase binding RISC-loading complex 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus 14-3-3 protein binding 14-3-3 protein binding cellular response to granulocyte macrophage colony-stimulating factor stimulus positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA regulation of keratinocyte apoptotic process negative regulation of polynucleotide adenylyltransferase activity positive regulation of intracellular mRNA localization ribonucleoprotein complex ribonucleoprotein complex positive regulation of gene silencing by miRNA
TC0900000113.mm.2	Gpr83	G protein-coupled receptor 83	9	14860209	NM_010287	14608	33	G protein-coupled receptor activity neuropeptide Y receptor activity plasma membrane cilium signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane response to glucocorticoid non-motile cilium	04080
TC0600001736.mm.2	Stk38l	serine/threonine kinase 38 like	6	146724929, 146724929	NM_172734, BC062170 NM_172734, BC062170	232533	22	nucleotide binding magnesium ion binding actin binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytoplasm cytosol cytoskeleton protein phosphorylation actin cytoskeleton membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction intracellular signal transduction metal ion binding regulation of cellular component organization
TC0100000923.mm.2	Gpr35	G protein-coupled receptor 35	1	92978902, 92973118, 92975346	NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429	64095	27	G protein-coupled receptor activity G protein-coupled receptor activity chemokine receptor activity plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane integral component of plasma membrane cytoskeleton organization signal transduction G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane C-X-C chemokine receptor activity positive regulation of Rho protein signal transduction macrophage chemotaxis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway chemokine-mediated signaling pathway negative regulation of voltage-gated calcium channel activity negative regulation of neuronal action potential	04080
TC1100002772.mm.2	Anxa6	annexin A6	11	-54978952	NM_001110211, NM_013472, BC005595 NM_001110211, NM_013472, BC005595 NM_001110211, NM_013472, BC005595	11749	58	neural crest cell migration plasma membrane repair phosphatidylserine binding growth plate cartilage chondrocyte differentiation calcium channel activity calcium ion binding GTP binding GTP binding calcium-dependent phospholipid binding calcium-dependent phospholipid binding nucleus cytoplasm cytoplasm lysosomal membrane cytosol focal adhesion calcium ion transport regulation of muscle contraction regulation of muscle contraction lipid binding intercalated disc ligand-gated ion channel activity ligand-gated ion channel activity cholesterol binding cholesterol binding membrane apical plasma membrane late endosome membrane protein-containing complex ion transmembrane transport chondroitin sulfate binding sarcolemma identical protein binding protein-containing complex binding calcium-dependent protein binding perinuclear region of cytoplasm actin filament binding negative regulation of sequestering of calcium ion mitochondrial calcium ion homeostasis mitochondrial calcium ion homeostasis collagen-containing extracellular matrix apoptotic signaling pathway apoptotic signaling pathway
MG-1-pos-10342553_st
TC1400002091.mm.2	Psme2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	14	-55587439, -55587439	NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859	19188	43	protein binding nucleoplasm cytoplasm positive regulation of endopeptidase activity antigen processing and presentation of exogenous antigen identical protein binding endopeptidase activator activity regulation of proteasomal protein catabolic process regulation of G1/S transition of mitotic cell cycle	03050 04612
TC0200001765.mm.2	Spint1	serine protease inhibitor, Kunitz type 1	2	119237359	NM_016907, BC005769 NM_016907, BC005769	20732	48	neural tube closure embryonic placenta development serine-type endopeptidase inhibitor activity extracellular region plasma membrane plasma membrane negative regulation of peptidase activity extracellular matrix organization peptidase inhibitor activity positive regulation of glial cell differentiation viral entry into host cell branching involved in labyrinthine layer morphogenesis placenta blood vessel development negative regulation of neural precursor cell proliferation
TC0700001913.mm.2	Htra1	HtrA serine peptidase 1	7	130936202	NM_019564, BC013516 NM_019564, BC013516	56213	71	placenta development serine-type endopeptidase activity protein binding insulin-like growth factor binding extracellular region cytoplasm plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane hydrolase activity growth factor binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway identical protein binding positive regulation of epithelial cell proliferation negative regulation of defense response to virus chorionic trophoblast cell differentiation collagen-containing extracellular matrix collagen-containing extracellular matrix
TC1700002813.mm.2	Ppt2	palmitoyl-protein thioesterase 2	17	-34616661, -34616661, -34616661, -34616661, -34616661	NM_019441, BC013462 NM_019441, BC013462	54397	22	lysosome palmitoyl-(protein) hydrolase activity hydrolase activity thiolester hydrolase activity intracellular membrane-bounded organelle intracellular membrane-bounded organelle palmitoyl hydrolase activity	00062 01100 04142
TC0800002597.mm.2	Junb	jun B proto-oncogene	8	-84976908	NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302	16477	179	RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific vasculogenesis osteoblast differentiation in utero embryonic development trophectodermal cell differentiation trophectodermal cell differentiation DNA binding DNA binding double-stranded DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm transcription regulator complex regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription factor binding cellular process osteoclast differentiation osteoblast proliferation transcription factor AP-1 complex regulation of cell population proliferation sequence-specific DNA binding positive regulation of cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II decidualization regulation of cell cycle regulation of cell cycle embryonic process involved in female pregnancy labyrinthine layer blood vessel development cellular response to calcium ion sequence-specific double-stranded DNA binding	04380
TC0600000609.mm.2	Snx10	sorting nexin 10	6	51524259, 51545292, 51524083, 51544522, 51523902	NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334	71982	30	gastric acid secretion 1-phosphatidylinositol binding nucleus nucleus cytoplasm endosome endoplasmic reticulum endoplasmic reticulum centrosome cytoskeleton endocytosis endosome organization lipid binding protein transport membrane cell projection organization secretory granule osteoclast differentiation extrinsic component of endosome membrane phosphatidylinositol binding bone mineralization involved in bone maturation tooth eruption bone resorption bone remodeling ATPase binding calcium ion homeostasis cilium assembly protein localization to cilium protein localization to centrosome apical cytoplasm ruffle assembly cellular response to leukemia inhibitory factor
TC1400001906.mm.2					NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475			phospholipase activity cytoplasm lipid metabolic process lipid catabolic process hydrolase activity sperm mitochondrion organization metal ion binding positive regulation of mitochondrial fission
TC0500003186.mm.2	Trafd1	TRAF type zinc finger domain containing 1	5	-121371724, -121371724	NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396	231712	19	protein binding zinc ion binding negative regulation of innate immune response metal ion binding
TC0900002377.mm.2	Csk	c-src tyrosine kinase	9	-57626645, -57626645	NM_007783, BC018394, BC052006 NM_007783, BC018394, BC052006 NM_007783, BC018394, BC052006	12988	138	nucleotide binding adaptive immune response immune system process protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding cytoplasm plasma membrane plasma membrane cell-cell junction protein phosphorylation protein phosphorylation negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of low-density lipoprotein particle clearance membrane kinase activity phosphorylation transferase activity protein phosphatase binding negative regulation of interleukin-6 production negative regulation of kinase activity protein kinase A catalytic subunit binding adherens junction organization intracellular signal transduction identical protein binding negative regulation of Golgi to plasma membrane protein transport positive regulation of MAP kinase activity membrane raft negative regulation of bone resorption protein autophosphorylation metal ion binding negative regulation of phagocytosis regulation of T cell activation regulation of Fc receptor mediated stimulatory signaling pathway regulation of Fc receptor mediated stimulatory signaling pathway proline-rich region binding negative regulation of ERK1 and ERK2 cascade cellular response to peptide hormone stimulus	04062 04722 04810
TC0200004545.mm.2	Sppl2a	signal peptide peptidase like 2A	2	-126890394	NM_023220, BC026578 NM_023220, BC026578	66552	31	aspartic-type endopeptidase activity lysosome lysosomal membrane lysosomal membrane endosome late endosome plasma membrane proteolysis membrane protein ectodomain proteolysis peptidase activity membrane integral component of membrane hydrolase activity Golgi-associated vesicle membrane Golgi-associated vesicle membrane membrane protein intracellular domain proteolysis late endosome membrane membrane protein proteolysis membrane protein proteolysis aspartic endopeptidase activity, intramembrane cleaving aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity intracellular membrane-bounded organelle regulation of immune response integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane
TC1300002013.mm.2	Nfil3	nuclear factor, interleukin 3, regulated	13	-52967208	NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384	18030	116	negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II immune response circadian rhythm positive regulation of gene expression positive regulation of gene expression negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated rhythmic process cellular response to interleukin-4
TC0900002806.mm.2	Bcl2a1d	B cell leukemia/lymphoma 2 related protein A1d	9	-88723287	NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240	12047	20	mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage T cell differentiation protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein-containing complex binding protein heterodimerization activity T cell receptor signaling pathway BH domain binding extrinsic apoptotic signaling pathway in absence of ligand
TC0200001448.mm.2	Trp53i11	transformation related protein 53 inducible protein 11	2	93187547, 93187547	NM_001025246, BC048398, BC098206 NM_001025246, BC048398, BC098206 NM_001025246, BC048398, BC098206	277414	18	molecular_function cellular_component biological_process membrane integral component of membrane
TC1500001491.mm.2					NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962			negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific skeletal system development hair follicle development chondrocyte differentiation nucleic acid binding DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transmembrane receptor protein serine/threonine kinase signaling pathway zinc ion binding protein domain specific binding regulation of chondrocyte differentiation protein-containing complex sequence-specific DNA binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
TC1000000571.mm.2	Ppa1	pyrophosphatase (inorganic) 1	10	61648620	NM_026438, BC010468 NM_026438, BC010468	67895	34	magnesium ion binding inorganic diphosphatase activity cytoplasm cytosol phosphate-containing compound metabolic process phosphate-containing compound metabolic process pyrophosphatase activity hydrolase activity metal ion binding	00190
TC0300002050.mm.2	Gpr171	G protein-coupled receptor 171	3	-59096447	NM_173398, BC024054 NM_173398, BC024054	229323	14	G protein-coupled receptor activity plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity negative regulation of myeloid cell differentiation negative regulation of myeloid cell differentiation
TC1500001623.mm.2	Cyrib	CYFIP related Rac1 interactor B	15	-63929093, -63929093, -63929093	NM_144846, BC011343 NM_144846, BC011343	223601	30	positive regulation of T cell mediated cytotoxicity protein binding mitochondrion cilium membrane MHC class Ib protein binding, via antigen binding groove regulation of cell migration negative regulation of actin filament polymerization small GTPase binding positive regulation of interferon-gamma production positive regulation of T cell activation positive regulation of T cell activation regulation of chemotaxis negative regulation of small GTPase mediated signal transduction negative regulation of small GTPase mediated signal transduction cellular response to molecule of bacterial origin cellular response to molecule of bacterial origin regulation of mitochondrial fission regulation of mitochondrial fission regulation of establishment of cell polarity positive regulation of memory T cell activation
TC0300000092.mm.2	Car13	carbonic anhydrase 13	3	14641726	NM_024495, BC064050 NM_024495, BC064050	71934	21	carbonate dehydratase activity carbonate dehydratase activity cytoplasm cytosol cytosol one-carbon metabolic process zinc ion binding lyase activity hydro-lyase activity myelin sheath intracellular membrane-bounded organelle metal ion binding	00910
TC0100002193.mm.2	Tmem131	transmembrane protein 131	1	-36792188	NM_018872	56030	27	molecular_function membrane integral component of membrane
TC0500001403.mm.2	Rnf34	ring finger protein 34	5	122850187	NM_030564, BC004042 NM_030564, BC004042	80751	23	p53 binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytoplasm plasma membrane plasma membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process apoptotic process membrane protein ubiquitination nuclear body transferase activity ubiquitin protein ligase binding nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to cold protein K48-linked ubiquitination protein K48-linked ubiquitination negative regulation of signal transduction by p53 class mediator phosphatidylinositol phosphate binding negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of oxygen metabolic process negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
TC0500002315.mm.2	Fbxl5	F-box and leucine-rich repeat protein 5	5	-43757748, -43744617	NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798	242960	30	iron ion binding cytoplasm protein ubiquitination SCF ubiquitin ligase complex SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process metal ion binding perinuclear region of cytoplasm iron ion homeostasis iron ion homeostasis iron ion homeostasis iron ion homeostasis positive regulation of cellular protein catabolic process
TC0800000679.mm.2	Marchf1	membrane associated ring-CH-type finger 1	8	65618039, 66386300, 65618524	NM_001166372, NM_001166375, NM_175188, BC066008 NM_001166372, NM_001166375, NM_175188, BC066008 NM_001166372, NM_001166375, NM_175188, BC066008 NM_001166372, NM_001166375, NM_175188, BC066008	72925	41	protein polyubiquitination protein polyubiquitination protein polyubiquitination immune system process antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II ubiquitin-protein transferase activity cytoplasm lysosome lysosome lysosomal membrane endosome endoplasmic reticulum membrane Golgi apparatus plasma membrane immune response immune response immune response zinc ion binding membrane integral component of membrane transferase activity cytoplasmic vesicle early endosome membrane early endosome membrane early endosome membrane late endosome membrane late endosome membrane late endosome membrane trans-Golgi network membrane MHC protein binding MHC protein binding metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity
TC1300002535.mm.2	Gtf2h2	general transcription factor II H, polypeptide 2	13	-100460229, -100468576, -100460229	NM_022011, BC016231, BC053382, XR_141179 NM_022011, BC016231, BC053382, XR_141179 NM_022011, BC016231, BC053382, XR_141179 NM_022011, BC016231, BC053382, XR_141179	23894	33	core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH core complex G protein-coupled receptor internalization nucleic acid binding nucleus transcription factor TFIID complex transcription factor TFIIH holo complex transcription factor TFIIH holo complex DNA repair nucleotide-excision repair transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter cellular response to DNA damage stimulus zinc ion binding RNA polymerase II general transcription initiation factor activity nuclear speck metal ion binding protein N-terminus binding positive regulation of DNA helicase activity	03022 03420
TC1200000959.mm.2	Gpr65	G-protein coupled receptor 65	12	98268634	NM_008152, BC011332 NM_008152, BC011332	14744	57	G protein-coupled receptor activity G protein-coupled receptor activity plasma membrane integral component of plasma membrane apoptotic process signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway response to acidic pH membrane integral component of membrane actin cytoskeleton reorganization positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of stress fiber assembly activation of GTPase activity
TC0600001964.mm.2	Zfp800	zinc finger protein 800	6	-28239930, -28239930	NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761	627049	12	nucleic acid binding DNA binding nucleus biological_process metal ion binding
TC0600000135.mm.2	St7	suppression of tumorigenicity 7	6	17749169, 17743591, 17693993	NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418	64213	21	membrane integral component of membrane
TC0400000458.mm.2	Glipr2	GLI pathogenesis-related 2	4	43957701	NM_027450, BC031750 NM_027450, BC031750	384009	25	Golgi membrane extracellular region extracellular space Golgi apparatus positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition membrane protein homodimerization activity positive regulation of ERK1 and ERK2 cascade
TC1200000530.mm.2	Wdr20rt	WD repeat domain 20, retrogene	12	65225516	NM_027614, BC050778 NM_027614, BC050778	70948	11	molecular_function cellular_component
TC1600002177.mm.2	Dexi	dexamethasone-induced transcript	16	-10530206	NM_021428, BC017551 NM_021428, BC017551	58239	17	molecular_function cellular_component biological_process
MG-1-neg-10341560_st
TC0700003778.mm.2	Tsku	tsukushi, small leucine rich proteoglycan	7	-98350667, -98350667	NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978	244152	28	protein binding extracellular region extracellular space extracellular space plasma membrane cholesterol metabolic process regulation of gene expression negative regulation of neuron projection development corpus callosum morphogenesis lateral ventricle development hippocampus development anterior commissure morphogenesis negative regulation of Wnt signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix negative regulation of transforming growth factor beta1 production cholesterol efflux wound healing cholesterol homeostasis positive regulation of hair cycle camera-type eye development transforming growth factor beta binding transforming growth factor beta binding inner ear receptor cell stereocilium organization ciliary body morphogenesis energy homeostasis negative regulation of myofibroblast differentiation
TC1200000652.mm.2	Hif1a	hypoxia inducible factor 1, alpha subunit	12	73907866, 73901323, 73907866	NM_010431, BC026139 NM_010431, BC026139	15251	1372	negative regulation of transcription by RNA polymerase II response to reactive oxygen species chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific angiogenesis blood vessel development response to hypoxia response to hypoxia response to hypoxia response to hypoxia neural crest cell migration epithelial to mesenchymal transition embryonic placenta development embryonic placenta development B-1 B cell homeostasis vasculature development heart looping p53 binding positive regulation of neuroblast proliferation connective tissue replacement involved in inflammatory response wound healing cytokine production involved in inflammatory response outflow tract morphogenesis cardiac ventricle morphogenesis DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm transcription regulator complex cytoplasm cytosol lactate metabolic process regulation of glycolytic process regulation of glycolytic process regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cellular iron ion homeostasis signal transduction lactation transcription factor binding positive regulation of cell population proliferation visual learning regulation of gene expression regulation of gene expression positive regulation of autophagy vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration response to muscle activity positive regulation of macroautophagy nuclear body nuclear speck axonal transport of mitochondrion enzyme binding protein kinase binding protein domain specific binding neural fold elevation formation cerebral cortex development cell differentiation cell differentiation negative regulation of ossification negative regulation of bone mineralization positive regulation of vascular endothelial growth factor receptor signaling pathway motile cilium ubiquitin protein ligase binding negative regulation of TOR signaling oxygen homeostasis oxygen homeostasis regulation of transforming growth factor beta2 production collagen metabolic process protein-containing complex histone acetyltransferase binding embryonic hemopoiesis nuclear hormone receptor binding positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell population proliferation hemoglobin biosynthetic process glucose homeostasis histone deacetylase binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration sequence-specific DNA binding sequence-specific DNA binding regulation of transcription from RNA polymerase II promoter in response to oxidative stress regulation of transcription from RNA polymerase II promoter in response to oxidative stress protein-containing complex binding positive regulation of erythrocyte differentiation positive regulation of gluconeogenesis positive regulation of angiogenesis positive regulation of transcription, DNA-templated negative regulation of vasoconstriction negative regulation of growth positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II muscle cell cellular homeostasis positive regulation of hormone biosynthetic process protein heterodimerization activity protein heterodimerization activity protein dimerization activity blood vessel morphogenesis digestive tract morphogenesis camera-type eye morphogenesis positive regulation of smooth muscle cell proliferation regulation of catalytic activity cartilage development elastin metabolic process Hsp90 protein binding intestinal epithelial cell maturation response to fungicide epithelial cell differentiation involved in mammary gland alveolus development iris morphogenesis retina vasculature development in camera-type eye positive regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of chemokine-mediated signaling pathway regulation of thymocyte apoptotic process negative regulation of thymocyte apoptotic process E-box binding cellular response to hypoxia cellular response to hypoxia cellular response to hypoxia dopaminergic neuron differentiation dopaminergic neuron differentiation RNA polymerase II transcription regulator complex hypoxia-inducible factor-1alpha signaling pathway cellular response to virus positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of autophagy of mitochondrion regulation of aerobic respiration positive regulation of signaling receptor activity negative regulation of reactive oxygen species metabolic process regulation of protein neddylation negative regulation of mesenchymal cell apoptotic process	04150 05200 05211
TC0900001802.mm.2	Zfp558	zinc finger protein 558	9	-18454053, -18454053	NM_028935	72230	13	negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific regulation of transcription by RNA polymerase II
TC0900001142.mm.2	Bcl2a1a	B cell leukemia/lymphoma 2 related protein A1a	9	88956919	NM_009742	12044	56	B cell homeostasis negative regulation of B cell apoptotic process protein binding cytoplasm mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein-containing complex binding protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand
TC1700002815.mm.2	C4a	complement component 4A (Rodgers blood group)	17	-34809091, -34809091	NM_011413, BC141050, BC172697 NM_011413, BC141050, BC172697 NM_011413, BC141050, BC172697	625018	62	complement binding complement component C1q complex binding extracellular region extracellular space extracellular space complement activation carbohydrate binding axon dendrite neuronal cell body other organism cell synapse
TC0200005181.mm.2	Znfx1	zinc finger, NFX1-type containing 1	2	-167035795, -167035796	NM_001033196	98999	24	DNA-binding transcription factor activity RNA binding nucleus regulation of transcription, DNA-templated zinc ion binding heterochromatin assembly by small RNA nuclear RNA-directed RNA polymerase complex metal ion binding
TC1100004060.mm.2	Cd300lf	CD300 molecule like family member F	11	-115116213	NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300	246746	50	virus receptor activity phosphatidylserine binding immune system process transmembrane signaling receptor activity interleukin-4 receptor binding protein binding plasma membrane lipid binding membrane integral component of membrane osteoclast differentiation negative regulation of mast cell activation negative regulation of mast cell activation negative regulation of MyD88-dependent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway interleukin-13-mediated signaling pathway ceramide binding ceramide binding positive regulation of interleukin-4-mediated signaling pathway negative regulation of apoptotic cell clearance positive regulation of apoptotic cell clearance positive regulation of apoptotic cell clearance
TC0200000484.mm.2	Gbgt1	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1	2	28496890	NM_139197, BC106831 NM_139197, BC106831	227671	6	Golgi apparatus carbohydrate metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation lipid glycosylation vesicle metal ion binding globoside alpha-N-acetylgalactosaminyltransferase activity globoside alpha-N-acetylgalactosaminyltransferase activity	00603 01100
TC0400001382.mm.2	Ppt1	palmitoyl-protein thioesterase 1	4	122836226	NM_008917, BC148714 NM_008917, BC148714	19063	82	protein depalmitoylation protein depalmitoylation protein depalmitoylation protein binding extracellular region extracellular space nucleus lysosome lysosome lysosome lysosome Golgi apparatus receptor-mediated endocytosis receptor-mediated endocytosis pinocytosis lysosome organization lysosomal lumen acidification neurotransmitter secretion nervous system development nervous system development brain development visual perception grooming behavior synaptic vesicle associative learning adult locomotory behavior palmitoyl-(protein) hydrolase activity palmitoyl-(protein) hydrolase activity palmitoyl-(protein) hydrolase activity palmitoyl-(protein) hydrolase activity protein transport lipid catabolic process palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity negative regulation of cell growth axon axon dendrite membrane raft organization regulation of phospholipase A2 activity lysophosphatidic acid binding neuron projection neuronal cell body neuronal cell body negative regulation of apoptotic process intracellular membrane-bounded organelle intracellular membrane-bounded organelle negative regulation of neuron apoptotic process cellular protein catabolic process cellular macromolecule catabolic process membrane raft synapse positive regulation of receptor-mediated endocytosis positive regulation of pinocytosis palmitoyl hydrolase activity sulfatide binding	00062 01100 04142
TC0900003121.mm.2	Tdgf1	teratocarcinoma-derived growth factor 1	9	-110939607	NM_011562, BC052646 NM_011562, BC052646	21667	158	activation of MAPK activity blood vessel development vasculogenesis in utero embryonic development morphogenesis of a branching structure positive regulation of cell-matrix adhesion cell migration involved in sprouting angiogenesis signaling receptor binding signaling receptor binding protein binding extracellular region extracellular region extracellular space extracellular space nucleus cytoplasm Golgi apparatus plasma membrane plasma membrane determination of left/right symmetry gastrulation heart development heart development heart development growth factor activity positive regulation of cell population proliferation anterior/posterior axis specification, embryo anterior/posterior axis specification anterior/posterior pattern specification regulation of signal transduction regulation of signal transduction cell surface cell surface cell surface positive regulation of endothelial cell migration coreceptor activity membrane apical plasma membrane Wnt-protein binding peptidyl-serine phosphorylation extrinsic component of plasma membrane cell differentiation regulation of cell migration positive regulation of cell migration positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway anchored component of membrane cellular response to hepatocyte growth factor stimulus nodal signaling pathway nodal signaling pathway nodal signaling pathway nodal binding nodal binding negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus membrane raft positive regulation of transcription by RNA polymerase II positive regulation of fibroblast proliferation perinuclear region of cytoplasm anatomical structure development positive regulation of peptidyl-tyrosine phosphorylation cardiac muscle cell differentiation activin receptor binding type I activin receptor binding cellular response to interferon-gamma cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus
TC1600000346.mm.2	Rtp4	receptor transporter protein 4	16	23609918	NM_023386, BC024872 NM_023386, BC024872	67775	15	detection of chemical stimulus involved in sensory perception of bitter taste detection of chemical stimulus involved in sensory perception of bitter taste protein binding cytoplasm cytoplasm protein targeting to membrane protein targeting to membrane membrane integral component of membrane olfactory receptor binding protein insertion into membrane defense response to virus
TC0600001421.mm.2	C1rl	complement component 1, r subcomponent-like	6	124493112	NM_181344, BC070472 NM_181344, BC070472	232371	14	immune system process serine-type endopeptidase activity extracellular region extracellular space extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation innate immune response blood microparticle
TC1100003790.mm.2	Stat3	signal transducer and activator of transcription 3	11	-100886805	NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168	20848	1720	chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II repressing transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific temperature homeostasis eye photoreceptor cell differentiation DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex cytoplasm cytoplasm mitochondrion mitochondrial inner membrane cytosol cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II protein import into nucleus defense response acute-phase response inflammatory response signal transduction receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT transcription factor binding cell population proliferation positive regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of autophagy positive regulation of gene expression positive regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process postsynaptic density phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway stem cell population maintenance protein kinase binding protein phosphatase binding sexual reproduction positive regulation of cell migration intracellular receptor signaling pathway chromatin DNA binding CCR5 chemokine receptor binding response to estradiol positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production cellular response to hormone stimulus leptin-mediated signaling pathway leptin-mediated signaling pathway leptin-mediated signaling pathway leptin-mediated signaling pathway response to cytokine glucocorticoid receptor binding regulation of multicellular organism growth regulation of cell population proliferation glucose homeostasis eating behavior mRNA transcription by RNA polymerase II identical protein binding identical protein binding protein homodimerization activity response to peptide hormone sequence-specific DNA binding sequence-specific DNA binding cellular response to leptin stimulus response to leptin response to leptin response to leptin positive regulation of erythrocyte differentiation positive regulation of Notch signaling pathway positive regulation of angiogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of mitochondrial membrane permeability protein dimerization activity astrocyte differentiation modulation of chemical synaptic transmission positive regulation of NF-kappaB transcription factor activity regulation of cell cycle regulation of cell cycle radial glial cell differentiation regulation of feeding behavior growth hormone receptor signaling pathway growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT negative regulation of cell death interleukin-6-mediated signaling pathway primary miRNA binding cellular response to cytokine stimulus cellular response to organic cyclic compound T-helper 17 type immune response T-helper 17 cell lineage commitment RNA polymerase II transcription regulator complex energy homeostasis Schaffer collateral - CA1 synapse glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of neuron death positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of metalloendopeptidase activity positive regulation of vascular endothelial cell proliferation positive regulation of miRNA mediated inhibition of translation negative regulation of primary miRNA processing positive regulation of gene silencing by miRNA negative regulation of stem cell differentiation positive regulation of ATP biosynthetic process negative regulation of neuron migration	04062 04630 04920 05145 05160 05200 05212 05221
TC1000002642.mm.2	Dram1	DNA-damage regulated autophagy modulator 1	10	-88322803	NM_027878, BC021433 NM_027878, BC021433	71712	16	molecular_function cytoplasm lysosome lysosome autophagy apoptotic process regulation of autophagy regulation of autophagy membrane integral component of membrane
TC0300000258.mm.2	Atp11b	ATPase, class VI, type 11B	3	35754062	NM_029570, BC076603 NM_029570, BC076603	76295	19	endoplasmic reticulum endoplasmic reticulum trans-Golgi network plasma membrane phospholipid translocation recycling endosome recycling endosome ATPase-coupled intramembrane lipid transporter activity
TC0100000766.mm.2	Sp100	nuclear antigen Sp100	1	85649987, 85649987, 85649987, 85650013	NM_013673, BC069183 NM_013673, BC069183	20684	27	DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding protein binding nucleus nucleus cytoplasm regulation of transcription by RNA polymerase II PML body
TC0200002876.mm.2	Camk1d	calcium/calmodulin-dependent protein kinase ID	2	-5293456, -5293456	NM_177343, BC141413, BC141414 NM_177343, BC141413, BC141414 NM_177343, BC141413, BC141414	227541	27	nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding intracellular anatomical structure nucleus cytoplasm cytoplasm protein phosphorylation inflammatory response nervous system development metabolic process positive regulation of neuron projection development kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation positive regulation of CREB transcription factor activity positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of phagocytosis regulation of dendrite development positive regulation of respiratory burst regulation of granulocyte chemotaxis positive regulation of neutrophil chemotaxis
TC0700003998.mm.2					NR_030719, NR_030720 NR_030719, NR_030720
TC0700004007.mm.2	Gvin-ps5	GTPase, very large interferon inducible, pseudogene 5	7	-106322395, -106075731	NR_030720	668128	7
TC0700002474.mm.2	Vasp	vasodilator-stimulated phosphoprotein	7	-19256929	NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289	22323	113	neural tube closure neural tube closure actin binding protein binding profilin binding profilin binding cytoplasm cytosol cytosol cytoskeleton plasma membrane bicellular tight junction focal adhesion focal adhesion axon guidance axon guidance actin polymerization or depolymerization membrane SH3 domain binding lamellipodium actin cytoskeleton organization actin cytoskeleton organization cell junction filopodium positive regulation of actin filament polymerization positive regulation of actin filament polymerization cell projection protein homotetramerization	04510 04666 04670
TC0800002634.mm.2	N4bp1	NEDD4 binding protein 1	8	-86841138	NM_030563	80750	27	RNA binding protein binding nucleus nucleus nucleolus PML body PML body negative regulation of protein ubiquitination negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to UV cellular response to UV
TC0100003102.mm.2	Btg2	BTG anti-proliferation factor 2	1	-134074864	NM_007570, BC132259, BC138639 NM_007570, BC132259, BC138639 NM_007570, BC132259, BC138639	12227	113	negative regulation of transcription by RNA polymerase II transcription corepressor activity protein binding nucleus cytoplasm protein methylation cellular response to DNA damage stimulus negative regulation of cell population proliferation negative regulation of cell population proliferation associative learning anterior/posterior pattern specification negative regulation of translation dentate gyrus development central nervous system neuron development neuron differentiation neuron projection development skeletal muscle cell differentiation negative regulation of apoptotic process negative regulation of neuron apoptotic process negative regulation of mitotic cell cycle positive regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of neural precursor cell proliferation	03018
TC1400000945.mm.2	Trim35	tripartite motif-containing 35	14	66297024	NM_029979, BC049105, BC145783, BC145809 NM_029979, BC049105, BC145783, BC145809 NM_029979, BC049105, BC145783, BC145809 NM_029979, BC049105, BC145783, BC145809	66854	29	protein binding nucleus cytoplasm cytoplasm apoptotic process zinc ion binding negative regulation of cell population proliferation protein ubiquitination positive regulation of apoptotic process positive regulation of apoptotic process positive regulation of apoptotic process innate immune response innate immune response negative regulation of mitotic cell cycle metal ion binding ubiquitin protein ligase activity negative regulation of viral release from host cell
TC0400000092.mm.2	Gem	GTP binding protein (gene overexpressed in skeletal muscle)	4	11704446	NM_010276, BC029668 NM_010276, BC029668	14579	35	nucleotide binding mitotic cell cycle magnesium ion binding GTPase activity calcium channel regulator activity protein binding GTP binding GTP binding nucleus plasma membrane signal transduction cytoplasmic side of plasma membrane membrane GDP binding midbody spindle midzone chromosome organization metaphase plate congression mitotic spindle negative regulation of high voltage-gated calcium channel activity
TC0100002725.mm.2	Sp110	Sp110 nuclear body protein	1	-85576898, -85576898	NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500	109032	29	DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding nucleus nucleoplasm regulation of transcription by RNA polymerase II apoptotic process response to bacterium response to bacterium positive regulation of apoptotic process innate immune response
TC0400000529.mm.2	Nr4a3	nuclear receptor subfamily 4, group A, member 3	4	48045304, 48045304	NM_015743, BC156736 NM_015743, BC156736	18124	115	negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific mesoderm formation DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity nucleus transcription regulator complex transcription regulator complex regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II gastrulation axon guidance zinc ion binding pyruvate oxidation positive regulation of cardiac muscle hypertrophy positive regulation of glucose transmembrane transport protein kinase binding hippocampus development adult behavior positive regulation of mast cell cytokine production histone acetyltransferase binding glucocorticoid receptor binding glucocorticoid receptor binding cAMP response element binding common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway inner ear morphogenesis response to hydrogen peroxide protein homodimerization activity negative regulation of apoptotic process mast cell degranulation negative regulation of neuron apoptotic process sequence-specific DNA binding cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation metal ion binding platelet-derived growth factor receptor signaling pathway regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation semicircular canal morphogenesis positive regulation of epithelial cell proliferation neuromuscular process controlling balance vestibular reflex regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation positive regulation of monocyte aggregation negative regulation of oxidative stress-induced neuron death negative regulation of hydrogen peroxide-induced neuron death positive regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of leukocyte apoptotic process positive regulation of feeding behavior
TC1000001183.mm.2	Btg1	BTG anti-proliferation factor 1	10	96617000	NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309	12226	44	protein binding nucleus nucleus cytoplasm cytoplasm protein methylation negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of cell population proliferation enzyme binding positive regulation of catalytic activity positive regulation of endothelial cell differentiation positive regulation of myoblast differentiation positive regulation of angiogenesis negative regulation of mitotic cell cycle positive regulation of fibroblast apoptotic process	03018
TC0200000525.mm.2	Tbc1d13	TBC1 domain family, member 13	2	30133745	NM_146252, BC025586 NM_146252, BC025586	70296	21	GTPase activator activity GTPase activator activity protein binding cytoplasm cytosol intracellular protein transport intracellular protein transport membrane small GTPase binding activation of GTPase activity
TC1100001657.mm.2	Ifi35	interferon-induced protein 35	11	101448411	NM_027320, BC008158 NM_027320, BC008158	70110	21	macrophage activation involved in immune response extracellular space extracellular space nucleus nucleus cytoplasm cytosol negative regulation of cell population proliferation membrane positive regulation of toll-like receptor 4 signaling pathway identical protein binding positive regulation of innate immune response positive regulation of innate immune response positive regulation of inflammatory response positive regulation of inflammatory response negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling
TC1900000689.mm.2	Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	19	46305694, 46304736, 46305929	NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423	18034	204	RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific follicular dendritic cell differentiation germinal center formation DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II signal transduction extracellular matrix organization Bcl3/NF-kappaB2 complex NIK/NF-kappaB signaling positive regulation of transcription by RNA polymerase II rhythmic process lymph node development spleen development sequence-specific double-stranded DNA binding	04010 04380 05200
TC0300000769.mm.2	Adar	adenosine deaminase, RNA-specific	3	89715021, 89730717, 89715237	NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505	56417	115	osteoblast differentiation in utero embryonic development hematopoietic progenitor cell differentiation immune system process somatic diversification of immune receptors via somatic mutation DNA binding left-handed Z-DNA binding RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity double-stranded RNA adenosine deaminase activity double-stranded RNA adenosine deaminase activity adenosine deaminase activity protein binding nucleus nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytoplasm cytoplasm adenosine to inosine editing adenosine to inosine editing adenosine to inosine editing adenosine to inosine editing RNA processing mRNA processing protein import into nucleus protein export from nucleus tRNA-specific adenosine deaminase activity response to virus base conversion or substitution editing nuclear speck hydrolase activity erythrocyte differentiation gene silencing by RNA pre-miRNA processing production of miRNAs involved in gene silencing by miRNA miRNA loading onto RISC involved in gene silencing by miRNA response to interferon-alpha negative regulation of apoptotic process negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of protein kinase activity by regulation of protein phosphorylation supraspliceosomal complex positive regulation of viral genome replication positive regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus definitive hemopoiesis negative regulation of type I interferon-mediated signaling pathway hematopoietic stem cell homeostasis cellular response to virus negative regulation of RNA interference	04623
TC1600000500.mm.2	Parp9	poly (ADP-ribose) polymerase family, member 9	16	35938469	NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466	80285	21	negative regulation of transcription by RNA polymerase II positive regulation of defense response to virus by host immune system process transcription corepressor activity transcription corepressor activity NAD+ ADP-ribosyltransferase activity enzyme inhibitor activity nucleus nucleus nucleoplasm cytoplasm cytoplasm mitochondrion cytosol DNA repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus posttranscriptional regulation of gene expression negative regulation of gene expression negative regulation of gene expression transferase activity enzyme binding protein-containing complex positive regulation of chromatin binding histone binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of catalytic activity ubiquitin-like protein ligase binding ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated defense response to virus regulation of response to interferon-gamma positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma-mediated signaling pathway protein poly-ADP-ribosylation ADP-D-ribose binding site of DNA damage STAT family protein binding protein mono-ADP-ribosylation positive regulation of protein localization to nucleus protein ADP-ribosylase activity positive regulation of double-strand break repair via nonhomologous end joining
TC0100003590.mm.2	Ifi214	interferon activated gene 214	1	-173521310	NM_001024721, BC094916 NM_001024721, BC094916	545384	12	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding
TC0400000698.mm.2	Slc31a1	solute carrier family 31, member 1	4	62360700	NM_175090, BC034674, BC058227 NM_175090, BC034674, BC058227 NM_175090, BC034674, BC058227	20529	55	copper ion transmembrane transporter activity copper ion transmembrane transporter activity copper ion transmembrane transporter activity protein binding cytoplasm late endosome plasma membrane plasma membrane ion transport copper ion transport cellular copper ion homeostasis cellular copper ion homeostasis copper ion import copper ion import membrane integral component of membrane copper ion transmembrane transport identical protein binding neuronal cell body recycling endosome transmembrane transport cellular response to cisplatin copper ion import across plasma membrane
TC0500002993.mm.2	Noc4l	NOC4 like	5	-110648418	NM_153570, BC024616 NM_153570, BC024616	100608	20	nucleus nucleoplasm nucleolus nucleolus membrane integral component of membrane Noc4p-Nop14p complex small-subunit processome ribosome biogenesis
TC1600001177.mm.2	Carhsp1	calcium regulated heat stable protein 1	16	-8658586	NM_025821, BC011225, BC086754 NM_025821, BC011225, BC086754 NM_025821, BC011225, BC086754	52502	33	cytoplasmic exosome (RNase complex) nucleic acid binding RNA binding mRNA 3'-UTR binding mRNA 3'-UTR binding protein binding cytoplasm cytoplasm cytosol P granule regulation of mRNA stability regulation of mRNA stability
TC1700000117.mm.2	Agpat4	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	17	12119283	NM_026644, BC047281 NM_026644, BC047281	68262	28	1-acylglycerol-3-phosphate O-acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity mitochondrial outer membrane mitochondrial outer membrane endoplasmic reticulum lipid metabolic process phospholipid metabolic process phospholipid metabolic process phospholipid biosynthetic process endomembrane system membrane integral component of membrane transferase activity transferase activity, transferring acyl groups lysophosphatidic acid acyltransferase activity	00561 00564 01100
TC1900000221.mm.2	Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	19	11469367, 11469367	NM_001166376, NM_028595, BC062247 NM_001166376, NM_028595, BC062247 NM_001166376, NM_028595, BC062247	73656	13	membrane integral component of membrane
TC1400001432.mm.2	Dnase1l3	deoxyribonuclease 1-like 3	14	-7965189	NM_007870, BC012671 NM_007870, BC012671	13421	25	DNA catabolic process, endonucleolytic DNA catabolic process, endonucleolytic neutrophil activation involved in immune response regulation of acute inflammatory response DNA binding DNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity deoxyribonuclease I activity deoxyribonuclease activity extracellular region nucleus nucleus nucleus endoplasmic reticulum DNA catabolic process apoptotic DNA fragmentation apoptotic DNA fragmentation apoptotic DNA fragmentation apoptotic process programmed cell death involved in cell development programmed cell death involved in cell development programmed cell death hydrolase activity regulation of neutrophil mediated cytotoxicity
TC1900001018.mm.2	Ccdc88b	coiled-coil domain containing 88B	19	-6844622	NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946	78317	12	positive regulation of cytokine production cytoplasm endoplasmic reticulum Golgi apparatus centrosome cytoskeleton microtubule binding membrane cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization positive regulation of T cell proliferation defense response to protozoan positive regulation of T cell activation dynein light intermediate chain binding
TC0700001273.mm.2	E230029C05Rik	RIKEN cDNA E230029C05 gene	7	90029158	NR_110364, NR_110365, NR_015614 NR_110364, NR_110365, NR_015614 NR_110364, NR_110365, NR_015614	319711	11
TC0500001338.mm.2	Slc8b1	solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	5	120511191	NM_001177594, NM_001177595, NM_133221, BC043689 NM_001177594, NM_001177595, NM_133221, BC043689 NM_001177594, NM_001177595, NM_133221, BC043689 NM_001177594, NM_001177595, NM_133221, BC043689	170756	37	calcium:sodium antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity mitochondrion mitochondrion mitochondrial inner membrane plasma membrane ion transport cation transport sodium ion transport calcium ion transport mitochondrial calcium ion transmembrane transport mitochondrial calcium ion transmembrane transport mitochondrial calcium ion transmembrane transport cellular calcium ion homeostasis cation transmembrane transporter activity antiporter activity membrane integral component of membrane mitochondrial crista mitochondrial crista integral component of mitochondrial membrane sodium ion transmembrane transport sarcolemma glucose homeostasis identical protein binding protein homodimerization activity protein homodimerization activity regulation of insulin secretion response to stimulus regulation of cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration mitochondrial calcium ion homeostasis mitochondrial calcium ion homeostasis mitochondrial calcium ion homeostasis transmembrane transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential calcium export from the mitochondrion calcium export from the mitochondrion calcium export from the mitochondrion regulation of lymphocyte chemotaxis regulation of store-operated calcium entry
TC0800001106.mm.2	Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	8	94386428	NM_022331, BC013523 NM_022331, BC013523	64209	48	protein binding endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process cellular calcium ion homeostasis response to unfolded protein membrane integral component of membrane ubiquitin-dependent ERAD pathway endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol regulation of protein ubiquitination endoplasmic reticulum calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress response to endoplasmic reticulum stress negative regulation of cysteine-type endopeptidase activity involved in apoptotic process endoplasmic reticulum quality control compartment ion channel binding ion channel binding protein targeting to ER regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of ER-associated ubiquitin-dependent protein catabolic process regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of ER-associated ubiquitin-dependent protein catabolic process Lewy body core ubiquitin ligase-substrate adaptor activity negative regulation of intrinsic apoptotic signaling pathway	04141
TC0400004170.mm.2	Agrn	agrin	4	-156165289, -156190167, -156165291	NM_021604, BC150703 NM_021604, BC150703	11603	172	regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of protein phosphorylation dystroglycan binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region basement membrane basement membrane extracellular space extracellular space extracellular space Golgi lumen plasma membrane plasma membrane organization chemical synaptic transmission chemical synaptic transmission multicellular organism development synapse assembly neuromuscular junction development neuromuscular junction development regulation of synaptic growth at neuromuscular junction animal organ morphogenesis tissue development cell surface membrane integral component of membrane cell junction cell differentiation acetylcholine receptor regulator activity positive regulation of protein binding chondroitin sulfate binding BMP binding ATPase inhibitor activity sarcolemma synaptic cleft regulation of GTPase activity receptor clustering receptor clustering receptor clustering receptor clustering receptor clustering heparan sulfate proteoglycan binding positive regulation of neuron apoptotic process positive regulation of GTPase activity axonal growth cone ion channel binding synapse synapse synapse neurotransmitter receptor metabolic process positive regulation of synaptic growth at neuromuscular junction positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II transforming growth factor beta binding positive regulation of peptidyl-tyrosine phosphorylation regulation of synapse organization positive regulation of filopodium assembly regulation of cardiac muscle contraction positive regulation of protein tyrosine kinase activity collagen-containing extracellular matrix collagen-containing extracellular matrix regulation of microtubule cytoskeleton organization skeletal muscle acetylcholine-gated channel clustering regulation of cardiac muscle cell membrane potential glutamatergic synapse regulation of axon guidance negative regulation of sodium ion export across plasma membrane negative regulation of sodium:potassium-exchanging ATPase activity positive regulation of protein geranylgeranylation	04512
TC0300003210.mm.2	Schip1	schwannomin interacting protein 1	3	68572367, 68064801, 68468182, 68494180	NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665	30953	28	luteinization kidney development protein binding cytoplasm plasma membrane nitrogen compound metabolic process estrogen metabolic process female gonad development post-embryonic development fibroblast migration cell junction positive regulation of hippo signaling identical protein binding protein homodimerization activity platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis smooth muscle tissue development roof of mouth development face morphogenesis
TC0800001132.mm.2	Usb1	U6 snRNA biogenesis 1	8	95332283	NM_133954, BC016418, U6 NM_133954, BC016418, U6 NM_133954, BC016418, U6	101985	15	3'-5'-exoribonuclease activity 3'-5'-exoribonuclease activity nuclease activity nucleus nucleus nucleoplasm RNA splicing hydrolase activity U6 snRNA 3'-end processing U6 snRNA 3'-end processing intercellular bridge
TC1700000625.mm.2	H2-Ob	histocompatibility 2, O region beta locus	17	34238904	NM_010389, BC127027, BC127028 NM_010389, BC127027, BC127028 NM_010389, BC127027, BC127028	15002	43	negative regulation of antigen processing and presentation of peptide antigen via MHC class II intracellular anatomical structure lysosome MHC class II protein complex binding MHC class II protein complex	04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416
MG-1-pos-10339750_st
TC0800002012.mm.2	Rbpms	RNA binding protein gene with multiple splicing	8	-33782643, -33803939	NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397	19663	48	nucleic acid binding transcription coactivator activity RNA binding mRNA binding nucleus nucleoplasm cytoplasm cytosol response to oxidative stress poly(A) binding cytoplasmic stress granule positive regulation of pathway-restricted SMAD protein phosphorylation protein homodimerization activity positive regulation of SMAD protein signal transduction
TC1700002216.mm.2	Foxp4	forkhead box P4	17	-47867132	NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110	74123	58	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II heart development identical protein binding sequence-specific DNA binding metal ion binding embryonic foregut morphogenesis lung secretory cell differentiation regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation
TC1100003379.mm.2	Slfn9	schlafen 9	11	-82980302	NM_172796	237886	12	tRNA binding nucleotide binding nuclease activity endonuclease activity endoribonuclease activity ATP binding nucleus cytoplasm zinc ion binding hydrolase activity metal ion binding defense response to virus
TC1700002814.mm.2	C4b	complement component 4B (Chido blood group)	17	-34728380	NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005	12268	187	complement binding complement component C1q complex binding extracellular region extracellular space extracellular space extracellular space extracellular space complement activation complement activation immunoglobulin mediated immune response carbohydrate binding axon dendrite neuronal cell body other organism cell synapse	04610 05150 05322
TC1100004124.mm.2	St6galnac2	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	11	-116676704	NM_009180	20446	19	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Golgi apparatus protein glycosylation protein O-linked glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein sialylation
TC0200003599.mm.2	Cd302	CD302 antigen	2	-60251992	NM_025422, BC005501, CD302 NM_025422, BC005501, CD302 NM_025422, BC005501, CD302	66205	16	cytoplasm cell cortex phagocytosis external side of plasma membrane membrane integral component of membrane filopodium carbohydrate binding signaling receptor activity cell projection
TC0400002799.mm.2	Akna	AT-hook transcription factor	4	-63367122, -63367122	NM_001045514, BC092227 NM_001045514, BC092227	100182	21	fibrillar center epithelial to mesenchymal transition DNA binding protein binding nucleus nucleoplasm cytoplasm centrosome centrosome centriole cytosol cytoskeleton microtubule nervous system development neuroblast division in subventricular zone intracellular membrane-bounded organelle positive regulation of transcription by RNA polymerase II regulation of inflammatory response delamination neuroblast delamination
TC1300002534.mm.2	Naip1	NLR family, apoptosis inhibitory protein 1	13	-100407769	NM_008670, BC132413 NM_008670, BC132413	17940	46	nucleotide binding cysteine-type endopeptidase inhibitor activity ATP binding cytoplasm cytoplasm apoptotic process inflammatory response negative regulation of peptidase activity detection of bacterium basolateral plasma membrane peptidase inhibitor activity defense response to bacterium neuron projection neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process perikaryon metal ion binding pyroptosis cellular response to estrogen stimulus IPAF inflammasome complex	04621
TC1100000494.mm.2	Trim7	tripartite motif-containing 7	11	48826137, 48837470	NM_053166, BC138188 NM_053166, BC138188	94089	21	nucleus nucleus cytoplasm cytoplasm cytoplasm zinc ion binding protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity
TC1000002664.mm.2	Apaf1	apoptotic peptidase activating factor 1	10	-90989310	NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684	11783	151	nucleotide binding neural tube closure ATP binding nucleus cytoplasm cytosol cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process multicellular organism development brain development activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c cysteine-type endopeptidase activator activity involved in apoptotic process cardiac muscle cell apoptotic process forebrain development heat shock protein binding protein-containing complex identical protein binding identical protein binding regulation of apoptotic process apoptosome ADP binding neuron apoptotic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to transforming growth factor beta stimulus apoptotic signaling pathway regulation of apoptotic DNA fragmentation positive regulation of apoptotic signaling pathway	04115 04210 05010 05012 05014 05016 05222
TC0700001876.mm.2	Itgax	integrin alpha X	7	128129549, 128129549	NM_021334, BC167225 NM_021334, BC167225	16411	159	cell adhesion integrin-mediated signaling pathway positive regulation of cell population proliferation integrin complex external side of plasma membrane cell surface positive regulation of gene expression positive regulation of gene expression membrane integral component of membrane positive regulation of cell migration receptor tyrosine kinase binding positive regulation of myelination heterotypic cell-cell adhesion positive regulation of angiogenesis metal ion binding defense response to virus positive regulation of endothelial tube morphogenesis	04810
TC1100000362.mm.2	Lcp2	lymphocyte cytosolic protein 2	11	34046927	NM_010696, BC006948 NM_010696, BC006948	16822	113	cytokine production protein binding cytoplasm cytosol cytosol cell-cell junction transmembrane receptor protein tyrosine kinase signaling pathway intracellular signal transduction TCR signalosome plasma membrane raft mast cell activation T cell receptor signaling pathway	04380 04650 04660 04664
TC1000000592.mm.2	Dna2	DNA replication helicase/nuclease 2	10	62947028, 62947028	NM_177372, BC115716 NM_177372, BC115716	327762	26	DNA replication checkpoint nucleotide binding telomere maintenance DNA double-strand break processing chromosome, telomeric region DNA binding RNA binding catalytic activity helicase activity nuclease activity endonuclease activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion gamma DNA polymerase complex DNA replication mitochondrial DNA replication DNA repair base-excision repair cellular response to DNA damage stimulus metabolic process hydrolase activity site-specific endodeoxyribonuclease activity, specific for altered base 5'-flap endonuclease activity 5'-flap endonuclease activity 5'-flap endonuclease activity single-stranded DNA helicase activity DNA replication, Okazaki fragment processing mitochondrial nucleoid DNA replication, removal of RNA primer 5'-3' DNA helicase activity mitochondrial DNA repair positive regulation of DNA replication metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding replication fork reversal nucleic acid phosphodiester bond hydrolysis mitotic telomere maintenance via semi-conservative replication	03030
TC1400002406.mm.2	Lrch1	leucine-rich repeats and calponin homology (CH) domain containing 1	14	-74754672	NM_001033439, NM_001252132 NM_001033439, NM_001252132	380916	23	protein binding cytoplasm cytoplasm negative regulation of GTPase activity negative regulation of GTPase activity cellular response to chemokine cellular response to chemokine cellular response to chemokine negative regulation of T cell migration negative regulation of T cell migration negative regulation of T cell migration
TC0200004733.mm.2	Flrt3	fibronectin leucine rich transmembrane protein 3	2	-140658197	NM_001172160, NM_178382, BC052043 NM_001172160, NM_178382, BC052043 NM_001172160, NM_178382, BC052043	71436	39	proepicardium cell migration involved in pericardium morphogenesis fibroblast growth factor receptor binding protein binding extracellular region extracellular space extracellular space endoplasmic reticulum cytosol plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane cell-cell junction focal adhesion cell adhesion multicellular organism development axon guidance axon guidance synapse assembly heart development fibroblast growth factor receptor signaling pathway postsynaptic density membrane integral component of membrane cell junction neuron projection development neuron projection development protein homodimerization activity cell projection axon terminus axonal growth cone chemorepellent activity embryonic morphogenesis response to axon injury synapse organization positive regulation of synapse assembly head development synaptic membrane cell-cell adhesion via plasma-membrane adhesion molecules cell-cell adhesion via plasma-membrane adhesion molecules glutamatergic synapse glutamatergic synapse integral component of postsynaptic membrane integral component of postsynaptic membrane integral component of postsynaptic membrane synaptic membrane adhesion synaptic membrane adhesion neuron projection extension
TC0500003178.mm.2	Oas1c	2'-5' oligoadenylate synthetase 1C	5	-120800198	NM_033541, BC108955, BC126877 NM_033541, BC108955, BC126877 NM_033541, BC108955, BC126877	114643	18	RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytosol immune response membrane transferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity
TC1100002176.mm.2	Myo1g	myosin IG	11	-6506547	NM_178440, BC113755, BC113954 NM_178440, BC113755, BC113954 NM_178440, BC113755, BC113954	246177	23	microfilament motor activity nucleotide binding phagocytic cup adaptive immune response immune system process T cell mediated immunity motor activity actin binding calmodulin binding ATP binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding nucleoplasm cytoplasm plasma membrane plasma membrane plasma membrane microvillus microvillus exocytosis phagocytosis actin filament organization lipid binding actin cytoskeleton membrane myosin complex lamellipodium vesicle transport along actin filament filopodium actin-dependent ATPase activity leading edge membrane cell-substrate adhesion vesicle Fc-gamma receptor signaling pathway involved in phagocytosis cell projection phosphatidylinositol-3,4-bisphosphate binding actin filament binding cell gliding T cell meandering migration
TC0400003679.mm.2	Xkr8	X-linked Kx blood group related 8	4	-132724903	NM_201368, BC057035 NM_201368, BC057035	381560	18	tolerance induction to self antigen molecular_function plasma membrane plasma membrane apoptotic process membrane integral component of membrane engulfment of apoptotic cell engulfment of apoptotic cell establishment of localization in cell phosphatidylserine exposure on apoptotic cell surface phosphatidylserine exposure on apoptotic cell surface phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development
TC0600002423.mm.2	Il12rb2	interleukin 12 receptor, beta 2	6	-67292017, -67292017	NM_008354, BC137745 NM_008354, BC137745	16162	111	cytokine receptor activity protein binding plasma membrane plasma membrane external side of plasma membrane external side of plasma membrane membrane integral component of membrane peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway protein kinase binding cytokine binding response to lipopolysaccharide interferon-gamma production positive regulation of interferon-gamma production response to cytokine receptor complex	04060 04630
TC0900002604.mm.2	Aqp9	aquaporin 9	9	-71110658, -71110658	NM_001271843, NM_022026, NR_073483, BC024105 NM_001271843, NM_022026, NR_073483, BC024105 NM_001271843, NM_022026, NR_073483, BC024105 NM_001271843, NM_022026, NR_073483, BC024105	64008	62	purine nucleobase transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane water transport water transport purine nucleobase transport response to organic substance urea transmembrane transporter activity water channel activity water channel activity glycerol channel activity urea channel activity channel activity canalicular bile acid transport polyol transport glycerol transport amine transport pyrimidine nucleobase transport membrane integral component of membrane basolateral plasma membrane intracellular membrane-bounded organelle response to mercury ion transmembrane transport urea transmembrane transport	04976
TC1100001981.mm.2	Pgs1	phosphatidylglycerophosphate synthase 1	11	117986856	NM_133757, BC151089, BC151185 NM_133757, BC151089, BC151185 NM_133757, BC151089, BC151185	74451	21	nucleotide binding catalytic activity ATP binding mitochondrion mitochondrion endoplasmic reticulum lipid metabolic process CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity phospholipid biosynthetic process transferase activity cardiolipin biosynthetic process	00564 01100
TC1700002820.mm.2	H2-T-ps	histocompatibility 2, T region locus, pseudogene	17	-36109029	NM_001271005, XM_003688945 NM_001271005, XM_003688945	667803	13
TC0300002994.mm.2	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	3	-135584654	NM_008689, BC138535, BC138536 NM_008689, BC138535, BC138536 NM_008689, BC138535, BC138536	18033	1492	negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific negative regulation of cytokine production DNA binding DNA binding chromatin binding double-stranded DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm mitochondrion cytosol cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process response to oxidative stress signal transduction positive regulation of gene expression negative regulation of gene expression negative regulation of calcidiol 1-monooxygenase activity response to organic cyclic compound enzyme binding heat shock protein binding negative regulation of interleukin-12 production protein-containing complex response to muscle stretch identical protein binding identical protein binding actinin binding neuron projection negative regulation of apoptotic process sequence-specific DNA binding sequence-specific DNA binding protein-containing complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II lymph node development negative regulation of inflammatory response cellular response to lipopolysaccharide cellular response to nicotine cellular response to carbohydrate stimulus cellular response to cytokine stimulus cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to dsRNA cellular response to organic cyclic compound positive regulation of canonical Wnt signaling pathway positive regulation of hyaluronan biosynthetic process cellular response to peptide positive regulation of pri-miRNA transcription by RNA polymerase II cellular response to angiotensin cellular response to diterpene cellular response to glucoside cellular response to brain-derived neurotrophic factor stimulus positive regulation of miRNA metabolic process positive regulation of gene silencing by miRNA	04010 04062 04210 04380 04620 04621 04622 04623 04660 04662 04722 04920 05140 05142 05145 05146 05160 05200 05212 05215 05220 05221 05222
TC0400004047.mm.2	Pik3cd	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	4	-149649167, -149649167, -149649167, -149649167	NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203	18707	187	nucleotide binding B cell homeostasis positive regulation of endothelial cell proliferation adaptive immune response immune system process protein binding ATP binding cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex chemotaxis inflammatory response cell surface receptor signaling pathway positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression phosphatidylinositol 3-kinase signaling phosphatidylinositol 3-kinase signaling membrane kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation cell migration transferase activity cell differentiation positive regulation of cell migration positive regulation of neutrophil apoptotic process phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process positive regulation of cell migration by vascular endothelial growth factor signaling pathway B cell activation innate immune response positive regulation of angiogenesis phosphatidylinositol phosphorylation phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol-mediated signaling homeostasis of number of cells defense response to fungus positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling phosphatidylinositol kinase activity positive regulation of epithelial tube formation	00562 04012 04062 04070 04150 04210 04370 04380 04510 04620 04630 04650 04660 04662 04664 04666 04670 04722 04810 04910 04914 04930 04960 04973 05100 05142 05145 05146 05160 05200 05210 05211 05212 05213 05214 05215 05218 05220 05221 05222 05223
TC0500003318.mm.2	Sbds	SBDS ribosome maturation factor	5	-130245731	NM_023248, BC003849 NM_023248, BC003849	66711	28	spindle pole inner cell mass cell proliferation hematopoietic progenitor cell differentiation nucleus nucleoplasm nucleolus cytoplasm cytosol cytoskeleton rRNA processing mitotic spindle organization microtubule binding rRNA binding bone mineralization leukocyte chemotaxis ribosome biogenesis mature ribosome assembly ribosome binding bone marrow development	03008
TC1400002454.mm.2	Lacc1	laccase domain containing 1	14	-77024200	NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140	210808	18	pattern recognition receptor signaling pathway cytokine production involved in immune response immune system process adenosine deaminase activity purine-nucleoside phosphorylase activity copper ion binding nucleus cytoplasm peroxisome endoplasmic reticulum inflammatory response transferase activity hydrolase activity S-methyl-5-thioadenosine phosphorylase activity regulation of cellular pH innate immune response metal ion binding guanosine phosphorylase activity regulation of inflammatory response nucleotide-binding oligomerization domain containing 2 signaling pathway regulation of purine nucleotide metabolic process
TC1000002490.mm.2	Sbno2	strawberry notch 2	10	-80062415, -80056991, -80056991, -80080409	NM_183426, BC056369 NM_183426, BC056369	216161	22	ossification macrophage activation involved in immune response macrophage activation involved in immune response macrophage activation involved in immune response protein binding nucleus regulation of transcription, DNA-templated cell differentiation bone mineralization osteoclast differentiation osteoclast differentiation chromatin DNA binding histone binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of inflammatory response regulation of inflammatory response regulation of inflammatory response bone trabecula morphogenesis cellular response to lipopolysaccharide cellular response to interleukin-11 cellular response to interleukin-6 cellular response to interleukin-6 cellular response to interleukin-6 multinuclear osteoclast differentiation osteoclast fusion cellular response to leukemia inhibitory factor
TC0300000765.mm.2	Pbxip1	pre B cell leukemia transcription factor interacting protein 1	3	89436703	NM_146131, BC026838, BC027771, BC034200 NM_146131, BC026838, BC027771, BC034200 NM_146131, BC026838, BC027771, BC034200 NM_146131, BC026838, BC027771, BC034200	229534	25	molecular_function transcription corepressor activity nucleus cytoplasm cytoskeleton microtubule membrane cell differentiation negative regulation of transcription, DNA-templated regulation of Rho guanyl-nucleotide exchange factor activity
TC1700002766.mm.2					NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264			transcription corepressor activity nucleus centriole biological_process
TC0700003938.mm.2	Trim12a	tripartite motif-containing 12A	7	-104299896, -104303594	NM_023835, BC094899 NM_023835, BC094899	76681	20	protein polyubiquitination ubiquitin-protein transferase activity nucleoplasm cytoplasm cytoplasm cytosol autophagy zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity
TC0700004316.mm.2	Tbc1d10b	TBC1 domain family, member 10b	7	-127197458	NM_144522, BC072576 NM_144522, BC072576	68449	24	GTPase activator activity GTPase activator activity cytoplasm plasma membrane intracellular protein transport retrograde transport, endosome to Golgi regulation of GTPase activity activation of GTPase activity
TC0400001525.mm.2	Marcksl1	MARCKS-like 1	4	129513580	NM_010807, BC006757 NM_010807, BC006757	17357	47	actin binding calmodulin binding cytoplasm cytoskeleton plasma membrane plasma membrane actin filament organization central nervous system development synaptic vesicle positive regulation of cell population proliferation membrane actin filament binding anchored component of presynaptic membrane presynaptic cytosol voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	04666 05140
TC0100003264.mm.2	Rgl1	ral guanine nucleotide dissociation stimulator,-like 1	1	-152516762, -152516762	NM_016846, BC017678, XR_140453 NM_016846, BC017678, XR_140453 NM_016846, BC017678, XR_140453	19731	18	guanyl-nucleotide exchange factor activity intracellular anatomical structure signal transduction small GTPase mediated signal transduction
TC0300002860.mm.2					NM_001114665, NM_153118, NR_106117, BC034510 NM_001114665, NM_153118, NR_106117, BC034510 NM_001114665, NM_153118, NR_106117, BC034510 NM_001114665, NM_153118, NR_106117, BC034510			cytoplasm cytoskeleton plasma membrane endocytosis autophagy signal transduction lipid binding membrane cytoplasmic vesicle cilium assembly
TC1300001366.mm.2	BC147527	cDNA sequence BC147527	13	120300391	NM_001037925, BC147527, BC147545 NM_001037925, BC147527, BC147545 NM_001037925, BC147527, BC147545	625360	8
TC0200005114.mm.2	Sdc4	syndecan 4	2	-164424246	NM_011521, BC005679 NM_011521, BC005679	20971	155	neural tube closure fibronectin binding protein kinase C binding protein binding extracellular region Golgi lumen focal adhesion cell surface cell surface cell surface regulation of fibroblast migration membrane integral component of membrane cell migration wound healing negative regulation of T cell proliferation identical protein binding costamere membrane raft positive regulation of protein kinase activity positive regulation of stress fiber assembly positive regulation of focal adhesion assembly inner ear receptor cell stereocilium organization thrombospondin receptor activity positive regulation of exosomal secretion positive regulation of extracellular exosome assembly	04512 04514 05144
TC1700002135.mm.2	Enpp4	ectonucleotide pyrophosphatase/phosphodiesterase 4	17	-44096309, -44096309	NM_199016, BC027749 NM_199016, BC027749	224794	17	catalytic activity plasma membrane blood coagulation hemostasis membrane integral component of membrane hydrolase activity positive regulation of blood coagulation purine ribonucleoside catabolic process metal ion binding bis(5'-adenosyl)-triphosphatase activity
TC0900001391.mm.2	Gmppb	GDP-mannose pyrophosphorylase B	9	108049263	NM_177910, BC061207 NM_177910, BC061207	331026	16	nucleotide binding mannose-1-phosphate guanylyltransferase activity GTP binding cytoplasm mitochondrion biosynthetic process transferase activity nucleotidyltransferase activity	00051 00520 01100
TC0900000533.mm.2	Jaml	junction adhesion molecule like	9	45079182	NM_001005421, BC050133 NM_001005421, BC050133	270152	14	immune system process integrin binding nucleoplasm plasma membrane plasma membrane bicellular tight junction cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane cell junction neutrophil chemotaxis monocyte extravasation protein homodimerization activity gamma-delta T cell activation cell adhesion molecule binding leukocyte migration positive regulation of epithelial cell proliferation involved in wound healing neutrophil extravasation
TC1700002774.mm.2	Cmtr1	cap methyltransferase 1	17	29660594	NM_028791, BC024691 NM_028791, BC024691	74157	25	nucleic acid binding mRNA (nucleoside-2'-O-)-methyltransferase activity mRNA (nucleoside-2'-O-)-methyltransferase activity nucleus nucleus nucleoplasm cytoplasm 7-methylguanosine mRNA capping 7-methylguanosine mRNA capping mRNA processing methyltransferase activity transferase activity methylation intracellular membrane-bounded organelle mRNA methylation cap1 mRNA methylation cap1 mRNA methylation
TC1700001033.mm.2	Vav1	vav 1 oncogene	17	57279099	NM_001163815, NM_001163816, NM_011691, BC020487 NM_001163815, NM_001163816, NM_011691, BC020487 NM_001163815, NM_001163816, NM_011691, BC020487 NM_001163815, NM_001163816, NM_011691, BC020487	22324	225	phosphotyrosine residue binding guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity protein binding cytosol cell-cell junction phagocytosis immune response G protein-coupled receptor signaling pathway integrin-mediated signaling pathway small GTPase mediated signal transduction T cell differentiation T cell differentiation neutrophil chemotaxis regulation of Rho protein signal transduction intracellular signal transduction T cell activation regulation of GTPase activity regulation of GTPase activity positive regulation of GTPase activity positive regulation of cell adhesion positive regulation of natural killer cell mediated cytotoxicity metal ion binding reactive oxygen species metabolic process phosphorylation-dependent protein binding	04062 04510 04650 04660 04662 04664 04666 04670 04810
TC0600001877.mm.2	Gpr85	G protein-coupled receptor 85	6	-13834451	NM_145066, BC026975, BC065154 NM_145066, BC026975, BC065154 NM_145066, BC026975, BC065154	64450	25	G protein-coupled receptor activity endoplasmic reticulum plasma membrane plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane
TC0100001202.mm.2	Ppp1r15b	protein phosphatase 1, regulatory subunit 15B	1	133131165	NM_133819, BC156913 NM_133819, BC156913	108954	23	protein phosphatase type 1 complex protein phosphatase type 1 complex protein phosphatase type 1 complex negative regulation of protein phosphorylation endoplasmic reticulum regulation of translation regulation of translational initiation response to oxidative stress response to oxidative stress ER overload response ER overload response protein phosphatase regulator activity protein phosphatase regulator activity positive regulation of phosphoprotein phosphatase activity response to endoplasmic reticulum stress response to endoplasmic reticulum stress response to hydrogen peroxide peptidyl-serine dephosphorylation negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
TC0100002177.mm.2	Neurl3	neuralized E3 ubiquitin protein ligase 3	1	-36264601	NM_153408, BC056622 NM_153408, BC056622	214854	15	protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity
TC1900000442.mm.2	Pdcd1lg2	programmed cell death 1 ligand 2	19	29410918	NM_021396, BC104138, BC104139 NM_021396, BC104138, BC104139 NM_021396, BC104138, BC104139	58205	98	adaptive immune response immune system process protein binding plasma membrane immune response cell surface receptor signaling pathway external side of plasma membrane membrane integral component of membrane T cell costimulation negative regulation of interferon-gamma production negative regulation of interleukin-10 production positive regulation of T cell proliferation positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of activated T cell proliferation cellular response to lipopolysaccharide	04514
TC1800000689.mm.2	Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	18	66458603	NM_021451, BC050821 NM_021451, BC050821	58801	126	release of cytochrome c from mitochondria release of cytochrome c from mitochondria protein binding mitochondrion mitochondrion mitochondrion mitochondrion apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus intrinsic apoptotic signaling pathway in response to DNA damage response to UV response to X-ray negative regulation of mitochondrial membrane potential intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process T cell homeostasis positive regulation of apoptotic process positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of neuron apoptotic process negative regulation of fibroblast proliferation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	04115
TC0200001849.mm.2	Slc28a2	solute carrier family 28 (sodium-coupled nucleoside transporter), member 2	2	122426434	NM_172980, BC055376 NM_172980, BC055376	269346	20	retina homeostasis retina homeostasis neurotransmitter transmembrane transporter activity nucleoside transmembrane transporter activity nucleoside transmembrane transporter activity purine nucleobase transmembrane transporter activity nucleoside:sodium symporter activity nucleoside:sodium symporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane neurotransmitter transport vesicle membrane purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transporter activity uridine transmembrane transporter activity symporter activity pyrimidine- and adenine-specific:sodium symporter activity purine nucleoside transmembrane transport purine nucleoside transmembrane transport uridine transport membrane integral component of membrane coated vesicle brush border membrane adenosine transport protein localization to cell surface inosine transport pyrimidine-containing compound transmembrane transport nucleoside transmembrane transport nucleoside transmembrane transport purine nucleobase transmembrane transport
TC1600000264.mm.2	B3gnt5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	16	19760233	NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076	108105	22	Golgi apparatus protein glycosylation multicellular organism development central nervous system development brain development acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sphingolipid biosynthetic process lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	00601 01100
TC0500003615.mm.2	Usp12	ubiquitin specific peptidase 12	5	-146734811	NM_011669, BC049274, BC068136 NM_011669, BC049274, BC068136 NM_011669, BC049274, BC068136	22217	25	cysteine-type endopeptidase activity cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity nucleus nucleus cytosol cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination protein deubiquitination protein deubiquitination hydrolase activity metal ion binding positive regulation of T cell receptor signaling pathway ubiquitinyl hydrolase activity ubiquitinyl hydrolase activity
TC1300001654.mm.2	Carmil1	capping protein regulator and myosin 1 linker 1	13	-24012483, -24012480, -24012480	NM_026825, BC167257 NM_026825, BC167257	68732	23	nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane membrane cell migration nuclear speck lamellipodium lamellipodium lamellipodium assembly positive regulation of cell migration positive regulation of cell migration positive regulation of actin filament polymerization cell leading edge ruffle organization filamentous actin cell projection macropinocytosis macropinosome protein-containing complex binding protein-containing complex binding urate metabolic process positive regulation of stress fiber assembly positive regulation of stress fiber assembly barbed-end actin filament uncapping actin filament network formation positive regulation of substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading positive regulation of lamellipodium organization positive regulation of lamellipodium organization negative regulation of barbed-end actin filament capping
TC0100001620.mm.2	Cfap45	cilia and flagella associated protein 45	1	172521129	NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055	71870	13	molecular_function nucleoplasm biological_process
TC1700002558.mm.2	Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	17	-78852549	NM_011163, BC016422 NM_011163, BC016422	19106	219	nucleotide binding activation of MAPKK activity positive regulation of cytokine production immune system process RNA binding double-stranded RNA binding double-stranded RNA binding protein kinase activity protein kinase activity protein kinase activity protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol cytosol translation protein phosphorylation protein phosphorylation response to virus response to toxic substance kinase activity phosphorylation transferase activity negative regulation of translation endoplasmic reticulum unfolded protein response response to lipopolysaccharide positive regulation of chemokine production positive regulation of stress-activated MAPK cascade response to vitamin E negative regulation of osteoblast proliferation cellular response to amino acid starvation response to interferon-alpha identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of viral genome replication negative regulation of viral genome replication innate immune response protein autophosphorylation protein autophosphorylation perinuclear region of cytoplasm positive regulation of NF-kappaB transcription factor activity defense response to virus regulation of NLRP3 inflammasome complex assembly positive regulation of NIK/NF-kappaB signaling regulation of hematopoietic progenitor cell differentiation regulation of hematopoietic stem cell proliferation regulation of hematopoietic stem cell differentiation	04141 05160
TC0800000916.mm.2	Tbc1d9	TBC1 domain family, member 9	8	83165351	NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027	71310	17	GTPase activator activity calcium ion binding intracellular protein transport activation of GTPase activity
TC1100002770.mm.2	Tnip1	TNFAIP3 interacting protein 1	11	-54910786	NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665	57783	44	MyD88-dependent toll-like receptor signaling pathway protein binding nucleus nucleoplasm cytoplasm cytosol inflammatory response leukocyte cell-cell adhesion glycoprotein biosynthetic process polyubiquitin modification-dependent protein binding polyubiquitin modification-dependent protein binding identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of inflammatory response positive regulation of inflammatory response mitogen-activated protein kinase binding mitogen-activated protein kinase binding negative regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade positive regulation of protein deubiquitination
TC1100002374.mm.2	Rel	reticuloendotheliosis oncogene	11	-23736849	NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770	19696	241	RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus transcription regulator complex cytoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II inflammatory response I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling negative regulation of gene expression negative regulation of interferon-beta production positive regulation of interleukin-12 production cellular response to stress response to cytokine NIK/NF-kappaB signaling sequence-specific DNA binding innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of neuron death
TC0500002945.mm.2	Mfsd7a	major facilitator superfamily domain containing 7A	5	-108441053	NM_172883, BC094512 NM_172883, BC094512	243197	13	cellular_component membrane integral component of membrane transmembrane transport
TC1900000224.mm.2	Gm8369	predicted gene 8369	19	11492037	NM_001164202	666926	8	molecular_function cellular_component biological_process
TC1800000909.mm.2	Cd226	CD226 antigen	18	89197426	NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226	225825	66	cytokine production cytokine production positive regulation of natural killer cell cytokine production positive regulation of natural killer cell cytokine production positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of immunoglobulin mediated immune response positive regulation of immunoglobulin mediated immune response integrin binding protein binding plasma membrane cell adhesion external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane protein kinase binding positive regulation of interferon-gamma production positive regulation of interferon-gamma production positive regulation of mast cell activation positive regulation of mast cell activation positive regulation of natural killer cell mediated cytotoxicity cell adhesion molecule binding positive regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway	04514
TC1900000219.mm.2	Ms4a4b	membrane-spanning 4-domains, subfamily A, member 4B	19	11443557	NM_021718, BC028433 NM_021718, BC028433	60361	19	integral component of plasma membrane
TC1000000011.mm.2	Plekhg1	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	10	3872666, 3740376	NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966	213783	22	nucleoplasm
TC1000000506.mm.2	Pkib	protein kinase inhibitor beta, cAMP dependent, testis specific	10	57650980, 57645868, 57631980	NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894	18768	20	protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity nucleus cytoplasm negative regulation of protein kinase activity positive regulation of telomere maintenance via telomerase positive regulation of telomerase activity positive regulation of telomere capping negative regulation of cAMP-dependent protein kinase activity negative regulation of cAMP-dependent protein kinase activity
TC1800000124.mm.2	Taf4b	TATA-box binding protein associated factor 4b	18	14783244	NM_001100449	72504	40	fibrillar center DNA binding DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm transcription regulator complex transcription factor TFIID complex transcription factor TFIID complex cytoplasm DNA-templated transcription, initiation regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter spermatogenesis RNA polymerase II general transcription initiation factor activity cell differentiation protein heterodimerization activity oogenesis NF-kappaB binding positive regulation of stem cell proliferation	03022 05016
TC1500001658.mm.2	St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	15	-67102874	NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693	20442	35	memory B cell differentiation beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity extracellular region Golgi apparatus protein phosphorylation protein glycosylation protein glycosylation sialyltransferase activity ganglioside biosynthetic process via lactosylceramide ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups trans-Golgi network membrane negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process Golgi medial cisterna membrane Golgi trans cisterna membrane protein sialylation protein sialylation protein sialylation	00512 00533 00603 00604 01100
TC0600001696.mm.2	Etnk1	ethanolamine kinase 1	6	143167229	NM_029250	75320	33	nucleotide binding ethanolamine kinase activity ATP binding cytoplasm lipid metabolic process phosphatidylethanolamine biosynthetic process phospholipid biosynthetic process kinase activity phosphorylation transferase activity	00564 01100
MG-1-pos-10341395_st
TC1000001744.mm.2	Rab32	RAB32, member RAS oncogene family	10	-10545038	NM_026405, BC016409, BC055945 NM_026405, BC016409, BC055945 NM_026405, BC016409, BC055945	67844	35	nucleotide binding GTPase activity GTPase activity protein binding GTP binding mitochondrion mitochondrion mitochondrion mitochondrial outer membrane early endosome endoplasmic reticulum Golgi apparatus trans-Golgi network intracellular protein transport mitochondrion organization endomembrane system membrane vesicle-mediated transport antigen processing and presentation GTP-dependent protein binding cytoplasmic vesicle vesicle melanosome organization melanosome membrane endosome to melanosome transport AP-1 adaptor complex binding AP-3 adaptor complex binding BLOC-2 complex binding melanosome melanosome melanosome mitochondria-associated endoplasmic reticulum membrane phagocytic vesicle protein localization to membrane phagosome maturation melanosome assembly
TC0500003464.mm.2	Pilrb1	paired immunoglobin-like type 2 receptor beta 1	5	-137852146	NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053	170741	12	myeloid dendritic cell activation protein binding plasma membrane membrane integral component of membrane MHC class I protein binding MHC class I protein binding negative regulation of osteoclast differentiation
TC0300001578.mm.2	Ptger3	prostaglandin E receptor 3 (subtype EP3)	3	157566875	NM_011196, BC058742 NM_011196, BC058742	19218	151	fever generation fever generation positive regulation of protein phosphorylation desensitization of G protein-coupled receptor signaling pathway G protein-coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity prostaglandin E receptor activity prostaglandin E receptor activity prostaglandin E receptor activity protein binding plasma membrane plasma membrane plasma membrane inflammatory response signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration cell surface positive regulation of gene expression negative regulation of norepinephrine secretion regulation of circadian sleep/wake cycle, wakefulness regulation of norepinephrine secretion intestine smooth muscle contraction intestine smooth muscle contraction urinary bladder smooth muscle contraction bicarbonate transport membrane integral component of membrane brush border membrane positive regulation of fever generation receptor internalization nuclear membrane response to lipopolysaccharide positive regulation of urine volume neuron projection neuronal cell body positive regulation of cAMP-mediated signaling positive regulation of vasoconstriction positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion negative regulation of gastric acid secretion negative regulation of gastric acid secretion negative regulation of platelet aggregation negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of potassium ion transmembrane transport negative regulation of calcium ion transmembrane transport negative regulation of gastrin-induced gastric acid secretion positive regulation of smooth muscle contraction involved in micturition cellular response to forskolin positive regulation of inhibitory G protein-coupled receptor phosphorylation negative regulation of circadian sleep/wake cycle, wakefulness positive regulation of myofibroblast contraction positive regulation of colon smooth muscle contraction positive regulation of gastric mucosal blood circulation prostaglandin receptor internalization proximal neuron projection positive regulation of neutrophil extravasation negative regulation of forebrain neuron differentiation	04020 04080
TC0500001098.mm.2	Dr1	down-regulator of transcription 1	5	108268896	NM_026106, BC013461 NM_026106, BC013461	13486	30	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II core promoter sequence-specific DNA binding DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex Ada2/Gcn5/Ada3 transcription activator complex Ada2/Gcn5/Ada3 transcription activator complex chromatin remodeling RNA polymerase II general transcription initiation factor activity TBP-class protein binding TBP-class protein binding negative cofactor 2 complex histone H3 acetylation positive regulation of transcription by RNA polymerase II protein heterodimerization activity RNA polymerase II preinitiation complex assembly RNA polymerase II transcription regulator complex
TC1500002042.mm.2	Dennd6b	DENN/MADD domain containing 6B	15	-89182212	NM_027081, BC139003 NM_027081, BC139003	69440	13	guanyl-nucleotide exchange factor activity cytoplasm endosome recycling endosome
TC1500000897.mm.2	Lrrk2	leucine-rich repeat kinase 2	15	91673223	NM_025730	66725	231	SNARE binding SNARE binding MAPK cascade nucleotide binding activation of MAPKK activity activation of MAPK activity magnesium ion binding negative regulation of protein phosphorylation positive regulation of protein phosphorylation actin binding GTPase activity protein kinase activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine phosphatase activity GTPase activator activity protein binding ATP binding GTP binding cytoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix lysosome lysosome endosome endosome endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus Golgi apparatus Golgi-associated vesicle trans-Golgi network cytosol cytosol plasma membrane plasma membrane plasma membrane microvillus protein phosphorylation protein phosphorylation protein phosphorylation protein phosphorylation protein import into nucleus protein import into nucleus endocytosis autophagy response to oxidative stress mitochondrion organization mitochondrion organization endoplasmic reticulum organization endoplasmic reticulum organization endoplasmic reticulum organization Golgi organization Golgi organization Golgi organization lysosome organization signal transduction neuromuscular junction development synaptic vesicle determination of adult lifespan cellular response to starvation regulation of gene expression regulation of autophagy positive regulation of autophagy positive regulation of autophagy positive regulation of autophagy regulation of protein kinase A signaling negative regulation of protein processing negative regulation of neuron projection development regulation of neuron maturation tubulin binding membrane inclusion body negative regulation of macroautophagy kinase activity phosphorylation transferase activity hydrolase activity syntaxin-1 binding peptidyl-serine phosphorylation peptidyl-threonine phosphorylation calcium-mediated signaling calcium-mediated signaling olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb cell junction cell differentiation signaling receptor complex adaptor activity clathrin binding axon axon dendrite dendrite growth cone small GTPase binding small GTPase binding positive regulation of protein ubiquitination cytoplasmic vesicle regulation of protein stability mitochondrial membrane negative regulation of protein binding positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process cytoplasmic side of mitochondrial outer membrane positive regulation of tumor necrosis factor production dendrite cytoplasm GTP-dependent protein kinase activity negative regulation of GTPase activity cellular response to oxidative stress cellular protein localization intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior regulation of lysosomal lumen pH synaptic vesicle recycling peroxidase inhibitor activity regulation of locomotion regulation of membrane potential regulation of membrane potential identical protein binding identical protein binding protein homodimerization activity cell projection neuron projection neuronal cell body positive regulation of programmed cell death terminal bouton perikaryon perikaryon intracellular membrane-bounded organelle intracellular membrane-bounded organelle ion channel binding amphisome autolysosome protein-containing complex binding membrane raft membrane raft synapse synapse GTP metabolic process protein autophosphorylation intracellular distribution of mitochondria neuron projection morphogenesis neuron projection morphogenesis protein kinase A binding protein kinase A binding protein kinase A binding mitochondrion localization positive regulation of nitric-oxide synthase biosynthetic process regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dopamine receptor signaling pathway regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of ER to Golgi vesicle-mediated transport regulation of canonical Wnt signaling pathway regulation of canonical Wnt signaling pathway regulation of dendritic spine morphogenesis regulation of dendritic spine morphogenesis regulation of dendritic spine morphogenesis endoplasmic reticulum exit site endoplasmic reticulum exit site endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site neuron death cellular response to manganese ion cellular response to organic cyclic compound reactive oxygen species metabolic process positive regulation of canonical Wnt signaling pathway negative regulation of excitatory postsynaptic potential multivesicular body, internal vesicle glutamatergic synapse glutamatergic synapse caveola neck presynaptic cytosol neuron projection arborization regulation of synaptic vesicle endocytosis regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis regulation of neuron death negative regulation of neuron death positive regulation of histone deacetylase activity negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of neuroblast proliferation regulation of synaptic vesicle transport regulation of synaptic vesicle transport negative regulation of autophagosome assembly negative regulation of autophagosome assembly negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of hydrogen peroxide-induced cell death negative regulation of protein targeting to mitochondrion cellular response to dopamine positive regulation of microglial cell activation beta-catenin destruction complex binding Wnt signalosome assembly Wnt signalosome assembly regulation of retrograde transport, endosome to Golgi regulation of retrograde transport, endosome to Golgi regulation of CAMKK-AMPK signaling cascade ribonucleoprotein complex Wnt signalosome Wnt signalosome regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis	05012
TC0X00000204.mm.2	Rp2	retinitis pigmentosa 2 homolog	X	20364480, 20364480	NM_133669, BC049698 NM_133669, BC049698	19889	26	nucleotide binding magnesium ion binding cell morphogenesis GTPase activator activity GTPase activator activity GTP binding nucleoplasm cytoplasm Golgi apparatus centriole plasma membrane plasma membrane cilium post-Golgi vesicle-mediated transport post-Golgi vesicle-mediated transport protein transport membrane nuclear body cytoplasmic vesicle ciliary basal body ciliary basal body cell projection periciliary membrane compartment periciliary membrane compartment
TC0200002594.mm.2	Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	2	167688914	NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327	12608	535	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II condensed chromosome, centromeric region chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific ovarian follicle development embryonic placenta development granuloma formation DNA binding DNA binding chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription factor binding positive regulation of gene expression nuclear matrix nuclear matrix kinase binding cell differentiation neuron differentiation response to lipopolysaccharide regulation of interleukin-6 production positive regulation of interleukin-4 production mammary gland epithelial cell proliferation response to endoplasmic reticulum stress histone acetyltransferase binding glucocorticoid receptor binding T-helper 1 cell activation CHOP-C/EBP complex negative regulation of T cell proliferation defense response to bacterium identical protein binding protein homodimerization activity histone deacetylase binding negative regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding ubiquitin-like protein ligase binding fat cell differentiation fat cell differentiation regulation of cell differentiation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein heterodimerization activity positive regulation of inflammatory response brown fat cell differentiation mammary gland epithelial cell differentiation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of biomineral tissue development cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to interleukin-1 hepatocyte proliferation hepatocyte proliferation RNA polymerase II transcription regulator complex liver regeneration positive regulation of cold-induced thermogenesis regulation of odontoblast differentiation regulation of odontoblast differentiation positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress sequence-specific double-stranded DNA binding positive regulation of sodium-dependent phosphate transport regulation of dendritic cell differentiation
TC1000002320.mm.2	Arid5b	AT rich interactive domain 5B (MRF1-like)	10	-68095592	NM_023598, BC165988 NM_023598, BC165988	71371	46	negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding kidney development DNA binding transcription coactivator activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II nitrogen compound metabolic process male gonad development female gonad development post-embryonic development fibroblast migration adrenal gland development multicellular organism growth fat cell differentiation platelet-derived growth factor receptor signaling pathway cell development muscle organ morphogenesis skeletal system morphogenesis positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity roof of mouth development face morphogenesis adipose tissue development fat pad development cellular response to leukemia inhibitory factor
TC0200000740.mm.2	Kynu	kynureninase	2	43555324, 43555324, 43555324	NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848	70789	13	catalytic activity nucleoplasm cytoplasm mitochondrion mitochondrion cytosol tryptophan catabolic process NAD biosynthetic process hydrolase activity pyridine nucleotide biosynthetic process tryptophan catabolic process to kynurenine tryptophan catabolic process to acetyl-CoA quinolinate biosynthetic process pyridoxal phosphate binding kynureninase activity kynureninase activity response to interferon-gamma response to vitamin B6 protein homodimerization activity anthranilate metabolic process anthranilate metabolic process 3-hydroxykynureninase activity	00380 01100
TC1100002310.mm.2	Aftph	aftiphilin	11	-20685084	NM_001252503, NM_181411, BC052036 NM_001252503, NM_181411, BC052036 NM_001252503, NM_181411, BC052036	216549	21	nucleoplasm cytoplasm Golgi apparatus cytosol protein transport AP-1 adaptor complex AP-1 adaptor complex clathrin binding clathrin binding trans-Golgi network membrane intracellular membrane-bounded organelle intracellular transport
TC1100003069.mm.2	Nlgn2	neuroligin 2	11	-69823122, -69823122	NM_198862, BC156963 NM_198862, BC156963	216856	99	thigmotaxis regulation of respiratory gaseous exchange by nervous system process protein binding cytoplasm plasma membrane integral component of plasma membrane cell adhesion neuron cell-cell adhesion neuron cell-cell adhesion chemical synaptic transmission synapse assembly jump response positive regulation of cell population proliferation cell surface cell surface membrane integral component of membrane sensory perception of pain cell junction positive regulation of insulin secretion positive regulation of synaptic transmission, GABAergic social behavior protein localization to synapse locomotory exploration behavior signaling receptor activity neurexin family protein binding neurexin family protein binding identical protein binding cell projection dendritic shaft synapse synapse postsynaptic membrane synaptic vesicle endocytosis modulation of chemical synaptic transmission modulation of chemical synaptic transmission synapse organization cell adhesion molecule binding neuromuscular process controlling balance positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic excitatory synapse excitatory synapse inhibitory synapse inhibitory synapse positive regulation of dendritic spine development terminal button organization postsynaptic membrane assembly postsynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering positive regulation of inhibitory postsynaptic potential positive regulation of inhibitory postsynaptic potential ribbon synapse glycinergic synapse glycinergic synapse glycinergic synapse dopaminergic synapse postsynaptic specialization assembly postsynaptic specialization assembly postsynaptic specialization assembly GABA-ergic synapse GABA-ergic synapse GABA-ergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane integral component of postsynaptic specialization membrane insulin metabolic process positive regulation of protein localization to synapse positive regulation of t-SNARE clustering inhibitory synapse assembly regulation of presynapse assembly regulation of AMPA receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering	04514
TC0700003594.mm.2	Furin	furin (paired basic amino acid cleaving enzyme)	7	-80389193, -80389193	NM_001081454, NM_011046, BC048234 NM_001081454, NM_011046, BC048234 NM_001081454, NM_011046, BC048234	18550	114	Golgi membrane blastocyst formation protease binding endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular region endosome early endosome endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane Golgi apparatus trans-Golgi network trans-Golgi network plasma membrane signal peptide processing proteolysis peptidase activity serine-type peptidase activity regulation of signal transduction cell surface trans-Golgi network transport vesicle membrane membrane integral component of membrane protein processing protein processing protein processing protein processing peptide hormone processing peptide hormone processing hydrolase activity trans-Golgi network transport vesicle integral component of Golgi membrane positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway zymogen activation Golgi cisterna regulation of cholesterol transport negative regulation of low-density lipoprotein particle receptor catabolic process nerve growth factor production negative regulation of transforming growth factor beta1 production secretion by cell regulation of protein catabolic process peptide binding peptide biosynthetic process membrane raft metal ion binding nerve growth factor binding regulation of endopeptidase activity dibasic protein processing zymogen inhibition positive regulation of transforming growth factor beta1 activation
TC0200001371.mm.2	Acp2	acid phosphatase 2, lysosomal	2	91202911	NM_007387, BC023343 NM_007387, BC023343	11432	37	skeletal system development phosphotyrosine residue binding acid phosphatase activity acid phosphatase activity acid phosphatase activity acid phosphatase activity phosphoprotein phosphatase activity lysosome lysosome lysosome lysosome lysosome organization lysosome organization response to organic substance membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity cytoplasmic vesicle neuron projection autophagic cell death	00740 04142
TC1200000359.mm.2	Dock4	dedicator of cytokinesis 4	12	40446052	NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663	238130	25	guanyl-nucleotide exchange factor activity GTPase activator activity nucleolus cytoplasm Golgi apparatus cytosol plasma membrane small GTPase mediated signal transduction membrane SH3 domain binding PDZ domain binding receptor tyrosine kinase binding small GTPase binding stereocilium stereocilium bundle cell chemotaxis negative regulation of vascular associated smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration
TC1600000558.mm.2	Tmem39a	transmembrane protein 39a	16	38562813, 38558697	NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318	67846	17	molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane autophagy membrane integral component of membrane positive regulation of viral genome replication negative regulation of autophagosome maturation negative regulation of autophagosome maturation negative regulation of autophagosome assembly negative regulation of autophagosome assembly
MG-1-neg-10341772_st
TC0600001424.mm.2	C1rb	complement component 1, r subcomponent B	6	124570429	NM_001113356	667277	4	immune system process serine-type endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular space extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation identical protein binding innate immune response blood microparticle
MG-1-neg-10341658_st
TC0900000824.mm.2	Dennd4a	DENN/MADD domain containing 4A	9	64811010	NM_001162917, BC172087 NM_001162917, BC172087	102442	13	guanyl-nucleotide exchange factor activity cytoplasmic vesicle regulation of Rab protein signal transduction
TC0600000250.mm.2	Strip2	striatin interacting protein 2	6	29917012	NM_001037740, NM_177204, NR_104576, BC147502 NM_001037740, NM_177204, NR_104576, BC147502 NM_001037740, NM_177204, NR_104576, BC147502 NM_001037740, NM_177204, NR_104576, BC147502	320609	16	molecular_function cytoplasm cytosol cytosol cytoskeleton organization cytoskeleton organization regulation of cell shape cell migration
TC1000001947.mm.2	Ncoa7	nuclear receptor coactivator 7	10	-30645581, -30645581	NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294	211329	27	nucleus regulation of transcription by RNA polymerase II response to oxidative stress nuclear receptor coactivator activity nuclear receptor coactivator activity nuclear hormone receptor binding positive regulation of transcription by RNA polymerase II negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death
TC0700003936.mm.2					XM_003688838, XM_992714 XM_003688838, XM_992714
TC1100003314.mm.2	Lgals9	lectin, galactose binding, soluble 9	11	-78962978	NM_001159301, NM_010708, BC003754 NM_001159301, NM_010708, BC003754 NM_001159301, NM_010708, BC003754	16859	104	positive regulation of cytokine production immune system process signaling receptor binding protein binding extracellular region extracellular region nucleus nucleus cytoplasm cytosol cytosol chemotaxis heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules female pregnancy positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation galactoside binding galactoside binding galactoside binding enzyme binding carbohydrate binding carbohydrate binding carbohydrate binding response to lipopolysaccharide negative regulation of interferon-gamma production negative regulation of interferon-gamma production negative regulation of interferon-gamma production positive regulation of chemokine production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of natural killer cell activation regulation of natural killer cell differentiation toll-like receptor 3 signaling pathway positive regulation of macrophage activation negative regulation of natural killer cell degranulation protein serine/threonine kinase activator activity positive regulation of innate immune response maintenance of protein location positive regulation of regulatory T cell differentiation negative regulation of inflammatory response positive regulation of oxidoreductase activity collagen-containing extracellular matrix cellular response to virus positive regulation of defense response to bacterium positive regulation of T cell migration negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of transcription regulatory region DNA binding
TC0200002580.mm.2					NM_001081005, NR_028540 NM_001081005, NR_028540			molecular_function cellular_component biological_process negative regulation of mammary gland epithelial cell proliferation mammary gland epithelial cell differentiation
TC0200003532.mm.2	Arl5a	ADP-ribosylation factor-like 5A	2	-52397950	NM_182994, BC048170, BC100307 NM_182994, BC048170, BC100307 NM_182994, BC048170, BC100307	75423	16	nucleotide binding GTP binding cytoplasm trans-Golgi network intracellular protein transport vesicle-mediated transport protein localization to Golgi membrane protein localization to Golgi membrane
TC0200000220.mm.2	Il2ra	interleukin 2 receptor, alpha chain	2	11642791	NM_008367, BC114437 NM_008367, BC114437	16184	301	immune system process inflammatory response to antigenic stimulus regulation of T cell tolerance induction interleukin-2 receptor activity interleukin-2 receptor activity interleukin-2 receptor activity protein binding activation-induced cell death of T cells inflammatory response Notch signaling pathway external side of plasma membrane cell surface membrane integral component of membrane interleukin-2 binding interleukin-2 binding positive regulation of T cell proliferation positive regulation of activated T cell proliferation negative regulation of T cell proliferation T cell homeostasis positive regulation of T cell differentiation regulation of T cell homeostatic proliferation negative regulation of lymphocyte proliferation negative regulation of inflammatory response	04060 04144 04630 04640
TC0500000710.mm.2	Kit	KIT proto-oncogene receptor tyrosine kinase	5	75574990, 75574986	NM_001122733, NM_021099, BC052457, BC075716 NM_001122733, NM_021099, BC052457, BC075716 NM_001122733, NM_021099, BC052457, BC075716 NM_001122733, NM_021099, BC052457, BC075716	16590	1574	nucleotide binding activation of MAPK activity ovarian follicle development fibrillar center acrosomal vesicle protease binding hematopoietic progenitor cell differentiation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation immature B cell differentiation dendritic cell cytokine production mast cell chemotaxis myeloid leukocyte differentiation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity stem cell factor receptor activity protein binding ATP binding extracellular space cytoplasm plasma membrane plasma membrane integral component of plasma membrane cell-cell junction protein phosphorylation glycosphingolipid metabolic process chemotaxis inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development germ cell development spermatogenesis spermatogenesis spermatid development positive regulation of cell population proliferation positive regulation of cell population proliferation germ cell migration regulation of cell shape visual learning response to radiation external side of plasma membrane external side of plasma membrane cytoplasmic side of plasma membrane cell surface positive regulation of gene expression membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine binding lamellipodium assembly hemopoiesis cell differentiation B cell differentiation T cell differentiation erythrocyte differentiation erythrocyte differentiation melanocyte differentiation positive regulation of cell migration positive regulation of cell migration positive regulation of pseudopodium assembly actin cytoskeleton reorganization mast cell cytokine production positive regulation of kinase activity somatic stem cell population maintenance embryonic hemopoiesis ectopic germ cell programmed cell death intracellular signal transduction hematopoietic stem cell migration megakaryocyte development Fc receptor signaling pathway Kit signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway SH2 domain binding positive regulation of tyrosine phosphorylation of STAT protein protein homodimerization activity negative regulation of programmed cell death negative regulation of programmed cell death receptor complex mast cell degranulation positive regulation of MAP kinase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade pigmentation pigmentation positive regulation of Notch signaling pathway positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via JAK-STAT protein autophosphorylation protein autophosphorylation metal ion binding developmental pigmentation developmental pigmentation somatic stem cell division positive regulation of long-term neuronal synaptic plasticity digestive tract development stem cell differentiation epithelial cell proliferation detection of mechanical stimulus involved in sensory perception of sound positive regulation of DNA-binding transcription factor activity cell chemotaxis mast cell differentiation cellular response to thyroid hormone stimulus melanocyte migration melanocyte adhesion positive regulation of pyloric antrum smooth muscle contraction regulation of bile acid metabolic process positive regulation of colon smooth muscle contraction positive regulation of small intestine smooth muscle contraction positive regulation of vascular associated smooth muscle cell differentiation	04060 04144 04640 04916 05200 05221
TC1600001048.mm.2	Morc3	microrchidia 3	16	93832120	NM_001045529, BC098072, BC145705 NM_001045529, BC098072, BC145705 NM_001045529, BC098072, BC145705	338467	28	RNA binding nucleus nucleus nucleoplasm nucleoplasm protein phosphorylation cell aging zinc ion binding post-embryonic development PML body PML body peptidyl-serine phosphorylation methylated histone binding metal ion binding negative regulation of fibroblast proliferation protein stabilization maintenance of protein location in nucleus
TC1400001930.mm.2	Gch1	GTP cyclohydrolase 1	14	-47153894	NM_008102, BC005643, BC069921 NM_008102, BC005643, BC069921 NM_008102, BC005643, BC069921	14528	72	nucleotide binding catalytic activity GTPase activity GTP cyclohydrolase I activity GTP cyclohydrolase I activity GTP cyclohydrolase I activity calcium ion binding GTP binding GTP binding nucleus nucleoplasm cytoplasm cytoplasm cytosol tetrahydrobiopterin biosynthetic process tetrahydrobiopterin biosynthetic process tetrahydrobiopterin biosynthetic process metabolic process regulation of blood pressure regulation of blood pressure zinc ion binding zinc ion binding positive regulation of heart rate regulation of lung blood pressure hydrolase activity GTP-dependent protein binding translation initiation factor binding cytoplasmic vesicle nuclear membrane protein-containing complex response to interferon-gamma response to tumor necrosis factor vasodilation dopamine biosynthetic process pteridine-containing compound biosynthetic process identical protein binding protein homodimerization activity protein-containing complex binding negative regulation of blood pressure tetrahydrofolate biosynthetic process metal ion binding response to pain neuromuscular process controlling posture positive regulation of nitric-oxide synthase activity mitogen-activated protein kinase binding dihydrobiopterin metabolic process protein-containing complex assembly cellular response to lipopolysaccharide regulation of serotonin biosynthetic process regulation of removal of superoxide radicals	00790 01100
TC0300002752.mm.2	Stxbp3	syntaxin binding protein 3	3	-108793179	NM_011504, BC062901 NM_011504, BC062901	20912	48	cellular glucose homeostasis cellular glucose homeostasis protein binding cytoplasm cytosol cytosol plasma membrane plasma membrane plasma membrane plasma membrane intracellular protein transport exocytosis vesicle docking involved in exocytosis neurotransmitter secretion brain development protein transport membrane vesicle-mediated transport basolateral plasma membrane apical plasma membrane apical plasma membrane syntaxin-1 binding syntaxin-1 binding syntaxin binding syntaxin binding syntaxin binding syntaxin binding protein to membrane docking insulin secretion secretory granule platelet alpha granule response to insulin response to insulin specific granule protein-containing complex binding phagocytic vesicle negative regulation of calcium ion-dependent exocytosis negative regulation of glucose import negative regulation of glucose import platelet aggregation tertiary granule cellular response to interferon-gamma presynapse
TC1100002746.mm.2
TC1800000092.mm.2	Rbbp8	retinoblastoma binding protein 8, endonuclease	18	11657348, 11633275	NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849	225182	36	single-stranded DNA endodeoxyribonuclease activity single-stranded DNA endodeoxyribonuclease activity G1/S transition of mitotic cell cycle Y-form DNA binding double-strand/single-strand DNA junction binding double-strand break repair via homologous recombination RNA polymerase II repressing transcription factor binding blastocyst hatching DNA binding damaged DNA binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding transcription corepressor activity nuclease activity endonuclease activity nucleus nucleoplasm chromosome DNA repair cellular response to DNA damage stimulus cell cycle DNA double-strand break processing involved in repair via single-strand annealing DNA double-strand break processing involved in repair via single-strand annealing hydrolase activity transcription repressor complex site of double-strand break identical protein binding intracellular membrane-bounded organelle cell division meiotic cell cycle flap-structured DNA binding
TC0800000297.mm.2	Sfrp1	secreted frizzled-related protein 1	8	23411501	NM_013834, BC024495, BC094662 NM_013834, BC024495, BC094662 NM_013834, BC024495, BC094662	20377	175	ureteric bud development somitogenesis somitogenesis neural tube closure hematopoietic progenitor cell differentiation cysteine-type endopeptidase activity frizzled binding protein binding extracellular region extracellular space extracellular space extracellular space cytosol plasma membrane multicellular organism development heparin binding positive regulation of cell population proliferation negative regulation of cell population proliferation male gonad development female gonad development dorsal/ventral axis specification anterior/posterior pattern specification cell surface regulation of cell cycle process negative regulation of gene expression negative regulation of gene expression negative regulation of epithelial to mesenchymal transition regulation of neuron projection development neural crest cell fate commitment response to organic cyclic compound Wnt signaling pathway Wnt-protein binding Wnt-protein binding neural tube development actin cytoskeleton organization hemopoiesis cell differentiation positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of ossification negative regulation of ossification negative regulation of ossification positive regulation of cell growth negative regulation of cell growth negative regulation of cell migration negative regulation of BMP signaling pathway negative regulation of osteoblast proliferation negative regulation of osteoblast proliferation substrate adhesion-dependent cell spreading somatic stem cell population maintenance non-canonical Wnt signaling pathway response to drug identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity cellular response to fibroblast growth factor stimulus stromal-epithelial cell signaling involved in prostate gland development negative regulation of B cell differentiation negative regulation of B cell differentiation positive regulation of fat cell differentiation negative regulation of osteoblast differentiation negative regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated development of primary male sexual characteristics negative regulation of insulin secretion negative regulation of bone remodeling negative regulation of fibroblast proliferation digestive tract morphogenesis positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of peptidyl-tyrosine phosphorylation canonical Wnt signaling pathway canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway hematopoietic stem cell differentiation bone trabecula formation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of branching involved in prostate gland morphogenesis negative regulation of androgen receptor signaling pathway collagen-containing extracellular matrix cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to estrogen stimulus cellular response to estrogen stimulus cellular response to X-ray cellular response to heparin dopaminergic neuron differentiation negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway regulation of establishment of planar polarity planar cell polarity pathway involved in neural tube closure Wnt signaling pathway involved in somitogenesis convergent extension involved in somitogenesis positive regulation of canonical Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of midbrain dopaminergic neuron differentiation negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of non-canonical Wnt signaling pathway negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation negative regulation of fibroblast apoptotic process positive regulation of fibroblast apoptotic process positive regulation of extrinsic apoptotic signaling pathway	04310
TC0300001292.mm.2	Tifa	TRAF-interacting protein with forkhead-associated domain	3	127790656, 127789871	NM_145133, BC065775 NM_145133, BC065775	211550	20	immune system process cytoplasmic pattern recognition receptor signaling pathway cytoplasmic pattern recognition receptor signaling pathway protein binding cytoplasm cytoplasm I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response innate immune response protein homooligomerization
TC1000000123.mm.2	Txlnb	taxilin beta	10	17796218	NM_138628, BC141023 NM_138628, BC141023	378431	12	molecular_function cytoplasm biological_process syntaxin binding
TC1100003128.mm.2	Nlrp1c-ps	NLR family, pyrin domain containing 1C, pseudogene	11	-71242429	NR_027858, BC141384 NR_027858, BC141384	627984	2
TC1300002011.mm.2	Auh	AU RNA binding protein/enoyl-coenzyme A hydratase	13	-52835109	NM_016709, BC049597 NM_016709, BC049597	11992	22	RNA binding mRNA 3'-UTR binding catalytic activity enoyl-CoA hydratase activity enoyl-CoA hydratase activity enoyl-CoA hydratase activity methylglutaconyl-CoA hydratase activity mitochondrion mitochondrion mitochondrion fatty acid beta-oxidation branched-chain amino acid catabolic process lyase activity itaconyl-CoA hydratase activity	00280 01100
TC0500000738.mm.2	Rest	RE1-silencing transcription factor	5	77265493	NM_011263, BC127065 NM_011263, BC127065	19712	200	negative regulation of transcription by RNA polymerase II regulation of alternative mRNA splicing, via spliceosome chromatin transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific response to hypoxia hematopoietic progenitor cell differentiation response to ischemia nucleic acid binding DNA binding DNA binding chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytosol cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription factor binding negative regulation of cell population proliferation regulation of gene expression regulation of gene expression positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of gene expression negative regulation of gene expression transcription repressor complex transcription repressor complex transcription repressor complex negative regulation of aldosterone biosynthetic process protein-containing complex cellular response to stress somatic stem cell population maintenance cellular response to drug identical protein binding positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process sequence-specific DNA binding sequence-specific DNA binding negative regulation by host of viral transcription protein-containing complex binding negative regulation of neuron differentiation negative regulation of neuron differentiation negative regulation of neuron differentiation negative regulation of neuron differentiation positive regulation of neuron differentiation regulation of osteoblast differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion metal ion binding negative regulation of neurogenesis neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound auditory receptor cell stereocilium organization cardiac muscle cell myoblast differentiation histone H4 deacetylation cellular response to electrical stimulus cellular response to glucocorticoid stimulus neuronal stem cell population maintenance modification of synaptic structure positive regulation of stem cell population maintenance regulation of oxidative stress-induced neuron death negative regulation of oxidative stress-induced neuron death positive regulation of oxidative stress-induced neuron death negative regulation of cortisol biosynthetic process negative regulation of transcription regulatory region DNA binding negative regulation of dense core granule biogenesis negative regulation of mesenchymal stem cell differentiation negative regulation of amniotic stem cell differentiation	05016
TC1700000765.mm.2	H2-M3	histocompatibility 2, M region locus 3	17	37270233	NM_013819, BC031984 NM_013819, BC031984	14991	41	negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin alpha-beta T cell activation involved in immune response peripheral B cell tolerance induction antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent positive regulation of tolerance induction positive regulation of T cell tolerance induction positive regulation of natural killer cell cytokine production immune response-inhibiting cell surface receptor signaling pathway signaling receptor binding signaling receptor binding extracellular space early endosome plasma membrane immune response external side of plasma membrane external side of plasma membrane negative regulation of angiogenesis MHC class Ib protein complex positive regulation of interferon-gamma production positive regulation of interleukin-12 production cis-Golgi network membrane negative regulation of T cell proliferation protection from natural killer cell mediated cytotoxicity peptide antigen binding peptide antigen binding peptide antigen binding peptide antigen binding CD8 receptor binding defense response to bacterium defense response to bacterium identical protein binding protein homodimerization activity positive regulation of nitric oxide biosynthetic process positive regulation of regulatory T cell differentiation negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity negative regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein homotrimerization negative regulation of G0 to G1 transition positive regulation of endothelial cell apoptotic process positive regulation of cellular senescence negative regulation of dendritic cell differentiation	04144 04145 04514 04612 04940 05320 05330 05332 05416
TC1100002397.mm.2	Vrk2	vaccinia related kinase 2	11	-26471401	NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520	69922	27	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleus nuclear envelope cytoplasm cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane protein phosphorylation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding protein domain specific binding mitochondrial membrane protein-containing complex cellular response to oxidative stress regulation of MAPK cascade protein autophosphorylation protein autophosphorylation regulation of interleukin-1-mediated signaling pathway
TC1600000861.mm.2	Usp25	ubiquitin specific peptidase 25	16	77014068	NM_013918, BC048171, BC063059 NM_013918, BC048171, BC063059 NM_013918, BC048171, BC063059	30940	28	proteasome complex cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm endoplasmic reticulum cytosol cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination protein deubiquitination hydrolase activity ubiquitin protein ligase binding SUMO binding SUMO binding ATPase binding protein K63-linked deubiquitination protein K48-linked deubiquitination negative regulation of ERAD pathway
TC1600001106.mm.2	Mefv	Mediterranean fever	16	-3707214	NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994	54483	28	immune system process actin binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytosol cytosol cytoskeleton microtubule microtubule associated complex inflammatory response zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination cytoplasmic vesicle negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production response to interferon-gamma identical protein binding cell projection innate immune response metal ion binding negative regulation of inflammatory response ubiquitin protein ligase activity negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of cytokine production involved in inflammatory response negative regulation of NLRP3 inflammasome complex assembly positive regulation of cysteine-type endopeptidase activity	04621
TC0100000292.mm.2	Il1r2	interleukin 1 receptor, type II	1	40084713, 40086092	NM_010555, BC032962 NM_010555, BC032962	16178	52	interleukin-1 receptor activity interleukin-1 receptor activity interleukin-1, type II, blocking receptor activity extracellular region cytoplasm plasma membrane negative regulation of protein processing membrane integral component of membrane interleukin-1 binding interleukin-1 binding negative regulation of interleukin-1 alpha production negative regulation of cytokine production involved in inflammatory response negative regulation of interleukin-1-mediated signaling pathway	04010 04060 04640 05146
TC1900001435.mm.2	Htr7	5-hydroxytryptamine (serotonin) receptor 7	19	-35958417, -35958417	NM_008315, BC116986 NM_008315, BC116986	15566	71	G protein-coupled receptor activity G protein-coupled serotonin receptor activity G protein-coupled serotonin receptor activity rough endoplasmic reticulum plasma membrane integral component of plasma membrane smooth muscle contraction signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission memory circadian rhythm synaptic vesicle positive regulation of neuron projection development negative regulation of serotonin secretion urinary bladder smooth muscle contraction membrane integral component of membrane dendrite dendrite neurotransmitter receptor activity neurotransmitter receptor activity vasoconstriction negative regulation of circadian sleep/wake cycle, REM sleep neuronal cell body axon terminus behavioral response to pain detection of mechanical stimulus involved in sensory perception of pain response to corticosterone micturition long-term synaptic potentiation regulation of vein smooth muscle contraction dopaminergic neuron differentiation integral component of postsynaptic membrane integral component of presynaptic membrane regulation of synaptic vesicle exocytosis	04020 04080
TC1200002526.mm.2	Serpina3h	serine (or cysteine) peptidase inhibitor, clade A, member 3H	12	104247895	NR_033450	546546	13
TC0100001031.mm.2	Serpinb8	serine (or cysteine) peptidase inhibitor, clade B, member 8	1	107590005, 107590005	NM_001159748, NM_011459, BC025121 NM_001159748, NM_011459, BC025121 NM_001159748, NM_011459, BC025121	20725	14	serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular space cytoplasm cytosol negative regulation of peptidase activity negative regulation of endopeptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity epithelial cell-cell adhesion
MG-1-neg-10340371_st
TC1000000711.mm.2	Adora2a	adenosine A2a receptor	10	75316876, 75324857, 75317599	NM_009630, BC110692 NM_009630, BC110692	11540	432	G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor activity synaptic transmission, dopaminergic G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway response to amphetamine G protein-coupled receptor activity protein binding intermediate filament plasma membrane plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated negative regulation of protein kinase activity signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway protein kinase C-activating G protein-coupled receptor signaling pathway synaptic transmission, cholinergic locomotory behavior locomotory behavior negative regulation of cell population proliferation endomembrane system positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion postsynaptic density membrane membrane integral component of membrane enzyme binding axon dendrite axolemma response to caffeine type 5 metabotropic glutamate receptor binding positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission, GABAergic asymmetric synapse synaptic transmission, glutamatergic positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of locomotion vasodilation presynaptic membrane eating behavior eating behavior identical protein binding neuronal cell body negative regulation of vascular permeability negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to alkaloid negative regulation of neuron apoptotic process protein-containing complex binding postsynaptic membrane positive regulation of circadian sleep/wake cycle, sleep negative regulation of alpha-beta T cell activation astrocyte activation presynaptic active zone neuron projection morphogenesis positive regulation of protein secretion negative regulation of inflammatory response alpha-actinin binding regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential prepulse inhibition glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of long-term synaptic potentiation regulation of synaptic vesicle exocytosis positive regulation of apoptotic signaling pathway	04020 04080 04270
TC1400001504.mm.2	Ube2e2	ubiquitin-conjugating enzyme E2E 2	14	-18573565, -18573565, -18573565	NM_144839, BC016265 NM_144839, BC016265	218793	19	nucleotide binding protein polyubiquitination ubiquitin-protein transferase activity ATP binding nucleus cellular response to DNA damage stimulus transferase activity ISG15-protein conjugation ISG15-protein conjugation ISG15 transferase activity ISG15 transferase activity ubiquitin conjugating enzyme activity ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K63-linked ubiquitination protein K48-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination protein K11-linked ubiquitination positive regulation of G1/S transition of mitotic cell cycle	04120 04141
TC0200003880.mm.2	Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	2	-84765359	NM_009776, BC002026 NM_009776, BC002026	12258	38	complement binding negative regulation of complement activation, lectin pathway immune system process serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space extracellular space extracellular space extracellular space complement activation, classical pathway blood coagulation hemostasis negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of blood coagulation peptidase inhibitor activity fibrinolysis innate immune response negative regulation of complement activation collagen-containing extracellular matrix	04610
TC1000001743.mm.2	Adgb	androglobin	10	-10335702	NM_001127353, BC153036 NM_001127353, BC153036	215772	11	calcium-dependent cysteine-type endopeptidase activity intracellular anatomical structure proteolysis oxygen binding heme binding
TC0700000756.mm.2	Siglecf	sialic acid binding Ig-like lectin F	7	43351340	NM_001271019, NM_145581, BC145038, BC145987 NM_001271019, NM_145581, BC145038, BC145987 NM_001271019, NM_145581, BC145038, BC145987 NM_001271019, NM_145581, BC145038, BC145987	233186	34	lysosome plasma membrane cell adhesion membrane integral component of membrane regulation of endocytosis carbohydrate binding sialic acid binding sialic acid binding monosaccharide binding
TC1_GL456211_random00000010.mm.2
TC0700004019.mm.2	Olfr700	olfactory receptor 700	7	-106805509	NM_146600, BC104091, BC106812 NM_146600, BC104091, BC106812 NM_146600, BC104091, BC106812	258593	6	olfactory receptor activity G protein-coupled receptor signaling pathway sensory perception of smell integral component of membrane	04740
TC1300000476.mm.2	Hivep1	human immunodeficiency virus type I enhancer binding protein 1	13	42052020	NM_007772, BC156925 NM_007772, BC156925	110521	28	negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding DNA binding DNA binding protein binding nucleus nucleus nucleus nucleoplasm mitochondrion cytosol regulation of transcription by RNA polymerase II zinc ion binding nuclear body BMP signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II metal ion binding HMG box domain binding sequence-specific double-stranded DNA binding
TC0200003801.mm.2	Pde11a	phosphodiesterase 11A	2	-75985807	NM_001081033, BC158125 NM_001081033, BC158125	241489	25	catalytic activity cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cytoplasm signal transduction phosphoric diester hydrolase activity metabolic process negative regulation of cGMP-mediated signaling negative regulation of cGMP-mediated signaling hydrolase activity cGMP binding perikaryon negative regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity	00230
TC0700003648.mm.2	Cemip	cell migration inducing protein, hyaluronan binding	7	-83932856	NM_030728, BC115873, BC116643 NM_030728, BC115873, BC116643 NM_030728, BC115873, BC116643	80982	33	hyalurononglucosaminidase activity hyalurononglucosaminidase activity hyaluronic acid binding hyaluronic acid binding extracellular region nucleus cytoplasm cytoplasm endoplasmic reticulum plasma membrane clathrin-coated pit sensory perception of sound metabolic process positive regulation of peptidyl-threonine phosphorylation membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hyaluronan catabolic process hyaluronan catabolic process positive regulation of cell migration clathrin-coated vesicle membrane clathrin heavy chain binding clathrin-coated endocytic vesicle ER retention sequence binding positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein targeting to membrane positive regulation of protein kinase C activity
TC1100000952.mm.2	Zmynd15	zinc finger, MYND-type containing 15	11	70459432	NM_001029929, BC151086 NM_001029929, BC151086	574428	12	nucleus cytoplasm spermatogenesis spermatid development spermatid development cell differentiation histone deacetylase binding histone deacetylase binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding
TC1700001027.mm.2	Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	17	57105384	NM_009404, BC138767, BC138770 NM_009404, BC138767, BC138770 NM_009404, BC138767, BC138770	21950	102	signaling receptor binding cytokine activity tumor necrosis factor receptor binding extracellular space plasma membrane plasma membrane immune response membrane integral component of membrane positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding positive regulation of activated T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation myeloid dendritic cell differentiation positive regulation of cytotoxic T cell differentiation positive regulation of cytotoxic T cell differentiation	04060
TC1100001242.mm.2	Slfn3	schlafen 3	11	83191329	NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134	20557	17	negative regulation of cell population proliferation
TC1000002383.mm.2	Gstt1	glutathione S-transferase, theta 1	10	-75783812, -75783812	NM_008185, BC012254, BC055020 NM_008185, BC012254, BC055020 NM_008185, BC012254, BC055020	14871	32	glutathione transferase activity glutathione transferase activity glutathione transferase activity glutathione peroxidase activity nucleus cytoplasm cytosol DNA modification glutathione metabolic process glutathione metabolic process glutathione metabolic process glutathione metabolic process transferase activity dichloromethane metabolic process alkylhalidase activity	00480 00980 00982
TC1700002597.mm.2	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	17	-81373104	NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673	20541	175	response to hypoxia embryonic placenta development regulation of the force of heart contraction regulation of heart rate regulation of sodium ion transport heart morphogenesis calcium:sodium antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity protein binding calmodulin binding nucleoplasm mitochondrion microtubule plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane ion transport sodium ion transport sodium ion transport calcium ion transport calcium ion transport cellular calcium ion homeostasis cellular sodium ion homeostasis cell communication positive regulation of cytosolic calcium ion concentration cytoskeletal protein binding post-embryonic development regulation of gene expression positive regulation of fibroblast migration regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion postsynaptic density intercalated disc vascular associated smooth muscle contraction antiporter activity cation:cation antiporter activity membrane membrane integral component of membrane basolateral plasma membrane metal ion transport Z disc T-tubule T-tubule axon axon dendrite positive regulation of bone mineralization ankyrin binding ankyrin binding response to ATP cellular response to reactive oxygen species embryonic heart tube development sodium ion transmembrane transport sodium ion transmembrane transport response to muscle stretch sodium ion export across plasma membrane sodium ion export across plasma membrane sarcolemma sarcolemma sarcolemma cell projection neuronal cell body dendritic spine dendritic shaft axon terminus ion channel binding relaxation of smooth muscle synapse synapse postsynaptic membrane metal ion binding muscle fiber development negative regulation of cytosolic calcium ion concentration regulation of calcium ion transport cardiac muscle cell development calcium ion homeostasis transmembrane transport cardiac muscle contraction calcium ion transport into cytosol calcium ion transport into cytosol calcium ion import calcium ion import calcium ion transmembrane transport calcium ion transmembrane transport cellular response to caffeine cellular response to cAMP negative regulation of protein serine/threonine kinase activity cell periphery regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential cell communication by electrical coupling involved in cardiac conduction calcium ion import across plasma membrane sodium ion import across plasma membrane sodium ion import across plasma membrane positive regulation of the force of heart contraction postsynapse integral component of postsynaptic membrane ion antiporter activity involved in regulation of postsynaptic membrane potential calcium ion export calcium ion export calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	04020 04260 04974 05410 05412 05414
MG-1-neg-10343761_st
TC0500003465.mm.2	Pilrb2	paired immunoglobin-like type 2 receptor beta 2	5	-137865828, -137865820	NM_001024932, BC147405, BC147406 NM_001024932, BC147405, BC147406 NM_001024932, BC147405, BC147406	545812	10	membrane integral component of membrane MHC class I protein binding
TC1400002293.mm.2	Dock5	dedicator of cytokinesis 5	14	-67751927	NM_177780, BC158046, BC158135, BC158138 NM_177780, BC158046, BC158135, BC158138 NM_177780, BC158046, BC158135, BC158138 NM_177780, BC158046, BC158135, BC158138	68813	38	guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm cytosol plasma membrane cytoskeleton organization small GTPase mediated signal transduction positive regulation of epithelial cell migration membrane cell migration positive regulation of substrate adhesion-dependent cell spreading negative regulation of vascular associated smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration
TC0100001468.mm.2	Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	1	161395437	NM_009452, BC153120 NM_009452, BC153120	22164	112	blood vessel development negative regulation of cytokine production positive regulation of cytokine production defense response to nematode acute inflammatory response positive regulation of immunoglobulin production positive regulation of immune effector process positive regulation of T cell cytokine production regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of type 2 immune response positive regulation of immunoglobulin mediated immune response cytokine activity tumor necrosis factor receptor binding protein binding extracellular space extracellular space inflammatory response inflammatory response immune response cholesterol metabolic process response to virus cell surface membrane integral component of membrane negative regulation of interferon-gamma production negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of interleukin-4 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding memory T cell activation T-helper 2 cell activation response to nitrogen dioxide cellular response to nitrogen dioxide CD4-positive, alpha-beta T cell costimulation T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of memory T cell differentiation negative regulation of DNA-binding transcription factor activity innate immune response negative regulation of regulatory T cell differentiation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation negative regulation of transcription, DNA-templated positive regulation of alpha-beta T cell proliferation regulation of inflammatory response positive regulation of inflammatory response positive regulation of B cell activation negative regulation of T cell apoptotic process negative regulation of activation-induced cell death of T cells cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus chemokine (C-C motif) ligand 11 production positive regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of T cell migration positive regulation of T cell costimulation positive regulation of memory T cell activation positive regulation of T-helper 2 cell activation positive regulation of interleukin-4-dependent isotype switching to IgE isotypes negative regulation of extrinsic apoptotic signaling pathway	04060
TC0900001720.mm.2	Birc2	baculoviral IAP repeat-containing 2	9	-7818225, -7818225	NM_007465, BC145985 NM_007465, BC145985	11797	90	protein polyubiquitination response to hypoxia XY body placenta development transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus nucleus cytoplasm cytoplasm apoptotic process zinc ion binding cytoplasmic side of plasma membrane transferase activity positive regulation of protein ubiquitination protein-containing complex CD40 receptor complex identical protein binding regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process protein-containing complex binding membrane raft metal ion binding protein N-terminus binding chaperone binding regulation of cell cycle regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity necroptotic process cellular response to tumor necrosis factor FBXO family protein binding regulation of NIK/NF-kappaB signaling negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination positive regulation of protein polyubiquitination regulation of reactive oxygen species metabolic process	04120 04210 04510 04621 05145 05200 05222
TC0600000240.mm.2	Tspan33	tetraspanin 33	6	29694213	NM_146173, BC024685 NM_146173, BC024685	232670	18	cytoplasm plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane enzyme binding enzyme binding cell junction pore complex pore complex pore complex assembly pore complex assembly protein maturation protein maturation protein maturation protein localization to plasma membrane protein localization to plasma membrane protein localization to plasma membrane tetraspanin-enriched microdomain
MG-1-neg-10339929_st
MG-1-pos-10343399_st
TC1100001543.mm.2	Mllt6	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6	11	97663411	NM_139311, BC152980 NM_139311, BC152980	246198	27	renal system process nucleus excretion positive regulation of sodium ion transport nucleosome binding nucleosome binding negative regulation of urine volume renal sodium excretion renal potassium excretion histone binding histone binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of histone H3-K79 methylation
TC1700000934.mm.2	Treml4	triggering receptor expressed on myeloid cells-like 4	17	48264294	NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666	224840	15	positive regulation of defense response to virus by host immune system process T cell antigen processing and presentation protein binding lysosomal membrane endoplasmic reticulum plasma membrane phagocytosis, engulfment protein localization cell surface endosome membrane membrane integral component of membrane positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 13 signaling pathway signaling receptor activity innate immune response defense response to virus
TC1500001730.mm.2	Ly6c2	lymphocyte antigen 6 complex, locus C2	15	-75108160, -75108160	NM_001099217, BC092082 NM_001099217, BC092082	100041546	8	plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway
MG-1-neg-10339892_st
TC1000000021.mm.2	Akap12	A kinase (PRKA) anchor protein (gravin) 12	10	4266328	NM_031185, BC138364, BC138365 NM_031185, BC138364, BC138365 NM_031185, BC138364, BC138365	83397	66	calmodulin binding cytoplasm cytosol cytoskeleton plasma membrane protein targeting signal transduction signal transduction adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase binding regulation of protein kinase A signaling positive regulation of protein kinase A signaling membrane signaling receptor complex adaptor activity positive regulation of tumor necrosis factor production neuronal cell body negative regulation of vascular permeability modulation of chemical synaptic transmission modulation of chemical synaptic transmission modulation of chemical synaptic transmission protein kinase A binding positive regulation of nitric-oxide synthase biosynthetic process positive regulation of hepatic stellate cell migration positive regulation of ERK1 and ERK2 cascade regulation of protein kinase C signaling Schaffer collateral - CA1 synapse Schaffer collateral - CA1 synapse positive regulation of oligodendrocyte apoptotic process
TC0600000182.mm.2	Cped1	cadherin-like and PC-esterase domain containing 1	6	21985909	NM_001081351, BC151018 NM_001081351, BC151018	214642	12	molecular_function endoplasmic reticulum biological_process
TC0900001392.mm.2	Amigo3	adhesion molecule with Ig like domain 3	9	108053158	NM_177275, BC157008 NM_177275, BC157008	320844	20	molecular_function cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nervous system development brain development negative regulation of neuron projection development membrane integral component of membrane integral component of membrane protein-containing complex binding positive regulation of synapse assembly
TC1300002774.mm.2	Zfp456	zinc finger protein 456	13	-67363583	NM_001001186, BC141197 NM_001001186, BC141197	408065	10	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific nucleus regulation of transcription by RNA polymerase II
TC0200003512.mm.2	Rnd3	Rho family GTPase 3	2	-51130438	NM_028810, BC009002 NM_028810, BC009002	74194	48	nucleotide binding GTPase activity protein binding GTP binding intracellular anatomical structure Golgi apparatus cytoskeleton plasma membrane cell cortex actin filament organization establishment or maintenance of cell polarity small GTPase mediated signal transduction regulation of cell shape membrane cell migration protein kinase binding cortical cytoskeleton organization cytoplasmic vesicle regulation of actin cytoskeleton organization cell projection intracellular membrane-bounded organelle
TC0200000485.mm.2
TC0200001913.mm.2	Dusp2	dual specificity phosphatase 2	2	127336158	NM_010090, BC048696 NM_010090, BC048696	13537	24	inactivation of MAPK activity endoderm formation phosphoprotein phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus nucleoplasm cytoplasm protein dephosphorylation protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity nuclear membrane peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation mitogen-activated protein kinase binding mitogen-activated protein kinase binding	04010
MG-1-neg-10339282_st
TC0300000881.mm.2	Rfx5	regulatory factor X, 5 (influences HLA class II expression)	3	94954107, 94954515	NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949	53970	32	negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II	04612 05340
TC1000002725.mm.2	Socs2	suppressor of cytokine signaling 2	10	-95411489, -95411489, -95411489, -95411489	NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153	216233	137	regulation of cell growth growth hormone receptor binding insulin-like growth factor receptor binding protein binding cytoplasm phosphatidylinositol 3-kinase complex lactation lactation JAK pathway signal transduction adaptor activity negative regulation of signal transduction response to estradiol cellular response to hormone stimulus intracellular signal transduction regulation of growth regulation of multicellular organism growth negative regulation of multicellular organism growth negative regulation of multicellular organism growth positive regulation of neuron differentiation negative regulation of receptor signaling pathway via JAK-STAT phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity growth hormone receptor signaling pathway mammary gland alveolus development mammary gland alveolus development	04630 04910 04930
TC0X00001682.mm.2	Gpm6b	glycoprotein m6b	X	166344552, 166238942	NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165	14758	39	ossification plasma membrane plasma membrane protein transport membrane integral component of membrane positive regulation of bone mineralization neuron projection development regulation of actin cytoskeleton organization membrane raft membrane raft negative regulation of serotonin uptake negative regulation of serotonin uptake regulation of focal adhesion assembly extracellular matrix assembly negative regulation of protein localization to cell surface
TC0900002770.mm.2	Tent5a	terminal nucleotidyltransferase 5A	9	-85320438, -85320438	NM_001160378, NM_001160379 NM_001160378, NM_001160379	212943	17	cellular_component response to bacterium mRNA stabilization RNA adenylyltransferase activity
TC0100000129.mm.2	Paqr8	progestin and adipoQ receptor family member VIII	1	20917839, 20890547	NM_028829, BC059813 NM_028829, BC059813	74229	23	steroid hormone receptor activity steroid binding Golgi apparatus plasma membrane plasma membrane multicellular organism development lipid binding membrane integral component of membrane cell differentiation signaling receptor activity oogenesis response to steroid hormone
TC1500001144.mm.2	Fbxo4	F-box protein 4	15	-3963563	NM_134099, BC040086 NM_134099, BC040086	106052	24	ubiquitin ligase complex protein polyubiquitination telomere maintenance ubiquitin-protein transferase activity protein binding cytoplasm ubiquitin-dependent protein catabolic process aging posttranscriptional regulation of gene expression protein ubiquitination SCF ubiquitin ligase complex SCF ubiquitin ligase complex cellular homeostasis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination regulation of protein stability protein destabilization positive regulation of telomere maintenance via telomerase common myeloid progenitor cell proliferation protein homodimerization activity negative regulation of fibroblast proliferation ubiquitin protein ligase activity cellular response to ionizing radiation negative regulation of protein localization to nucleus positive regulation of protein polyubiquitination regulation of DNA damage checkpoint	04120
TC1000000100.mm.2	Hivep2	human immunodeficiency virus type I enhancer binding protein 2	10	13966378, 13966074	NM_010437, BC150704, XR_105340 NM_010437, BC150704, XR_105340 NM_010437, BC150704, XR_105340	15273	44	RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific nucleic acid binding DNA binding DNA-binding transcription factor activity nucleus nucleoplasm transcription regulator complex transcription, DNA-templated regulation of transcription by RNA polymerase II signal transduction positive regulation of transcription by RNA polymerase II metal ion binding
TC0X00001288.mm.2	Armcx3	armadillo repeat containing, X-linked 3	X	134756551, 134756750	NM_027870, BC051113, BC011101 NM_027870, BC051113, BC011101 NM_027870, BC051113, BC011101	71703	22	protein binding nucleus cytoplasm mitochondrion mitochondrion mitochondrial outer membrane cytosol mitochondrion organization membrane integral component of membrane axonal transport of mitochondrion integral component of mitochondrial outer membrane cellular protein localization cellular protein localization positive regulation of transcription by RNA polymerase II
TC0100003361.mm.2	Gpr52	G protein-coupled receptor 52	1	-160574716	NM_001146330	620246	5	G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway phototransduction locomotory behavior G protein-coupled photoreceptor activity membrane integral component of membrane response to drug cellular response to light stimulus
TC0600003613.mm.2	Klra3	killer cell lectin-like receptor, subfamily A, member 3	6	-130323288	NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193	16634	50	plasma membrane	04650 05332

681 Genes