| Probe |
Symbol |
Description |
Chromosome |
Chromosome Location |
GenBank |
Gene |
PubMed |
Gene Ontology |
Pathway |
| TC1100000681.mm.2 |
Gm12250 |
predicted gene 12250 |
11 |
58183842 |
NM_001135115 |
631323 |
9 |
|
|
| TC0500002755.mm.2 |
Cxcl9 |
chemokine (C-X-C motif) ligand 9 |
5 |
-92321330 |
NM_008599, BC003343 NM_008599, BC003343 |
17329 |
118 |
cytokine activity extracellular region extracellular space extracellular space chemotaxis defense response inflammatory response immune response chemokine activity response to bacterium external side of plasma membrane neutrophil chemotaxis CXCR chemokine receptor binding positive regulation of myoblast differentiation defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of myoblast fusion |
04060 04062 04620 |
| TC1000001994.mm.2 |
Calhm6 |
calcium homeostasis modulator family member 6 |
10 |
-34126066 |
NM_175449, BC095946 NM_175449, BC095946 |
215900 |
16 |
cation channel activity integral component of plasma membrane ion transport membrane integral component of membrane |
|
| TC0300001444.mm.2 |
|
|
|
|
NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 |
|
|
nucleotide binding immune system process GTPase activity protein binding GTP binding extracellular region cytoplasm Golgi apparatus Golgi apparatus cytosol plasma membrane inflammatory response response to bacterium membrane hydrolase activity GMP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle interleukin-1 beta production interleukin-1 beta production interleukin-18 production protein localization to Golgi apparatus cellular response to interferon-beta identical protein binding protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host positive regulation of innate immune response perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium protein homotetramerization defense response to virus cellular response to interferon-gamma cellular response to interferon-gamma positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly |
|
| TC0500003731.mm.2 |
Gbp4 |
guanylate binding protein 4 |
5 |
-105115766 |
NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 |
17472 |
11 |
negative regulation of transcription by RNA polymerase II negative regulation of protein phosphorylation GTPase activity protein binding GTP binding negative regulation of protein ubiquitination cytoplasmic vesicle negative regulation of interferon-alpha production negative regulation of protein import into nucleus defense response to protozoan regulation of defense response to virus defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1400001182.mm.2 |
Acod1 |
aconitate decarboxylase 1 |
14 |
103047011 |
NM_008392 |
16365 |
38 |
immune system process positive regulation of antimicrobial humoral response positive regulation of antimicrobial humoral response mitochondrion mitochondrion defense response defense response defense response inflammatory response embryo implantation response to bacterium lyase activity negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production response to lipopolysaccharide negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway cellular response to interferon-beta innate immune response negative regulation of innate immune response aconitate decarboxylase activity aconitate decarboxylase activity aconitate decarboxylase activity aconitate decarboxylase activity negative regulation of inflammatory response defense response to virus cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to progesterone stimulus tolerance induction to lipopolysaccharide tolerance induction to lipopolysaccharide positive regulation of reactive oxygen species metabolic process |
|
| TC1700000077.mm.2 |
Tagap |
T cell activation Rho GTPase activating protein |
17 |
7925999 |
NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 |
72536 |
28 |
guanyl-nucleotide exchange factor activity GTPase activator activity signal transduction defense response to virus |
|
| TC1500001728.mm.2 |
Ly6a |
lymphocyte antigen 6 complex, locus A |
15 |
-74994876 |
NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 |
110454 |
177 |
protein binding intracellular anatomical structure plasma membrane response to bacterium external side of plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| TC1800000610.mm.2 |
Iigp1 |
interferon inducible GTPase 1 |
18 |
60376028, 60373615 |
NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649 |
60440 |
44 |
nucleotide binding immune system process GTPase activity GTPase activity GTPase activity protein binding GTP binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus defense response response to bacterium regulation of autophagy membrane hydrolase activity GDP binding cytokine-mediated signaling pathway symbiont-containing vacuole membrane cellular response to interferon-beta cellular response to interferon-beta identical protein binding identical protein binding defense response to protozoan innate immune response defense response to Gram-negative bacterium |
|
| TC1900000102.mm.2 |
Batf2 |
basic leucine zipper transcription factor, ATF-like 2 |
19 |
6164438 |
NM_028967, BC024521 NM_028967, BC024521 |
74481 |
28 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cell differentiation defense response to protozoan myeloid dendritic cell differentiation |
|
| TC0200002544.mm.2 |
Cd40 |
CD40 antigen |
2 |
165055635 |
NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 |
21939 |
573 |
positive regulation of protein phosphorylation immune system process regulation of immunoglobulin production immune response-regulating cell surface receptor signaling pathway immune response-regulating cell surface receptor signaling pathway antigen binding antigen binding protein binding extracellular region extracellular space cytoplasm plasma membrane cellular calcium ion homeostasis cellular calcium ion homeostasis inflammatory response inflammatory response external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane enzyme binding protein domain specific binding CD40 signaling pathway CD40 signaling pathway positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of B cell proliferation ubiquitin protein ligase binding positive regulation of interleukin-12 production positive regulation of interleukin-12 production response to interferon-gamma CD40 receptor complex CD40 receptor complex TRIF-dependent toll-like receptor signaling pathway signaling receptor activity B cell activation B cell activation B cell activation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein defense response to protozoan defense response to protozoan neuronal cell body positive regulation of I-kappaB kinase/NF-kappaB signaling varicosity intracellular membrane-bounded organelle positive regulation of MAP kinase activity protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of blood vessel endothelial cell migration positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of isotype switching to IgG isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of protein kinase C signaling positive regulation of endothelial cell apoptotic process positive regulation of endothelial cell apoptotic process |
04060 04514 04620 04672 05144 05145 05310 05320 05322 05330 05340 05416 |
| TC0600003229.mm.2 |
Cd69 |
CD69 antigen |
6 |
-129267323 |
NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 |
12515 |
114 |
calcium ion binding external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane carbohydrate binding protein-containing complex cellular response to drug identical protein binding |
|
| TC0500002623.mm.2 |
Kdr |
kinase insert domain protein receptor |
5 |
-75957364, -75932826 |
NM_010612, BC020530 NM_010612, BC020530 |
16542 |
1021 |
nucleotide binding angiogenesis ovarian follicle development branching involved in blood vessel morphogenesis vasculogenesis response to hypoxia positive regulation of protein phosphorylation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lymph vessel development cell migration involved in sprouting angiogenesis positive regulation of mesenchymal cell proliferation hematopoietic progenitor cell differentiation endocardium development endothelium development endochondral bone growth protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding extracellular region nucleus cytoplasm cytoplasm endosome early endosome endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cytosolic calcium ion concentration multicellular organism development positive regulation of cell population proliferation regulation of cell shape male gonad development external side of plasma membrane cell surface positive regulation of endothelial cell migration positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane positive regulation of macroautophagy kinase activity phosphorylation cell migration cell migration transferase activity peptidyl-tyrosine phosphorylation growth factor binding growth factor binding cell junction hemopoiesis cell differentiation lung development positive regulation of cell migration positive regulation of BMP signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway cytoplasmic vesicle positive regulation of TOR signaling positive regulation of kinase activity embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation vascular endothelial growth factor signaling pathway vascular endothelial growth factor binding response to drug identical protein binding neuron projection neuronal cell body negative regulation of apoptotic process surfactant homeostasis receptor complex positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration membrane raft cell fate commitment cadherin binding endothelial cell differentiation endothelial cell differentiation endothelial cell differentiation endothelial cell differentiation positive regulation of angiogenesis positive regulation of angiogenesis positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation post-embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of calcium-mediated signaling positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization calcium ion homeostasis blood vessel endothelial cell differentiation vascular wound healing ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cell periphery positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission sorting endosome regulation of hematopoietic progenitor cell differentiation regulation of bone development cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis |
04060 04144 04370 04510 |
| TC1700001596.mm.2 |
Mmp25 |
matrix metallopeptidase 25 |
17 |
-23629175 |
NM_001033339, BC112379 NM_001033339, BC112379 |
240047 |
20 |
metalloendopeptidase activity plasma membrane plasma membrane proteolysis inflammatory response peptidase activity metallopeptidase activity zinc ion binding cell surface membrane integral component of membrane peptidase activator activity hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix anchored component of membrane metal ion binding hard palate development |
|
| TC1700002781.mm.2 |
H2-Ab1 |
histocompatibility 2, class II antigen A, beta 1 |
17 |
34263226 |
NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 |
14961 |
780 |
adaptive immune response B cell affinity maturation immune system process immunoglobulin production involved in immunoglobulin-mediated immune response humoral immune response mediated by circulating immunoglobulin antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of antigen processing and presentation positive regulation of T-helper 1 type immune response protein binding intracellular anatomical structure early endosome multivesicular body Golgi apparatus plasma membrane immune response transcription factor binding external side of plasma membrane cell surface toxic substance binding membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II ubiquitin protein ligase binding negative regulation of T cell proliferation peptide antigen binding MHC class II protein complex protein-containing complex binding positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell activation antigen processing and presentation of peptide antigen T cell receptor signaling pathway cellular response to interferon-gamma protein antigen binding |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1100002643.mm.2 |
|
|
|
|
NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 |
|
|
GTPase activity GTPase activity GTP binding endoplasmic reticulum membrane defense response immune response response to virus response to bacterium response to interferon-gamma response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta |
|
| TC1600002148.mm.2 |
Mx1 |
MX dynamin-like GTPase 1 |
16 |
-97447036, -97447034 |
NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113 |
17857 |
108 |
mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission GTPase activity nucleus cytoplasm plasma membrane microtubule binding postsynaptic density microtubule cytoskeleton membrane synaptic vesicle budding from presynaptic endocytic zone membrane axon cytoplasmic vesicle receptor internalization mitochondrial membrane dendritic spine head regulation of synapse structure or activity membrane fusion postsynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization |
|
| TC1200002525.mm.2 |
Serpina3g |
serine (or cysteine) peptidase inhibitor, clade A, member 3G |
12 |
104236146, 104214453 |
NM_009251 |
20715 |
30 |
adaptive immune response immune system process serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm apoptotic process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone |
|
| TC1100002649.mm.2 |
|
|
|
|
NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 |
|
|
GTPase activity GTPase activity GTP binding endoplasmic reticulum membrane defense response immune response response to virus response to bacterium response to interferon-gamma response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta |
|
| TC0500000171.mm.2 |
Fgl2 |
fibrinogen-like protein 2 |
5 |
21372672 |
NM_008013, BC028893 NM_008013, BC028893 |
14190 |
70 |
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell immunoglobulin production involved in immunoglobulin-mediated immune response negative regulation of dendritic cell antigen processing and presentation negative regulation of macrophage antigen processing and presentation signaling receptor binding extracellular region extracellular space peptidase activity cytolysis negative regulation of memory T cell differentiation negative regulation of defense response to virus collagen-containing extracellular matrix |
|
| TC0100003591.mm.2 |
Ifi213 |
interferon activated gene 213 |
1 |
-173591956, -173580356, -173573955, -173566282 |
NM_001177349, NM_001177350 NM_001177349, NM_001177350 |
623121 |
10 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding |
|
| TC0300001447.mm.2 |
Gbp2 |
guanylate binding protein 2 |
3 |
142620662 |
NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882 |
14469 |
54 |
nucleotide binding GTPase activity GTPase activity GTP binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol response to bacterium membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle protein localization to nucleus cellular response to interferon-beta protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC0700001841.mm.2 |
Itgal |
integrin alpha L |
7 |
127296259 |
NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 |
16408 |
202 |
immunological synapse T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell plasma membrane cell-cell junction phagocytosis cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion cell surface receptor signaling pathway integrin-mediated signaling pathway integrin complex external side of plasma membrane cell surface membrane integral component of membrane regulation of cell-cell adhesion positive regulation of cell-cell adhesion ICAM-3 receptor activity integrin alphaL-beta2 complex memory T cell extravasation positive regulation of T cell proliferation receptor clustering protein-containing complex binding metal ion binding activated T cell proliferation cell adhesion molecule binding positive regulation of calcium-mediated signaling cell-cell adhesion cell-cell adhesion |
04514 04650 04670 04810 05144 05150 05323 05416 |
| TC0300003133.mm.2 |
Ifi44 |
interferon-induced protein 44 |
3 |
-151730922 |
NM_133871, BC111882 NM_133871, BC111882 |
99899 |
16 |
molecular_function cytoplasm immune response response to bacterium |
|
| TC0200002374.mm.2 |
Procr |
protein C receptor, endothelial |
2 |
155751216 |
NM_011171, BC028755 NM_011171, BC028755 |
19124 |
78 |
extracellular space extracellular space centrosome blood coagulation hemostasis protein C-terminus binding membrane integral component of membrane signaling receptor activity perinuclear region of cytoplasm negative regulation of coagulation negative regulation of coagulation negative regulation of coagulation |
|
| TC1100001222.mm.2 |
Ccl12 |
chemokine (C-C motif) ligand 12 |
11 |
82101844 |
NM_011331, BC027520 NM_011331, BC027520 |
20293 |
33 |
MAPK cascade angiogenesis monocyte chemotaxis monocyte chemotaxis monocyte chemotaxis positive regulation of leukocyte migration cytokine activity extracellular region extracellular space chemotaxis inflammatory response inflammatory response inflammatory response immune response cytoskeleton organization G protein-coupled receptor signaling pathway chemokine activity regulation of cell shape cytokine-mediated signaling pathway neutrophil chemotaxis lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding negative regulation of glial cell apoptotic process protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration CCR chemokine receptor binding eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of calcium ion import negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process negative regulation of natural killer cell chemotaxis |
04060 04062 |
| TC0200000551.mm.2 |
|
|
|
|
NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 |
|
|
urea cycle urea cycle citrulline metabolic process argininosuccinate metabolic process argininosuccinate metabolic process nucleotide binding argininosuccinate synthase activity argininosuccinate synthase activity protein binding ATP binding nucleus cytoplasm cytoplasm mitochondrion mitochondrial outer membrane lysosome endoplasmic reticulum cytosol arginine biosynthetic process arginine biosynthetic process aspartate metabolic process circadian rhythm circadian rhythm cellular amino acid biosynthetic process response to zinc ion response to mycotoxin toxic substance binding amino acid binding ligase activity identical protein binding neuron projection neuronal cell body perikaryon myelin sheath positive regulation of nitric oxide biosynthetic process response to glucocorticoid cell body fiber cellular response to laminar fluid shear stress negative regulation of leukocyte cell-cell adhesion |
|
| TC0200001854.mm.2 |
|
|
|
|
NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633 |
|
|
molecular_function cytochrome-c oxidase activity cellular_component nucleus mitochondrion mitochondrial respiratory chain complex IV response to bacterium BMP signaling pathway negative regulation of inflammatory response cellular response to lipopolysaccharide |
|
| TC0500002895.mm.2 |
|
|
|
|
NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 |
|
|
GTPase activity GTP binding response to bacterium symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle cellular response to interferon-beta defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1200002524.mm.2 |
Serpina3f |
serine (or cysteine) peptidase inhibitor, clade A, member 3F |
12 |
104214543, 104214632 |
NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 |
238393 |
19 |
serine-type endopeptidase inhibitor activity extracellular space response to bacterium negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone |
|
| TC0200004599.mm.2 |
Il1a |
interleukin 1 alpha |
2 |
-129299609 |
NM_010554, BC003727 NM_010554, BC003727 |
16175 |
389 |
fever generation positive regulation of cytokine production connective tissue replacement involved in inflammatory response wound healing cytokine activity cytokine activity interleukin-1 receptor binding copper ion binding extracellular region extracellular space extracellular space extracellular space cytoplasm cytosol plasma membrane cellular sodium ion homeostasis inflammatory response inflammatory response immune response negative regulation of cell population proliferation cell surface positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of steroid biosynthetic process cytokine-mediated signaling pathway cytokine-mediated signaling pathway keratinization positive regulation of prostaglandin secretion positive regulation of interleukin-2 production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade regulation of actin cytoskeleton organization positive regulation of immature T cell proliferation in thymus cellular response to heat ectopic germ cell programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade response to copper ion positive regulation of protein secretion regulation of nitric-oxide synthase activity positive regulation of cell division regulation of sensory perception of pain positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of monocyte chemotactic protein-1 production extrinsic apoptotic signaling pathway in absence of ligand positive regulation of neutrophil migration negative regulation of establishment of Sertoli cell barrier positive regulation of neutrophil extravasation |
04010 04060 04210 04380 04640 04940 05020 05140 05323 05332 |
| TC1700002352.mm.2 |
C3 |
complement component 3 |
17 |
-57203966 |
NM_009778, BC043338 NM_009778, BC043338 |
12266 |
585 |
positive regulation of type IIa hypersensitivity positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex immune system process endopeptidase inhibitor activity protein binding extracellular region extracellular space extracellular space extracellular space extracellular space lipid metabolic process fatty acid metabolic process inflammatory response complement activation complement activation complement activation complement activation complement activation, alternative pathway complement activation, classical pathway blood coagulation lipid binding response to bacterium cell surface positive regulation of vascular endothelial growth factor production positive regulation of glucose transmembrane transport regulation of triglyceride biosynthetic process positive regulation of lipid storage neuron remodeling C5L2 anaphylatoxin chemotactic receptor binding protein-containing complex oviduct epithelium development vascular associated smooth muscle cell differentiation innate immune response positive regulation of G protein-coupled receptor signaling pathway positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of receptor-mediated endocytosis positive regulation of developmental growth positive regulation of phagocytosis retina development in camera-type eye positive regulation of phagocytosis, engulfment positive regulation of phagocytosis, engulfment positive regulation of ERK1 and ERK2 cascade amyloid-beta clearance amyloid-beta clearance complement-dependent cytotoxicity complement-mediated synapse pruning vertebrate eye-specific patterning cell surface receptor signaling pathway involved in cell-cell signaling positive regulation of apoptotic cell clearance |
04145 04610 05140 05142 05150 05322 |
| TC1400002162.mm.2 |
Phf11b |
PHD finger protein 11B |
14 |
-59320963 |
NM_001164327 |
236451 |
3 |
molecular_function nucleus nucleoplasm biological_process nuclear membrane |
|
| TC0300001446.mm.2 |
Gbp3 |
guanylate binding protein 3 |
3 |
142560355, 142560043 |
NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 |
55932 |
23 |
nucleotide binding GTPase activity GTPase activity GTP binding nucleus cytoplasm Golgi apparatus cytosol cytosol plasma membrane membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle cellular response to interferon-beta protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1100001223.mm.2 |
Ccl8 |
chemokine (C-C motif) ligand 8 |
11 |
82115184 |
NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103 |
20307 |
40 |
monocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space chemotaxis inflammatory response immune response G protein-coupled receptor signaling pathway chemokine activity heparin binding neutrophil chemotaxis positive regulation of GTPase activity positive regulation of myoblast differentiation CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of myoblast fusion |
04060 04062 |
| TC0500002757.mm.2 |
Cxcl11 |
chemokine (C-X-C motif) ligand 11 |
5 |
-92359544, -92359544 |
NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903 |
56066 |
38 |
extracellular space inflammatory response chemokine activity neutrophil chemotaxis CXCR chemokine receptor binding antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide |
04060 04062 04620 |
| TC0100003575.mm.2 |
Slamf8 |
SLAM family member 8 |
1 |
-172581376 |
NM_029084, BC024587 NM_029084, BC024587 |
74748 |
14 |
leukocyte chemotaxis involved in inflammatory response B-1 B cell lineage commitment negative regulation of macrophage chemotaxis membrane integral component of membrane regulation of NAD(P)H oxidase activity cellular response to drug signaling receptor activity defense response to bacterium identical protein binding regulation of kinase activity regulation of B cell differentiation negative regulation of respiratory burst involved in inflammatory response negative regulation of monocyte chemotaxis phagosome acidification negative regulation of neutrophil migration negative regulation of dendritic cell chemotaxis |
|
| TC0500002896.mm.2 |
Gbp11 |
guanylate binding protein 11 |
5 |
-105323025, -105323025 |
NM_001039647, BC111039 NM_001039647, BC111039 |
634650 |
3 |
GTPase activity GTP binding cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma |
|
| TC0300001445.mm.2 |
Gbp7 |
guanylate binding protein 7 |
3 |
142530335 |
NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229 |
229900 |
15 |
GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle defense response to protozoan defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC0500002756.mm.2 |
Cxcl10 |
chemokine (C-X-C motif) ligand 10 |
5 |
-92346638 |
NM_021274, BC030067 NM_021274, BC030067 |
15945 |
278 |
positive regulation of leukocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space extracellular space chemotaxis defense response inflammatory response immune response G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway chemokine activity chemokine activity heparin binding positive regulation of cell population proliferation response to bacterium external side of plasma membrane T cell chemotaxis regulation of T cell chemotaxis negative regulation of angiogenesis positive regulation of cell migration neutrophil chemotaxis killing of cells of other organism chemoattractant activity endothelial cell activation regulation of cell population proliferation regulation of apoptotic process CXCR chemokine receptor binding negative regulation of myoblast differentiation CXCR3 chemokine receptor binding positive regulation of release of sequestered calcium ion into cytosol defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis regulation of endothelial tube morphogenesis negative regulation of myoblast fusion positive regulation of T cell migration |
04060 04062 04620 04622 04623 |
| TC1800000606.mm.2 |
Gm4951 |
predicted gene 4951 |
18 |
60212076 |
NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147 |
240327 |
12 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta cellular response to interferon-beta |
|
| TC1700000835.mm.2 |
Pla2g7 |
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) |
17 |
43568450 |
NM_013737, BC010726 NM_013737, BC010726 |
27226 |
49 |
1-alkyl-2-acetylglycerophosphocholine esterase activity 1-alkyl-2-acetylglycerophosphocholine esterase activity phospholipid binding extracellular region extracellular space cytoplasm lipid metabolic process inflammatory response phospholipid catabolic process lipid catabolic process hydrolase activity low-density lipoprotein particle high-density lipoprotein particle low-density lipoprotein particle remodeling lipid oxidation plasma lipoprotein particle oxidation phosphatidylcholine catabolic process platelet activating factor metabolic process calcium-independent phospholipase A2 activity platelet activating factor catabolic process positive regulation of monocyte chemotaxis |
00565 01100 |
| human-RPTR-AJ510163-1_st |
|
|
|
|
|
|
|
|
|
| TC0200004396.mm.2 |
Rasgrp1 |
RAS guanyl releasing protein 1 |
2 |
-117279983 |
NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341 |
19419 |
77 |
cytokine production positive regulation of protein phosphorylation inflammatory response to antigenic stimulus guanyl-nucleotide exchange factor activity calcium ion binding intracellular anatomical structure cytoplasm endoplasmic reticulum Golgi apparatus cytosol cytosol plasma membrane plasma membrane small GTPase mediated signal transduction zinc ion binding regulation of phosphatidylinositol 3-kinase signaling membrane diacylglycerol binding natural killer cell activation cell differentiation phosphatidylcholine binding secretory granule localization positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell differentiation positive regulation of T cell differentiation in thymus intracellular signal transduction T cell proliferation B cell proliferation T cell activation B cell activation identical protein binding mast cell degranulation positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of natural killer cell mediated cytotoxicity positive regulation of JNK cascade positive regulation of Ras protein signal transduction metal ion binding vesicle transport along microtubule regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade activation of GTPase activity activation of GTPase activity |
04010 04660 |
| TC0200003355.mm.2 |
Traf1 |
TNF receptor-associated factor 1 |
2 |
-34941749 |
NM_009421, BC096595 NM_009421, BC096595 |
22029 |
63 |
tumor necrosis factor receptor binding tumor necrosis factor receptor binding protein binding cytoplasm apoptotic process signal transduction zinc ion binding cytoplasmic side of plasma membrane ubiquitin protein ligase binding ubiquitin protein ligase binding thioesterase binding tumor necrosis factor-mediated signaling pathway identical protein binding regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade positive regulation of NF-kappaB transcription factor activity protein K63-linked ubiquitination plasma membrane signaling receptor complex regulation of extrinsic apoptotic signaling pathway |
05200 05222 |
| TC1400002160.mm.2 |
Phf11 |
PHD finger protein 11 |
14 |
|
NM_001164329 |
628693 |
3 |
|
|
| TC0700002128.mm.2 |
Tarm1 |
T cell-interacting, activating receptor on myeloid cells 1 |
7 |
-3486499, -3489068 |
NM_177363 |
245126 |
10 |
adaptive immune response immune system process plasma membrane plasma membrane membrane integral component of membrane immunoglobulin receptor binding innate immune response positive regulation of cytokine production involved in inflammatory response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation |
|
| TC0400001543.mm.2 |
Fabp3 |
fatty acid binding protein 3, muscle and heart |
4 |
130308737 |
NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542 |
14077 |
90 |
long-chain fatty acid transporter activity fatty acid binding extracellular space extracellular space cytoplasm cytosol cytosol cytoskeletal protein binding lipid binding long-chain fatty acid transport long-chain fatty acid transport long-chain fatty acid transport sarcoplasm intracellular lipid transport long-chain fatty acid binding cholesterol homeostasis regulation of fatty acid oxidation icosatetraenoic acid binding brown fat cell differentiation phospholipid homeostasis oleic acid binding positive regulation of phospholipid biosynthetic process positive regulation of long-chain fatty acid import into cell positive regulation of long-chain fatty acid import into cell regulation of phosphatidylcholine biosynthetic process |
03320 |
| TC1100001241.mm.2 |
Slfn4 |
schlafen 4 |
11 |
83175185 |
NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770 |
20558 |
22 |
molecular_function cellular_component response to bacterium |
|
| TC0100001634.mm.2 |
Ifi208 |
interferon activated gene 208 |
1 |
173673664, 173673664 |
NM_001162938 |
100033459 |
63 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding |
|
| TC1700002816.mm.2 |
Cfb |
complement factor B |
17 |
-34856373 |
NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451 |
14962 |
166 |
immune system process serine-type endopeptidase activity extracellular region extracellular space proteolysis complement activation complement activation, alternative pathway complement activation, alternative pathway complement activation, alternative pathway peptidase activity serine-type peptidase activity cell population proliferation hydrolase activity innate immune response response to thyroid hormone |
04610 05150 |
| TC1100001239.mm.2 |
Slfn1 |
schlafen 1 |
11 |
83116819 |
NM_011407, BC052869 NM_011407, BC052869 |
20555 |
22 |
negative regulation of transcription by RNA polymerase II negative regulation of protein phosphorylation protein binding nucleus cytoplasm cell cycle arrest negative regulation of cell population proliferation negative regulation of T cell proliferation negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter negative regulation of G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle |
|
| TC0100001604.mm.2 |
Slamf6 |
SLAM family member 6 |
1 |
171917461, 171917461 |
NM_030710, BC030031 NM_030710, BC030031 |
30925 |
44 |
natural killer cell differentiation natural killer cell proliferation adaptive immune response immune system process plasma membrane integral component of plasma membrane membrane integral component of membrane positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity T-helper 17 cell lineage commitment |
|
| TC1400002161.mm.2 |
Phf11a |
PHD finger protein 11A |
14 |
-59276912 |
NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760 |
219131 |
13 |
molecular_function nucleus nucleoplasm nuclear membrane metal ion binding regulation of immune response |
|
| TC1400002869.mm.2 |
Phf11d |
PHD finger protein 11D |
14 |
-59347406 |
NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673 |
219132 |
18 |
molecular_function nucleus nucleoplasm biological_process nuclear membrane metal ion binding |
|
| rat-RPTR-AJ510163-1_st |
|
|
|
|
|
|
|
|
|
| TC0200003209.mm.2 |
Slc2a6 |
solute carrier family 2 (facilitated glucose transporter), member 6 |
2 |
-27021364, -27021366 |
NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 |
227659 |
20 |
transporter activity lysosome lysosomal membrane regulation of glycolytic process regulation of glycolytic process carbohydrate transport membrane integral component of membrane transmembrane transporter activity transmembrane transport |
|
| human-RPTR-U57609-2_st |
|
|
|
|
|
|
|
|
|
| TC1100003115.mm.2 |
Scimp |
SLP adaptor and CSK interacting membrane protein |
11 |
-70790931 |
NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178 |
327957 |
16 |
ruffle immunological synapse immunological synapse cytokine production involved in immune response positive regulation of dendritic cell cytokine production protein binding plasma membrane membrane integral component of membrane filopodium leading edge membrane uropod membrane cytoplasmic vesicle positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of stress-activated MAPK cascade toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor TLR1:TLR2 signaling pathway cell projection receptor complex phagocytic vesicle molecular adaptor activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin tetraspanin-enriched microdomain |
|
| TC0700004530.mm.2 |
Irf7 |
interferon regulatory factor 7 |
7 |
-141263182 |
NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 |
54123 |
230 |
transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding immune system process regulation of adaptive immune response DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of gene expression immunoglobulin mediated immune response positive regulation of type I interferon production type I interferon production interferon-alpha production interferon-beta production positive regulation of interferon-alpha production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production regulation of MyD88-dependent toll-like receptor signaling pathway regulation of MyD88-independent toll-like receptor signaling pathway innate immune response regulation of innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II defense response to virus defense response to virus type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway sequence-specific double-stranded DNA binding |
04620 04622 04623 05160 |
| TC0200000868.mm.2 |
Gpd2 |
glycerol phosphate dehydrogenase 2, mitochondrial |
2 |
57237677, 57238381 |
NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359 |
14571 |
55 |
glycerol-3-phosphate dehydrogenase [NAD+] activity glycerol-3-phosphate dehydrogenase (quinone) activity calcium ion binding mitochondrion mitochondrion mitochondrion mitochondrial inner membrane glycerol-3-phosphate metabolic process glycerol-3-phosphate metabolic process gluconeogenesis NADH metabolic process glycerol-3-phosphate dehydrogenase complex membrane oxidoreductase activity multicellular organism growth camera-type eye development metal ion binding sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity |
00564 |
| TC0600003237.mm.2 |
Olr1 |
oxidized low density lipoprotein (lectin-like) receptor 1 |
6 |
-129485247, -129485246 |
NM_138648 |
108078 |
104 |
immune system process low-density lipoprotein particle receptor activity low-density lipoprotein particle receptor activity extracellular region nucleoplasm plasma membrane plasma membrane inflammatory response inflammatory response cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell death cell death negative regulation of gene expression membrane integral component of membrane extrinsic component of plasma membrane carbohydrate binding lipoprotein metabolic process lipoprotein metabolic process identical protein binding intracellular membrane-bounded organelle receptor complex receptor complex |
03320 04145 |
| TC1900001253.mm.2 |
Gda |
guanine deaminase |
19 |
-21391306 |
NM_010266, BC076583 NM_010266, BC076583 |
14544 |
33 |
protein binding cytosol cytosol guanine catabolic process zinc ion binding guanine deaminase activity guanine deaminase activity guanine deaminase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds deaminase activity positive regulation of microtubule polymerization GMP catabolic process dGMP catabolic process guanine metabolic process metal ion binding |
00230 01100 |
| TC0600003169.mm.2 |
Ccnd2 |
cyclin D2 |
6 |
-127125708 |
NM_009829, BC049086 NM_009829, BC049086 |
12444 |
357 |
regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex cyclin-dependent protein kinase holoenzyme complex chromatin positive regulation of protein phosphorylation protein binding nucleus nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cell cycle long-term memory positive regulation of cell population proliferation adult locomotory behavior membrane cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding nuclear membrane negative regulation of apoptotic process mitotic cell cycle phase transition positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of epithelial cell proliferation cell division regulation of cell cycle cellular response to X-ray cyclin D2-CDK4 complex positive regulation of G1/S transition of mitotic cell cycle positive regulation of G1/S transition of mitotic cell cycle |
04110 04115 04310 04510 04630 |
| TC1100003097.mm.2 |
Cxcl16 |
chemokine (C-X-C motif) ligand 16 |
11 |
-70455188, -70454388 |
NM_023158, BC019961 NM_023158, BC019961 |
66102 |
81 |
low-density lipoprotein particle receptor activity low-density lipoprotein particle receptor activity scavenger receptor activity scavenger receptor activity cytokine activity extracellular space extracellular space extracellular space extracellular space receptor-mediated endocytosis chemotaxis chemokine activity chemokine activity chemokine activity T cell chemotaxis T cell chemotaxis membrane integral component of membrane positive regulation of cell growth positive regulation of cell migration positive regulation of cell migration response to cytokine response to interferon-gamma response to tumor necrosis factor chemokine receptor binding lymphocyte chemotaxis cellular response to lipopolysaccharide |
04060 04062 |
| TC1900001418.mm.2 |
Ch25h |
cholesterol 25-hydroxylase |
19 |
-34473783 |
NM_009890, BC039919 NM_009890, BC039919 |
12642 |
45 |
C-4 methylsterol oxidase activity cholesterol 25-hydroxylase activity monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process cholesterol metabolic process steroid hydroxylase activity steroid hydroxylase activity lipid biosynthetic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity B cell chemotaxis metal ion binding |
00120 |
| TC0500002753.mm.2 |
Naaa |
N-acylethanolamine acid amidase |
5 |
-92257659 |
NM_001163687, NM_025972, BC004572 NM_001163687, NM_025972, BC004572 NM_001163687, NM_025972, BC004572 |
67111 |
24 |
cytoplasm lysosome lysosome lipid metabolic process fatty acid metabolic process sphingosine metabolic process transcription factor binding membrane lipid catabolic process hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds N-acylsphingosine amidohydrolase activity fatty acid amide hydrolase activity extrinsic component of membrane N-(long-chain-acyl)ethanolamine deacylase activity N-acylethanolamine metabolic process N-acylphosphatidylethanolamine metabolic process |
|
| TC0600003606.mm.2 |
Klrb1b |
killer cell lectin-like receptor subfamily B member 1B |
6 |
-128813705, -128813705 |
NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 NM_030599, BC055379, BC100580, BC132126, BC132128, BC145389 |
80782 |
31 |
protein binding plasma membrane integral component of plasma membrane external side of plasma membrane membrane integral component of membrane carbohydrate binding signaling receptor activity identical protein binding negative regulation of natural killer cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity |
|
| TC1700001905.mm.2 |
H2-Aa |
histocompatibility 2, class II antigen A, alpha |
17 |
-34282743 |
NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 |
14960 |
115 |
adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosome plasma membrane immune response external side of plasma membrane membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II response to interferon-gamma negative regulation of T cell proliferation peptide antigen binding MHC class II protein complex protein-containing complex binding positive regulation of T cell differentiation antigen processing and presentation of peptide antigen |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1800000617.mm.2 |
|
|
|
|
NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) |
|
|
activation of MAPK activity prostaglandin biosynthetic process amyloid-beta binding positive regulation of protein phosphorylation positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway adaptive immune response T cell activation involved in immune response immune system process positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process cytokine receptor activity cytokine receptor activity cytokine receptor activity protein binding extracellular space nucleus cytoplasm cytoplasm lysosome endosome late endosome multivesicular body vacuole endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane plasma membrane integral component of plasma membrane intracellular protein transport intracellular protein transport defense response immune response cell population proliferation external side of plasma membrane cell surface cell surface positive regulation of gene expression membrane integral component of membrane immunoglobulin mediated immune response antigen processing and presentation antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II cytokine binding cytokine binding MHC class II protein complex binding negative regulation of cell migration positive regulation of B cell proliferation positive regulation of prostaglandin biosynthetic process positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-8 production protein-containing complex positive regulation of kinase activity positive regulation of kinase activity response to interferon-gamma response to interferon-gamma macrophage migration inhibitory factor signaling pathway macrophage migration inhibitory factor receptor complex macrophage migration inhibitory factor receptor complex NOS2-CD74 complex macrophage migration inhibitory factor binding macrophage migration inhibitory factor binding MHC class II protein binding MHC class II protein binding CD4 receptor binding MHC class II protein complex MHC class II protein complex MHC class II protein binding, via antigen binding groove negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator protein folding chaperone positive thymic T cell selection negative thymic T cell selection positive regulation of innate immune response negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated negative regulation of viral entry into host cell positive regulation of viral entry into host cell positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation protein stabilization nitric-oxide synthase binding chaperone cofactor-dependent protein refolding chaperone cofactor-dependent protein refolding positive regulation of macrophage cytokine production positive regulation of macrophage cytokine production protein-containing complex assembly protein trimerization positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of macrophage migration inhibitory factor signaling pathway |
|
| TC0200005290.mm.2 |
Zbp1 |
Z-DNA binding protein 1 |
2 |
-173206611, -173213735 |
NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033 |
58203 |
62 |
activation of innate immune response immune system process DNA binding DNA binding DNA binding left-handed Z-DNA binding RNA binding double-stranded RNA binding protein binding nucleus nucleus nucleus cytoplasm cytoplasm cytosol cytosol apoptotic process programmed cell death viral process identical protein binding positive regulation of apoptotic process positive regulation of apoptotic process innate immune response regulation of inflammatory response positive regulation of inflammatory response defense response to virus defense response to virus defense response to virus positive regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway positive regulation of necroptotic process positive regulation of necroptotic process positive regulation of necroptotic process pyroptosis regulation of interleukin-1-mediated signaling pathway |
04623 |
| TC0500001240.mm.2 |
Oasl1 |
2'-5' oligoadenylate synthetase-like 1 |
5 |
114923239 |
NM_145209, BC032152 NM_145209, BC032152 |
231655 |
23 |
immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytosol cytosol immune response response to virus membrane transferase activity negative regulation of viral genome replication negative regulation of viral genome replication innate immune response defense response to virus defense response to virus regulation of ribonuclease activity |
|
| mouse-RPTR-AJ510163-1_st |
|
|
|
|
|
|
|
|
|
| TC0600003537.mm.2 |
Clec9a |
C-type lectin domain family 9, member a |
6 |
129408861 |
NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 |
232414 |
47 |
positive regulation of cytokine production receptor-mediated endocytosis receptor-mediated endocytosis receptor-mediated endocytosis cell surface cell surface cell surface membrane integral component of membrane carbohydrate binding |
|
| TC1600000116.mm.2 |
Ciita |
class II transactivator |
16 |
10480071, 10489780, 10488177 |
NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 |
12265 |
178 |
negative regulation of transcription by RNA polymerase II nucleotide binding transcription regulatory region sequence-specific DNA binding ATP binding GTP binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated inflammatory response protein C-terminus binding cell surface kinase activity phosphorylation PML body transferase activity transferase activity, transferring acyl groups activating transcription factor binding activating transcription factor binding response to interferon-gamma response to interferon-gamma protein-containing complex binding positive regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of viral entry into host cell response to antibiotic |
04612 05145 05340 |
| TC0200005438.mm.2 |
Helz2 |
helicase with zinc finger 2, transcriptional coactivator |
2 |
-181227614 |
NM_183162 |
229003 |
19 |
nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay DNA binding RNA binding RNA helicase activity helicase activity ribonuclease activity ATP binding nucleus nucleoplasm cytoplasm hydrolase activity nuclear receptor coactivator activity positive regulation of transcription by RNA polymerase II metal ion binding |
|
| TC1800001396.mm.2 |
Gm4841 |
predicted gene 4841 |
18 |
-60268300 |
NM_001034859, BC150900 NM_001034859, BC150900 |
225594 |
9 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta |
|
| TC0600002425.mm.2 |
Il23r |
interleukin 23 receptor |
6 |
-67422931 |
NM_144548, BC112425 NM_144548, BC112425 |
209590 |
93 |
positive regulation of defense response to virus by host immune system process leukocyte mediated immunity positive regulation of T-helper 1 type immune response cytokine receptor activity interleukin-12 receptor binding interleukin-12 receptor binding plasma membrane plasma membrane integral component of plasma membrane inflammatory response receptor signaling pathway via JAK-STAT external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine binding response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of interferon-gamma production positive regulation of interleukin-12 production response to interferon-gamma interleukin-23 binding interleukin-23 binding interleukin-23 receptor activity receptor complex receptor complex innate immune response interleukin-23 receptor complex interleukin-23 receptor complex |
04060 04630 |
| TC1500001727.mm.2 |
Ly6i |
lymphocyte antigen 6 complex, locus I |
15 |
-74979533 |
NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 |
57248 |
13 |
plasma membrane plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| TC1100002641.mm.2 |
Irgm1 |
immunity-related GTPase family M member 1 |
11 |
-48865244 |
NM_008326, BC145957 NM_008326, BC145957 |
15944 |
77 |
autophagosome assembly nucleotide binding immune system process GTPase activity GTP binding lysosome endosome late endosome autophagosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane autophagy defense response defense response response to bacterium membrane hydrolase activity cytoplasmic vesicle cellular response to interferon-beta cell projection autolysosome innate immune response phagocytic vesicle positive regulation of interferon-gamma-mediated signaling pathway cellular response to interferon-gamma positive regulation by symbiont of host autophagy positive regulation of autophagosome maturation |
|
| mouse-RPTR-U57609-2_st |
|
|
|
|
|
|
|
|
|
| TC1700002782.mm.2 |
H2-Eb1 |
histocompatibility 2, class II antigen E beta |
17 |
34305866 |
NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 |
14969 |
80 |
adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosomal membrane immune response membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II late endosome membrane response to interferon-gamma MHC class II protein complex |
04145 04514 04612 04640 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1700000618.mm.2 |
H2-DMa |
histocompatibility 2, class II, locus DMa |
17 |
34122831, 34125517 |
NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992 |
14998 |
91 |
adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of germinal center formation positive regulation of humoral immune response protein binding intracellular anatomical structure lysosome lysosomal membrane lysosomal membrane endosome late endosome multivesicular body immune response cell surface endosome membrane protein transport membrane integral component of membrane immunoglobulin mediated immune response antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle positive thymic T cell selection positive regulation of T cell differentiation inner ear development positive regulation of immune response chaperone cofactor-dependent protein refolding chaperone cofactor-dependent protein refolding protein-containing complex assembly |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1300000157.mm.2 |
Aoah |
acyloxyacyl hydrolase |
13 |
20794112, 20794112 |
NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767 |
27052 |
35 |
calcium ion binding calcium ion binding calcium ion binding extracellular region lipid metabolic process fatty acid metabolic process lipopolysaccharide metabolic process lipopolysaccharide catabolic process lipopolysaccharide catabolic process hydrolase activity hydrolase activity, acting on ester bonds cytoplasmic vesicle intracellular membrane-bounded organelle metal ion binding acyloxyacyl hydrolase activity acyloxyacyl hydrolase activity acyloxyacyl hydrolase activity negative regulation of inflammatory response negative regulation of inflammatory response |
|
| TC0600001369.mm.2 |
Usp18 |
ubiquitin specific peptidase 18 |
6 |
121245905 |
NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577 |
24110 |
69 |
cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleus cytosol cytosol ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity response to bacterium protein deubiquitination hydrolase activity ISG15-specific protease activity response to stilbenoid intracellular membrane-bounded organelle regulation of inflammatory response |
|
| TC0600003329.mm.2 |
Plbd1 |
phospholipase B domain containing 1 |
6 |
-136612070 |
NM_025806, BC019793 NM_025806, BC019793 |
66857 |
16 |
phospholipase activity extracellular region extracellular space lysosome lipid metabolic process phospholipid catabolic process lipid catabolic process hydrolase activity |
|
| rat-RPTR-U57609-2_st |
|
|
|
|
|
|
|
|
|
| TC1600001580.mm.2 |
Cd86 |
CD86 antigen |
16 |
-36603868 |
NM_019388, BC013807, CD86 NM_019388, BC013807, CD86 NM_019388, BC013807, CD86 |
12524 |
335 |
toll-like receptor signaling pathway adaptive immune response immune system process immunoglobulin production negative regulation of T cell anergy signaling receptor binding protein binding plasma membrane immune response cell surface receptor signaling pathway activation of phospholipase C activity external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane CD40 signaling pathway T cell costimulation toll-like receptor 3 signaling pathway centriolar satellite positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation B cell activation negative regulation of T cell proliferation intracellular membrane-bounded organelle defense response to virus extracellular exosome cellular response to lipopolysaccharide cellular response to lipopolysaccharide positive regulation of NIK/NF-kappaB signaling activation of protein kinase C activity |
04514 04620 04672 04940 05320 05322 05323 05330 05332 05416 |
| TC1300000498.mm.2 |
Cd83 |
CD83 antigen |
13 |
43785111 |
NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 |
12522 |
58 |
external side of plasma membrane response to organic cyclic compound membrane integral component of membrane negative regulation of interleukin-4 production positive regulation of interleukin-10 production positive regulation of interleukin-2 production positive regulation of CD4-positive, alpha-beta T cell differentiation |
|
| TC0900000184.mm.2 |
Icam1 |
intercellular adhesion molecule 1 |
9 |
21015939 |
NM_010493, BC008626 NM_010493, BC008626 |
15894 |
567 |
immunological synapse T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation integrin binding integrin binding extracellular space plasma membrane integral component of plasma membrane cell adhesion cell adhesion cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion sensory perception of sound regulation of cell shape external side of plasma membrane cell surface membrane integral component of membrane positive regulation of actin filament polymerization cell adhesion mediated by integrin positive regulation of GTPase activity adhesion of symbiont to host protein-containing complex binding membrane raft positive regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity negative regulation of calcium ion transport establishment of endothelial barrier extracellular exosome positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus T cell extravasation establishment of endothelial intestinal barrier establishment of Sertoli cell barrier cell-cell adhesion regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cellular response to amyloid-beta positive regulation of leukocyte adhesion to vascular endothelial cell cellular response to leukemia inhibitory factor negative regulation of endothelial cell apoptotic process |
04514 04650 04670 05143 05144 05150 05323 05416 |
| TSUnmapped00000047.mm.2 |
Cd83 |
CD83 antigen |
13 |
43785111 |
NM_001289915 |
12522 |
58 |
external side of plasma membrane response to organic cyclic compound membrane integral component of membrane negative regulation of interleukin-4 production positive regulation of interleukin-10 production positive regulation of interleukin-2 production positive regulation of CD4-positive, alpha-beta T cell differentiation |
|
| TC1100003396.mm.2 |
Ccl5 |
chemokine (C-C motif) ligand 5 |
11 |
-83525778 |
NM_013653, BC033508 NM_013653, BC033508 |
20304 |
216 |
MAPK cascade positive regulation of defense response to virus by host monocyte chemotaxis phosphatidylinositol phospholipase C activity protein kinase activity cytokine activity protein binding extracellular region extracellular space extracellular space extracellular space cytoplasm calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response inflammatory response inflammatory response immune response leukocyte cell-cell adhesion G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling chemokine activity chemokine activity heparin binding response to toxic substance positive regulation of gene expression positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis positive regulation of T cell chemotaxis positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration phospholipase activator activity receptor signaling protein tyrosine kinase activator activity positive regulation of cell migration neutrophil chemotaxis pseudopodium assembly positive regulation of cellular biosynthetic process activation of phospholipase D activity positive regulation of fever generation lipopolysaccharide-mediated signaling pathway CCR1 chemokine receptor binding CCR1 chemokine receptor binding CCR5 chemokine receptor binding positive regulation of cell-cell adhesion mediated by integrin response to cytokine positive regulation of homotypic cell-cell adhesion response to interferon-gamma response to tumor necrosis factor T-helper 1 cell diapedesis chemoattractant activity positive regulation of T cell proliferation neutrophil activation positive regulation of phosphorylation chemokine receptor binding positive regulation of tyrosine phosphorylation of STAT protein identical protein binding protein homodimerization activity protein kinase B signaling positive regulation of GTPase activity protein self-association negative regulation by host of viral transcription negative regulation of viral genome replication positive regulation of neuron differentiation positive regulation of osteoclast differentiation negative regulation of G protein-coupled receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion chemokine receptor antagonist activity CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis lymphocyte chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation regulation of insulin secretion regulation of T cell activation positive regulation of calcium ion transport negative regulation of cell death positive regulation of mast cell chemotaxis chemokine-mediated signaling pathway chemokine-mediated signaling pathway negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of monocyte chemotaxis positive regulation of monocyte chemotaxis regulation of neuron death negative regulation of neuron death negative regulation of macrophage apoptotic process positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of T cell migration positive regulation of natural killer cell chemotaxis |
04060 04062 04620 04621 04623 05020 05142 05323 |
| TC1400000745.mm.2 |
Mmp14 |
matrix metallopeptidase 14 (membrane-inserted) |
14 |
54431597 |
NM_008608, BC076638 NM_008608, BC076638 |
17387 |
211 |
skeletal system development ossification endochondral ossification endopeptidase activity metalloendopeptidase activity metalloendopeptidase activity metalloendopeptidase activity integrin binding extracellular space nucleus cytoplasm cytosol plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding response to hormone positive regulation of myotube differentiation positive regulation of protein processing membrane integral component of membrane cell migration hydrolase activity extracellular matrix organization positive regulation of cell growth lung development positive regulation of cell migration collagen catabolic process collagen catabolic process extracellular matrix cytoplasmic vesicle zymogen activation zymogen activation zymogen activation chondrocyte proliferation macropinosome intermediate filament cytoskeleton positive regulation of B cell differentiation negative regulation of Notch signaling pathway metal ion binding embryonic cranial skeleton morphogenesis branching morphogenesis of an epithelial tube tissue remodeling negative regulation of focal adhesion assembly head development bone development metalloaminopeptidase activity craniofacial suture morphogenesis regulation of protein localization to plasma membrane positive regulation of macrophage migration |
04912 |
| TC1900001123.mm.2 |
AW112010 |
expressed sequence AW112010 |
19 |
-11047611 |
NR_102366, NM_001177351 NR_102366, NM_001177351 |
107350 |
10 |
molecular_function cellular_component biological_process |
|
| TC0300002051.mm.2 |
|
|
|
|
NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 |
|
|
G protein-coupled receptor activity plasma membrane immune response signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity hematopoietic stem cell homeostasis |
|
| TC1900000504.mm.2 |
Ifit1 |
interferon-induced protein with tetratricopeptide repeats 1 |
19 |
34640888 |
NM_008331, BC003768 NM_008331, BC003768 |
15957 |
59 |
immune system process RNA binding protein binding cytoplasm cytosol response to virus response to bacterium cellular response to interferon-alpha cellular response to interferon-beta innate immune response defense response to virus |
05160 |
| TC0300000096.mm.2 |
Car2 |
carbonic anhydrase 2 |
3 |
14886268, 14886287 |
NM_009801, BC055291 NM_009801, BC055291 |
12349 |
152 |
morphogenesis of an epithelium arylesterase activity carbonate dehydratase activity carbonate dehydratase activity carbonate dehydratase activity carbonate dehydratase activity extracellular space cytoplasm cytoplasm cytosol plasma membrane plasma membrane microvillus one-carbon metabolic process regulation of pH zinc ion binding carbon dioxide transport carbon dioxide transport carbon dioxide transport membrane basolateral plasma membrane lyase activity hydro-lyase activity axon positive regulation of synaptic transmission, GABAergic positive regulation of cellular pH reduction positive regulation of cellular pH reduction angiotensin-activated signaling pathway myelin sheath myelin sheath regulation of anion transport apical part of cell apical part of cell positive regulation of osteoclast differentiation positive regulation of bone resorption metal ion binding secretion regulation of intracellular pH regulation of intracellular pH positive regulation of dipeptide transmembrane transport regulation of chloride transport |
00910 04966 04971 04972 04976 |
| TC0900003250.mm.2 |
Csrnp1 |
cysteine-serine-rich nuclear protein 1 |
9 |
-119971162, -119971162, -119971162, -119971162 |
NM_153287, BC050066 NM_153287, BC050066 |
215418 |
24 |
DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process post-embryonic development sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis roof of mouth development face morphogenesis |
|
| TC0X00002999.mm.2 |
Armcx6 |
armadillo repeat containing, X-linked 6 |
X |
-134748454 |
NM_001007578, BC027264 NM_001007578, BC027264 |
278097 |
14 |
molecular_function mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane |
|
| TC0700002644.mm.2 |
Axl |
AXL receptor tyrosine kinase |
7 |
-25756499 |
NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 |
26362 |
152 |
nucleotide binding virus receptor activity neuron migration neuron migration natural killer cell differentiation natural killer cell differentiation phosphatidylserine binding negative regulation of cytokine production positive regulation of cytokine-mediated signaling pathway blood vessel remodeling immune system process protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding ATP binding extracellular space plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis phagocytosis phagocytosis inflammatory response enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development spermatogenesis nervous system development cell surface actin cytoskeleton membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity forebrain cell migration cell differentiation platelet activation platelet activation cellular response to extracellular stimulus myosin heavy chain binding negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of natural killer cell differentiation secretion by cell positive regulation of kinase activity erythrocyte homeostasis erythrocyte homeostasis substrate adhesion-dependent cell spreading cellular response to interferon-alpha ovulation cycle negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle receptor complex apoptotic cell clearance apoptotic cell clearance protein kinase B signaling protein kinase B signaling negative regulation of neuron apoptotic process negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding innate immune response viral entry into host cell positive regulation of pinocytosis negative regulation of lymphocyte activation positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling vagina development cellular response to hydrogen peroxide cellular response to lipopolysaccharide neutrophil clearance positive regulation of viral life cycle negative regulation of dendritic cell apoptotic process |
|
| TC0400001047.mm.2 |
Pde4b |
phosphodiesterase 4B, cAMP specific |
4 |
102589842, 102254938, 102254741, 102570059, 102587557, 102421554 |
NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 |
18578 |
65 |
gamma-tubulin complex neutrophil homeostasis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleus nucleus cytoplasm centrosome cytosol cytosol cytosol voltage-gated calcium channel complex signal transduction synaptic vesicle response to heat postsynaptic density membrane Z disc cAMP binding neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of interleukin-2 production cellular response to drug gamma-tubulin binding dendritic spine ion channel binding ion channel binding perinuclear region of cytoplasm perinuclear region of cytoplasm T cell receptor signaling pathway leukocyte migration excitatory synapse cellular response to lipopolysaccharide cellular response to epinephrine stimulus cell periphery regulation of cardiac muscle cell contraction negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process regulation of high voltage-gated calcium channel activity negative regulation of relaxation of cardiac muscle |
00230 |
| TC1600001198.mm.2 |
Socs1 |
suppressor of cytokine signaling 1 |
16 |
-10783808 |
NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 |
12703 |
310 |
regulation of cytokine production regulation of protein phosphorylation insulin-like growth factor receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol phosphatidylinositol 3-kinase complex receptor signaling pathway via JAK-STAT negative regulation of signal transduction regulation of activation of Janus kinase activity kinase inhibitor activity cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein kinase binding cytoplasmic vesicle intracellular signal transduction cytoplasmic ribonucleoprotein granule regulation of growth regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein positive regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation fat cell differentiation positive regulation of regulatory T cell differentiation regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity regulation of interferon-gamma-mediated signaling pathway cellular response to amino acid stimulus cellular response to cytokine stimulus cellular response to organic cyclic compound |
04120 04380 04630 04910 04930 05145 |
| TC1900000441.mm.2 |
Cd274 |
CD274 antigen |
19 |
29367437 |
NM_021893, BC066841, CD274 NM_021893, BC066841, CD274 NM_021893, BC066841, CD274 |
60533 |
389 |
adaptive immune response immune system process positive regulation of tolerance induction to tumor cell protein binding nucleoplasm endosome plasma membrane immune response immune response signal transduction cell surface receptor signaling pathway cell surface receptor signaling pathway external side of plasma membrane external side of plasma membrane cell surface actin cytoskeleton membrane integral component of membrane positive regulation of cell migration T cell costimulation T cell costimulation early endosome membrane negative regulation of interferon-gamma production negative regulation of interleukin-10 production positive regulation of interleukin-10 production response to cytokine positive regulation of T cell proliferation positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of activated T cell proliferation recycling endosome membrane extracellular exosome cellular response to lipopolysaccharide toxin transport negative regulation of tumor necrosis factor superfamily cytokine production positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD8-positive, alpha-beta T cell activation |
04514 |
| TC1700000864.mm.2 |
Nfkbie |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon |
17 |
45555699 |
NM_008690, BC030923 NM_008690, BC030923 |
18037 |
38 |
fibrillar center protein binding nucleoplasm cytoplasm Golgi apparatus cytosol D-serine transport negative regulation of transcription, DNA-templated perinuclear region of cytoplasm |
04660 04662 04722 04920 |
| TC1400000574.mm.2 |
Pnp |
purine-nucleoside phosphorylase |
14 |
50944302 |
NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679 |
18950 |
86 |
nucleoside binding positive regulation of T cell mediated cytotoxicity purine nucleobase binding catalytic activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity extracellular region nucleus cytoplasm cytoplasm cytosol cytosol cytoskeleton nucleobase-containing compound metabolic process inosine catabolic process inosine catabolic process inosine catabolic process deoxyinosine catabolic process adenosine catabolic process adenosine catabolic process deoxyguanosine catabolic process GTP biosynthetic process AMP catabolic process AMP catabolic process IMP catabolic process IMP catabolic process intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes nucleoside metabolic process response to gamma radiation transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups urate biosynthetic process urate biosynthetic process positive regulation of T cell proliferation positive regulation of T cell proliferation purine nucleoside metabolic process purine nucleoside metabolic process purine nucleoside metabolic process phosphate ion binding identical protein binding positive regulation of B cell differentiation positive regulation of DNA repair GMP catabolic process GMP catabolic process dGMP catabolic process dGMP catabolic process dAMP catabolic process dAMP catabolic process dGTP metabolic process guanosine catabolic process positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell differentiation negative regulation of T cell apoptotic process |
00230 00240 00760 01100 |
| TC0100003589.mm.2 |
|
|
|
|
XM_136331 |
|
|
|
|
| TC1900000502.mm.2 |
Ifit3b |
interferon-induced protein with tetratricopeptide repeats 3B |
19 |
34607956 |
NM_001005858 |
667370 |
10 |
RNA binding cytoplasm mitochondrion cytosol cytosol identical protein binding defense response to virus |
|
| TC0400002737.mm.2 |
Lpar1 |
lysophosphatidic acid receptor 1 |
4 |
-58435251, -58435251, -58435251 |
NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425 |
14745 |
150 |
activation of MAPK activity G-protein alpha-subunit binding G protein-coupled receptor activity protein binding phospholipid binding cytoplasm cytoplasm endosome plasma membrane plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activation of phospholipase C activity activation of phospholipase C activity regulation of cell shape regulation of cell shape cell surface positive regulation of cell death negative regulation of neuron projection development negative regulation of neuron projection development negative regulation of neuron projection development membrane integral component of membrane regulation of metabolic process neurogenesis endocytic vesicle PDZ domain binding bleb assembly positive regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction lysophosphatidic acid binding neuron projection neuronal cell body positive regulation of apoptotic process dendritic spine dendritic shaft positive regulation of MAPK cascade negative regulation of cAMP-mediated signaling positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of stress fiber assembly cell chemotaxis positive regulation of dendritic spine development lysophosphatidic acid receptor activity lysophosphatidic acid receptor activity lysophosphatidic acid receptor activity positive regulation of smooth muscle cell chemotaxis cellular response to 1-oleoyl-sn-glycerol 3-phosphate |
04080 04540 |
| TC0700004288.mm.2 |
Nupr1 |
nuclear protein transcription regulator 1 |
7 |
-126623245 |
NM_019738, BC002109 NM_019738, BC002109 |
56312 |
64 |
acute inflammatory response DNA binding chromatin binding transcription coactivator activity protein binding nucleus nucleus nucleoplasm cytoplasm protein acetylation negative regulation of cell population proliferation male gonad development response to toxic substance negative regulation of autophagy negative regulation of autophagy negative regulation of cardiac muscle cell apoptotic process acetyltransferase activator activity positive regulation of protein modification process protein-DNA complex skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity intercellular bridge negative regulation of cell cycle negative regulation of cell cycle negative regulation of cell cycle positive regulation of cell cycle negative regulation of glycolytic process negative regulation of fibroblast proliferation perinuclear region of cytoplasm negative regulation of epithelial cell proliferation negative regulation of programmed necrotic cell death protein-containing complex assembly positive regulation of neuroinflammatory response positive regulation of proteasomal protein catabolic process negative regulation of autophagosome assembly positive regulation of oxidative phosphorylation negative regulation of epithelial cell apoptotic process negative regulation of type B pancreatic cell proliferation regulation of response to endoplasmic reticulum stress regulation of female gonad development positive regulation of intrinsic apoptotic signaling pathway |
|
| TC1700001902.mm.2 |
Psmb9 |
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) |
17 |
-34182098 |
NM_013585, BC116364 NM_013585, BC116364 |
16912 |
91 |
proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol cytosol proteasome core complex proteasome core complex proteolysis peptidase activity response to bacterium proteasomal ubiquitin-independent protein catabolic process hydrolase activity antigen processing and presentation antigen processing and presentation proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process proteasome binding spermatoproteasome complex regulation of cysteine-type endopeptidase activity |
03050 |
| TC1400000071.mm.2 |
Flnb |
filamin, beta |
14 |
7817956 |
NM_134080 |
286940 |
65 |
stress fiber keratinocyte development epithelial cell morphogenesis actin binding protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane brush border focal adhesion skeletal muscle tissue development actin cytoskeleton organization cell differentiation identical protein binding neuron projection neuronal cell body phagocytic vesicle cellular response to interferon-gamma |
04010 04510 |
| TC0200000486.mm.2 |
Ralgds |
ral guanine nucleotide dissociation stimulator |
2 |
28533463, 28513166 |
NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 |
19730 |
32 |
guanyl-nucleotide exchange factor activity protein binding intracellular anatomical structure nucleus cytoplasm cytosol brush border signal transduction small GTPase mediated signal transduction GTPase regulator activity |
05200 05210 05212 |
| TC1900000501.mm.2 |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
19 |
34583528 |
NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563 |
15959 |
31 |
immune system process RNA binding protein binding cytoplasm mitochondrion cytosol cytosol response to bacterium cellular response to interferon-alpha cellular response to interferon-beta response to stilbenoid identical protein binding innate immune response defense response to virus |
|
| TC0400004171.mm.2 |
Isg15 |
ISG15 ubiquitin-like modifier |
4 |
-156199423 |
NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 |
100038882 |
94 |
integrin binding protein binding extracellular region nucleus cytoplasm integrin-mediated signaling pathway response to bacterium modification-dependent protein catabolic process modification-dependent protein catabolic process cytosolic small ribosomal subunit positive regulation of bone mineralization protein tag protein tag negative regulation of protein ubiquitination ubiquitin protein ligase binding ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation interferon-gamma production interleukin-10 production regulation of interferon-gamma production response to type I interferon defense response to bacterium defense response to bacterium negative regulation of viral genome replication positive regulation of erythrocyte differentiation defense response to virus defense response to virus |
04622 |
| TC0300001109.mm.2 |
Kcna3 |
potassium voltage-gated channel, shaker-related subfamily, member 3 |
3 |
107036161 |
NM_008418, BC132349, BC137667 NM_008418, BC132349, BC137667 NM_008418, BC132349, BC137667 |
16491 |
82 |
ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity delayed rectifier potassium channel activity potassium channel activity plasma membrane integral component of plasma membrane ion transport potassium ion transport voltage-gated potassium channel complex outward rectifier potassium channel activity membrane integral component of membrane axon axon regulation of ion transmembrane transport calyx of Held membrane raft protein homooligomerization transmembrane transport potassium ion transmembrane transport potassium ion transmembrane transport glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane |
|
| TC1100001236.mm.2 |
Slfn5 |
schlafen 5 |
11 |
82952101 |
NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910 |
327978 |
19 |
nucleotide binding ATP binding nucleus cell differentiation |
|
| TC0500000466.mm.2 |
Bst1 |
bone marrow stromal cell antigen 1 |
5 |
43818892 |
NM_009763 |
12182 |
37 |
uropod regulation of cell-matrix adhesion NAD+ nucleosidase activity plasma membrane positive regulation of cell population proliferation membrane transferase activity hydrolase activity phosphorus-oxygen lyase activity extrinsic component of membrane positive regulation of B cell proliferation anchored component of membrane regulation of actin cytoskeleton organization NAD(P)+ nucleosidase activity regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling NAD+ nucleotidase, cyclic ADP-ribose generating ADP-ribosyl cyclase activity cyclic ADP-ribose hydrolase regulation of neutrophil chemotaxis |
00760 01100 04020 04970 04972 |
| TC1100004150.mm.2 |
Socs3 |
suppressor of cytokine signaling 3 |
11 |
-117966086 |
NM_007707, BC052031 NM_007707, BC052031 |
12702 |
427 |
phosphotyrosine residue binding regulation of protein phosphorylation protein binding cytoplasm cytosol phosphatidylinositol 3-kinase complex signal transduction receptor signaling pathway via JAK-STAT negative regulation of signal transduction intracellular signal transduction regulation of growth negative regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process regulation of cell differentiation regulation of cell differentiation positive regulation of cell differentiation positive regulation of cell differentiation negative regulation of receptor signaling pathway via JAK-STAT negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity negative regulation of inflammatory response branching involved in labyrinthine layer morphogenesis placenta blood vessel development trophoblast giant cell differentiation trophoblast giant cell differentiation spongiotrophoblast differentiation spongiotrophoblast differentiation cellular response to leukemia inhibitory factor |
04120 04380 04630 04910 04920 04930 05160 |
| TC1600001092.mm.2 |
Mx2 |
MX dynamin-like GTPase 2 |
16 |
97536080, 97536082 |
NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127 |
17858 |
25 |
mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission GTPase activity nucleus cytoplasm plasma membrane microtubule binding postsynaptic density microtubule cytoskeleton membrane synaptic vesicle budding from presynaptic endocytic zone membrane axon cytoplasmic vesicle receptor internalization mitochondrial membrane dendritic spine head regulation of synapse structure or activity membrane fusion postsynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization |
|
| TC1900000500.mm.2 |
Ifit2 |
interferon-induced protein with tetratricopeptide repeats 2 |
19 |
34551087, 34550693 |
NM_008332, BC050835 NM_008332, BC050835 |
15958 |
39 |
immune system process RNA binding cytoplasm endoplasmic reticulum cytosol apoptotic process response to virus response to virus negative regulation of protein binding cellular response to interferon-alpha positive regulation of apoptotic process innate immune response defense response to virus |
|
| TC0300002802.mm.2 |
Vcam1 |
vascular cell adhesion molecule 1 |
3 |
-116110019 |
NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823 |
22329 |
334 |
podosome integrin binding integrin binding extracellular space early endosome endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane microvillus cell adhesion cell adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion heart development primary amine oxidase activity amine metabolic process external side of plasma membrane cell surface membrane integral component of membrane viral process filopodium anchored component of membrane heterotypic cell-cell adhesion calcium-mediated signaling using intracellular calcium source positive regulation of T cell proliferation sarcolemma apical part of cell cell adhesion molecule binding leukocyte tethering or rolling cell chemotaxis innervation embryonic placenta morphogenesis chorio-allantoic fusion cardiac neuron differentiation visceral serous pericardium development alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex cellular response to glucose stimulus cell periphery cell-cell adhesion cell-cell adhesion in response to extracellular stimulus cellular response to amyloid-beta |
04514 04670 05143 05144 |
| TC0900001339.mm.2 |
Tlr9 |
toll-like receptor 9 |
9 |
106222597 |
NM_031178, BC172644 NM_031178, BC172644 |
81897 |
855 |
microglial cell activation regulation of cytokine production positive regulation of cytokine production regulation of protein phosphorylation activation of innate immune response toll-like receptor signaling pathway toll-like receptor signaling pathway response to molecule of bacterial origin immune system process positive regulation of immunoglobulin production regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity interleukin-1 receptor binding protein binding cytoplasm lysosome endosome endoplasmic reticulum plasma membrane plasma membrane plasma membrane plasma membrane inflammatory response immune response immune response signal transduction I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation response to virus positive regulation of autophagy positive regulation of gene expression membrane integral component of membrane basolateral plasma membrane apical plasma membrane maintenance of gastrointestinal epithelium positive regulation of B cell proliferation cytoplasmic vesicle early phagosome negative regulation of NF-kappaB transcription factor activity tumor necrosis factor production tumor necrosis factor production negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 9 signaling pathway siRNA binding endolysosome endolysosome endolysosome pattern recognition receptor activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of JUN kinase activity innate immune response unmethylated CpG binding phagocytic vesicle regulation of B cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus defense response to virus positive regulation of nitric-oxide synthase biosynthetic process positive regulation of NIK/NF-kappaB signaling negative regulation of ATPase-coupled calcium transmembrane transporter activity cellular response to chloroquine |
04620 05142 05143 05144 |
| TC1900000105.mm.2 |
Majin |
membrane anchored junction protein |
19 |
6184344 |
NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092 |
622554 |
13 |
chromosome, telomeric region molecular_function DNA binding nucleus integral component of nuclear inner membrane integral component of nuclear inner membrane chromosome homologous chromosome pairing at meiosis homologous chromosome pairing at meiosis membrane integral component of membrane meiotic telomere clustering meiotic cell cycle meiotic attachment of telomere to nuclear envelope meiotic attachment of telomere to nuclear envelope |
|
| TC0900003125.mm.2 |
Ccrl2 |
chemokine (C-C motif) receptor-like 2 |
9 |
-111054833, -111054833, -111054833 |
NM_017466, BC038631 NM_017466, BC038631 |
54199 |
35 |
G protein-coupled receptor activity chemokine receptor activity cytoplasm plasma membrane integral component of plasma membrane chemotaxis inflammatory response inflammatory response immune response signal transduction G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity C-C chemokine receptor activity calcium-mediated signaling C-C chemokine binding chemokine receptor binding chemokine receptor binding CCR chemokine receptor binding cell chemotaxis |
|
| TC1800001181.mm.2 |
Sting1 |
stimulator of interferon response cGAMP interactor 1 |
18 |
-35733677 |
NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 |
72512 |
348 |
autophagosome assembly autophagosome assembly autophagosome assembly nucleotide binding activation of innate immune response activation of innate immune response activation of innate immune response positive regulation of defense response to virus by host immune system process protein binding nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane endosome autophagosome autophagosome autophagosome peroxisome endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane autophagy transcription factor binding regulation of gene expression membrane integral component of membrane positive regulation of macroautophagy positive regulation of macroautophagy positive regulation of macroautophagy protein kinase binding integral component of endoplasmic reticulum membrane regulation of cellular metabolic process cytoplasmic vesicle ubiquitin protein ligase binding positive regulation of protein binding positive regulation of type I interferon production positive regulation of type I interferon production positive regulation of type I interferon production interferon-beta production interferon-beta production cyclic-di-GMP binding cyclic-di-GMP binding cyclic-di-GMP binding cellular response to interferon-beta identical protein binding protein homodimerization activity innate immune response innate immune response innate immune response positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II perinuclear region of cytoplasm regulation of inflammatory response positive regulation of DNA-binding transcription factor activity protein complex oligomerization defense response to virus defense response to virus defense response to virus cyclic-GMP-AMP binding cyclic-GMP-AMP binding cyclic-GMP-AMP binding reticulophagy reticulophagy cellular response to exogenous dsRNA cellular response to organic cyclic compound cellular response to organic cyclic compound integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane |
04622 04623 |
| TC0100001632.mm.2 |
Ifi209 |
interferon activated gene 209 |
1 |
173630858 |
NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 |
236312 |
17 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta cellular response to interferon-beta identical protein binding |
|
| TC1100004265.mm.2 |
Igtp |
interferon gamma induced GTPase |
11 |
58199555 |
NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607 |
16145 |
50 |
GTPase activity GTPase activity endoplasmic reticulum membrane cytosol defense response cellular response to interferon-beta cellular response to interferon-beta |
05145 |
| TC0600002663.mm.2 |
Rab43 |
RAB43, member RAS oncogene family |
6 |
-87788852, -87788852, -87788852, -87788852 |
NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 |
69834 |
23 |
autophagosome assembly nucleotide binding GTPase activity GTPase activity GTP binding Golgi apparatus intracellular protein transport Golgi organization endomembrane system membrane virion assembly cytoplasmic vesicle retrograde transport, plasma membrane to Golgi phagocytic vesicle phagocytic vesicle cellular response to interferon-gamma phagosome maturation toxin transport |
|
| TC0600002641.mm.2 |
Mxd1 |
MAX dimerization protein 1 |
6 |
-86647044 |
NM_010751, BC034860 NM_010751, BC034860 |
17119 |
48 |
negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding protein binding nucleus nucleoplasm mitochondrion cytosol regulation of transcription by RNA polymerase II protein dimerization activity |
|
| TC0300001110.mm.2 |
AI504432 |
expressed sequence AI504432 |
3 |
107039503 |
NR_033498 |
229694 |
11 |
|
|
| TC1700002780.mm.2 |
H2-DMb1 |
histocompatibility 2, class II, locus Mb1 |
17 |
34153190 |
NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718 |
14999 |
23 |
adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II lysosome lysosomal membrane endosome immune response membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle chaperone cofactor-dependent protein refolding |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1100000119.mm.2 |
Upp1 |
uridine phosphorylase 1 |
11 |
9118007, 9118102, 9118506 |
NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 |
22271 |
43 |
catalytic activity uridine phosphorylase activity uridine phosphorylase activity nucleoplasm cytoplasm cytosol uridine catabolic process uridine catabolic process pyrimidine nucleotide metabolic process CMP catabolic process dCMP catabolic process dCMP catabolic process thymidine phosphorylase activity nucleoside metabolic process nucleotide catabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups identical protein binding UMP catabolic process dTMP catabolic process dUMP catabolic process uridine metabolic process deoxyuridine phosphorylase activity |
00240 00983 01100 |
| TC1600001556.mm.2 |
Parp14 |
poly (ADP-ribose) polymerase family, member 14 |
16 |
-35832877 |
NM_001039530, BC138874 NM_001039530, BC138874 |
547253 |
32 |
immune system process transcription corepressor activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity protein binding nucleus cytoplasm cytoplasm cytoplasm cytosol plasma membrane protein ADP-ribosylation negative regulation of gene expression negative regulation of gene expression transferase activity transferase activity, transferring glycosyl groups enzyme binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein innate immune response negative regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway protein poly-ADP-ribosylation protein poly-ADP-ribosylation NAD+ binding protein mono-ADP-ribosylation protein mono-ADP-ribosylation positive regulation of interleukin-4-mediated signaling pathway positive regulation of interleukin-4-mediated signaling pathway protein ADP-ribosylase activity protein ADP-ribosylase activity |
|
| TC0200003689.mm.2 |
Stk39 |
serine/threonine kinase 39 |
2 |
-68210446 |
NM_016866, BC051964, BC064443 NM_016866, BC051964, BC064443 NM_016866, BC051964, BC064443 |
53416 |
90 |
nucleotide binding activation of MAPK activity activation of MAPK activity negative regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleoplasm cytoplasm cytosol cytosol cytoskeleton protein phosphorylation protein phosphorylation signal transduction regulation of blood pressure positive regulation of T cell chemotaxis membrane kinase activity kinase activity phosphorylation basolateral plasma membrane apical plasma membrane transferase activity peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation extrinsic component of membrane protein kinase binding positive regulation of ion transmembrane transporter activity intracellular signal transduction intracellular signal transduction maintenance of lens transparency chemokine (C-X-C motif) ligand 12 signaling pathway intracellular membrane-bounded organelle positive regulation of potassium ion transport protein autophosphorylation protein autophosphorylation protein autophosphorylation regulation of inflammatory response ion homeostasis cellular hypotonic response negative regulation of pancreatic juice secretion negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transport negative regulation of creatine transmembrane transporter activity cellular response to chemokine negative regulation of sodium ion transmembrane transporter activity |
|
| TC0500002840.mm.2 |
Plac8 |
placenta-specific 8 |
5 |
-100553725, -100553725 |
NM_139198, BC010789 NM_139198, BC010789 |
231507 |
35 |
chromatin binding protein binding nucleus positive regulation of cell population proliferation response to cold negative regulation of multicellular organism growth defense response to bacterium negative regulation of apoptotic process negative regulation of apoptotic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II brown fat cell differentiation positive regulation of cold-induced thermogenesis |
|
| TC0600002323.mm.2 |
Nod1 |
nucleotide-binding oligomerization domain containing 1 |
6 |
-54923941, -54923941 |
NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670 |
107607 |
170 |
nucleotide binding pattern recognition receptor signaling pathway immune system process positive regulation of dendritic cell antigen processing and presentation protein binding ATP binding cytoplasm cytosol plasma membrane apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response positive regulation of cell death membrane detection of bacterium basolateral plasma membrane positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade intracellular signal transduction intracellular signal transduction pattern recognition receptor activity defense response to bacterium identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein-containing complex binding innate immune response phagocytic vesicle positive regulation of JNK cascade anchored component of plasma membrane CARD domain binding defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade cellular response to muramyl dipeptide positive regulation of NIK/NF-kappaB signaling positive regulation of xenophagy |
04621 |
| TC0500003243.mm.2 |
Hcar2 |
hydroxycarboxylic acid receptor 2 |
5 |
-123863569 |
NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296 |
80885 |
66 |
purinergic nucleotide receptor activity neutrophil apoptotic process G protein-coupled receptor activity GTP binding plasma membrane apoptotic process signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway membrane integral component of membrane cell junction positive regulation of neutrophil apoptotic process negative regulation of lipid catabolic process positive regulation of adiponectin secretion nicotinic acid receptor activity |
|
| TC0800000482.mm.2 |
Slc7a2 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
8 |
40862366 |
NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082 |
11988 |
62 |
L-ornithine transmembrane transporter activity L-ornithine transmembrane transporter activity nitric oxide production involved in inflammatory response high-affinity arginine transmembrane transporter activity high-affinity lysine transmembrane transporter activity plasma membrane plasma membrane nitric oxide biosynthetic process amino acid transport amino acid transmembrane transporter activity amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity arginine transmembrane transporter activity arginine transmembrane transporter activity arginine transmembrane transporter activity L-lysine transmembrane transporter activity L-lysine transmembrane transporter activity L-amino acid transport arginine transport membrane integral component of membrane transmembrane transporter activity cell junction macrophage activation regulation of macrophage activation regulation of inflammatory response transmembrane transport L-arginine transmembrane transporter activity L-arginine transmembrane transporter activity amino acid import across plasma membrane low-affinity L-arginine transmembrane transporter activity high-affinity L-ornithine transmembrane transporter activity L-arginine import across plasma membrane L-arginine import across plasma membrane L-arginine import across plasma membrane L-lysine import across plasma membrane L-ornithine import across plasma membrane L-arginine transport L-alpha-amino acid transmembrane transport L-ornithine transmembrane transport L-ornithine transmembrane transport |
|
| TC0600000459.mm.2 |
Zyx |
zyxin |
6 |
42349827, 42349827 |
NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 |
22793 |
63 |
stress fiber stress fiber protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane adherens junction focal adhesion focal adhesion focal adhesion cell adhesion cell-matrix adhesion signal transduction transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway actin cytoskeleton cell junction stress fiber assembly phagocytic vesicle metal ion binding cellular response to interferon-gamma |
04510 |
| TC0300001232.mm.2 |
Cnn3 |
calponin 3, acidic |
3 |
121426540 |
NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268 |
71994 |
43 |
actin binding protein binding calmodulin binding cytosol microtubule binding postsynaptic density actin cytoskeleton dendrite actomyosin structure organization negative regulation of ATPase activity neuronal cell body dendritic spine |
|
| TC0500000468.mm.2 |
Cd38 |
CD38 antigen |
5 |
43868808 |
NM_007646, BC046312, CD38 NM_007646, BC046312, CD38 NM_007646, BC046312, CD38 |
12494 |
193 |
response to hypoxia NAD+ nucleosidase activity NAD+ nucleosidase activity nucleus plasma membrane plasma membrane positive regulation of cytosolic calcium ion concentration positive regulation of cell population proliferation response to hormone cell surface negative regulation of neuron projection development artery smooth muscle contraction membrane integral component of membrane basolateral plasma membrane transferase activity hydrolase activity hydrolase activity, acting on glycosyl bonds phosphorus-oxygen lyase activity phosphorus-oxygen lyase activity positive regulation of cell growth secretory granule membrane positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of insulin secretion response to hydroperoxide response to drug identical protein binding negative regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of bone resorption negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasoconstriction NAD(P)+ nucleosidase activity B cell receptor signaling pathway long-term synaptic depression NAD+ nucleotidase, cyclic ADP-ribose generating |
00760 01100 04020 04640 04970 04972 |
| TC0500003730.mm.2 |
Gbp9 |
guanylate-binding protein 9 |
5 |
-105076465 |
NM_172777, BC057170 NM_172777, BC057170 |
236573 |
13 |
GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC0500000283.mm.2 |
Il6 |
interleukin 6 |
5 |
30013113 |
NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766 |
16193 |
2037 |
neutrophil apoptotic process neutrophil apoptotic process neutrophil apoptotic process myeloid cell homeostasis germinal center B cell differentiation immunoglobulin production hepatic immune response positive regulation of immunoglobulin production positive regulation of acute inflammatory response signaling receptor binding cytokine activity cytokine activity interleukin-6 receptor binding interleukin-6 receptor binding protein binding extracellular region extracellular space extracellular space cytoplasm interleukin-6 receptor complex interleukin-6 receptor complex negative regulation of protein kinase activity acute-phase response inflammatory response immune response growth factor activity positive regulation of cell population proliferation negative regulation of cell population proliferation regulation of cell shape response to wounding external side of plasma membrane gene expression vascular endothelial growth factor production regulation of vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of neuron projection development positive regulation of gliogenesis response to activity cytokine-mediated signaling pathway endocrine pancreas development neuron projection development interleukin-21 production negative regulation of chemokine production negative regulation of chemokine production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation cellular response to hepatocyte growth factor stimulus positive regulation of T cell proliferation T cell activation regulation of cell population proliferation positive regulation of protein import into nucleus positive regulation of tyrosine phosphorylation of STAT protein glucose homeostasis glucose homeostasis glucose homeostasis defense response to protozoan regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of nitric oxide biosynthetic process cell redox homeostasis positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of gluconeogenesis positive regulation of translation positive regulation of DNA replication negative regulation of bone resorption negative regulation of bone resorption negative regulation of membrane potential positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of receptor signaling pathway via JAK-STAT muscle cell cellular homeostasis negative regulation of hormone secretion negative regulation of muscle organ development positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of insulin secretion regulation of insulin secretion positive regulation of B cell activation positive regulation of DNA-binding transcription factor activity response to glucocorticoid defense response to virus positive regulation of protein kinase B signaling positive regulation of transmission of nerve impulse positive regulation of glial cell proliferation branching involved in salivary gland morphogenesis branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis T follicular helper cell differentiation glucagon secretion regulation of glucagon secretion regulation of glucagon secretion interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of cell proliferation in bone marrow T-helper 17 cell lineage commitment T-helper 17 cell lineage commitment hepatocyte proliferation positive regulation of extracellular matrix disassembly liver regeneration cellular response to virus positive regulation of cytokine production involved in inflammatory response negative regulation of neuron death positive regulation of apoptotic DNA fragmentation positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of T-helper 2 cell cytokine production negative regulation of primary miRNA processing negative regulation of interleukin-1-mediated signaling pathway |
04060 04620 04621 04623 04630 04640 04672 05020 05142 05143 05144 05146 05200 05323 05332 05410 |
| TC1700000684.mm.2 |
H2-Q4 |
histocompatibility 2, Q region locus 4 |
17 |
35379616 |
NM_001143689, BC010602 NM_001143689, BC010602 |
15015 |
32 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site |
|
| TC1800000609.mm.2 |
F830016B08Rik |
RIKEN cDNA F830016B08 gene |
18 |
60293379 |
NM_001101475 |
240328 |
9 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta |
|
| TC0500003176.mm.2 |
Oas3 |
2'-5' oligoadenylate synthetase 3 |
5 |
-120753097 |
NM_145226, BC141055 NM_145226, BC141055 |
246727 |
19 |
nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol plasma membrane immune response response to virus membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus defense response to virus regulation of ribonuclease activity regulation of ribonuclease activity |
05160 |
| TC0200000933.mm.2 |
Gca |
grancalcin |
2 |
62664326 |
NM_145523, BC021450 NM_145523, BC021450 |
227960 |
17 |
calcium ion binding cytoplasm cytosol cytosol plasma membrane membrane protein homodimerization activity metal ion binding protein heterodimerization activity |
|
| TC0100000039.mm.2 |
Adhfe1 |
alcohol dehydrogenase, iron containing, 1 |
1 |
9547947 |
NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584 |
76187 |
17 |
alcohol dehydrogenase (NAD+) activity mitochondrion mitochondrion glutamate catabolic process via 2-oxoglutarate oxidoreductase activity metal ion binding hydroxyacid-oxoacid transhydrogenase activity |
|
| TC0700002034.mm.2 |
Ifitm1 |
interferon induced transmembrane protein 1 |
7 |
140967428, 140968075, 140968027 |
NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 |
68713 |
35 |
ossification somitogenesis immune system process molecular_function early endosome plasma membrane response to virus anterior/posterior pattern specification membrane integral component of membrane protein-containing complex response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response negative regulation of viral entry into host cell negative regulation of viral entry into host cell defense response to virus defense response to virus type I interferon signaling pathway |
04662 |
| TC1000002794.mm.2 |
Tmtc2 |
transmembrane and tetratricopeptide repeat containing 2 |
10 |
-105187663 |
NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 |
278279 |
12 |
mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane transferase activity protein O-linked mannosylation calcium ion homeostasis |
|
| TC1700001952.mm.2 |
Aif1 |
allograft inflammatory factor 1 |
17 |
-35170985 |
NM_019467, BC021539 NM_019467, BC021539 |
11629 |
177 |
ruffle microglial cell activation phagocytic cup positive regulation of protein phosphorylation actin binding calcium ion binding calcium ion binding protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytoskeleton actin filament actin filament actin filament plasma membrane phagocytosis, engulfment positive regulation of cell population proliferation negative regulation of gene expression positive regulation of muscle hyperplasia membrane Rac protein signal transduction lamellipodium lamellipodium actin filament polymerization parallel actin filament bundle assembly positive regulation of cell migration ruffle membrane ruffle membrane ruffle membrane positive regulation of chemokine production positive regulation of interleukin-6 production cellular response to oxidative stress positive regulation of T cell proliferation cell projection negative regulation of apoptotic process perikaryon positive regulation of nitric oxide biosynthetic process metal ion binding perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation positive regulation of chemotaxis actin filament binding actin filament binding actin filament binding actin filament bundle assembly actin filament bundle assembly actin filament bundle assembly actin crosslink formation negative regulation of smooth muscle cell chemotaxis positive regulation of smooth muscle cell chemotaxis positive regulation of mononuclear cell migration positive regulation of monocyte chemotaxis positive regulation of fibroblast growth factor production ruffle assembly ruffle assembly ruffle assembly positive regulation of G1/S transition of mitotic cell cycle positive regulation of T cell migration |
|
| TC1700002823.mm.2 |
H2-T10 |
histocompatibility 2, T region locus 10 |
17 |
-36115875, -36115870 |
NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 |
15024 |
23 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC0600003084.mm.2 |
Clec4e |
C-type lectin domain family 4, member e |
6 |
-123281788 |
NM_019948, BC003218 NM_019948, BC003218 |
56619 |
84 |
positive regulation of cytokine production pattern recognition receptor signaling pathway T cell differentiation involved in immune response immune system process calcium ion binding protein binding immune response membrane integral component of membrane carbohydrate binding signaling receptor activity Fc-gamma receptor signaling pathway pattern recognition receptor activity defense response to bacterium innate immune response metal ion binding |
|
| TC0200004602.mm.2 |
Il1b |
interleukin 1 beta |
2 |
-129364577 |
NM_008361, BC011437 NM_008361, BC011437 |
16176 |
1139 |
negative regulation of transcription by RNA polymerase II MAPK cascade activation of MAPK activity fever generation positive regulation of protein phosphorylation cytokine activity cytokine activity interleukin-1 receptor binding integrin binding extracellular region extracellular space extracellular space extracellular space cytoplasm lysosome inflammatory response inflammatory response immune response positive regulation of cytosolic calcium ion concentration memory positive regulation of cell population proliferation negative regulation of cell population proliferation response to carbohydrate vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of glucose transmembrane transport positive regulation of cell death negative regulation of glutamate secretion cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein domain specific binding secretory granule hyaluronan biosynthetic process positive regulation of cell migration neutrophil chemotaxis sequestering of triglyceride positive regulation of prostaglandin biosynthetic process cytoplasmic vesicle positive regulation of fever generation lipopolysaccharide-mediated signaling pathway vesicle positive regulation of prostaglandin secretion response to lipopolysaccharide response to lipopolysaccharide response to lipopolysaccharide interleukin-1 beta production interleukin-6 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of stress-activated MAPK cascade positive regulation of immature T cell proliferation in thymus positive regulation of immature T cell proliferation in thymus response to ATP response to ATP positive regulation of heterotypic cell-cell adhesion social behavior ectopic germ cell programmed cell death positive regulation of myosin light chain kinase activity cellular response to drug positive regulation of T cell proliferation positive regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of angiogenesis positive regulation of angiogenesis negative regulation of lipid metabolic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of complement activation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of JNK cascade positive regulation of JNK cascade negative regulation of insulin receptor signaling pathway astrocyte activation positive regulation of astrocyte differentiation regulation of defense response to virus by host positive regulation of inflammatory response positive regulation of phagocytosis regulation of neurogenesis negative regulation of neurogenesis regulation of insulin secretion negative regulation of synaptic transmission leukocyte migration negative regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of nitric-oxide synthase activity regulation of nitric-oxide synthase activity regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of cell division positive regulation of glial cell proliferation positive regulation of calcidiol 1-monooxygenase activity negative regulation of adiponectin secretion regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade monocyte aggregation interleukin-1-mediated signaling pathway response to interleukin-1 cellular response to lipopolysaccharide cellular response to organic substance cellular response to organic cyclic compound positive regulation of monocyte chemotactic protein-1 production positive regulation of neutrophil chemotaxis extrinsic apoptotic signaling pathway in absence of ligand positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling positive regulation of RNA biosynthetic process regulation of establishment of endothelial barrier negative regulation of gap junction assembly negative regulation of branching morphogenesis of a nerve negative regulation of neural precursor cell proliferation positive regulation of T-helper 1 cell cytokine production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
04010 04060 04210 04380 04620 04621 04623 04640 04940 05010 05020 05140 05142 05143 05144 05146 05323 05332 |
| TC0200001866.mm.2 |
Sema6d |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D |
2 |
124089968, 124610295, 124653580 |
NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 NM_172537, NM_199238, NM_199239, NM_199240, NM_199241, BC060680 |
214968 |
53 |
neural crest cell migration protein binding extracellular space cytoplasm Golgi apparatus plasma membrane integral component of plasma membrane multicellular organism development nervous system development axon guidance cell surface positive regulation of smooth muscle cell migration negative regulation of smooth muscle cell migration membrane integral component of membrane ventricular system development ventricular system development cell differentiation semaphorin receptor binding semaphorin receptor binding positive regulation of cell migration negative regulation of axon extension chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis collagen-containing extracellular matrix semaphorin-plexin signaling pathway |
04360 |
| TC1100000496.mm.2 |
|
|
|
|
NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 |
|
|
GTPase activity G protein-coupled receptor activity olfactory receptor activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane defense response defense response signal transduction G protein-coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane cellular response to interferon-beta response to stimulus |
|
| TC0800000115.mm.2 |
F10 |
coagulation factor X |
8 |
13037307 |
NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 |
14058 |
49 |
serine-type endopeptidase activity calcium ion binding phospholipid binding extracellular region extracellular space endoplasmic reticulum proteolysis blood coagulation blood coagulation hemostasis peptidase activity serine-type peptidase activity membrane hydrolase activity intracellular membrane-bounded organelle positive regulation of protein kinase B signaling |
04610 |
| TC0800001078.mm.2 |
Lpcat2 |
lysophosphatidylcholine acyltransferase 2 |
8 |
92855332 |
NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 |
270084 |
21 |
1-acylglycerol-3-phosphate O-acyltransferase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Golgi stack lipid droplet plasma membrane lipid metabolic process platelet activating factor biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups phosphatidylcholine acyl-chain remodeling metal ion binding 1-acylglycerophosphocholine O-acyltransferase activity 1-acylglycerophosphocholine O-acyltransferase activity 1-alkylglycerophosphocholine O-acetyltransferase activity plasmalogen synthase activity membrane organization |
00564 00565 01100 |
| TC1900001422.mm.2 |
Ifit1bl1 |
interferon induced protein with tetratricpeptide repeats 1B like 1 |
19 |
-34592887, -34592887 |
NM_001101605, NM_001110517 NM_001101605, NM_001110517 |
667373 |
13 |
RNA binding RNA binding cytoplasm cytosol cytosol defense response to virus |
05160 |
| TC1700000621.mm.2 |
Tap1 |
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
17 |
34187555 |
NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 |
21354 |
256 |
nucleotide binding adaptive immune response immune system process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ATP binding mitochondrion endoplasmic reticulum defense response protein transport ABC-type peptide antigen transporter activity ABC-type peptide antigen transporter activity ABC-type peptide antigen transporter activity ABC-type peptide transporter activity peptide transport peptide transport membrane integral component of membrane integral component of membrane ATPase activity antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I MHC class Ib protein binding integral component of endoplasmic reticulum membrane phagocytic vesicle membrane centriolar satellite protection from natural killer cell mediated cytotoxicity MHC protein binding MHC class I protein binding MHC class I protein binding peptide antigen binding ATPase-coupled transmembrane transporter activity protein homodimerization activity MHC class I peptide loading complex MHC class I peptide loading complex TAP complex intracellular membrane-bounded organelle ADP binding protein-containing complex binding cytosol to endoplasmic reticulum transport TAP1 binding TAP1 binding TAP2 binding tapasin binding transmembrane transport peptide transmembrane transporter activity |
02010 04145 04612 05340 |
| TC0700000693.mm.2 |
1600014C10Rik |
RIKEN cDNA 1600014C10 gene |
7 |
38183786, 38183216 |
NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 |
72244 |
15 |
molecular_function cytoplasm mitochondrion endoplasmic reticulum cytosol autophagy apoptotic process response to oxidative stress membrane integral component of membrane mitochondrial membrane mitochondrial calcium ion homeostasis |
|
| TC1300000691.mm.2 |
Tgfbi |
transforming growth factor, beta induced |
13 |
56609585 |
NM_009369, BC129900, BC129901 NM_009369, BC129900, BC129901 NM_009369, BC129900, BC129901 |
21810 |
77 |
integrin binding extracellular matrix structural constituent collagen binding extracellular region basement membrane extracellular space extracellular space extracellular space extracellular space trans-Golgi network cell adhesion cell adhesion cell population proliferation extracellular matrix organization extracellular matrix organization extracellular matrix extracellular matrix identical protein binding cell adhesion molecule binding extracellular matrix binding collagen-containing extracellular matrix |
|
| TC0800001110.mm.2 |
|
|
|
|
NM_001033207, NR_106040 NM_001033207, NR_106040 |
|
|
nucleotide binding RNA polymerase II cis-regulatory region sequence-specific DNA binding immune system process ATP binding nucleus nucleus nucleus cytoplasm centrosome cytosol cytosol response to bacterium negative regulation of NF-kappaB transcription factor activity negative regulation of NF-kappaB transcription factor activity intracellular signal transduction regulation of kinase activity innate immune response innate immune response positive regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway |
|
| TC1000001596.mm.2 |
Stat2 |
signal transducer and activator of transcription 2 |
10 |
128270497 |
NM_019963, BC167243 NM_019963, BC167243 |
20847 |
120 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific regulation of protein phosphorylation DNA binding DNA-binding transcription factor activity protein binding nucleus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II defense response signal transduction receptor signaling pathway via JAK-STAT cytokine-mediated signaling pathway regulation of cell population proliferation identical protein binding response to peptide hormone ubiquitin-like protein ligase binding defense response to virus type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway regulation of mitochondrial fission |
04062 04380 04630 05160 |
| TC0500001239.mm.2 |
Oasl2 |
2'-5' oligoadenylate synthetase-like 2 |
5 |
114896933 |
NM_011854, BC034361 NM_011854, BC034361 |
23962 |
21 |
nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytosol purine nucleotide biosynthetic process immune response response to virus membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding defense response to virus regulation of ribonuclease activity |
|
| TC0200002223.mm.2 |
Cst7 |
cystatin F (leukocystatin) |
2 |
150570414 |
NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049 |
13011 |
25 |
cysteine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular region extracellular space extracellular space extracellular space cytoplasm lysosome lysosome lysosome endosome late endosome late endosome multivesicular body endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus Golgi apparatus negative regulation of peptidase activity negative regulation of peptidase activity peptidase inhibitor activity peptidase inhibitor activity cytoplasmic vesicle cytoplasmic vesicle positive regulation of myelination positive regulation of myelination protein homodimerization activity inhibition of cysteine-type endopeptidase activity inhibition of cysteine-type endopeptidase activity negative regulation of microglial cell activation negative regulation of microglial cell activation |
|
| TC0100000375.mm.2 |
Stat1 |
signal transducer and activator of transcription 1 |
1 |
52119437, 52119621 |
NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 |
20846 |
857 |
chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific negative regulation of endothelial cell proliferation positive regulation of defense response to virus by host DNA binding double-stranded DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity tumor necrosis factor receptor binding protein binding nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cytosol transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II activation of cysteine-type endopeptidase activity involved in apoptotic process defense response signal transduction receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT response to nutrient blood circulation positive regulation of cell population proliferation response to mechanical stimulus response to bacterium macrophage derived foam cell differentiation negative regulation of angiogenesis cytokine-mediated signaling pathway cytokine-mediated signaling pathway enzyme binding axon dendrite lipopolysaccharide-mediated signaling pathway CCR5 chemokine receptor binding response to lipopolysaccharide positive regulation of interferon-alpha production cellular response to insulin stimulus protein-containing complex tumor necrosis factor-mediated signaling pathway response to cytokine negative regulation of macrophage fusion response to type I interferon histone acetyltransferase binding nuclear hormone receptor binding response to interferon-beta cellular response to interferon-beta regulation of cell population proliferation histone binding response to drug identical protein binding protein homodimerization activity negative regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to peptide hormone response to peptide hormone sequence-specific DNA binding ubiquitin-like protein ligase binding positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation by virus of viral protein levels in host cell perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation response to cAMP defense response to virus protein phosphatase 2A binding positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway renal tubule development repressing transcription factor binding cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interferon-gamma cellular response to organic cyclic compound promoter-specific chromatin binding |
04062 04380 04620 04630 05140 05145 05160 05200 05212 |
| TC0700002499.mm.2 |
Nectin2 |
nectin cell adhesion molecule 2 |
7 |
-19724160, -19716643 |
NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 |
19294 |
73 |
acrosome assembly acrosome assembly positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of immunoglobulin mediated immune response positive regulation of immunoglobulin mediated immune response protein binding plasma membrane plasma membrane cell-cell junction cell-cell junction zonula adherens cytoskeleton organization cytoskeleton organization cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules spermatid development spermatid nucleus differentiation fertilization cell surface membrane integral component of membrane integral component of membrane virion attachment to host cell fusion of virus membrane with host plasma membrane fusion of virus membrane with host plasma membrane sperm mitochondrion organization cell part morphogenesis positive regulation of mast cell activation positive regulation of mast cell activation susceptibility to natural killer cell mediated cytotoxicity susceptibility to natural killer cell mediated cytotoxicity identical protein binding identical protein binding protein homodimerization activity protein homodimerization activity apical junction complex apical junction complex cell-cell contact zone adhesion of symbiont to host cilium organization positive regulation of natural killer cell mediated cytotoxicity regulation of viral entry into host cell regulation of viral entry into host cell coreceptor-mediated virion attachment to host cell coreceptor-mediated virion attachment to host cell cell adhesion molecule binding cell adhesion molecule binding cell adhesion molecule binding positive regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway establishment of mitochondrion localization establishment of mitochondrion localization susceptibility to T cell mediated cytotoxicity susceptibility to T cell mediated cytotoxicity |
04514 04520 |
| TC0700001258.mm.2 |
Ctsc |
cathepsin C |
7 |
88278084, 88278084 |
NM_009982, BC067063 NM_009982, BC067063 |
13032 |
77 |
T cell mediated cytotoxicity cysteine-type endopeptidase activity serine-type endopeptidase activity extracellular space nucleoplasm cytoplasm lysosome lysosome endoplasmic reticulum Golgi apparatus centrosome proteolysis proteolysis peptidase activity cysteine-type peptidase activity cysteine-type peptidase activity response to organic substance peptidase activator activity involved in apoptotic process hydrolase activity phosphatase binding chloride ion binding negative regulation of myelination negative regulation of myelination identical protein binding intracellular membrane-bounded organelle protein self-association chaperone binding proteolysis involved in cellular protein catabolic process collagen-containing extracellular matrix positive regulation of proteolysis involved in cellular protein catabolic process positive regulation of microglial cell activation positive regulation of apoptotic signaling pathway |
04142 |
| TC1700000464.mm.2 |
Pacsin1 |
protein kinase C and casein kinase substrate in neurons 1 |
17 |
27685238, 27655590 |
NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 |
23969 |
44 |
protein binding phospholipid binding phospholipid binding phospholipid binding cytoplasm cytoplasm cytoplasm endosome cytoskeleton plasma membrane plasma membrane endocytosis cytoskeleton organization cytoskeleton organization actin filament organization signal transduction cytoskeletal protein binding lipid binding membrane cell junction regulation of endocytosis COPI-coated vesicle cytoplasmic vesicle ruffle membrane identical protein binding cell projection neuron projection myelin sheath axon terminus synapse negative regulation of endocytosis perinuclear region of cytoplasm synaptic vesicle endocytosis synaptic vesicle endocytosis neuron development neuron projection morphogenesis neuron projection morphogenesis protein localization to membrane protein localization to plasma membrane plasma membrane tubulation plasma membrane tubulation plasma membrane tubulation photoreceptor ribbon synapse presynaptic endocytic zone postsynaptic density membrane glutamatergic synapse regulation of postsynaptic neurotransmitter receptor internalization positive regulation of dendrite development positive regulation of dendrite development |
|
| TC0400001425.mm.2 |
|
|
|
|
NM_008385, NR_030480, BC028864 NM_008385, NR_030480, BC028864 NM_008385, NR_030480, BC028864 |
|
|
in utero embryonic development phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity cytoplasm endosome cytosol cytosol cytosol signal transduction spermatogenesis membrane membrane integral component of membrane hydrolase activity flagellated sperm motility cytoplasmic vesicle inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol dephosphorylation metal ion binding inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol phosphate phosphatase activity regulation of protein processing |
|
| TC1100004266.mm.2 |
Irgm2 |
immunity-related GTPase family M member 2 |
11 |
58214976 |
NM_019440 |
54396 |
22 |
autophagosome assembly Golgi membrane positive regulation of protein phosphorylation GTPase activity GTPase activity mitochondrion endoplasmic reticulum membrane Golgi apparatus Golgi apparatus cytosol defense response response to bacterium positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation protein kinase binding symbiont-containing vacuole protein destabilization positive regulation of peptidyl-serine phosphorylation response to interferon-gamma response to interferon-gamma cellular response to interferon-beta defense response to bacterium defense response to bacterium defense response to protozoan regulation of protein-containing complex assembly protein serine/threonine kinase activator activity innate immune response CARD domain binding protein stabilization defense response to Gram-negative bacterium BH3 domain binding positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide positive regulation of protein serine/threonine kinase activity positive regulation by symbiont of host autophagy cellular response to virus positive regulation of autophagosome maturation |
|
| TC1100000989.mm.2 |
Xaf1 |
XIAP associated factor 1 |
11 |
72301628 |
NM_001037713, BC153050 NM_001037713, BC153050 |
327959 |
16 |
nucleus nucleoplasm cytoplasm mitochondrion apoptotic process negative regulation of protein-containing complex assembly response to interferon-beta metal ion binding |
|
| TC0900001722.mm.2 |
Birc3 |
baculoviral IAP repeat-containing 3 |
9 |
-7848700 |
NM_007464, BC011338 NM_007464, BC011338 |
11796 |
101 |
ubiquitin-protein transferase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol apoptotic process transferase activity positive regulation of protein ubiquitination positive regulation of protein ubiquitination protein-containing complex negative regulation of phosphorylation regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process protein-containing complex binding membrane raft metal ion binding regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity necroptotic process cellular response to tumor necrosis factor regulation of NIK/NF-kappaB signaling positive regulation of protein polyubiquitination negative regulation of reactive oxygen species metabolic process |
04120 04210 04510 04621 05145 05200 05222 |
| TC1700002779.mm.2 |
H2-DMb2 |
histocompatibility 2, class II, locus Mb2 |
17 |
34145248, 34143228 |
NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 |
15000 |
23 |
protein binding lysosome lysosomal membrane lysosomal membrane late endosome multivesicular body endosome membrane integral component of membrane antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle chaperone cofactor-dependent protein refolding |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1700000148.mm.2 |
Sod2 |
superoxide dismutase 2, mitochondrial |
17 |
13007838 |
NM_013671, BC010548 NM_013671, BC010548 |
20656 |
394 |
response to reactive oxygen species response to superoxide response to superoxide age-dependent response to oxidative stress age-dependent response to reactive oxygen species release of cytochrome c from mitochondria liver development detection of oxygen acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure DNA binding superoxide dismutase activity superoxide dismutase activity superoxide dismutase activity superoxide dismutase activity protein binding cytoplasm mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial inner membrane mitochondrial matrix regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II glutathione metabolic process superoxide metabolic process superoxide metabolic process response to oxidative stress response to oxidative stress mitochondrion organization heart development locomotory behavior regulation of blood pressure negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes post-embryonic development response to gamma radiation positive regulation of hydrogen peroxide biosynthetic process response to activity oxidoreductase activity removal of superoxide radicals removal of superoxide radicals oxygen binding enzyme binding respiratory electron transport chain hemopoiesis manganese ion binding manganese ion binding positive regulation of cell migration response to nutrient levels oxygen homeostasis vasodilation response to drug response to hydrogen peroxide superoxide anion generation mitochondrial nucleoid hydrogen peroxide metabolic process identical protein binding negative regulation of apoptotic process myelin sheath negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation metal ion binding negative regulation of fibroblast proliferation neuron development response to axon injury erythrophore differentiation hydrogen peroxide biosynthetic process regulation of catalytic activity protein homotetramerization regulation of mitochondrial membrane potential iron ion homeostasis response to hyperoxia negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of membrane hyperpolarization negative regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching |
04146 05016 |
| TC0700004011.mm.2 |
Gvin3 |
GTPase, very large interferon inducible, family member 3 |
7 |
-106595548 |
NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 |
434223 |
8 |
molecular_function cellular_component biological_process |
|
| TC1100003382.mm.2 |
Slfn8 |
schlafen 8 |
11 |
-83002157, -83002157 |
NM_001167743, NM_181545 NM_001167743, NM_181545 |
276950 |
15 |
tRNA binding nucleotide binding immune system process nuclease activity endonuclease activity endoribonuclease activity endoribonuclease activity ATP binding cytoplasm zinc ion binding rRNA catabolic process tRNA catabolic process hydrolase activity metal ion binding defense response to virus |
|
| TC0900000032.mm.2 |
Casp4 |
caspase 4, apoptosis-related cysteine peptidase |
9 |
5308848, 5308859 |
NM_007609, BC061255 NM_007609, BC061255 |
12363 |
223 |
immune system process cysteine-type endopeptidase activity cysteine-type endopeptidase activity protein binding extracellular region cytoplasm mitochondrion endoplasmic reticulum cytosol plasma membrane proteolysis inflammatory response actin filament organization peptidase activity cysteine-type peptidase activity programmed cell death membrane protein autoprocessing protein autoprocessing hydrolase activity positive regulation of interleukin-1 beta production protein-containing complex ectopic germ cell programmed cell death ectopic germ cell programmed cell death regulation of apoptotic process neuron projection neuronal cell body innate immune response CARD domain binding regulation of inflammatory response regulation of inflammatory response regulation of inflammatory response inflammasome complex intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pyroptosis pyroptosis pyroptosis IPAF inflammasome complex NLRP3 inflammasome complex scaffold protein binding AIM2 inflammasome complex intrinsic apoptotic signaling pathway cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway cellular response to amyloid-beta |
|
| TC0500003729.mm.2 |
Gbp8 |
guanylate-binding protein 8 |
5 |
-105014152 |
NM_029509, BC031475 NM_029509, BC031475 |
76074 |
11 |
GTPase activity GTP binding cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1700002822.mm.2 |
|
|
|
|
NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819 |
|
|
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
|
| TC0200005013.mm.2 |
Samhd1 |
SAM domain and HD domain, 1 |
2 |
-157119560, -157097533 |
NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 |
56045 |
46 |
nucleotide binding double-strand break repair via homologous recombination immune system process nucleic acid binding single-stranded DNA binding RNA binding catalytic activity GTP binding nucleus nucleus nucleoplasm chromosome plasma membrane dGTP catabolic process dGTP catabolic process DNA replication DNA repair cellular response to DNA damage stimulus metabolic process zinc ion binding dGTPase activity dGTPase activity dGTPase activity deoxyribonucleotide catabolic process somatic hypermutation of immunoglobulin genes hydrolase activity triphosphoric monoester hydrolase activity triphosphoric monoester hydrolase activity dGTP binding site of double-strand break identical protein binding innate immune response regulation of innate immune response regulation of innate immune response dATP catabolic process dATP catabolic process metal ion binding protein homotetramerization protein homotetramerization defense response to virus defense response to virus negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway tetraspanin-enriched microdomain DNA strand resection involved in replication fork processing |
|
| TC1700000935.mm.2 |
Treml2 |
triggering receptor expressed on myeloid cells-like 2 |
17 |
48300037 |
NM_001033405, BC160362 NM_001033405, BC160362 |
328833 |
17 |
plasma membrane cell surface cell surface membrane integral component of membrane signaling receptor activity signaling receptor activity T cell activation T cell activation |
|
| TC0800001952.mm.2 |
Rab11fip1 |
RAB11 family interacting protein 1 (class I) |
8 |
-27138772 |
NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 |
75767 |
17 |
endosome cytosol protein transport membrane small GTPase binding cytoplasmic vesicle intracellular membrane-bounded organelle intracellular membrane-bounded organelle regulated exocytosis negative regulation of adiponectin secretion |
04144 |
| TC0200003630.mm.2 |
Ifih1 |
interferon induced with helicase C domain 1 |
2 |
-62595792 |
NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200 |
71586 |
136 |
nucleotide binding immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding nucleus cytoplasm zinc ion binding zinc ion binding response to virus response to virus hydrolase activity protein sumoylation positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production MDA-5 signaling pathway identical protein binding ribonucleoprotein complex binding innate immune response innate immune response metal ion binding defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA |
04622 |
| TC0200003624.mm.2 |
Dpp4 |
dipeptidylpeptidase 4 |
2 |
-62330072, -62333222 |
NM_001159543, NM_010074, BC022183 NM_001159543, NM_010074, BC022183 NM_001159543, NM_010074, BC022183 |
13482 |
183 |
virus receptor activity behavioral fear response response to hypoxia protease binding regulation of T cell mediated immunity aminopeptidase activity serine-type endopeptidase activity signaling receptor binding collagen binding extracellular region endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane proteolysis proteolysis cell adhesion peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity dipeptidyl-peptidase activity positive regulation of cell population proliferation cell surface negative regulation of extracellular matrix disassembly membrane integral component of membrane apical plasma membrane hydrolase activity lamellipodium cell junction endocytic vesicle T cell costimulation regulation of cell-cell adhesion mediated by integrin locomotory exploration behavior psychomotor behavior T cell activation peptide binding identical protein binding protein homodimerization activity cell projection endothelial cell migration chemorepellent activity intercellular canaliculus establishment of localization negative regulation of neutrophil chemotaxis |
04974 |
| TC0200001729.mm.2 |
Thbs1 |
thrombospondin 1 |
2 |
118111875 |
NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917 |
21825 |
301 |
activation of MAPK activity phosphatidylserine binding negative regulation of endothelial cell proliferation negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion fibronectin binding sprouting angiogenesis negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation outflow tract morphogenesis endocardial cushion development growth plate cartilage development growth plate cartilage development integrin binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region fibrinogen complex extracellular space extracellular space extracellular space cytoplasm endoplasmic reticulum inflammatory response inflammatory response response to unfolded protein cell cycle arrest cell adhesion heparin binding positive regulation of cell population proliferation response to mechanical stimulus response to glucose external side of plasma membrane cell surface positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of long-chain fatty acid import across plasma membrane negative regulation of nitric oxide mediated signal transduction negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of macrophage chemotaxis positive regulation of fibroblast migration positive regulation of cell-substrate adhesion cell migration negative regulation of angiogenesis negative regulation of angiogenesis negative regulation of angiogenesis negative regulation of angiogenesis sarcoplasmic reticulum fibroblast growth factor binding peptide cross-linking secretory granule low-density lipoprotein particle binding positive regulation of blood coagulation positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway extracellular matrix platelet alpha granule response to magnesium ion negative regulation of interleukin-12 production positive regulation of tumor necrosis factor production response to endoplasmic reticulum stress negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process laminin binding positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis behavioral response to pain blood vessel morphogenesis positive regulation of smooth muscle cell proliferation transforming growth factor beta binding extracellular matrix binding positive regulation of chemotaxis response to calcium ion positive regulation of protein kinase B signaling negative regulation of fibrinolysis collagen-containing extracellular matrix collagen-containing extracellular matrix fibrinogen binding collagen V binding monocyte aggregation positive regulation of transforming growth factor beta production cellular response to nitric oxide negative regulation of cell migration involved in sprouting angiogenesis positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of sprouting angiogenesis positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis |
04115 04145 04350 04510 04512 05144 05219 |
| TC0300002312.mm.2 |
|
|
|
|
NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 |
|
|
angiogenesis neural crest cell migration adaptive immune response T cell differentiation involved in immune response immune system process extracellular space plasma membrane integral component of plasma membrane multicellular organism development nervous system development axonogenesis axon guidance regulation of cell shape regulation of endothelial cell migration membrane integral component of membrane negative regulation of angiogenesis cell differentiation semaphorin receptor binding positive regulation of cell migration T-helper 1 cell differentiation chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway positive regulation of excitatory synapse assembly positive regulation of inhibitory synapse assembly |
|
| TC0700001116.mm.2 |
Isg20 |
interferon-stimulated protein |
7 |
78913423, 78913764, 78914234 |
NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751 |
57444 |
17 |
3'-5'-exoribonuclease activity DNA catabolic process, exonucleolytic DNA catabolic process, exonucleolytic immune system process nucleic acid binding RNA binding nuclease activity exonuclease activity exonuclease activity nucleus nucleus nucleolus cytoplasm rRNA processing RNA catabolic process RNA catabolic process single-stranded DNA 3'-5' exodeoxyribonuclease activity exoribonuclease II activity response to virus Cajal body PML body hydrolase activity U1 snRNA binding U2 snRNA binding U3 snoRNA binding negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus defense response to virus |
|
| TC0500000488.mm.2 |
Lap3 |
leucine aminopeptidase 3 |
5 |
45493373 |
NM_024434, BC016536 NM_024434, BC016536 |
66988 |
31 |
aminopeptidase activity intracellular anatomical structure nucleoplasm cytoplasm mitochondrion trans-Golgi network cytosol proteolysis peptidase activity metalloexopeptidase activity hydrolase activity protein metabolic process manganese ion binding midbody metal ion binding |
00330 00480 01100 |
| TC0600001193.mm.2 |
Itpr1 |
inositol 1,4,5-trisphosphate receptor 1 |
6 |
108213095 |
NM_010585, BC172648 NM_010585, BC172648 |
16438 |
282 |
response to hypoxia response to hypoxia ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding nuclear envelope nuclear envelope nuclear inner membrane nucleolus cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane plasma membrane plasma membrane calcineurin complex ion transport calcium ion transport apoptotic process positive regulation of cytosolic calcium ion concentration protein C-terminus binding post-embryonic development positive regulation of neuron projection development postsynaptic density postsynaptic density calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum calcium channel inhibitor activity protein phosphatase binding integral component of endoplasmic reticulum membrane dendrite cytoplasmic vesicle membrane secretory granule membrane secretory granule membrane smooth endoplasmic reticulum membrane platelet dense granule membrane platelet dense tubular network cytoplasmic vesicle endoplasmic reticulum calcium ion homeostasis protein-containing complex protein-containing complex phosphatidylinositol binding phosphatidylinositol binding epithelial fluid transport identical protein binding neuronal cell body positive regulation of apoptotic process intracellular membrane-bounded organelle ion channel binding protein-containing complex binding membrane raft perinuclear region of cytoplasm negative regulation of calcium-mediated signaling voluntary musculoskeletal movement release of sequestered calcium ion into cytosol release of sequestered calcium ion into cytosol release of sequestered calcium ion into cytosol positive regulation of calcium ion transport transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding cellular response to cAMP synaptic membrane liver regeneration Schaffer collateral - CA1 synapse Schaffer collateral - CA1 synapse inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels presynapse postsynapse GABA-ergic synapse negative regulation of neuron death positive regulation of hepatocyte proliferation |
04020 04070 04114 04270 04540 04720 04730 04912 04970 04971 04972 05010 05016 |
| TC0300001937.mm.2 |
Slc7a11 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 |
3 |
-50364935 |
NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408 |
26570 |
91 |
amino acid transmembrane transport rough endoplasmic reticulum cytoskeleton plasma membrane plasma membrane glutathione metabolic process amino acid transport brain development visual learning response to toxic substance cell surface response to organic cyclic compound L-amino acid transmembrane transporter activity membrane integral component of membrane ventricular system development striatum development transmembrane transporter activity adult behavior brush border membrane regulation of neutrophil apoptotic process cellular response to stress cellular response to oxidative stress glutathione transmembrane transport regulation of cell population proliferation intracellular membrane-bounded organelle apical part of cell regulation of melanin biosynthetic process lung alveolus development modulation of chemical synaptic transmission regulation of synapse organization regulation of protein transport response to redox state transmembrane transport limb development platelet aggregation organic substance transport glutamate homeostasis glutamate homeostasis astrocyte projection L-glutamate import across plasma membrane dipeptide import across plasma membrane regulation of cellular response to oxidative stress regulation of cysteine metabolic process negative regulation of oxidative stress-induced neuron death negative regulation of oxidative stress-induced neuron death regulation of glutathione biosynthetic process regulation of AMPA glutamate receptor clustering regulation of glutamate metabolic process |
|
| TC0400001392.mm.2 |
Nt5c1a |
5'-nucleotidase, cytosolic IA |
4 |
123201484 |
NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 |
230718 |
9 |
nucleotide binding magnesium ion binding cytoplasm cytosol cytosol 5'-nucleotidase activity 5'-nucleotidase activity nucleotide metabolic process purine nucleoside monophosphate catabolic process hydrolase activity dAMP catabolic process adenosine metabolic process adenosine metabolic process |
00230 00240 00760 01100 |
| TC0400001510.mm.2 |
Rnf19b |
ring finger protein 19B |
4 |
129058143 |
NM_029219 |
75234 |
19 |
ubiquitin ligase complex protein polyubiquitination adaptive immune response immune system process ubiquitin-protein transferase activity cytoplasm endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process interferon-gamma production natural killer cell mediated cytotoxicity ubiquitin binding cytolytic granule cytolytic granule metal ion binding protein autoubiquitination ubiquitin protein ligase activity ubiquitin protein ligase activity |
|
| TC0100003890.mm.2 |
Mndal |
myeloid nuclear differentiation antigen like |
1 |
-173857219, -173857221 |
NM_001170853 |
100040462 |
12 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleus nucleoplasm nucleolus nucleolus cytosol transcription factor binding response to bacterium negative regulation of cell growth positive regulation of interleukin-1 beta production cellular response to interferon-beta regulation of growth identical protein binding |
|
| TC0700003943.mm.2 |
Trim30a |
tripartite motif-containing 30A |
7 |
-104409025, -104409025 |
NM_009099, BC005447 NM_009099, BC005447 |
20128 |
34 |
protein polyubiquitination DNA binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytoplasm cytosol autophagy zinc ion binding response to bacterium regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production regulation of protein localization negative regulation of toll-like receptor signaling pathway protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of protein catabolic process regulation of viral entry into host cell positive regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus protein autoubiquitination ubiquitin protein ligase activity negative regulation of NLRP3 inflammasome complex assembly negative regulation of reactive oxygen species metabolic process |
|
| TC1200001552.mm.2 |
Rsad2 |
radical S-adenosyl methionine domain containing 2 |
12 |
-26442742 |
NM_021384, BC057868 NM_021384, BC057868 |
58185 |
39 |
ossification fibrillar center immune system process catalytic activity protein binding mitochondrion mitochondrion mitochondrial outer membrane mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane lipid droplet response to virus response to virus membrane regulation of ossification positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation protein self-association negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding negative regulation of protein secretion positive regulation of immune response iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding defense response to virus defense response to virus defense response to virus positive regulation of T-helper 2 cell cytokine production |
|
| TC0700003039.mm.2 |
Saa3 |
serum amyloid A 3 |
7 |
-46711997 |
NM_011315, BC055885 NM_011315, BC055885 |
20210 |
76 |
extracellular region extracellular space acute-phase response I-kappaB phosphorylation response to bacterium high-density lipoprotein particle response to stilbenoid Toll-like receptor 4 binding chemoattractant activity cell chemotaxis cellular response to interleukin-1 |
|
| TC0100001574.mm.2 |
Fcgr4 |
Fc receptor, IgG, low affinity IV |
1 |
171018925 |
NM_144559, BC027310 NM_144559, BC027310 |
246256 |
54 |
transmembrane signaling receptor activity plasma membrane integral component of plasma membrane cell surface receptor signaling pathway external side of plasma membrane cell surface cell surface membrane integral component of membrane IgE receptor activity IgG receptor activity IgE binding IgG binding neutrophil activation positive regulation of bone resorption regulation of immune response regulation of sensory perception of pain cellular response to lipopolysaccharide |
04145 04380 04650 05140 05150 05322 |
| TC1100001171.mm.2 |
Nos2 |
nitric oxide synthase 2, inducible |
11 |
78925290, 78920786, 78924739 |
NM_010927, BC062378 NM_010927, BC062378 |
18126 |
1387 |
response to hypoxia actin binding nitric-oxide synthase activity nitric-oxide synthase activity nitric-oxide synthase activity protein binding calmodulin binding extracellular space nucleus nucleus cytoplasm cytoplasm peroxisome cytosol cytosol cytosol plasma membrane arginine catabolic process arginine catabolic process arginine catabolic process superoxide metabolic process nitric oxide biosynthetic process nitric oxide biosynthetic process nitric oxide biosynthetic process inflammatory response inflammatory response nitric oxide mediated signal transduction circadian rhythm beta-catenin binding cAMP-dependent protein kinase regulator activity response to bacterium response to hormone FMN binding FMN binding negative regulation of gene expression negative regulation of gene expression vesicle membrane vesicle membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen peptidyl-cysteine S-nitrosylation protein kinase binding heme binding cortical cytoskeleton positive regulation of guanylate cyclase activity prostaglandin secretion response to lipopolysaccharide response to lipopolysaccharide interleukin-6 production interleukin-8 production tetrahydrobiopterin binding arginine binding cellular response to drug regulation of cell population proliferation negative regulation of protein catabolic process defense response to bacterium defense response to bacterium defense response to bacterium identical protein binding protein homodimerization activity cadherin binding negative regulation of blood pressure metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm flavin adenine dinucleotide binding flavin adenine dinucleotide binding NADP binding regulation of insulin secretion nitric-oxide synthase binding positive regulation of killing of cells of other organism Hsp90 protein binding cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interferon-gamma cellular response to organic cyclic compound regulation of cytokine production involved in inflammatory response |
00330 01100 04020 04146 05140 05142 05145 05146 05200 05222 |
| TC0800001118.mm.2 |
Ccl22 |
chemokine (C-C motif) ligand 22 |
8 |
94745683 |
NM_009137, BC012658 NM_009137, BC012658 |
20299 |
54 |
monocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space chemotaxis inflammatory response immune response G protein-coupled receptor signaling pathway chemokine activity neutrophil chemotaxis killing of cells of other organism positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor |
04060 04062 |
| TC1500002316.mm.2 |
Gpr84 |
G protein-coupled receptor 84 |
15 |
-103308234 |
NM_030720, BC023249 NM_030720, BC023249 |
80910 |
22 |
urotensin II receptor activity G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway neuropeptide signaling pathway G protein-coupled peptide receptor activity membrane integral component of membrane receptor complex |
|
| TC1400002744.mm.2 |
Gpr18 |
G protein-coupled receptor 18 |
14 |
-121911433 |
NM_182806, BC034872 NM_182806, BC034872 |
110168 |
23 |
CD8-positive, alpha-beta intraepithelial T cell differentiation CD8-positive, alpha-beta intraepithelial T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation negative regulation of leukocyte chemotaxis G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane cytoplasmic vesicle negative regulation of tumor necrosis factor production positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
|
| TC0800001037.mm.2 |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
8 |
88647346 |
NM_145857, BC168407 NM_145857, BC168407 |
257632 |
337 |
nucleotide binding pattern recognition receptor signaling pathway innate immune response in mucosa activation of immune response cytokine production involved in immune response immune system process immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of dendritic cell antigen processing and presentation negative regulation of T cell mediated immunity positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin actin binding protein binding ATP binding cytoplasm cytoplasm Golgi apparatus cytosol cytosol cytosol cytoskeleton plasma membrane defense response inflammatory response positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria signal transduction positive regulation of cell population proliferation detection of biotic stimulus cell surface membrane detection of bacterium basolateral plasma membrane endodeoxyribonuclease activity, producing 5'-phosphomonoesters enzyme binding protein kinase binding maintenance of gastrointestinal epithelium Hsp70 protein binding positive regulation of protein ubiquitination vesicle negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to peptidoglycan response to muramyl dipeptide response to muramyl dipeptide response to muramyl dipeptide response to muramyl dipeptide response to lipopolysaccharide detection of muramyl dipeptide muramyl dipeptide binding muramyl dipeptide binding negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-2 production negative regulation of tumor necrosis factor production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade positive regulation of stress-activated MAPK cascade protein-containing complex negative regulation of toll-like receptor 2 signaling pathway intracellular signal transduction intracellular signal transduction pattern recognition receptor activity defense response to bacterium defense response to bacterium peptidoglycan binding peptidoglycan binding regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity protein-containing complex binding innate immune response positive regulation of innate immune response positive regulation of innate immune response phagocytic vesicle positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of JNK cascade anchored component of plasma membrane positive regulation of epithelial cell proliferation CARD domain binding regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase biosynthetic process Hsp90 protein binding positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to muramyl dipeptide macrophage inflammatory protein-1 alpha production positive regulation of monocyte chemotactic protein-1 production regulation of neutrophil chemotaxis positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination positive regulation of xenophagy negative regulation of macrophage apoptotic process positive regulation of prostaglandin-E synthase activity |
04621 |
| TC0200004511.mm.2 |
Gatm |
glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
2 |
-122594472 |
NM_025961, BC003879 NM_025961, BC003879 |
67092 |
37 |
mitochondrion mitochondrion mitochondrion mitochondrial inner membrane mitochondrial intermembrane space creatine metabolic process creatine biosynthetic process creatine biosynthetic process multicellular organism development response to nutrient learning or memory response to organic substance muscle atrophy amidinotransferase activity amidinotransferase activity glycine amidinotransferase activity membrane transferase activity response to peptide hormone response to mercury ion positive regulation of cold-induced thermogenesis |
00260 00330 01100 |
| TC0500003181.mm.2 |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
5 |
-120896256 |
NM_145211, BC013715, BC057878 NM_145211, BC013715, BC057878 NM_145211, BC013715, BC057878 |
246730 |
33 |
2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol purine nucleotide biosynthetic process response to virus membrane negative regulation of viral genome replication negative regulation of viral process defense response to virus regulation of ribonuclease activity |
05160 |
| TC1500000688.mm.2 |
Apobec3 |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 |
15 |
79895022, 79892407 |
NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314 |
80287 |
101 |
P-body hematopoietic progenitor cell differentiation immune system process RNA binding catalytic activity cytidine deaminase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm zinc ion binding negative regulation of transposition negative regulation of transposition negative regulation of transposition cytidine to uridine editing hydrolase activity negative regulation of viral genome replication innate immune response negative regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding deoxycytidine deaminase activity deoxycytidine deaminase activity regulation of defense response to virus defense response to virus defense response to virus DNA cytosine deamination DNA demethylation regulation of viral life cycle |
|
| TC1200001729.mm.2 |
Gpr33 |
G protein-coupled receptor 33 |
12 |
-52023003 |
NM_008159, BC064084 NM_008159, BC064084 |
14762 |
10 |
complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity plasma membrane inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane |
|
| TC1900000439.mm.2 |
Jak2 |
Janus kinase 2 |
19 |
29251802 |
NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 |
16452 |
481 |
nucleotide binding activation of MAPKK activity euchromatin microglial cell activation adaptive immune response immune system process protein kinase activity protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signaling receptor binding growth hormone receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cytosol cytoskeleton plasma membrane caveola focal adhesion chromatin organization protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process response to oxidative stress signal transduction enzyme linked receptor protein signaling pathway G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein protein C-terminus binding positive regulation of cell population proliferation negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to oxidative stress hormone-mediated signaling pathway negative regulation of cardiac muscle cell apoptotic process positive regulation of cell-substrate adhesion positive regulation of phosphatidylinositol 3-kinase signaling membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein kinase binding heme binding negative regulation of cell-cell adhesion myeloid cell differentiation cell differentiation erythrocyte differentiation erythrocyte differentiation positive regulation of cell migration axon regeneration type 1 angiotensin receptor binding mineralocorticoid receptor signaling pathway positive regulation of insulin secretion response to lipopolysaccharide positive regulation of phosphoprotein phosphatase activity positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production acetylcholine receptor binding response to hydroperoxide tumor necrosis factor-mediated signaling pathway programmed cell death induced by symbiont response to tumor necrosis factor post-embryonic hemopoiesis histone kinase activity (H3-Y41 specific) histone kinase activity (H3-Y41 specific) histone H3-Y41 phosphorylation histone H3-Y41 phosphorylation intracellular signal transduction interleukin-12-mediated signaling pathway cellular response to interleukin-3 SH2 domain binding positive regulation of protein import into nucleus histone binding positive regulation of tyrosine phosphorylation of STAT protein identical protein binding activation of Janus kinase activity regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of DNA binding negative regulation of DNA binding negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding insulin receptor substrate binding innate immune response membrane raft positive regulation of MHC class II biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of heart contraction positive regulation of transcription by RNA polymerase II response to antibiotic protein autophosphorylation protein autophosphorylation metal ion binding platelet-derived growth factor receptor signaling pathway regulation of inflammatory response positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation modulation of chemical synaptic transmission positive regulation of cell activation positive regulation of DNA-binding transcription factor activity peptide hormone receptor binding positive regulation of nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway positive regulation of SMAD protein signal transduction growth hormone receptor signaling pathway growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT positive regulation of growth hormone receptor signaling pathway negative regulation of cell death mammary gland epithelium development response to interleukin-12 cellular response to lipopolysaccharide cellular response to dexamethasone stimulus response to granulocyte macrophage colony-stimulating factor extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway postsynapse glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of cold-induced thermogenesis positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of epithelial cell apoptotic process positive regulation of vascular associated smooth muscle cell proliferation positive regulation of signaling receptor activity positive regulation of apoptotic signaling pathway |
04062 04630 04920 05140 05145 |
| TC1300002725.mm.2 |
Parp8 |
poly (ADP-ribose) polymerase family, member 8 |
13 |
-116850843 |
NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881 |
52552 |
20 |
NAD+ ADP-ribosyltransferase activity intracellular anatomical structure protein ADP-ribosylation transferase activity transferase activity, transferring glycosyl groups protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity |
|
| TC1900000217.mm.2 |
Ms4a4c |
membrane-spanning 4-domains, subfamily A, member 4C |
19 |
11407660 |
NM_029499, BC027496 NM_029499, BC027496 |
64380 |
12 |
molecular_function cellular_component biological_process |
|
| TC0100001338.mm.2 |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
1 |
150100030 |
NM_011198, BC052900 NM_011198, BC052900 |
19225 |
998 |
prostaglandin biosynthetic process prostaglandin biosynthetic process angiogenesis peroxidase activity prostaglandin-endoperoxide synthase activity prostaglandin-endoperoxide synthase activity protein binding nuclear inner membrane nuclear inner membrane nuclear outer membrane nuclear outer membrane cytoplasm cytoplasm cytoplasm endoplasmic reticulum caveola lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process inflammatory response response to oxidative stress embryo implantation embryo implantation learning memory regulation of blood pressure positive regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of vascular endothelial growth factor production positive regulation of cell death membrane oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen sensory perception of pain cyclooxygenase pathway cyclooxygenase pathway enzyme binding heme binding keratinocyte differentiation bone mineralization ovulation positive regulation of prostaglandin biosynthetic process positive regulation of fever generation positive regulation of fever generation positive regulation of synaptic plasticity negative regulation of synaptic transmission, dopaminergic response to lipopolysaccharide protein-containing complex positive regulation of peptidyl-serine phosphorylation response to cytokine maintenance of blood-brain barrier regulation of cell population proliferation positive regulation of protein import into nucleus anagen protein homodimerization activity neuron projection neuron projection positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle positive regulation of nitric oxide biosynthetic process negative regulation of cell cycle positive regulation of vasoconstriction negative regulation of smooth muscle contraction positive regulation of smooth muscle contraction decidualization decidualization metal ion binding positive regulation of smooth muscle cell proliferation brown fat cell differentiation dioxygenase activity negative regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic cellular response to non-ionic osmotic stress cellular response to fluid shear stress positive regulation of transforming growth factor beta production positive regulation of cell migration involved in sprouting angiogenesis positive regulation of fibroblast growth factor production positive regulation of brown fat cell differentiation positive regulation of platelet-derived growth factor production regulation of neuroinflammatory response negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
00590 01100 04370 05140 05200 05222 |
| TC0700003946.mm.2 |
Trim30d |
tripartite motif-containing 30D |
7 |
-104470013 |
NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631 |
209387 |
13 |
protein polyubiquitination nucleoplasm cytoplasm cytosol regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity |
|
| TC1100002003.mm.2 |
|
|
|
|
XM_001477846 |
|
|
|
|
| TC0800000538.mm.2 |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
8 |
46490965, 46471036 |
NM_007981, BC056644 NM_007981, BC056644 |
14081 |
64 |
very long-chain fatty acid metabolic process very long-chain fatty acid metabolic process nucleotide binding long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding mitochondrion mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane endoplasmic reticulum endoplasmic reticulum plasma membrane lipid metabolic process fatty acid metabolic process lipid biosynthetic process lipid biosynthetic process response to organic substance positive regulation of long-chain fatty acid import across plasma membrane fatty acid transport membrane integral component of membrane ligase activity triglyceride biosynthetic process adiponectin-activated signaling pathway long-chain fatty-acyl-CoA biosynthetic process long-chain fatty-acyl-CoA biosynthetic process xenobiotic catabolic process intracellular membrane-bounded organelle acetate-CoA ligase (ADP-forming) activity long-chain fatty acid import into cell arachidonate-CoA ligase activity arachidonate-CoA ligase activity phytanate-CoA ligase activity positive regulation of protein serine/threonine kinase activity oleoyl-CoA ligase activity decanoate-CoA ligase activity positive regulation of cold-induced thermogenesis |
00071 01100 03320 04146 04920 |
| TC0700004002.mm.2 |
|
|
|
|
NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 |
|
|
molecular_function cellular_component biological_process |
|
| TC1700001954.mm.2 |
Tnf |
tumor necrosis factor |
17 |
-35199366 |
NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 |
21926 |
2923 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II MAPK cascade activation of MAPKKK activity activation of MAPK activity transcription regulatory region sequence-specific DNA binding microglial cell activation microglial cell activation cell activation positive regulation of cytokine production phagocytic cup regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation protease binding protease binding negative regulation of L-glutamate import across plasma membrane leukocyte activation involved in inflammatory response chronic inflammatory response to antigenic stimulus regulation of immunoglobulin production negative regulation of cytokine production involved in immune response positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of systemic arterial blood pressure cytokine activity cytokine activity cytokine activity tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding protein binding extracellular region extracellular space extracellular space extracellular space intracellular anatomical structure cytoplasm plasma membrane integral component of plasma membrane integral component of plasma membrane glucose metabolic process regulation of transcription by RNA polymerase II apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response inflammatory response inflammatory response inflammatory response immune response humoral immune response signal transduction JNK cascade multicellular organism development positive regulation of cell population proliferation negative regulation of cell population proliferation extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage response to virus animal organ morphogenesis external side of plasma membrane external side of plasma membrane cell surface cell surface response to organic substance negative regulation of heart rate vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of gene expression negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane calcium-mediated signaling secretory granule extracellular matrix organization osteoclast differentiation sequestering of triglyceride cortical actin cytoskeleton organization positive regulation of protein-containing complex assembly positive regulation of fever generation negative regulation of myelination lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide negative regulation of interleukin-6 production positive regulation of chemokine production positive regulation of fractalkine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of peptidyl-serine phosphorylation tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway positive regulation of heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion toll-like receptor 3 signaling pathway negative regulation of myosin-light-chain-phosphatase activity regulation of cell population proliferation regulation of cell population proliferation vasodilation positive regulation of tyrosine phosphorylation of STAT protein defense response to bacterium identical protein binding neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of protein-containing complex disassembly positive regulation of protein-containing complex disassembly positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration negative regulation of viral genome replication membrane raft membrane raft cellular extravasation positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of osteoclast differentiation positive regulation of protein catabolic process positive regulation of action potential positive regulation of cell adhesion positive regulation of mitotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of translational initiation by iron negative regulation of glucose import negative regulation of glucose import positive regulation of JNK cascade positive regulation of JNK cascade positive regulation of receptor signaling pathway via JAK-STAT positive regulation of smooth muscle cell proliferation regulation of protein secretion regulation of inflammatory response positive regulation of inflammatory response positive regulation of phagocytosis regulation of insulin secretion positive regulation of synaptic transmission positive regulation of synaptic transmission regulation of synapse organization defense response to Gram-positive bacterium leukocyte migration leukocyte tethering or rolling detection of mechanical stimulus involved in sensory perception of pain negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of nitrogen compound metabolic process positive regulation of protein transport response to glucocorticoid positive regulation of hair follicle development positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling recycling endosome positive regulation of glial cell proliferation positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity epithelial cell proliferation involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of vascular wound healing negative regulation of branching involved in lung morphogenesis positive regulation of calcineurin-NFAT signaling cascade cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to nicotine cellular response to organic cyclic compound positive regulation of podosome assembly endothelial cell apoptotic process protein localization to plasma membrane negative regulation of oxidative phosphorylation apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway necroptotic signaling pathway necroptotic signaling pathway negative regulation of bile acid secretion positive regulation of interleukin-33 production positive regulation of cytokine production involved in inflammatory response negative regulation of amyloid-beta clearance positive regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of synoviocyte proliferation positive regulation of superoxide dismutase activity positive regulation of amyloid-beta formation positive regulation of neutrophil activation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of protein localization to plasma membrane positive regulation of protein localization to plasma membrane regulation of establishment of endothelial barrier positive regulation of oxidative stress-induced neuron death negative regulation of bicellular tight junction assembly positive regulation of I-kappaB phosphorylation negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of vascular associated smooth muscle cell proliferation positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell positive regulation of protein localization to cell surface negative regulation of signaling receptor activity positive regulation of blood microparticle formation positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of hepatocyte proliferation regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process negative regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
04010 04060 04210 04350 04380 04612 04620 04621 04622 04640 04650 04660 04664 04920 04930 04940 05010 05014 05140 05142 05143 05144 05145 05146 05160 05310 05322 05323 05330 05332 05410 05414 |
| TC0400003681.mm.2 |
Themis2 |
thymocyte selection associated family member 2 |
4 |
-132782356 |
NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126 |
230787 |
18 |
immune system process protein binding nucleus nucleus cytoplasm cytoplasm inflammatory response T cell receptor signaling pathway T cell receptor signaling pathway |
|
| TC1800000924.mm.2 |
Crem |
cAMP responsive element modulator |
18 |
-3294165, -3266353, -3266353, -3266353, -3266353, -3266353 |
NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 |
12916 |
153 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus transcription regulator complex transcription regulator complex cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II glycosphingolipid metabolic process spermatogenesis spermatogenesis circadian rhythm circadian regulation of gene expression negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II rhythmic process response to cAMP ATF4-CREB1 transcription factor complex sequence-specific double-stranded DNA binding |
|
| TC1500002183.mm.2 |
Rnd1 |
Rho family GTPase 1 |
15 |
-98669204 |
NM_172612, BC048531 NM_172612, BC048531 |
223881 |
18 |
nucleotide binding GTPase activity signaling receptor binding GTP binding intracellular anatomical structure cytoplasm cytosol cytoskeleton plasma membrane plasma membrane adherens junction cell cortex actin filament organization actin filament organization negative regulation of cell adhesion establishment or maintenance of cell polarity small GTPase mediated signal transduction regulation of cell shape actin cytoskeleton membrane neuron remodeling cell migration protein kinase binding cortical cytoskeleton organization cytoplasmic vesicle regulation of actin cytoskeleton organization cell projection intracellular membrane-bounded organelle intracellular membrane-bounded organelle |
04360 |
| TC1400000580.mm.2 |
Rnase6 |
ribonuclease, RNase A family, 6 |
14 |
51123907, 51129036, 51129063 |
NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 |
78416 |
15 |
nucleic acid binding nuclease activity endonuclease activity ribonuclease activity ribonuclease activity extracellular region extracellular space extracellular space extracellular space lysosome hydrolase activity antibacterial humoral response antibacterial humoral response antibacterial humoral response cytoplasmic vesicle defense response to bacterium innate immune response innate immune response innate immune response defense response to Gram-negative bacterium defense response to Gram-negative bacterium defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide RNA phosphodiester bond hydrolysis |
|
| TC0900002197.mm.2 |
Il10ra |
interleukin 10 receptor, alpha |
9 |
-45253836 |
NM_008348, BC146496 NM_008348, BC146496 |
16154 |
73 |
cytokine receptor activity interleukin-10 receptor activity cytoplasm cytosol plasma membrane plasma membrane negative regulation of autophagy membrane integral component of membrane cytokine-mediated signaling pathway interleukin-10 binding positive regulation of receptor signaling pathway via JAK-STAT regulation of synapse organization ubiquitin-dependent endocytosis |
04060 04630 05145 |
| TC0900001768.mm.2 |
Endod1 |
endonuclease domain containing 1 |
9 |
-14353989 |
NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490 |
71946 |
19 |
nucleic acid binding nuclease activity endonuclease activity extracellular region biological_process hydrolase activity metal ion binding |
04210 |
| TC0700004003.mm.2 |
|
|
|
|
NR_040453, NR_040456 NR_040453, NR_040456 |
|
|
|
|
| TC0700001793.mm.2 |
Il4ra |
interleukin 4 receptor, alpha |
7 |
125552270 |
NM_001008700, BC112911 NM_001008700, BC112911 |
16190 |
384 |
immune system process production of molecular mediator involved in inflammatory response positive regulation of immunoglobulin production cytokine receptor activity protein binding extracellular region extracellular space nucleoplasm plasma membrane membrane integral component of membrane immunoglobulin mediated immune response positive regulation of chemokine production centriolar satellite regulation of cell population proliferation defense response to protozoan positive regulation of macrophage activation receptor complex positive regulation of mast cell degranulation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of cold-induced thermogenesis positive regulation of myoblast fusion |
04060 04630 04640 |
| TC1300000624.mm.2 |
Hrh2 |
histamine receptor H2 |
13 |
54192128, 54192132 |
NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958 |
15466 |
62 |
gastric acid secretion histamine-induced gastric acid secretion gastrin-induced gastric acid secretion epithelial cell morphogenesis G protein-coupled receptor activity histamine receptor activity G protein-coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission memory visual learning membrane integral component of membrane dendrite neurotransmitter receptor activity positive regulation of vasoconstriction regulation of synaptic plasticity digestive tract development gland development negative regulation of arachidonic acid secretion heterocyclic compound binding toxin transport |
04020 04080 04971 |
| TC0500001896.mm.2 |
Fzd1 |
frizzled class receptor 1 |
5 |
-4753838 |
NM_021457, BC053010 NM_021457, BC053010 |
14362 |
86 |
positive regulation of protein phosphorylation membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis transmembrane signaling receptor activity G protein-coupled receptor activity signaling receptor binding frizzled binding plasma membrane plasma membrane signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling cell-cell signaling multicellular organism development cell surface positive regulation of neuron projection development membrane integral component of membrane Wnt signaling pathway Wnt-protein binding Wnt-protein binding Wnt-protein binding PDZ domain binding negative regulation of BMP signaling pathway epithelial cell differentiation epithelial cell differentiation autocrine signaling non-canonical Wnt signaling pathway astrocyte-dopaminergic neuron signaling response to drug identical protein binding protein homodimerization activity Wnt-activated receptor activity Wnt-activated receptor activity neuron projection canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein heterodimerization activity positive regulation of DNA-binding transcription factor activity hard palate development canonical Wnt signaling pathway canonical Wnt signaling pathway canonical Wnt signaling pathway canonical Wnt signaling pathway ventricular septum morphogenesis negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure negative regulation of oxidative stress-induced neuron death regulation of presynapse assembly regulation of presynapse assembly |
04310 04916 05200 05217 |
| TC1100003779.mm.2 |
Dhx58 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
11 |
-100694883 |
NM_030150, BC029209 NM_030150, BC029209 |
80861 |
36 |
nucleotide binding immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity ATP binding cytoplasm cytoplasm zinc ion binding zinc ion binding response to virus response to virus response to bacterium hydrolase activity negative regulation of type I interferon production negative regulation of type I interferon production positive regulation of type I interferon production positive regulation of interferon-beta production negative regulation of MDA-5 signaling pathway negative regulation of RIG-I signaling pathway negative regulation of RIG-I signaling pathway innate immune response regulation of innate immune response negative regulation of innate immune response negative regulation of innate immune response metal ion binding defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway |
04622 |
| TC0600003305.mm.2 |
Mansc1 |
MANSC domain containing 1 |
6 |
-134609206 |
NM_026345, BC039930 NM_026345, BC039930 |
67729 |
14 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC0200000222.mm.2 |
Il15ra |
interleukin 15 receptor, alpha chain |
2 |
11705711, 11705292 |
NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 |
16169 |
143 |
extracellular region nucleus plasma membrane plasma membrane plasma membrane receptor signaling pathway via JAK-STAT cell surface negative regulation of neuron projection development membrane integral component of membrane protein kinase binding cytoplasmic vesicle positive regulation of natural killer cell differentiation interleukin-15-mediated signaling pathway interleukin-15-mediated signaling pathway interleukin-15 receptor activity interleukin-15 receptor activity positive regulation of phagocytosis |
04060 04630 04672 |
| TC0600002114.mm.2 |
Parp12 |
poly (ADP-ribose) polymerase family, member 12 |
6 |
-39086411 |
NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645 |
243771 |
25 |
NAD+ ADP-ribosyltransferase activity cellular_component nucleus protein ADP-ribosylation transferase activity protein phosphopantetheinylation metal ion binding protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity |
|
| TC1200000279.mm.2 |
Nampt |
nicotinamide phosphoribosyltransferase |
12 |
32820334 |
NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358 |
59027 |
155 |
nucleotide binding microglial cell activation catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity cytokine activity extracellular region extracellular space nucleus cytoplasm cytoplasm cytosol plasma membrane circadian rhythm NAD biosynthetic process negative regulation of autophagy regulation of lung blood pressure nuclear speck transferase activity transferase activity, transferring glycosyl groups pyridine nucleotide biosynthetic process cell junction circadian regulation of gene expression identical protein binding identical protein binding positive regulation of transcription by RNA polymerase II nicotinamide phosphoribosyltransferase activity nicotinamide phosphoribosyltransferase activity rhythmic process positive regulation of smooth muscle cell proliferation positive regulation of nitric-oxide synthase biosynthetic process negative regulation of cellular senescence |
00760 |
| TC1700000505.mm.2 |
Pim1 |
proviral integration site 1 |
17 |
29493084, 29490784 |
NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 |
18712 |
186 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding ATP binding nucleus nucleolus cytoplasm cytoplasm cytosol plasma membrane protein phosphorylation protein phosphorylation apoptotic process cell cycle transcription factor binding membrane kinase activity phosphorylation transferase activity regulation of transmembrane transporter activity manganese ion binding manganese ion binding ribosomal small subunit binding negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity protein serine/threonine kinase activator activity positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated protein autophosphorylation protein autophosphorylation metal ion binding protein stabilization positive regulation of cardiac muscle cell proliferation vitamin D receptor signaling pathway positive regulation of protein serine/threonine kinase activity positive regulation of brown fat cell differentiation regulation of hematopoietic stem cell proliferation positive regulation of cardioblast proliferation cellular detoxification |
04630 05221 |
| TC1800000834.mm.2 |
Pstpip2 |
proline-serine-threonine phosphatase-interacting protein 2 |
18 |
77794549 |
NM_013831, BC002123, BC057654 NM_013831, BC002123, BC057654 NM_013831, BC002123, BC057654 |
19201 |
37 |
actin binding protein binding cytoplasm cytosol cytoskeleton cytoskeleton actin filament plasma membrane cytoskeleton organization membrane cell migration actin filament polymerization actin filament binding |
|
| TC1500002347.mm.2 |
Parp10 |
poly (ADP-ribose) polymerase family, member 10 |
15 |
-76232994 |
NM_001163575, NM_001163576 NM_001163575, NM_001163576 |
671535 |
16 |
transcription corepressor activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity nucleus nucleus nucleolus cytoplasm cytoplasm Golgi apparatus cytosol DNA repair protein ADP-ribosylation cellular response to DNA damage stimulus negative regulation of gene expression negative regulation of gene expression regulation of chromatin assembly transferase activity transferase activity, transferring glycosyl groups translesion synthesis negative regulation of NF-kappaB transcription factor activity negative regulation of viral genome replication negative regulation of fibroblast proliferation protein poly-ADP-ribosylation protein poly-ADP-ribosylation protein auto-ADP-ribosylation K63-linked polyubiquitin modification-dependent protein binding protein mono-ADP-ribosylation protein mono-ADP-ribosylation negative regulation of protein K63-linked ubiquitination protein ADP-ribosylase activity protein ADP-ribosylase activity |
|
| TC1100000792.mm.2 |
Adora2b |
adenosine A2b receptor |
11 |
62248983 |
NM_007413, BC116415, BC116416 NM_007413, BC116415, BC116416 NM_007413, BC116415, BC116416 |
11541 |
178 |
G protein-coupled adenosine receptor activity positive regulation of endothelial cell proliferation G protein-coupled adenosine receptor signaling pathway positive regulation of chronic inflammatory response to non-antigenic stimulus G protein-coupled receptor activity plasma membrane plasma membrane signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cell population proliferation negative regulation of cell population proliferation cell surface positive regulation of vascular endothelial growth factor production positive regulation of endothelial cell migration positive regulation of norepinephrine secretion positive regulation of cGMP-mediated signaling positive regulation of steroid biosynthetic process regulation of glucose metabolic process membrane integral component of membrane positive regulation of guanylate cyclase activity cellular response to extracellular stimulus positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-6 production negative regulation of collagen biosynthetic process positive regulation of catecholamine secretion positive regulation of mast cell degranulation positive regulation of cAMP-mediated signaling synapse relaxation of vascular associated smooth muscle Schaffer collateral - CA1 synapse Schaffer collateral - CA1 synapse glutamatergic synapse glutamatergic synapse glutamatergic synapse glutamatergic synapse response to angiotensin regulation of synaptic vesicle exocytosis regulation of synaptic vesicle exocytosis |
04020 04080 04270 |
| TC0300002659.mm.2 |
Mov10 |
Mov10 RISC complex RNA helicase |
3 |
-104794833, -104794833 |
NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 |
17454 |
39 |
nucleotide binding P-body RNA binding RNA binding helicase activity protein binding ATP binding nucleus cytoplasm cytosol cytosol cytosol negative regulation of transposition, RNA-mediated negative regulation of transposition, RNA-mediated hydrolase activity gene silencing by RNA 5'-3' RNA helicase activity post-transcriptional gene silencing by RNA gene silencing by miRNA mRNA cleavage involved in gene silencing by miRNA cytoplasmic ribonucleoprotein granule P granule defense response to virus positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization regulation of neuron projection arborization |
|
| TC1100003663.mm.2 |
Arl5c |
ADP-ribosylation factor-like 5C |
11 |
-97989579 |
NM_207231, BC065791 NM_207231, BC065791 |
217151 |
11 |
nucleotide binding GTP binding cytoplasm trans-Golgi network intracellular protein transport vesicle-mediated transport protein localization to Golgi membrane |
|
| TC0700003862.mm.2 |
Trim21 |
tripartite motif-containing 21 |
7 |
-102557919 |
NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580 |
20821 |
59 |
protein polyubiquitination protein polyubiquitination DNA binding transcription coactivator activity RNA binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytoplasm cytosol protein monoubiquitination cell cycle zinc ion binding regulation of gene expression positive regulation of autophagy positive regulation of autophagy protein ubiquitination protein ubiquitination transferase activity SCF ubiquitin ligase complex protein kinase binding cytoplasmic vesicle protein destabilization negative regulation of NF-kappaB transcription factor activity positive regulation of protein binding regulation of protein localization negative regulation of viral transcription response to interferon-gamma identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response innate immune response positive regulation of cell cycle negative regulation of innate immune response regulation of viral entry into host cell positive regulation of viral entry into host cell metal ion binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination ubiquitin protein ligase activity ubiquitin protein ligase activity protein K63-linked ubiquitination negative regulation of protein deubiquitination negative regulation of viral release from host cell |
05322 |
| TC0800002330.mm.2 |
Tma16 |
translation machinery associated 16 |
8 |
-66476342 |
NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844 |
66282 |
15 |
molecular_function nucleus nucleoplasm nucleolus biological_process |
|
| TC0500000816.mm.2 |
Dck |
deoxycytidine kinase |
5 |
88765012 |
NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062 |
13178 |
28 |
nucleotide binding magnesium ion binding deoxyadenosine kinase activity deoxycytidine kinase activity deoxycytidine kinase activity deoxyguanosine kinase activity ATP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol nucleobase-containing compound metabolic process pyrimidine nucleotide metabolic process drug binding kinase activity transferase activity deoxynucleoside kinase activity nucleoside kinase activity pyrimidine deoxyribonucleoside binding protein homodimerization activity deoxycytidine metabolic process nucleotide phosphorylation |
00230 00240 01100 |
| TC0500003180.mm.2 |
Oas1g |
2'-5' oligoadenylate synthetase 1G |
5 |
-120876141 |
NM_011852, BC018470, BC043339 NM_011852, BC018470, BC043339 NM_011852, BC018470, BC043339 |
23960 |
17 |
2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol membrane negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity |
|
| TC0700003996.mm.2 |
|
|
|
|
NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 |
|
|
molecular_function cellular_component biological_process |
|
| TC0100002711.mm.2 |
|
|
|
|
XR_140448 |
|
|
|
|
| TC1000001813.mm.2 |
Tnfaip3 |
tumor necrosis factor, alpha-induced protein 3 |
10 |
-19000909, -19000909 |
NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 |
21929 |
188 |
B-1 B cell homeostasis protease binding response to molecule of bacterial origin response to molecule of bacterial origin marginal zone B cell differentiation negative regulation of granuloma formation regulation of germinal center formation regulation of immunoglobulin production negative regulation of chronic inflammatory response DNA binding catalytic activity ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleus cytoplasm cytoplasm lysosome proteolysis apoptotic process inflammatory response cytoskeleton organization protein C-terminus binding metabolic process peptidase activity cysteine-type peptidase activity zinc ion binding response to wounding negative regulation of autophagy cell migration protein ubiquitination protein deubiquitination transferase activity hydrolase activity kinase binding positive regulation of Wnt signaling pathway negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of heterotypic cell-cell adhesion negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K29-linked deubiquitination protein K11-linked deubiquitination identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding protein self-association regulation of innate immune response positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of innate immune response metal ion binding negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of B cell activation negative regulation of cell death Lys63-specific deubiquitinase activity cellular response to hydrogen peroxide negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway K63-linked polyubiquitin modification-dependent protein binding protein K63-linked deubiquitination protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process protein K33-linked deubiquitination positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process |
04621 |
| TC0700003517.mm.2 |
Slco3a1 |
solute carrier organic anion transporter family, member 3a1 |
7 |
-74275417, -74281915 |
NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059 |
108116 |
23 |
positive regulation of protein phosphorylation transporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane ion transport oligopeptide transport organic anion transmembrane transporter activity basal plasma membrane cell surface sodium-independent organic anion transmembrane transporter activity organic anion transport prostaglandin transport prostaglandin transport membrane integral component of membrane apical plasma membrane oligopeptide transmembrane transporter activity sodium-independent organic anion transport positive regulation of NF-kappaB transcription factor activity transmembrane transport |
|
| TC1400000851.mm.2 |
Spata13 |
spermatogenesis associated 13 |
14 |
60634704, 60732903 |
NM_001033272, BC138455, BC145285 NM_001033272, BC138455, BC145285 NM_001033272, BC138455, BC145285 |
219140 |
30 |
guanyl-nucleotide exchange factor activity nucleoplasm cytoplasm cytosol plasma membrane membrane cell migration lamellipodium lamellipodium assembly filopodium regulation of cell migration ruffle membrane regulation of Rho protein signal transduction intracellular signal transduction identical protein binding cell projection filopodium assembly |
|
| TC0300002188.mm.2 |
Rapgef2 |
Rap guanine nucleotide exchange factor (GEF) 2 |
3 |
-79062510, -79062510 |
NM_001099624 |
76089 |
38 |
blood vessel development neuron migration guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity GTPase activator activity intracellular anatomical structure cytoplasm endosome late endosome cytosol plasma membrane bicellular tight junction signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide signaling pathway small GTPase mediated signal transduction multicellular organism development nervous system development negative regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of neuron projection development membrane apical plasma membrane protein kinase binding cAMP-mediated signaling cAMP-mediated signaling ventricular system development forebrain neuron development microvillus assembly cell junction endocytic vesicle cell differentiation PDZ domain binding neuron projection development neuron projection development brain-derived neurotrophic factor receptor signaling pathway beta-1 adrenergic receptor binding positive regulation of protein binding Rap protein signal transduction protein-containing complex nerve growth factor signaling pathway regulation of cell population proliferation neuron projection neuronal cell body positive regulation of GTPase activity positive regulation of GTPase activity positive regulation of GTPase activity positive regulation of cAMP-mediated signaling synapse positive regulation of protein kinase activity positive regulation of protein kinase activity negative regulation of melanin biosynthetic process regulation of synaptic plasticity perinuclear region of cytoplasm WW domain binding negative regulation of dendrite morphogenesis negative regulation of dendrite morphogenesis establishment of endothelial barrier phosphatidic acid binding positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to cAMP cellular response to cAMP cellular response to cGMP adenylate cyclase-activating adrenergic receptor signaling pathway protein localization to plasma membrane establishment of endothelial intestinal barrier regulation of cell junction assembly cellular response to nerve growth factor stimulus positive regulation of cAMP-dependent protein kinase activity positive regulation of cAMP-dependent protein kinase activity positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell apoptotic process positive regulation of vasculogenesis positive regulation of neuron migration |
04010 |
| TC1900001019.mm.2 |
Prdx5 |
peroxiredoxin 5 |
19 |
-6906696 |
NM_012021, BC008174 NM_012021, BC008174 |
54683 |
60 |
RNA polymerase III transcription regulatory region sequence-specific DNA binding peroxidase activity signaling receptor binding signaling receptor binding protein binding nucleus cytoplasm cytoplasm cytoplasm mitochondrion mitochondrion mitochondrion peroxisome peroxisome peroxisomal matrix peroxisomal matrix cytosol response to oxidative stress response to oxidative stress thioredoxin peroxidase activity thioredoxin peroxidase activity antioxidant activity antioxidant activity negative regulation of transcription by RNA polymerase III oxidoreductase activity cytoplasmic vesicle positive regulation of collagen biosynthetic process cellular response to oxidative stress cellular response to reactive oxygen species hydrogen peroxide catabolic process hydrogen peroxide catabolic process hydrogen peroxide catabolic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle cell redox homeostasis perinuclear region of cytoplasm negative regulation of oxidoreductase activity peroxiredoxin activity regulation of apoptosis involved in tissue homeostasis NADPH oxidation peroxynitrite reductase activity reactive nitrogen species metabolic process |
04146 |
| TC0300002506.mm.2 |
Fcgr1 |
Fc receptor, IgG, high affinity I |
3 |
-96282908 |
NM_010186, BC160240 NM_010186, BC160240 |
14129 |
186 |
antibody-dependent cellular cytotoxicity positive regulation of type IIa hypersensitivity positive regulation of type III hypersensitivity immune system process transmembrane signaling receptor activity plasma membrane integral component of plasma membrane receptor-mediated endocytosis phagocytosis, recognition phagocytosis, engulfment cell surface receptor signaling pathway cell surface receptor signaling pathway response to bacterium external side of plasma membrane membrane integral component of membrane IgG receptor activity IgG binding IgG binding antigen processing and presentation of exogenous antigen leukotriene receptor binding antigen processing and presentation of exogenous peptide antigen via MHC class I defense response to bacterium innate immune response membrane raft positive regulation of phagocytosis regulation of immune response regulation of immune response positive regulation of phagocytosis, engulfment positive regulation of protein tyrosine kinase activity |
04145 04380 04640 04666 05140 05150 05322 |
| TC1600001557.mm.2 |
Dtx3l |
deltex 3-like, E3 ubiquitin ligase |
16 |
-35926514 |
NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694 |
209200 |
18 |
positive regulation of defense response to virus by host immune system process ubiquitin-protein transferase activity enzyme inhibitor activity nucleus nucleoplasm nucleoplasm cytoplasm lysosome endosome early endosome cytosol DNA repair double-strand break repair chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus Notch signaling pathway enzyme activator activity endosome to lysosome transport histone monoubiquitination protein transport membrane protein ubiquitination transferase activity enzyme binding positive regulation of protein binding protein-containing complex histone H2A ubiquitination histone H2B ubiquitination positive regulation of chromatin binding histone binding ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated metal ion binding negative regulation of ubiquitin-protein transferase activity defense response to virus protein autoubiquitination ubiquitin protein ligase activity protein K48-linked ubiquitination STAT family protein binding positive regulation of protein localization to nucleus positive regulation of NAD+ ADP-ribosyltransferase activity positive regulation of protein localization to early endosome positive regulation of receptor catabolic process positive regulation of double-strand break repair via nonhomologous end joining |
04330 |
| TC1400001086.mm.2 |
Epsti1 |
epithelial stromal interaction 1 (breast) |
14 |
77904238, 77904238 |
NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 |
108670 |
13 |
molecular_function cellular_component biological_process |
|
| TC0200004636.mm.2 |
Slc4a11 |
solute carrier family 4, sodium bicarbonate transporter-like, member 11 |
2 |
-130684107 |
NM_001081162, BC111884 NM_001081162, BC111884 |
269356 |
26 |
sodium channel activity inorganic anion exchanger activity plasma membrane plasma membrane ion transport sodium ion transport anion transport vesicle membrane bicarbonate transmembrane transporter activity proton channel activity symporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane basolateral plasma membrane basolateral plasma membrane apical plasma membrane transmembrane transporter activity cellular cation homeostasis fluid transport borate transport active borate transmembrane transporter activity protein dimerization activity ion homeostasis ion homeostasis transmembrane transport proton transmembrane transport |
|
| TC1200000225.mm.2 |
Cmpk2 |
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
12 |
26469214 |
NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565 |
22169 |
17 |
nucleotide binding cytidylate kinase activity cytidylate kinase activity nucleoside diphosphate kinase activity nucleoside diphosphate kinase activity thymidylate kinase activity thymidylate kinase activity ATP binding nucleoplasm cytoplasm mitochondrion mitochondrion nucleoside diphosphate phosphorylation pyrimidine nucleotide biosynthetic process dUDP biosynthetic process dUDP biosynthetic process dTDP biosynthetic process dTDP biosynthetic process dTTP biosynthetic process uridylate kinase activity uridylate kinase activity nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity UMP kinase activity nucleoside monophosphate kinase activity cellular response to lipopolysaccharide |
00240 01100 |
| TC0300000161.mm.2 |
Tnfsf10 |
tumor necrosis factor (ligand) superfamily, member 10 |
3 |
27317076 |
NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808 |
22035 |
189 |
cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space plasma membrane apoptotic process immune response zinc ion binding membrane integral component of membrane tumor necrosis factor receptor superfamily binding identical protein binding positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process TRAIL binding metal ion binding positive regulation of release of cytochrome c from mitochondria positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway |
04060 04210 04650 |
| TC1300001526.mm.2 |
Gpr141 |
G protein-coupled receptor 141 |
13 |
-19749681 |
NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587 |
353346 |
13 |
G protein-coupled receptor activity cellular_component plasma membrane signal transduction membrane integral component of membrane |
|
| TC1400000575.mm.2 |
Pnp2 |
purine-nucleoside phosphorylase 2 |
14 |
50956140 |
NM_001123371 |
667034 |
10 |
nucleoside binding purine nucleobase binding purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity extracellular region nucleus cytoplasm cytoplasm cytosol phosphate ion binding identical protein binding |
00230 00240 00760 01100 |
| TC0600000637.mm.2 |
Creb5 |
cAMP responsive element binding protein 5 |
6 |
53573373, 53287302 |
NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 |
231991 |
23 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cAMP response element binding identical protein binding fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II adipose tissue development sequence-specific double-stranded DNA binding |
04962 05016 05215 |
| TC0200003560.mm.2 |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
2 |
-57107225, -57107225 |
NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715 |
18227 |
310 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific response to hypoxia neuron migration response to amphetamine DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleus nucleoplasm transcription regulator complex cytoplasm transcription, DNA-templated transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II nervous system development zinc ion binding adult locomotory behavior post-embryonic development response to inorganic substance gene expression regulation of gene expression nuclear speck response to insecticide central nervous system projection neuron axonogenesis central nervous system neuron differentiation central nervous system neuron differentiation habenula development neuron differentiation cellular response to extracellular stimulus cellular response to extracellular stimulus cellular response to oxidative stress glucocorticoid receptor binding glucocorticoid receptor binding regulation of dopamine metabolic process dopamine biosynthetic process dopamine metabolic process neuron maturation positive regulation of catalytic activity negative regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding regulation of respiratory gaseous exchange fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding protein heterodimerization activity general adaptation syndrome cellular response to corticotropin-releasing hormone stimulus cellular response to corticotropin-releasing hormone stimulus dopaminergic neuron differentiation dopaminergic neuron differentiation dopaminergic neuron differentiation sequence-specific double-stranded DNA binding negative regulation of apoptotic signaling pathway |
|
| TC1700000685.mm.2 |
H2-Q5 |
histocompatibility 2, Q region locus 5 |
17 |
35394098 |
NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944 |
15016 |
29 |
|
|
| TC0600001481.mm.2 |
Parp11 |
poly (ADP-ribose) polymerase family, member 11 |
6 |
127453626, 127446839 |
NM_181402, BC040269 NM_181402, BC040269 |
101187 |
18 |
NAD+ ADP-ribosyltransferase activity nucleus nuclear envelope nuclear pore nucleoplasm cytosol protein ADP-ribosylation nuclear envelope organization spermatogenesis protein transport nuclear body transferase activity transferase activity, transferring glycosyl groups protein phosphopantetheinylation cell differentiation mRNA transport protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity |
|
| TC1700000622.mm.2 |
Psmb8 |
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) |
17 |
34198194 |
NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450 |
16913 |
114 |
proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity protein binding nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteasome core complex proteolysis peptidase activity proteasomal ubiquitin-independent protein catabolic process hydrolase activity antigen processing and presentation cell differentiation proteasome-mediated ubiquitin-dependent protein catabolic process fat cell differentiation fat cell differentiation proteolysis involved in cellular protein catabolic process regulation of endopeptidase activity spermatoproteasome complex |
03050 |
| TC0100000758.mm.2 |
|
|
|
|
XM_979370 |
|
|
|
|
| TC1700000600.mm.2 |
Daxx |
Fas death domain-associated protein |
17 |
33909497, 33909600, 33909444 |
NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373 |
13163 |
100 |
negative regulation of transcription by RNA polymerase II mitotic cytokinesis chromosome, centromeric region heterochromatin XY body positive regulation of protein phosphorylation p53 binding transcription coactivator activity transcription coactivator activity transcription corepressor activity transcription corepressor activity transcription corepressor activity protein binding nucleus nucleus nucleoplasm chromosome cytoplasm cytosol microtubule cell cortex chromatin organization nucleosome assembly nucleosome assembly nucleosome assembly chromatin remodeling regulation of transcription, DNA-templated apoptotic process transcription factor binding transcription factor binding JUN kinase binding negative regulation of myotube differentiation nuclear body PML body PML body PML body kinesin binding enzyme binding protein kinase binding protein kinase activator activity androgen receptor signaling pathway PML body organization regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of histone phosphorylation cellular response to heat cellular response to unfolded protein regulation of multicellular organism growth histone binding histone binding histone binding protein homodimerization activity regulation of apoptotic process neuron projection positive regulation of apoptotic process negative regulation of apoptotic process cell body positive regulation of protein kinase activity negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein N-terminus binding androgen receptor binding protein localization to chromatin cellular response to cadmium ion cellular response to copper ion cellular response to diamide apoptotic signaling pathway sumo-dependent protein binding transcription regulator inhibitor activity positive regulation of neuron death cellular response to sodium arsenite positive regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway |
04010 05014 |
| TC0100003889.mm.2 |
Ifi211 |
interferon activated gene 211 |
1 |
-173896340 |
NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 |
381308 |
19 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus nucleolus cytosol transcription factor binding response to bacterium nuclear speck positive regulation of interleukin-1 beta production nuclear periphery cellular response to interferon-beta identical protein binding |
|
| TC0800001698.mm.2 |
Rab20 |
RAB20, member RAS oncogene family |
8 |
-11453389 |
NM_011227, BC089570 NM_011227, BC089570 |
19332 |
33 |
nucleotide binding GTPase activity GTP binding Golgi apparatus intracellular protein transport endomembrane system protein transport membrane cytoplasmic vesicle intracellular membrane-bounded organelle phagocytic vesicle phagocytic vesicle cellular response to interferon-gamma phagosome acidification phagosome-lysosome fusion |
|
| TC0700003942.mm.2 |
|
|
|
|
XM_485980 |
|
|
|
|
| TC0200004109.mm.2 |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
2 |
-91184060, -91184060 |
NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646 |
22259 |
438 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II chromatin transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity nuclear receptor activity nuclear receptor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol regulation of transcription, DNA-templated fatty acid biosynthetic process zinc ion binding positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of cholesterol efflux negative regulation of cholesterol storage negative regulation of cholesterol storage cell differentiation positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone sterol response element binding positive regulation of toll-like receptor 4 signaling pathway phosphatidylcholine acyl-chain remodeling cholesterol homeostasis cholesterol homeostasis cholesterol homeostasis negative regulation of macrophage activation receptor complex apoptotic cell clearance sequence-specific DNA binding cellular lipid metabolic process protein-containing complex binding positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding retinoid X receptor binding negative regulation of pinocytosis negative regulation of inflammatory response negative regulation of inflammatory response positive regulation of lipoprotein lipase activity lipid homeostasis lipid homeostasis sterol homeostasis triglyceride homeostasis triglyceride homeostasis cellular response to lipopolysaccharide cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes RNA polymerase II transcription regulator complex RNA polymerase II transcription regulator complex negative regulation of cold-induced thermogenesis negative regulation of response to endoplasmic reticulum stress |
03320 05160 |
| TC0800001451.mm.2 |
Irf8 |
interferon regulatory factor 8 |
8 |
120736357, 120738638 |
NM_008320, BC005450 NM_008320, BC005450 |
15900 |
289 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific plasmacytoid dendritic cell differentiation immune system process DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II phagocytosis autophagy immune response response to bacterium myeloid cell differentiation regulation of type I interferon production positive regulation of interferon-gamma production positive regulation of interleukin-12 production defense response to bacterium defense response to protozoan positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription initiation from RNA polymerase II promoter cellular response to lipopolysaccharide cellular response to interferon-gamma dendritic cell differentiation sequence-specific double-stranded DNA binding |
|
| TC1100002642.mm.2 |
Gm5431 |
predicted gene 5431 |
11 |
-48887421 |
NM_001024230 |
432555 |
9 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta |
|
| TC0700003941.mm.2 |
Trim30b |
tripartite motif-containing 30B |
7 |
-104355397 |
NM_175648 |
244183 |
14 |
protein polyubiquitination nucleoplasm cytoplasm cytosol regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity |
|
| TC0600003503.mm.2 |
Herc6 |
hect domain and RLD 6 |
6 |
57580991 |
NM_025992 |
67138 |
17 |
hematopoietic progenitor cell differentiation immune system process ubiquitin-protein transferase activity nucleoplasm cytoplasm cytosol response to bacterium protein ubiquitination transferase activity protein phosphopantetheinylation cyclin binding innate immune response ubiquitin protein ligase activity |
|
| TC0300002053.mm.2 |
P2ry13 |
purinergic receptor P2Y, G-protein coupled 13 |
3 |
-59207893 |
NM_028808, BC119043 NM_028808, BC119043 |
74191 |
40 |
G protein-coupled receptor activity endoplasmic reticulum plasma membrane signal transduction G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity G protein-coupled purinergic nucleotide receptor activity cellular response to organic cyclic compound |
04080 |
| TC1_GL456212_random00000013.mm.2 |
Sp110 |
Sp110 nuclear body protein |
1 |
-85576898, -85576898 |
BC039938 |
109032 |
29 |
DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding nucleus nucleoplasm regulation of transcription by RNA polymerase II apoptotic process response to bacterium response to bacterium positive regulation of apoptotic process innate immune response |
|
| TC1600001742.mm.2 |
Nfkbiz |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta |
16 |
-55811376, -55811376 |
NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 |
80859 |
64 |
protein binding nucleus nucleus inflammatory response regulation of gene expression nuclear speck cytoplasmic ribonucleoprotein granule positive regulation of inflammatory response T cell receptor signaling pathway positive regulation of T-helper 17 cell differentiation |
|
| TC1700001993.mm.2 |
H2-T24 |
histocompatibility 2, T region locus 24 |
17 |
-36005694 |
NM_008207, BC156693 NM_008207, BC156693 |
15042 |
11 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC0100003888.mm.2 |
Ifi204 |
interferon activated gene 204 |
1 |
-173747293 |
NM_008329 |
15951 |
60 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding double-stranded DNA binding transcription coregulator activity protein binding nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytosol regulation of transcription by RNA polymerase II multicellular organism development transcription factor binding response to bacterium response to bacterium nuclear speck positive regulation of interleukin-1 beta production cellular response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta nuclear inclusion body intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding positive regulation of osteoblast differentiation inner ear development |
|
| TC0200005175.mm.2 |
Prex1 |
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
2 |
-166566344 |
NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940 |
277360 |
42 |
guanyl-nucleotide exchange factor activity phospholipid binding cytoplasm cytosol plasma membrane plasma membrane G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway membrane T cell differentiation positive regulation of cell migration growth cone neutrophil chemotaxis regulation of actin filament polymerization regulation of Rho protein signal transduction intracellular signal transduction dendritic shaft positive regulation of GTPase activity positive regulation of cell adhesion perinuclear region of cytoplasm regulation of dendrite development reactive oxygen species metabolic process positive regulation of substrate adhesion-dependent cell spreading |
04062 |
| TC0600003108.mm.2 |
C1s1 |
complement component 1, s subcomponent 1 |
6 |
-124530343, -124530343 |
NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 |
50908 |
16 |
immune system process serine-type endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular region extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity identical protein binding innate immune response metal ion binding |
04610 05150 05322 |
| TC0600001258.mm.2 |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
6 |
113638466 |
NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324 |
108960 |
42 |
nucleotide binding regulation of cytokine-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway protein kinase activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm plasma membrane protein phosphorylation inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity intracellular signal transduction protein homodimerization activity regulation of apoptotic process negative regulation of DNA-binding transcription factor activity protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 |
04210 04722 |
| TC0700004538.mm.2 |
Slc25a22 |
solute carrier family 25 (mitochondrial carrier, glutamate), member 22 |
7 |
-141429748, -141429748, -141429748 |
NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949 |
68267 |
35 |
L-glutamate transmembrane transporter activity L-glutamate transmembrane transporter activity mitochondrion mitochondrial inner membrane transport L-aspartate transmembrane transporter activity symporter activity aspartate transmembrane transport L-glutamate transmembrane transport L-glutamate transmembrane transport membrane integral component of membrane transmembrane transporter activity malate-aspartate shuttle transmembrane transport |
|
| TC0600003307.mm.2 |
Dusp16 |
dual specificity phosphatase 16 |
6 |
-134715467 |
NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 |
70686 |
39 |
inactivation of MAPK activity inactivation of MAPK activity phosphoprotein phosphatase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol protein dephosphorylation protein tyrosine/threonine phosphatase activity dephosphorylation phosphatase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation negative regulation of MAPK cascade mitogen-activated protein kinase binding |
04010 |
| TC0200002410.mm.2 |
Src |
Rous sarcoma oncogene |
2 |
157424292 |
NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953 |
20779 |
555 |
nucleotide binding primary ovarian follicle growth positive regulation of cytokine production podosome immune system process protein kinase activity protein kinase activity protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding signaling receptor binding signaling receptor binding insulin receptor binding integrin binding protein binding ATP binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm mitochondrion mitochondrion mitochondrial inner membrane mitochondrial inner membrane lysosome late endosome cytosol cytosol cytoskeleton actin filament plasma membrane plasma membrane plasma membrane caveola caveola focal adhesion protein phosphorylation cell cycle cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway protein C-terminus binding cell population proliferation positive regulation of gene expression regulation of epithelial cell migration positive regulation of epithelial cell migration positive regulation of glucose metabolic process positive regulation of protein processing postsynaptic density positive regulation of smooth muscle cell migration membrane membrane kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation enzyme binding kinase binding protein kinase binding protein domain specific binding heme binding regulation of cell-cell adhesion cell junction cell differentiation estrogen receptor binding forebrain development extrinsic component of cytoplasmic side of plasma membrane negative regulation of protein-containing complex assembly ubiquitin protein ligase binding protein destabilization positive regulation of protein autophosphorylation activation of protein kinase B activity negative regulation of telomere maintenance via telomerase ruffle membrane regulation of intracellular estrogen receptor signaling pathway substrate adhesion-dependent cell spreading cellular response to reactive oxygen species positive regulation of dephosphorylation intracellular signal transduction intracellular signal transduction osteoclast development osteoclast development cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation SH2 domain binding odontogenesis neuron projection positive regulation of apoptotic process negative regulation of apoptotic process stress fiber assembly negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of protein binding positive regulation of MAP kinase activity positive regulation of phosphatidylinositol 3-kinase activity ion channel binding protein-containing complex binding transcytosis innate immune response bone resorption bone resorption positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of insulin receptor signaling pathway protein autophosphorylation ephrin receptor binding ephrin receptor binding neurotrophin TRK receptor signaling pathway focal adhesion assembly perinuclear region of cytoplasm perinuclear region of cytoplasm oogenesis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding progesterone receptor signaling pathway progesterone receptor signaling pathway positive regulation of small GTPase mediated signal transduction phosphoprotein binding positive regulation of protein transport negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization negative regulation of telomerase activity uterus development branching involved in mammary gland duct morphogenesis regulation of cell projection assembly intestinal epithelial cell development intestinal epithelial cell development interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade response to interleukin-1 BMP receptor binding growth factor receptor binding growth factor receptor binding connexin binding cellular response to peptide hormone stimulus cellular response to progesterone stimulus cellular response to fluid shear stress cellular response to transforming growth factor beta stimulus positive regulation of podosome assembly positive regulation of podosome assembly positive regulation of protein serine/threonine kinase activity angiotensin-activated signaling pathway involved in heart process positive regulation of canonical Wnt signaling pathway scaffold protein binding scaffold protein binding regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse postsynaptic specialization, intracellular component positive regulation of protein localization to nucleus positive regulation of intracellular signal transduction positive regulation of ovarian follicle development positive regulation of lamellipodium morphogenesis positive regulation of DNA biosynthetic process positive regulation of platelet-derived growth factor receptor-beta signaling pathway regulation of early endosome to late endosome transport negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway regulation of caveolin-mediated endocytosis |
04012 04144 04370 04510 04520 04530 04540 04912 05100 |
| TC1500001155.mm.2 |
Ptger4 |
prostaglandin E receptor 4 (subtype EP4) |
15 |
-5233398 |
NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 |
19219 |
209 |
negative regulation of cytokine production positive regulation of cytokine production positive regulation of protein phosphorylation negative regulation of peptide secretion G protein-coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity prostaglandin E receptor activity prostaglandin E receptor activity plasma membrane plasma membrane inflammatory response signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration JNK cascade positive regulation of cell population proliferation positive regulation of gene expression negative regulation of hydrogen peroxide metabolic process regulation of circadian sleep/wake cycle, wakefulness positive regulation of smooth muscle cell migration membrane integral component of membrane regulation of ossification nuclear membrane response to lipopolysaccharide negative regulation of interleukin-1 alpha production negative regulation of tumor necrosis factor production positive regulation of interleukin-10 production positive regulation of interleukin-8 production negative regulation of integrin activation positive regulation of urine volume positive regulation of renal sodium excretion T-helper cell differentiation negative regulation of circadian sleep/wake cycle, REM sleep chemokinesis positive regulation of tyrosine phosphorylation of STAT protein neuronal cell body positive regulation of cAMP-mediated signaling neuron projection terminus positive regulation of osteoblast differentiation positive regulation of ossification positive regulation of bone resorption positive regulation of cell adhesion positive regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of protein secretion negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of inflammatory response positive regulation of inflammatory response regulation of stress fiber assembly negative regulation of nitric-oxide synthase biosynthetic process bone development positive regulation of mucus secretion ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to prostaglandin E stimulus positive regulation of wound healing ductus arteriosus closure positive regulation of hyaluronan biosynthetic process negative regulation of ductus arteriosus closure negative regulation of small intestine smooth muscle contraction positive regulation of calcitonin secretion positive regulation of chemokinesis positive regulation of substance P secretion positive regulation of matrix metallopeptidase secretion negative regulation of endothelin production positive regulation of substance P secretion, neurotransmission positive regulation of ovarian follicle development positive regulation of antral ovarian follicle growth positive regulation of neutrophil extravasation negative regulation of eosinophil extravasation |
04080 |
| TC0300002680.mm.2 |
I830077J02Rik |
RIKEN cDNA I830077J02 gene |
3 |
-105925890 |
NM_001033780, BC147821, BC147828 NM_001033780, BC147821, BC147828 NM_001033780, BC147821, BC147828 |
433638 |
10 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC1200000280.mm.2 |
Gdap10 |
ganglioside-induced differentiation-associated-protein 10 |
12 |
32824115 |
NR_045032, BC052902 NR_045032, BC052902 |
100504486 |
5 |
molecular_function cellular_component response to bacterium |
|
| TC1000000778.mm.2 |
Icosl |
icos ligand |
10 |
78069367 |
NM_015790, BC029227 NM_015790, BC029227 |
50723 |
107 |
regulation of cytokine production adaptive immune response immune system process signaling receptor binding signaling receptor binding protein binding plasma membrane integral component of plasma membrane signal transduction external side of plasma membrane external side of plasma membrane membrane integral component of membrane positive regulation of interleukin-4 production cytoplasmic ribonucleoprotein granule positive regulation of activated T cell proliferation T cell activation B cell activation identical protein binding isotype switching T cell receptor signaling pathway |
04514 04672 |
| TC0200001158.mm.2 |
Itga4 |
integrin alpha 4 |
2 |
79255425 |
NM_010576, BC068313 NM_010576, BC068313 |
16401 |
250 |
fibronectin binding fibronectin binding blood vessel remodeling positive regulation of leukocyte migration cell-matrix adhesion involved in ameboidal cell migration antigen binding plasma membrane cell-cell junction cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion cell-matrix adhesion integrin-mediated signaling pathway heart development integrin complex external side of plasma membrane cell surface cell surface membrane integral component of membrane cell migration C-X3-C chemokine binding growth cone cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading integrin alpha4-beta7 complex neuronal cell body receptor clustering metal ion binding cell adhesion molecule binding leukocyte tethering or rolling diapedesis face development axonogenesis involved in innervation mesenchyme development chorio-allantoic fusion visceral serous pericardium development extracellular exosome T cell migration negative regulation of protein homodimerization activity cell-cell adhesion import into cell cell-cell adhesion in response to extracellular stimulus positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte tethering or rolling cellular response to amyloid-beta positive regulation of vascular endothelial cell proliferation neuron projection extension protein antigen binding clathrin-dependent extracellular exosome endocytosis positive regulation of endothelial cell apoptotic process positive regulation of T cell migration |
04510 04512 04514 04640 04670 04672 04810 05140 05410 05412 05414 |
| TC1100002567.mm.2 |
Pttg1 |
pituitary tumor-transforming gene 1 |
11 |
-43420243, -43420243 |
NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324 |
30939 |
83 |
regulation of cell growth cysteine-type endopeptidase inhibitor activity nucleus nucleus nucleus cytoplasm cytosol DNA repair cellular response to DNA damage stimulus cell cycle chromosome segregation mitotic sister chromatid cohesion negative regulation of cell population proliferation cellular process SH3 domain binding heat shock protein binding ribosome binding homologous chromosome segregation homologous chromosome segregation chromosome organization cell division negative regulation of mitotic sister chromatid separation |
04110 04114 |
| TC0400003917.mm.2 |
Pdpn |
podoplanin |
4 |
-143267408 |
NM_010329, BC026551 NM_010329, BC026551 |
14726 |
331 |
cell morphogenesis cell morphogenesis ruffle lymphangiogenesis signaling receptor binding signaling receptor binding protein binding mitochondrion cytosol plasma membrane plasma membrane prostaglandin metabolic process movement of cell or subcellular component cell adhesion signal transduction Rho protein signal transduction Rho protein signal transduction multicellular organism development cell population proliferation negative regulation of cell population proliferation regulation of cell shape external side of plasma membrane positive regulation of platelet activation positive regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition membrane integral component of membrane basolateral plasma membrane basolateral plasma membrane apical plasma membrane apical plasma membrane chemokine binding chemokine binding lamellipodium lamellipodium cell junction regulation of cell adhesion filopodium filopodium lung development lung development positive regulation of cell migration positive regulation of cell migration lamellipodium membrane cytoplasmic vesicle filopodium membrane microvillus membrane ruffle membrane tube morphogenesis tube morphogenesis cell projection negative regulation of apoptotic process wound healing, spreading of cells membrane raft lung alveolus development lymph node development chaperone binding chaperone binding positive regulation of cellular component movement response to hyperoxia lymphatic endothelial cell fate commitment visceral serous pericardium development leading edge of lamellipodium actin-mediated cell contraction actin-mediated cell contraction positive regulation of extracellular matrix disassembly positive regulation of extracellular matrix disassembly tetraspanin-enriched microdomain cell-cell adhesion cell-cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of substrate adhesion-dependent cell spreading positive regulation of platelet aggregation positive regulation of platelet aggregation positive regulation of platelet aggregation positive regulation of platelet aggregation regulation of myofibroblast contraction regulation of myofibroblast contraction regulation of G1/S transition of mitotic cell cycle regulation of lamellipodium morphogenesis regulation of lamellipodium morphogenesis |
|
| TC0900001511.mm.2 |
Bcl2a1c |
B cell leukemia/lymphoma 2 related protein A1c |
9 |
114330134 |
NM_007535, BC120720 NM_007535, BC120720 |
12046 |
4 |
mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity protein heterodimerization activity extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC0400000495.mm.2 |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
4 |
45799021 |
NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768 |
72535 |
32 |
aldehyde dehydrogenase (NAD+) activity nucleoplasm mitochondrion mitochondrion cytosol oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor intracellular membrane-bounded organelle |
00010 00040 00053 00071 00280 00310 00330 00340 00380 00410 00561 00620 00640 01100 |
| TC0800002431.mm.2 |
Bst2 |
bone marrow stromal cell antigen 2 |
8 |
-71534255 |
NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 |
69550 |
43 |
immune system process cytoplasm endosome Golgi apparatus plasma membrane metalloendopeptidase inhibitor activity response to virus cell surface cell surface cell surface membrane integral component of membrane apical plasma membrane anchored component of membrane regulation of actin cytoskeleton organization response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response innate immune response defense response to virus negative regulation of intracellular transport of viral material negative regulation of intracellular transport of viral material |
|
| TC0500002818.mm.2 |
Rasgef1b |
RasGEF domain family, member 1B |
5 |
-99217419 |
NM_145839, NM_181318, BC050858, BC052726 NM_145839, NM_181318, BC050858, BC052726 NM_145839, NM_181318, BC050858, BC052726 NM_145839, NM_181318, BC050858, BC052726 |
320292 |
21 |
guanyl-nucleotide exchange factor activity regulation of catalytic activity |
|
| TC1700002071.mm.2 |
H2-M2 |
histocompatibility 2, M region locus 2 |
17 |
-37480850 |
NM_008204, BC150676 NM_008204, BC150676 |
14990 |
17 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane cell surface peptide antigen binding |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC0100000697.mm.2 |
Nyap2 |
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 |
1 |
81077406, 81077307, 81077203, 81076949 |
NM_172849, BC082310 NM_172849, BC082310 |
241134 |
15 |
protein binding phosphatidylinositol 3-kinase signaling neuron projection morphogenesis |
|
| TC1500000549.mm.2 |
Ly6e |
lymphocyte antigen 6 complex, locus E |
15 |
74955024 |
NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 NM_001164036, NM_001164037, NM_001164038, NM_001164039, NM_001164040, NM_008529, BC002116, BC003926, BC005684, BC019113, BC040691, BC053523, BC080711 |
17069 |
39 |
in utero embryonic development plasma membrane membrane adrenal gland development acetylcholine receptor inhibitor activity acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding organ growth norepinephrine metabolic process negative regulation of viral entry into host cell negative regulation of viral entry into host cell epinephrine secretion ventricular cardiac muscle tissue morphogenesis acetylcholine receptor signaling pathway |
|
| TC1200001902.mm.2 |
Rtn1 |
reticulon 1 |
12 |
-72211748, -72211748, -72211748 |
NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 NM_001007596, NM_001286448, NM_153457, NR_104446, BC030455, BC053926, BC058579 |
104001 |
42 |
Golgi membrane endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane smooth endoplasmic reticulum Golgi apparatus membrane integral component of membrane negative regulation of amyloid-beta formation |
|
| TC0500003175.mm.2 |
Oas2 |
2'-5' oligoadenylate synthetase 2 |
5 |
-120730332 |
NM_145227 |
246728 |
27 |
nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytoplasm cytosol RNA catabolic process immune response response to virus response to bacterium membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding perinuclear region of cytoplasm defense response to virus defense response to virus type I interferon signaling pathway regulation of ribonuclease activity regulation of lactation |
05160 |
| TC0200003574.mm.2 |
Cytip |
cytohesin 1 interacting protein |
2 |
-58129138 |
NM_139200, BC007144 NM_139200, BC007144 |
227929 |
22 |
nucleoplasm cytoplasm endosome cytosol cell cortex cell cortex regulation of cell adhesion regulation of cell adhesion |
|
| TC0100001018.mm.2 |
Phlpp1 |
PH domain and leucine rich repeat protein phosphatase 1 |
1 |
106171868 |
NM_133821, BC059254 NM_133821, BC059254 |
98432 |
54 |
regulation of protein phosphorylation regulation of T cell anergy catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein serine/threonine phosphatase activity nucleus nucleoplasm cytoplasm cytoplasm plasma membrane protein dephosphorylation apoptotic process signal transduction entrainment of circadian clock membrane hydrolase activity nuclear membrane regulation of apoptotic process intracellular membrane-bounded organelle regulation of MAPK cascade regulation of JNK cascade metal ion binding positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade positive regulation of protein kinase C signaling negative regulation of protein kinase C signaling regulation of p38MAPK cascade |
|
| TC0600000131.mm.2 |
Met |
met proto-oncogene |
6 |
17463956 |
NM_008591 |
17295 |
399 |
negative regulation of transcription by RNA polymerase II nucleotide binding activation of MAPK activity neuron migration endothelial cell morphogenesis liver development liver development placenta development protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity hepatocyte growth factor-activated receptor activity hepatocyte growth factor-activated receptor activity hepatocyte growth factor-activated receptor activity protein binding ATP binding extracellular space cytoplasm plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway chemical synaptic transmission multicellular organism development nervous system development brain development muscle organ development muscle organ development skeletal muscle tissue development beta-catenin binding basal plasma membrane basal plasma membrane positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation positive regulation of glucose transmembrane transport positive regulation of neuron projection development postsynaptic density muscle cell migration myotube differentiation membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity semaphorin receptor activity protein phosphatase binding neuron differentiation flagellated sperm motility dendrite adult behavior pancreas development positive regulation of microtubule polymerization regulation of interleukin-6 production positive regulation of peptidyl-serine phosphorylation positive regulation of kinase activity negative regulation of Rho protein signal transduction sperm flagellum glucose homeostasis identical protein binding neuron projection neuronal cell body receptor complex phospholipase binding phosphatidylinositol 3-kinase binding protein-containing complex binding postsynaptic membrane positive regulation of DNA replication positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II protein autophosphorylation protein autophosphorylation hepatocyte growth factor receptor signaling pathway branching morphogenesis of an epithelial tube positive regulation of dendrite morphogenesis modulation of chemical synaptic transmission positive chemotaxis positive chemotaxis myoblast proliferation negative regulation of stress fiber assembly positive regulation of protein kinase B signaling cardiac muscle cell development cardiac muscle contraction excitatory synapse excitatory postsynaptic potential regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling establishment of skin barrier negative regulation of thrombin-activated receptor signaling pathway semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway negative regulation of transforming growth factor beta production reactive oxygen species metabolic process regulation of cellular response to oxidative stress positive regulation of p38MAPK cascade negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of guanyl-nucleotide exchange factor activity positive regulation of endothelial cell chemotaxis |
04060 04144 04360 04510 04520 05100 05144 05200 05211 05218 |
| TC1500000776.mm.2 |
Tspo |
translocator protein |
15 |
83563572 |
NM_009775, BC002055 NM_009775, BC002055 |
12257 |
111 |
androgen binding mitochondrion mitochondrion mitochondrion mitochondrial outer membrane endoplasmic reticulum cytosol steroid biosynthetic process ion transport chloride transport lipid transport glial cell migration benzodiazepine receptor activity negative regulation of mitochondrion organization positive regulation of necrotic cell death cholesterol binding membrane integral component of membrane negative regulation of protein ubiquitination negative regulation of tumor necrosis factor production positive regulation of apoptotic process intracellular membrane-bounded organelle ion channel binding negative regulation of nitric oxide biosynthetic process behavioral response to pain regulation of steroid biosynthetic process positive regulation of mitochondrial depolarization positive regulation of calcium ion transport contact inhibition positive regulation of glial cell proliferation negative regulation of glial cell proliferation establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion negative regulation of autophagy of mitochondrion negative regulation of ATP metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process |
04080 |
| TC1800000590.mm.2 |
Isoc1 |
isochorismatase domain containing 1 |
18 |
58659481 |
NM_025478, BC016576 NM_025478, BC016576 |
66307 |
21 |
molecular_function catalytic activity cytoplasm peroxisome peroxisome biological_process |
|
| TC0200003278.mm.2 |
Ptges |
prostaglandin E synthase |
2 |
-30889470 |
NM_022415, BC024960 NM_022415, BC024960 |
64292 |
186 |
prostaglandin biosynthetic process prostaglandin biosynthetic process prostaglandin biosynthetic process glutathione transferase activity glutathione peroxidase activity prostaglandin-D synthase activity prostaglandin-D synthase activity prostaglandin-D synthase activity nuclear envelope lumen cytoplasm lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process negative regulation of cell population proliferation membrane integral component of membrane integral component of membrane oxidoreductase activity transferase activity isomerase activity sensory perception of pain regulation of fever generation positive regulation of prostaglandin secretion intracellular membrane-bounded organelle glutathione binding perinuclear region of cytoplasm prostaglandin-E synthase activity prostaglandin-E synthase activity regulation of inflammatory response |
00590 01100 |
| TC0200000781.mm.2 |
Acvr2a |
activin receptor IIA |
2 |
48814108 |
NM_007396, BC138823 NM_007396, BC138823 |
11480 |
112 |
nucleotide binding gastrulation with mouth forming second positive regulation of protein phosphorylation protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein binding ATP binding cytoplasm plasma membrane plasma membrane protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway spermatogenesis determination of left/right symmetry mesoderm development male gonad development anterior/posterior pattern specification regulation of signal transduction cell surface positive regulation of pathway-restricted SMAD protein phosphorylation coreceptor activity membrane integral component of membrane kinase activity phosphorylation transferase activity activin-activated receptor activity activin-activated receptor activity growth factor binding growth factor binding PDZ domain binding positive regulation of bone mineralization BMP signaling pathway BMP signaling pathway activin receptor signaling pathway activin receptor signaling pathway positive regulation of activin receptor signaling pathway inhibin-betaglycan-ActRII complex inhibin binding inhibin binding sperm ejaculation penile erection receptor complex receptor complex protein self-association positive regulation of erythrocyte differentiation positive regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of follicle-stimulating hormone secretion activin receptor complex activin binding activin binding activin binding embryonic skeletal system development regulation of nitric-oxide synthase activity Sertoli cell proliferation cellular response to growth factor stimulus cellular response to BMP stimulus BMP receptor activity |
04060 04350 |
| TC0600001403.mm.2 |
Clec4n |
C-type lectin domain family 4, member n |
6 |
123229842 |
NM_001190320, NM_001190321, NM_020001, BC023008 NM_001190320, NM_001190321, NM_020001, BC023008 NM_001190320, NM_001190321, NM_020001, BC023008 NM_001190320, NM_001190321, NM_020001, BC023008 |
56620 |
78 |
positive regulation of cytokine production adaptive immune response immune system process calcium ion binding protein binding mannose binding plasma membrane membrane integral component of membrane carbohydrate binding carbohydrate binding positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response metal ion binding defense response to fungus |
|
| TC1700001395.mm.2 |
Tagap1 |
T cell activation GTPase activating protein 1 |
17 |
-6954964 |
NM_147155, BC165956 NM_147155, BC165956 |
380608 |
14 |
GTPase activator activity cellular_component |
|
| TC1700002788.mm.2 |
|
|
|
|
NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754 |
|
|
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface phagocytic vesicle membrane beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site integral component of lumenal side of endoplasmic reticulum membrane |
|
| TC1200001041.mm.2 |
Serpina3i |
serine (or cysteine) peptidase inhibitor, clade A, member 3I |
12 |
104263121 |
NM_001199940 |
628900 |
12 |
serine-type endopeptidase inhibitor activity extracellular space negative regulation of endopeptidase activity response to cytokine response to peptide hormone |
|
| TC1000003161.mm.2 |
Dgka |
diacylglycerol kinase, alpha |
10 |
-128720135, -128720135, -128720135, -128720135 |
NM_016811, BC006713 NM_016811, BC006713 |
13139 |
57 |
nucleotide binding NAD+ kinase activity diacylglycerol kinase activity diacylglycerol kinase activity diacylglycerol kinase activity calcium ion binding ATP binding phospholipid binding cytoplasm cytosol cytosol plasma membrane plasma membrane lipid metabolic process phosphatidic acid biosynthetic process signal transduction protein kinase C-activating G protein-coupled receptor signaling pathway lipid binding kinase activity phosphorylation transferase activity intracellular signal transduction diacylglycerol metabolic process diacylglycerol metabolic process glycerolipid metabolic process lipid phosphorylation lipid phosphorylation metal ion binding |
00561 00564 01100 04070 |
| TC1400001052.mm.2 |
Rubcnl |
RUN and cysteine rich domain containing beclin 1 interacting protein like |
14 |
75016026, 75016035 |
NM_198642, BC052668 NM_198642, BC052668 |
271221 |
11 |
autophagosome membrane autophagosome membrane lipid metabolic process autophagy lipid binding phosphatidylinositol-5-phosphate binding membrane regulation of lipid metabolic process cytoplasmic vesicle phosphatidylinositol-3-phosphate binding intracellular membrane-bounded organelle autophagosome-lysosome fusion autophagosome-lysosome fusion autophagosome-endosome fusion autophagosome-endosome fusion phosphatidylinositol-4-phosphate binding regulation of glycogen metabolic process autophagosome maturation autophagosome maturation autophagosome maturation phosphatidylinositol phosphate binding |
|
| TC1700002778.mm.2 |
Tapbp |
TAP binding protein |
17 |
33919477 |
NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074 |
21356 |
69 |
Golgi membrane MHC class Ib protein complex assembly antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent protein binding endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane defense response regulation of gene expression membrane integral component of membrane antigen processing and presentation of endogenous peptide antigen via MHC class I phagocytic vesicle membrane MHC class I peptide loading complex TAP1 binding TAP2 binding peptide antigen stabilization regulation of protein complex stability TAP complex binding protein-containing complex assembly |
04612 |
| TC0100000300.mm.2 |
Il18rap |
interleukin 18 receptor accessory protein |
1 |
40515361 |
NM_010553, BC120598, BC120600 NM_010553, BC120598, BC120600 NM_010553, BC120598, BC120600 |
16174 |
16 |
interleukin-1 receptor activity plasma membrane inflammatory response signal transduction cell population proliferation membrane integral component of membrane hydrolase activity interferon-gamma production interleukin-6 production interleukin-18-mediated signaling pathway interleukin-18-mediated signaling pathway interleukin-18-mediated signaling pathway T-helper 1 cell cytokine production interleukin-18 receptor activity interleukin-18 receptor activity neutrophil activation interleukin-18 receptor complex positive regulation of natural killer cell mediated cytotoxicity NAD(P)+ nucleosidase activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity NAD+ nucleotidase, cyclic ADP-ribose generating cellular response to interleukin-18 |
04060 |
| TC1300000113.mm.2 |
Inhba |
inhibin beta-A |
13 |
16011850 |
NM_008380, BC053527 NM_008380, BC053527 |
16323 |
200 |
G1/S transition of mitotic cell cycle ovarian follicle development mesoderm formation hair follicle development hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation signaling receptor binding cytokine activity cytokine activity hormone activity extracellular region extracellular region extracellular space extracellular space extracellular space regulation of transcription by RNA polymerase II cell cycle arrest growth factor activity negative regulation of cell population proliferation male gonad development positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation peptide hormone binding striatal medium spiny neuron differentiation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway inhibin binding endodermal cell differentiation odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion identical protein binding activin A complex inhibin A complex protein-containing complex binding positive regulation of erythrocyte differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of follicle-stimulating hormone secretion mesodermal cell differentiation perinuclear region of cytoplasm negative regulation of hair follicle development roof of mouth development positive regulation of ovulation SMAD protein signal transduction eyelid development in camera-type eye type II activin receptor binding cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol GABAergic neuron differentiation extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
04060 04350 |
| TC0800001079.mm.2 |
Capns2 |
calpain, small subunit 2 |
8 |
92901394 |
NM_027112 |
69543 |
8 |
calcium ion binding protein binding cytoplasm plasma membrane plasma membrane membrane metal ion binding |
|
| TC0400001924.mm.2 |
Mthfr |
methylenetetrahydrofolate reductase |
4 |
148039076, 148041188 |
NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 |
17769 |
98 |
neural tube closure catalytic activity methylenetetrahydrofolate reductase (NAD(P)H) activity methylenetetrahydrofolate reductase (NAD(P)H) activity methylenetetrahydrofolate reductase (NAD(P)H) activity cytosol cytosol methionine metabolic process metabolic process methionine biosynthetic process methionine biosynthetic process oxidoreductase activity regulation of histone methylation tetrahydrofolate interconversion tetrahydrofolate interconversion protein-containing complex binding synapse tetrahydrofolate metabolic process flavin adenine dinucleotide binding NADP binding homocysteine metabolic process heterochromatin maintenance FAD binding modified amino acid binding |
00670 01100 |
| TC1200002440.mm.2 |
Gpr132 |
G protein-coupled receptor 132 |
12 |
-112850875 |
NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524 |
56696 |
46 |
G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway negative regulation of G2/M transition of mitotic cell cycle negative regulation of G2/M transition of mitotic cell cycle membrane integral component of membrane |
|
| TC1200000715.mm.2 |
Arg2 |
arginase type II |
12 |
79130787 |
NM_009705, BC023349 NM_009705, BC023349 |
11847 |
105 |
urea cycle ureteric bud development adaptive immune response immune system process negative regulation of type 2 immune response arginase activity arginase activity cytoplasm mitochondrion mitochondrion mitochondrion mitochondrion arginine metabolic process striated muscle contraction regulation of L-arginine import hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines arginine catabolic process to ornithine arginine catabolic process to ornithine manganese ion binding regulation of interleukin-1 beta production negative regulation of interleukin-13 production negative regulation of interleukin-17 production negative regulation of tumor necrosis factor production negative regulation of tumor necrosis factor production innate immune response negative regulation of striated muscle contraction metal ion binding nitric-oxide synthase binding negative regulation of nitric-oxide synthase activity negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of chemokine (C-C motif) ligand 4 production negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of defense response to bacterium regulation of reactive oxygen species biosynthetic process negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of cellular senescence |
00330 01100 05146 |
| TC0900003335.mm.2 |
Uba7 |
ubiquitin-like modifier activating enzyme 7 |
9 |
107975566 |
NM_023738, BC138843 NM_023738, BC138843 |
74153 |
30 |
ubiquitin-protein transferase activity nucleus cytoplasm cellular protein modification process cellular response to DNA damage stimulus ISG15 activating enzyme activity ISG15 activating enzyme activity ISG15 activating enzyme activity modification-dependent protein catabolic process ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation protein modification by small protein conjugation |
04120 05012 |
| TC1000000529.mm.2 |
Sowahc |
sosondowah ankyrin repeat domain family member C |
10 |
59221921 |
NM_172939 |
268301 |
13 |
molecular_function cellular_component biological_process |
|
| TC0900003331.mm.2 |
|
|
|
|
NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 |
|
|
B cell homeostasis negative regulation of B cell apoptotic process protein binding cytoplasm mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein-containing complex binding protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC1000001761.mm.2 |
Stx11 |
syntaxin 11 |
10 |
-12939982 |
NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 |
74732 |
21 |
SNARE binding T cell mediated cytotoxicity SNAP receptor activity Golgi apparatus plasma membrane intracellular protein transport exocytosis vesicle fusion synaptic vesicle endomembrane system protein transport membrane integral component of membrane vesicle-mediated transport SNARE complex synaptic vesicle fusion to presynaptic active zone membrane natural killer cell mediated cytotoxicity neutrophil degranulation cytotoxic T cell degranulation natural killer cell degranulation phagocytic vesicle vesicle docking presynaptic active zone membrane cellular response to interferon-gamma |
04130 |
| TC0900001365.mm.2 |
Cish |
cytokine inducible SH2-containing protein |
9 |
107296658 |
NM_009895, BC003783, BC022178 NM_009895, BC003783, BC022178 NM_009895, BC003783, BC022178 |
12700 |
61 |
protein binding plasma membrane phosphatidylinositol 3-kinase complex protein kinase C-activating G protein-coupled receptor signaling pathway negative regulation of signal transduction intracellular signal transduction regulation of growth phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity |
04630 |
| TC1100001016.mm.2 |
P2rx5 |
purinergic receptor P2X, ligand-gated ion channel, 5 |
11 |
73160387 |
NM_033321, BC138189, BC145181 NM_033321, BC138189, BC145181 NM_033321, BC138189, BC145181 |
94045 |
24 |
extracellularly ATP-gated cation channel activity extracellularly ATP-gated cation channel activity extracellularly ATP-gated cation channel activity integral component of nuclear inner membrane cytosol plasma membrane integral component of plasma membrane cell surface receptor signaling pathway identical protein binding regulation of skeletal muscle tissue regeneration positive regulation of calcium ion import across plasma membrane |
04020 04080 |
| TC1900000111.mm.2 |
Ehd1 |
EH-domain containing 1 |
19 |
6276895 |
NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828 |
13660 |
48 |
nucleotide binding calcium ion binding protein binding ATP binding GTP binding cytoplasm endosome early endosome early endosome lipid droplet plasma membrane plasma membrane cilium intracellular protein transport endocytosis endocytosis endocytosis endosome membrane positive regulation of cholesterol storage positive regulation of neuron projection development protein transport membrane endosomal transport endosomal transport ciliary pocket membrane cell projection organization endocytic vesicle endocytic vesicle platelet dense tubular network membrane neuron projection development small GTPase binding cytoplasmic vesicle early endosome membrane endocytic recycling endocytic recycling low-density lipoprotein particle clearance cholesterol homeostasis identical protein binding cell projection myelin sheath intracellular membrane-bounded organelle metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm protein homooligomerization recycling endosome membrane recycling endosome membrane cilium assembly cilium assembly cilium assembly protein localization to cilium protein localization to plasma membrane positive regulation of myoblast fusion cellular response to nerve growth factor stimulus positive regulation of endocytic recycling |
04144 |
| TC1200001237.mm.2 |
Tnfaip2 |
tumor necrosis factor, alpha-induced protein 2 |
12 |
111442660 |
NM_009396, BC138106, BC138107 NM_009396, BC138106, BC138107 NM_009396, BC138106, BC138107 |
21928 |
26 |
exocyst SNARE binding angiogenesis exocytosis multicellular organism development cell differentiation exocyst localization |
|
| TC0400003794.mm.2 |
C1qa |
complement component 1, q subcomponent, alpha polypeptide |
4 |
-136895915 |
NM_007572, BC002086 NM_007572, BC002086 |
12259 |
212 |
microglial cell activation immune system process protein binding extracellular region collagen trimer extracellular space complement activation, classical pathway aging aging neuron remodeling innate immune response synapse synapse synapse astrocyte activation synapse organization postsynapse synapse pruning complement-mediated synapse pruning vertebrate eye-specific patterning positive regulation of neuron death |
04610 05020 05142 05150 05322 |
| TC0100003320.mm.2 |
Tor3a |
torsin family 3, member A |
1 |
-156653616 |
NM_023141, BC071216 NM_023141, BC071216 |
30935 |
24 |
nucleotide binding protein binding ATP binding nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum lumen endoplasmic reticulum lumen ATPase activity ATPase activity |
|
| TC0X00002637.mm.2 |
Pdk3 |
pyruvate dehydrogenase kinase, isoenzyme 3 |
X |
-93764615 |
NM_145630, BC008126 NM_145630, BC008126 |
236900 |
29 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity ATP binding nucleolus mitochondrion mitochondrion mitochondrion carbohydrate metabolic process glucose metabolic process protein phosphorylation regulation of acetyl-CoA biosynthetic process from pyruvate regulation of glucose metabolic process regulation of glucose metabolic process kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peroxisome proliferator activated receptor signaling pathway cellular response to glucose stimulus cellular response to fatty acid hypoxia-inducible factor-1alpha signaling pathway regulation of reactive oxygen species metabolic process |
|
| TC0100003891.mm.2 |
Ifi203 |
interferon activated gene 203 |
1 |
-173920400, -173920400 |
BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328 |
15950 |
26 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta cellular response to interferon-beta identical protein binding |
|
| TC1300001270.mm.2 |
Plpp1 |
phospholipid phosphatase 1 |
13 |
112800776 |
NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161 |
19012 |
35 |
diacylglycerol diphosphate phosphatase activity diacylglycerol diphosphate phosphatase activity diacylglycerol diphosphate phosphatase activity plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane integral component of plasma membrane caveola lipid metabolic process phospholipid metabolic process phospholipid metabolic process phospholipid metabolic process diacylglycerol biosynthetic process sphingosine metabolic process sphingosine metabolic process sphingosine metabolic process ceramide metabolic process ceramide metabolic process ceramide metabolic process signal transduction signal transduction signal transduction phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity sphingosine-1-phosphate phosphatase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity lipid phosphatase activity phospholipid dephosphorylation phospholipid dephosphorylation phospholipid dephosphorylation phospholipid dephosphorylation ceramide-1-phosphate phosphatase activity ceramide-1-phosphate phosphatase activity |
00561 00564 00565 00600 01100 04666 04975 |
| TC1200000838.mm.2 |
Batf |
basic leucine zipper transcription factor, ATF-like |
12 |
85686719 |
NM_016767, BC132410, BC132412 NM_016767, BC132410, BC132412 NM_016767, BC132410, BC132412 |
53314 |
75 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production lymphoid progenitor cell differentiation DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cellular response to DNA damage stimulus cell differentiation DNA damage response, signal transduction by p53 class mediator defense response to protozoan myeloid dendritic cell differentiation sequence-specific DNA binding T-helper 2 cell differentiation isotype switching positive regulation of transcription by RNA polymerase II hematopoietic stem cell differentiation T-helper 17 cell differentiation T-helper 17 cell lineage commitment sequence-specific double-stranded DNA binding |
|
| TC1900001423.mm.2 |
Ifit1bl2 |
interferon induced protein with tetratricopeptide repeats 1B like 2 |
19 |
-34617048, -34617048 |
NM_053217, BC138202 NM_053217, BC138202 |
112419 |
14 |
RNA binding RNA binding cytoplasm cytosol cytosol defense response to virus |
|
| TC1300001395.mm.2 |
Pfkp |
phosphofructokinase, platelet |
13 |
-6579873 |
NM_019703, BC006926 NM_019703, BC006926 |
56421 |
58 |
nucleotide binding catalytic activity 6-phosphofructokinase activity 6-phosphofructokinase activity 6-phosphofructokinase activity ATP binding ATP binding cytoplasm cytosol 6-phosphofructokinase complex 6-phosphofructokinase complex fructose 6-phosphate metabolic process fructose 6-phosphate metabolic process glycolytic process metabolic process membrane AMP binding kinase activity phosphorylation transferase activity fructose 1,6-bisphosphate metabolic process fructose 1,6-bisphosphate metabolic process identical protein binding identical protein binding protein-containing complex binding metal ion binding monosaccharide binding glycolytic process through fructose-6-phosphate canonical glycolysis fructose-6-phosphate binding fructose-6-phosphate binding cellular response to leukemia inhibitory factor |
00010 00030 00051 00052 01100 |
| TC0800002822.mm.2 |
Tppp3 |
tubulin polymerization-promoting protein family member 3 |
8 |
-105467491 |
NM_026481, BC010788 NM_026481, BC010788 |
67971 |
32 |
microtubule bundle formation microtubule bundle formation cytoplasm cytoskeleton microtubule embryo implantation tubulin binding tubulin binding positive regulation of protein polymerization decidualization microtubule polymerization perinuclear region of cytoplasm microtubule bundle |
|
| TC1300002392.mm.2 |
Vcan |
versican |
13 |
-89655309, -89709947 |
NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 |
13003 |
200 |
skeletal system development ureteric bud development calcium ion binding hyaluronic acid binding extracellular region cell adhesion central nervous system development heart development glial cell migration cell surface protein phosphatase binding extracellular matrix structural constituent conferring compression resistance carbohydrate binding extracellular matrix extracellular matrix cell projection regulation of phosphoprotein phosphatase activity synapse collagen-containing extracellular matrix collagen-containing extracellular matrix perineuronal net |
04514 |
| TC0500003043.mm.2 |
Cmklr1 |
chemokine-like receptor 1 |
5 |
-113612354, -113612354 |
NM_008153, BC100612 NM_008153, BC100612 |
14747 |
65 |
complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity plasma membrane plasma membrane chemotaxis chemotaxis inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of macrophage chemotaxis positive regulation of macrophage chemotaxis membrane integral component of membrane negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-12 production positive regulation of fat cell differentiation regulation of calcium-mediated signaling regulation of calcium-mediated signaling positive regulation of cold-induced thermogenesis |
|
| TC1300000364.mm.2 |
Serpinb9 |
serine (or cysteine) peptidase inhibitor, clade B, member 9 |
13 |
33004540 |
NM_009256, BC029900 NM_009256, BC029900 |
20723 |
40 |
T cell mediated cytotoxicity protease binding acute inflammatory response to antigenic stimulus serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding extracellular space extracellular space nucleus nucleoplasm cytoplasm cytoplasm cytoplasm Golgi apparatus cytosol immune response response to bacterium positive regulation of gene expression negative regulation of endopeptidase activity negative regulation of endopeptidase activity negative regulation by symbiont of host apoptotic process protection from natural killer cell mediated cytotoxicity defense response to bacterium cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process collagen-containing extracellular matrix negative regulation of T cell apoptotic process |
05146 |
| TC1700000214.mm.2 |
|
|
|
|
NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 |
|
|
amyloid-beta binding amyloid-beta binding microglial cell activation positive regulation of protein phosphorylation complement receptor mediated signaling pathway immune response-regulating cell surface receptor signaling pathway complement receptor activity G protein-coupled receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane plasma membrane receptor-mediated endocytosis chemotaxis chemotaxis inflammatory response signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane calcium-mediated signaling positive regulation of superoxide anion generation signaling receptor activity signaling receptor activity cargo receptor activity defense response to bacterium negative regulation of neuron apoptotic process positive regulation of innate immune response positive regulation of G protein-coupled receptor signaling pathway astrocyte activation negative regulation of inflammatory response positive regulation of phagocytosis RAGE receptor binding positive chemotaxis positive regulation of protein kinase B signaling positive regulation of 1-phosphatidylinositol-3-kinase activity positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotaxis cellular response to amyloid-beta cellular response to amyloid-beta |
|
| TC0400001599.mm.2 |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
4 |
132974094 |
NM_010208, BC057863 NM_010208, BC057863 |
14191 |
111 |
nucleotide binding phosphotyrosine residue binding phosphotyrosine residue binding positive regulation of cytokine production immune system process protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signaling receptor binding protein binding ATP binding cytoplasm mitochondrion mitochondrial inner membrane cytosol cytoskeleton plasma membrane plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway integrin-mediated signaling pathway regulation of cell shape positive regulation of phosphatidylinositol 3-kinase signaling actin cytoskeleton membrane aggresome kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation protein kinase binding protein kinase binding cell differentiation bone mineralization positive regulation of cell migration extrinsic component of cytoplasmic side of plasma membrane ruffle membrane negative regulation of natural killer cell activation regulation of actin cytoskeleton organization immunoglobulin receptor binding Fc-gamma receptor I complex binding cell projection positive regulation of mast cell degranulation positive regulation of phosphatidylinositol 3-kinase activity innate immune response regulation of innate immune response regulation of protein kinase activity protein autophosphorylation skeletal system morphogenesis regulation of phagocytosis defense response to Gram-positive bacterium defense response to Gram-positive bacterium |
04062 |
| TC0600001968.mm.2 |
Lrrc4 |
leucine rich repeat containing 4 |
6 |
-28828125 |
NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834 |
192198 |
30 |
protein binding plasma membrane membrane integral component of membrane cell junction dendritic spine neuron spine synapse postsynaptic membrane modulation of chemical synaptic transmission synapse organization excitatory synapse postsynaptic density protein 95 clustering Schaffer collateral - CA1 synapse glutamatergic synapse glutamatergic synapse integral component of postsynaptic density membrane integral component of postsynaptic density membrane synaptic membrane adhesion excitatory synapse assembly |
|
| TC1000000171.mm.2 |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
10 |
21993889, 21992222, 21882183, 21978671, 21986103, 21994665 |
NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 |
20393 |
198 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus nucleus cytoplasm cytoplasm mitochondrion endoplasmic reticulum cytosol cytosol plasma membrane protein phosphorylation cellular sodium ion homeostasis apoptotic process cellular response to DNA damage stimulus microtubule depolymerization long-term memory visual learning positive regulation of sodium ion transport potassium channel regulator activity membrane kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation peptidyl-serine phosphorylation positive regulation of cell growth negative regulation of microtubule polymerization cellular response to insulin stimulus regulation of protein localization intracellular signal transduction neuron projection negative regulation of apoptotic process glucocorticoid mediated signaling pathway 3-phosphoinositide-dependent protein kinase binding tau protein binding perinuclear region of cytoplasm neuron projection morphogenesis neuron projection morphogenesis positive regulation of dendrite morphogenesis regulation of cell cycle cellular response to aldosterone |
04960 |
| TC0700001520.mm.2 |
|
|
|
|
NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966 |
|
|
protein polyubiquitination nucleoplasm cytoplasm cytosol zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity |
|
| TC1100004291.mm.2 |
Psme2b |
protease (prosome, macropain) activator subunit 2B |
11 |
-48945351 |
NM_001281472 |
621823 |
13 |
molecular_function cellular_component biological_process |
|
| TC0400002434.mm.2 |
Ddx58 |
DEAD/H box helicase 58 |
4 |
-40203776 |
NM_172689, BC167209 NM_172689, BC167209 |
230073 |
157 |
nucleotide binding positive regulation of defense response to virus by host immune system process positive regulation of myeloid dendritic cell cytokine production DNA binding double-stranded DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding cytoplasm cytoplasm cytosol cytosol cytoskeleton plasma membrane bicellular tight junction zinc ion binding zinc ion binding detection of virus response to virus response to virus positive regulation of gene expression actin cytoskeleton membrane hydrolase activity cell junction regulation of cell migration ubiquitin protein ligase binding ruffle membrane positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production RIG-I signaling pathway identical protein binding cell projection response to exogenous dsRNA innate immune response innate immune response innate immune response positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of DNA-binding transcription factor activity defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA antiviral innate immune response ribonucleoprotein complex |
04622 04623 05160 |
| TC1700000948.mm.2 |
Mocs1 |
molybdenum cofactor synthesis 1 |
17 |
49428363 |
NM_020042, NM_028464 NM_020042, NM_028464 |
56738 |
18 |
nucleotide binding catalytic activity GTP binding Mo-molybdopterin cofactor biosynthetic process lyase activity molybdopterin synthase complex molybdopterin cofactor biosynthetic process metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding GTP 3',8'-cyclase activity GTP 3',8'-cyclase activity cyclic pyranopterin monophosphate synthase activity cyclic pyranopterin monophosphate synthase activity |
04122 |
| TC1700000703.mm.2 |
Ier3 |
immediate early response 3 |
17 |
35821712 |
NM_133662, BC006950 NM_133662, BC006950 |
15937 |
42 |
response to protozoan negative regulation of systemic arterial blood pressure protein binding nucleus nucleus nucleus regulation of DNA repair mitotic G2 DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage membrane integral component of membrane negative regulation of apoptotic process positive regulation of protein catabolic process negative regulation of glycolytic process regulation of nucleocytoplasmic transport negative regulation of inflammatory response negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of reactive oxygen species metabolic process regulation of response to DNA damage stimulus regulation of response to DNA damage stimulus regulation of response to DNA damage stimulus |
|
| TC1200000278.mm.2 |
Ccdc71l |
coiled-coil domain containing 71 like |
12 |
32378788 |
NM_001162903 |
72123 |
9 |
molecular_function cellular_component biological_process |
|
| TC1500000673.mm.2 |
Maff |
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) |
15 |
79347519, 79348060, 79346620, 79348401 |
NM_010755, BC022952 NM_010755, BC022952 |
17133 |
36 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific in utero embryonic development DNA binding DNA-binding transcription factor activity nucleus nucleoplasm nucleoplasm mitochondrion regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II skeletal muscle cell differentiation sequence-specific DNA binding regulation of epidermal cell differentiation regulation of epidermal cell differentiation positive regulation of transcription by RNA polymerase II sequence-specific double-stranded DNA binding |
|
| TC0400003680.mm.2 |
Smpdl3b |
sphingomyelin phosphodiesterase, acid-like 3B |
4 |
-132732965 |
NM_133888, BC009087 NM_133888, BC009087 |
100340 |
25 |
immune system process sphingomyelin phosphodiesterase activity protein binding extracellular region extracellular space plasma membrane lipid metabolic process sphingomyelin catabolic process inflammatory response phosphoric diester hydrolase activity phosphoric diester hydrolase activity phosphoric diester hydrolase activity phosphoric diester hydrolase activity metabolic process zinc ion binding membrane lipid catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds anchored component of membrane negative regulation of toll-like receptor signaling pathway innate immune response negative regulation of innate immune response membrane lipid catabolic process metal ion binding negative regulation of inflammatory response |
|
| TC0300000210.mm.2 |
Skil |
SKI-like |
3 |
31095057 |
NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 |
20482 |
57 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific acrosomal vesicle blastocyst formation lymphocyte homeostasis chromatin binding protein binding nucleus nucleus nucleus transcription regulator complex cytoplasm cell cycle arrest transforming growth factor beta receptor signaling pathway skeletal muscle tissue development PML body protein domain specific binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway protein-containing complex identical protein binding protein-containing complex binding negative regulation of cell differentiation SMAD binding SMAD binding positive regulation of axonogenesis lens fiber cell differentiation response to growth factor positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
|
| TC1900000497.mm.2 |
Fas |
Fas (TNF receptor superfamily member 6) |
19 |
34290658, 34290658 |
NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160 |
14102 |
1558 |
positive regulation of protein phosphorylation protease binding immunoglobulin production transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity tumor necrosis factor-activated receptor activity protein binding calmodulin binding extracellular region extracellular space cytoplasm cytosol plasma membrane apoptotic process apoptotic process activation-induced cell death of T cells activation-induced cell death of T cells activation-induced cell death of T cells inflammatory cell apoptotic process inflammatory cell apoptotic process immune response signal transduction circadian rhythm extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors response to toxic substance external side of plasma membrane external side of plasma membrane cell surface cell surface gene expression regulation of gene expression negative regulation of Schwann cell proliferation positive regulation of cell death membrane integral component of membrane apical plasma membrane nuclear body B cell mediated immunity kinase binding secretory granule dendrite regeneration death-inducing signaling complex CD95 death-inducing signaling complex CD95 death-inducing signaling complex CD95 death-inducing signaling complex positive regulation of protein-containing complex assembly regulation of stress-activated MAPK cascade regulation of stress-activated MAPK cascade cellular response to amino acid starvation Fas signaling pathway regulation of cell population proliferation sarcolemma identical protein binding identical protein binding regulation of apoptotic process neuron projection neuronal cell body T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process protein-containing complex binding negative thymic T cell selection membrane raft membrane raft regulation of lymphocyte differentiation regulation of myeloid cell differentiation perinuclear region of cytoplasm spleen development negative regulation of B cell activation response to glucocorticoid neuron apoptotic process lymphocyte apoptotic process cellular response to lithium ion cellular response to hyperoxia positive regulation of release of cytochrome c from mitochondria motor neuron apoptotic process motor neuron apoptotic process apoptotic signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process apical dendrite necroptotic signaling pathway necroptotic signaling pathway necroptotic signaling pathway negative regulation of Schwann cell migration positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
04010 04060 04115 04210 04650 04940 05010 05142 05143 05200 05320 05330 05332 |
| TC0200001222.mm.2 |
Ube2l6 |
ubiquitin-conjugating enzyme E2L 6 |
2 |
84798827 |
NM_019949, BC008238 NM_019949, BC008238 |
56791 |
22 |
ubiquitin ligase complex nucleotide binding protein polyubiquitination protein binding ATP binding nucleus ubiquitin-dependent protein catabolic process transferase activity ubiquitin-like protein transferase activity modification-dependent protein catabolic process ubiquitin protein ligase binding ISG15-protein conjugation ISG15-protein conjugation ISG15 transferase activity ISG15 transferase activity ubiquitin binding ubiquitin conjugating enzyme activity |
04120 05012 |
| TC0100000374.mm.2 |
Stat4 |
signal transducer and activator of transcription 4 |
1 |
51987147, 52008239 |
NM_011487, BC098499 NM_011487, BC098499 |
20849 |
318 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein phosphorylation defense response signal transduction receptor signaling pathway via JAK-STAT cell population proliferation positive regulation of gene expression cytokine-mediated signaling pathway cytokine-mediated signaling pathway regulation of cell population proliferation identical protein binding response to peptide hormone sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II hematopoietic stem cell homeostasis cellular response to organic substance |
04630 |
| TC0800002947.mm.2 |
Mlkl |
mixed lineage kinase domain-like |
8 |
-111311797 |
NM_029005, BC023755 NM_029005, BC023755 |
74568 |
139 |
nucleotide binding JUN kinase kinase kinase activity protein binding ATP binding ATP binding nucleus cytoplasm cytoplasm cytosol plasma membrane plasma membrane cell surface receptor signaling pathway activation of JUN kinase activity programmed cell death membrane protein kinase binding cell junction identical protein binding protein-containing complex binding defense response to virus defense response to virus protein homotrimerization necroptotic process necroptotic process necroptotic signaling pathway necroptotic signaling pathway execution phase of necroptosis execution phase of necroptosis |
|
| TC1100001238.mm.2 |
Slfn2 |
schlafen 2 |
11 |
83065111 |
NM_011408, BC138749, BC138750 NM_011408, BC138749, BC138750 NM_011408, BC138749, BC138750 |
20556 |
19 |
negative regulation of cell population proliferation response to bacterium |
|
| TC1700002789.mm.2 |
|
|
|
|
NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 |
|
|
positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response embryo implantation external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane phagocytic vesicle membrane beta-2-microglobulin binding MHC class Ib protein complex positive regulation of interferon-gamma production peptide binding peptide antigen binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding defense response to virus TAP complex binding endoplasmic reticulum exit site cellular response to interferon-gamma integral component of lumenal side of endoplasmic reticulum membrane |
|
| TC0X00000072.mm.2 |
Kcnd1 |
potassium voltage-gated channel, Shal-related family, member 1 |
X |
7823758 |
NM_008423, BC139325, BC139327 NM_008423, BC139325, BC139327 NM_008423, BC139325, BC139327 |
16506 |
38 |
ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity A-type (transient outward) potassium channel activity potassium channel activity ion transport potassium ion transport voltage-gated potassium channel complex postsynaptic density membrane integral component of membrane regulation of ion transmembrane transport cell projection neuronal cell body dendritic spine postsynaptic membrane metal ion binding protein homooligomerization transmembrane transport potassium ion transmembrane transport |
|
| TC0100000765.mm.2 |
Sp140 |
Sp140 nuclear body protein |
1 |
85600702 |
NM_001013817, BC069971 NM_001013817, BC069971 |
434484 |
5 |
fibrillar center mitochondrion |
|
| TC1600001607.mm.2 |
Poglut1 |
protein O-glucosyltransferase 1 |
16 |
-38525057 |
NM_172380, BC026809 NM_172380, BC026809 |
224143 |
26 |
somitogenesis protein binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum lumen protein O-linked glycosylation protein O-linked glycosylation protein O-linked glycosylation multicellular organism development gastrulation regulation of Notch signaling pathway regulation of gastrulation endomembrane system transferase activity transferase activity, transferring glycosyl groups protein O-linked glycosylation via serine protein O-linked glycosylation via serine UDP-glucosyltransferase activity UDP-glucosyltransferase activity UDP-glucosyltransferase activity UDP-glucosyltransferase activity UDP-xylosyltransferase activity UDP-xylosyltransferase activity UDP-xylosyltransferase activity UDP-xylosyltransferase activity positive regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of Notch signaling pathway glucosyltransferase activity glucosyltransferase activity glucosyltransferase activity axial mesoderm development paraxial mesoderm development muscle tissue development circulatory system development |
00514 |
| TC1700001953.mm.2 |
Lst1 |
leukocyte specific transcript 1 |
17 |
-35185094 |
NM_010734, BC086881 NM_010734, BC086881 |
16988 |
21 |
cell morphogenesis immune system process immune response regulation of cell shape membrane integral component of membrane dendrite development dendrite development |
|
| TC1900000995.mm.2 |
Capn1 |
calpain 1 |
19 |
-5988544, -5988544 |
NM_001110504, NM_007600, BC026138, BC050276 NM_001110504, NM_007600, BC026138, BC050276 NM_001110504, NM_007600, BC026138, BC050276 NM_001110504, NM_007600, BC026138, BC050276 |
12333 |
173 |
calcium-dependent cysteine-type endopeptidase activity calcium-dependent cysteine-type endopeptidase activity calcium-dependent cysteine-type endopeptidase activity calcium-dependent cysteine-type endopeptidase activity calcium ion binding protein binding intracellular anatomical structure cytoplasm mitochondrion mitochondrion lysosome cytosol cytosol plasma membrane plasma membrane proteolysis proteolysis proteolysis cytoskeletal protein binding peptidase activity cysteine-type peptidase activity positive regulation of cardiac muscle cell apoptotic process membrane protein autoprocessing hydrolase activity enzyme binding negative regulation of actin filament polymerization receptor catabolic process positive regulation of vascular permeability metal ion binding regulation of catalytic activity mammary gland involution cellular response to hydrogen peroxide self proteolysis negative regulation of NIK/NF-kappaB signaling positive regulation of leukocyte tethering or rolling response to angiotensin |
04141 04210 05010 |
| TC1500002318.mm.2 |
Itga5 |
integrin alpha 5 (fibronectin receptor alpha) |
15 |
-103344285 |
NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829 |
16402 |
224 |
epidermal growth factor receptor binding integrin binding integrin binding protein binding cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane cell-cell junction focal adhesion cell-substrate junction assembly cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion integrin-mediated signaling pathway memory integrin complex external side of plasma membrane cell surface cell surface positive regulation of cell-substrate adhesion membrane integral component of membrane CD40 signaling pathway cell junction positive regulation of cell migration cytoplasmic vesicle cell-substrate adhesion ruffle membrane cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion integrin alpha5-beta1 complex endodermal cell differentiation synapse regulation of angiogenesis metal ion binding positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding positive regulation of sprouting angiogenesis negative regulation of anoikis |
04145 04510 04512 04640 04810 05100 05410 05412 05414 |
| TC1900000443.mm.2 |
Ric1 |
RAB6A GEF complex partner 1 |
19 |
29522281 |
NM_001081319 |
226089 |
17 |
Golgi membrane regulation of extracellular matrix constituent secretion guanyl-nucleotide exchange factor activity cytoplasm cytosol cytosol intracellular protein transport membrane small GTPase binding protein-containing complex Ric1-Rgp1 guanyl-nucleotide exchange factor complex Ric1-Rgp1 guanyl-nucleotide exchange factor complex retrograde transport, endosome to Golgi retrograde transport, endosome to Golgi positive regulation of GTPase activity negative regulation of cellular protein catabolic process cranial skeletal system development |
|
| TC0600003231.mm.2 |
Klrk1 |
killer cell lectin-like receptor subfamily K, member 1 |
6 |
-129610322, -129610322 |
NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 |
27007 |
199 |
stimulatory C-type lectin receptor signaling pathway adaptive immune response immune system process positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target protein binding plasma membrane plasma membrane external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane kinase binding natural killer cell activation natural killer cell activation cell differentiation carbohydrate binding positive regulation of myeloid dendritic cell activation MHC class Ib receptor activity positive regulation of interferon-gamma production signaling receptor activity MHC class I protein binding identical protein binding positive regulation of apoptotic process innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity defense response to Gram-positive bacterium cellular response to lipopolysaccharide |
04650 |
| TC1700001463.mm.2 |
Gpr31b |
G protein-coupled receptor 31, D17Leh66b region |
17 |
-13051320 |
NM_001013832, BC160363 NM_001013832, BC160363 |
436440 |
11 |
response to molecule of bacterial origin response to ischemia G protein-coupled receptor activity plasma membrane signal transduction G protein-coupled receptor signaling pathway response to acidic pH membrane integral component of membrane bioactive lipid receptor activity arachidonic acid binding negative regulation of inflammatory response positive regulation of immune response |
|
| TC0500003024.mm.2 |
Grk3 |
G protein-coupled receptor kinase 3 |
5 |
-112910477 |
NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 |
320129 |
40 |
nucleotide binding positive regulation of protein phosphorylation desensitization of G protein-coupled receptor signaling pathway protein kinase activity protein serine/threonine kinase activity G protein-coupled receptor kinase activity G protein-coupled receptor kinase activity ATP binding nucleus cytosol cilium protein phosphorylation intracellular protein transport signal transduction membrane kinase activity phosphorylation transferase activity Z disc axon receptor internalization D1 dopamine receptor binding dendritic spine dendritic shaft inositol phosphate metabolic process dendrite terminus membrane raft synapse rhodopsin metabolic process beta-adrenergic receptor kinase activity perinuclear region of cytoplasm sperm midpiece |
04740 |
| TC1900000991.mm.2 |
Cdc42ep2 |
CDC42 effector protein (Rho GTPase binding) 2 |
19 |
-5917555 |
NM_026772, BC034884 NM_026772, BC034884 |
104252 |
20 |
opioid peptide activity GTPase activator activity cytoplasm cytoplasm cytosol cytoskeleton plasma membrane plasma membrane Rho protein signal transduction regulation of cell shape regulation of cell shape microtubule cytoskeleton membrane actin cytoskeleton organization positive regulation of actin filament polymerization positive regulation of actin filament polymerization small GTPase binding positive regulation of pseudopodium assembly positive regulation of pseudopodium assembly phagocytic vesicle cellular response to interferon-gamma |
|
| TC1700001032.mm.2 |
Trip10 |
thyroid hormone receptor interactor 10 |
17 |
57249450 |
NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 NM_001242389, NM_001242390, NM_001242391, NM_134125, BC003249 |
106628 |
30 |
epithelial to mesenchymal transition protein binding nucleoplasm cytoplasm lysosome Golgi apparatus cytoskeleton microtubule plasma membrane endocytosis signal transduction lipid binding negative regulation of cardiac muscle cell apoptotic process membrane actin cytoskeleton organization hyperosmotic salinity response identical protein binding cell projection intracellular membrane-bounded organelle positive regulation of cell growth involved in cardiac muscle cell development |
04910 |
| TC1300000586.mm.2 |
Fbxw17 |
F-box and WD-40 domain protein 17 |
13 |
50417863 |
NM_175401, BC040428 NM_175401, BC040428 |
109082 |
14 |
molecular_function cellular_component |
|
| TC0500001724.mm.2 |
Fscn1 |
fascin actin-bundling protein 1 |
5 |
142960354 |
NM_007984, BC052408 NM_007984, BC052408 |
14086 |
66 |
stress fiber ruffle ruffle podosome actin binding protein binding cytoplasm cytoplasm cytosol cytoskeleton plasma membrane microvillus microvillus cell-cell junction actin filament organization cell-cell junction assembly establishment or maintenance of cell polarity drug binding drug binding positive regulation of lamellipodium assembly actin cytoskeleton actin cytoskeleton cell migration cell migration cell migration lamellipodium lamellipodium lamellipodium microspike assembly actin cytoskeleton organization parallel actin filament bundle assembly cell junction filopodium filopodium filopodium dendrite growth cone growth cone growth cone protein-macromolecule adaptor activity cell projection membrane cell projection membrane regulation of microvillus assembly regulation of actin cytoskeleton organization establishment of apical/basal cell polarity cell projection myelin sheath microspike cell motility actin filament binding actin filament binding actin filament binding actin filament bundle assembly actin filament bundle assembly actin filament bundle assembly positive regulation of filopodium assembly positive regulation of filopodium assembly positive regulation of podosome assembly positive regulation of extracellular matrix disassembly |
|
| TC0100003550.mm.2 |
Slamf7 |
SLAM family member 7 |
1 |
-171632404, -171632402 |
NM_144539, BC011154 NM_144539, BC011154 |
75345 |
25 |
adaptive immune response immune system process protein binding plasma membrane external side of plasma membrane membrane integral component of membrane regulation of natural killer cell activation identical protein binding innate immune response |
|
| TC0400001327.mm.2 |
Svbp |
small vasohibin binding protein |
4 |
119195309, 119195524 |
NM_001038998, NM_024462, BC002274 NM_001038998, NM_024462, BC002274 NM_001038998, NM_024462, BC002274 |
69216 |
16 |
protein binding extracellular region cytoplasm cytoskeleton proteolysis proteolysis microtubule binding protein secretion protein secretion negative regulation of endothelial cell migration negative regulation of protein ubiquitination negative regulation of protein ubiquitination apical part of cell apical part of cell axon development axon development regulation of metallopeptidase activity |
|
| TC1100000464.mm.2 |
Adam19 |
a disintegrin and metallopeptidase domain 19 (meltrin beta) |
11 |
46054501, 46055983, 46127903 |
NM_009616 |
11492 |
57 |
metalloendopeptidase activity metalloendopeptidase activity protein binding nucleus Golgi apparatus membrane protein ectodomain proteolysis membrane protein ectodomain proteolysis membrane protein ectodomain proteolysis heart development peptidase activity metallopeptidase activity positive regulation of gene expression membrane integral component of membrane protein processing hydrolase activity SH3 domain binding amyloid precursor protein catabolic process metal ion binding collagen-containing extracellular matrix metalloendopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of cell-cell adhesion mediated by cadherin |
|
| TC0100000216.mm.2 |
Dst |
dystonin |
1 |
34160259, 33908224, 34011594 |
NM_001276764, NM_010081, NM_133833, NM_134448 NM_001276764, NM_010081, NM_133833, NM_134448 NM_001276764, NM_010081, NM_133833, NM_134448 NM_001276764, NM_010081, NM_133833, NM_134448 |
13518 |
135 |
stress fiber actin binding structural molecule activity calcium ion binding protein binding nucleus nuclear envelope cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytoskeleton microtubule intermediate filament plasma membrane focal adhesion focal adhesion cytoskeleton organization cell adhesion axonogenesis microtubule binding microtubule binding retrograde axonal transport cytoskeletal protein binding cytoplasmic side of plasma membrane postsynaptic density intercalated disc actin cytoskeleton microtubule cytoskeleton membrane membrane integral component of membrane Z disc cell junction hemidesmosome hemidesmosome axon regulation of microtubule polymerization or depolymerization cytoplasmic microtubule organization cytoplasmic microtubule organization cytoplasmic vesicle hemidesmosome assembly H zone wound healing sarcolemma protein homodimerization activity cell projection intermediate filament cytoskeleton organization metal ion binding intracellular transport perinuclear region of cytoplasm neurofilament cytoskeleton perinuclear endoplasmic reticulum |
|
| TC0500001615.mm.2 |
|
|
|
|
NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 |
|
|
in utero embryonic development endothelial cell morphogenesis catalytic activity iron ion binding extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum Golgi apparatus trans-Golgi network protein O-linked glycosylation protein localization metabolic process procollagen-lysine 5-dioxygenase activity procollagen-lysine 5-dioxygenase activity procollagen-lysine 5-dioxygenase activity negative regulation of gene expression membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen transferase activity transferase activity, transferring glycosyl groups peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation neural tube development collagen fibril organization L-ascorbic acid binding collagen metabolic process procollagen glucosyltransferase activity procollagen glucosyltransferase activity procollagen glucosyltransferase activity vasodilation metal ion binding hydroxylysine biosynthetic process epidermis morphogenesis procollagen galactosyltransferase activity dioxygenase activity lung morphogenesis collagen-containing extracellular matrix collagen-containing extracellular matrix basement membrane assembly positive regulation of stem cell proliferation |
|
| TC0100000743.mm.2 |
Gm7609 |
predicted pseudogene 7609 |
1 |
85199610 |
NM_001081746 |
665378 |
10 |
|
|
| TC0800001984.mm.2 |
Nrg1 |
neuregulin 1 |
8 |
-31814550, -31820775, -31814550, -31820775, -31837204, -31837204 |
NM_178591, BC151113, BC160344 NM_178591, BC151113, BC160344 NM_178591, BC151113, BC160344 |
211323 |
368 |
MAPK cascade cell morphogenesis startle response cardiac conduction system development transcription coregulator activity signaling receptor binding ErbB-2 class receptor binding ErbB-2 class receptor binding protein binding extracellular region extracellular space nucleus cytoplasm plasma membrane integral component of plasma membrane activation of transmembrane receptor protein tyrosine kinase activity nervous system development nervous system development synapse assembly synapse assembly brain development peripheral nervous system development heart development muscle organ development locomotory behavior axon ensheathment external side of plasma membrane glial cell differentiation positive regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling cell migration glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex neurogenesis neurogenesis myelination in peripheral nervous system cell differentiation protein tyrosine kinase activator activity axon dendrite axolemma receptor tyrosine kinase binding neuromuscular junction positive regulation of myelination intracellular signal transduction negative regulation of protein catabolic process cellular protein complex disassembly cell body synapse neurotransmitter receptor metabolic process chemorepellent activity chemorepellent activity regulation of cell differentiation positive regulation of axon extension positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of Ras protein signal transduction animal organ development neuron fate commitment oligodendrocyte differentiation cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation positive regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cardiac muscle cell differentiation positive regulation of dendritic spine development positive regulation of calcineurin-NFAT signaling cascade glutamatergic synapse glutamatergic synapse GABA-ergic synapse GABA-ergic synapse postsynapse to nucleus signaling pathway postsynapse to nucleus signaling pathway positive regulation of protein localization to cell surface positive regulation of cardiac muscle cell differentiation negative regulation of neuron migration |
04012 |
| TC0600001579.mm.2 |
Etv6 |
ets variant 6 |
6 |
134035699 |
NM_007961, BC052163 NM_007961, BC052163 |
14011 |
83 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus nucleolus cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II vitellogenesis protein domain specific binding neurogenesis cell differentiation cell differentiation sequence-specific DNA binding positive regulation of transcription by RNA polymerase II hematopoietic stem cell proliferation mesenchymal cell apoptotic process |
04320 |
| TC1000002164.mm.2 |
Cep85l |
centrosomal protein 85-like |
10 |
-53273442 |
NM_001204983 |
100038725 |
10 |
molecular_function centrosome biological_process |
|
| TC1700000528.mm.2 |
Abcg1 |
ATP binding cassette subfamily G member 1 |
17 |
31057693 |
NM_009593, BC119471 NM_009593, BC119471 |
11307 |
166 |
nucleotide binding ATP binding mitochondrion endosome endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane lipid transport cholesterol metabolic process external side of plasma membrane external side of plasma membrane negative regulation of macrophage derived foam cell differentiation regulation of cholesterol esterification positive regulation of cholesterol efflux negative regulation of lipid storage membrane integral component of membrane ATPase activity toxin transmembrane transporter activity cholesterol transport intracellular cholesterol transport cholesterol efflux cholesterol efflux cholesterol efflux phospholipid efflux response to lipid ABC-type sterol transporter activity ABC-type sterol transporter activity low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling glycoprotein transport cholesterol homeostasis cholesterol homeostasis protein homodimerization activity amyloid precursor protein catabolic process ADP binding reverse cholesterol transport positive regulation of cholesterol biosynthetic process protein heterodimerization activity positive regulation of protein secretion recycling endosome transmembrane transport phospholipid homeostasis cellular response to high density lipoprotein particle stimulus phosphatidylcholine floppase activity cholesterol transfer activity floppase activity positive regulation of amyloid-beta formation |
02010 |
| TC0700000501.mm.2 |
Gmfg |
glia maturation factor, gamma |
7 |
28437468, 28440936, 28440990 |
NM_001039192, NM_022024, BC011488 NM_001039192, NM_022024, BC011488 NM_001039192, NM_022024, BC011488 |
63986 |
24 |
actin binding intracellular anatomical structure growth factor activity negative regulation of Arp2/3 complex-mediated actin nucleation negative regulation of Arp2/3 complex-mediated actin nucleation actin filament debranching actin filament debranching Arp2/3 complex binding Arp2/3 complex binding regulation of actin cytoskeleton reorganization |
|
| TC0100001496.mm.2 |
Sell |
selectin, lymphocyte |
1 |
164062075 |
NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681 |
20343 |
263 |
protease binding calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion external side of plasma membrane cell surface cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding response to ATP regulation of apoptotic process metal ion binding cell adhesion molecule binding leukocyte migration leukocyte tethering or rolling glycolipid binding oligosaccharide binding positive regulation of neutrophil chemotaxis |
04514 |
| TC0900003310.mm.2 |
Lztfl1 |
leucine zipper transcription factor-like 1 |
9 |
-123694405 |
NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224 |
93730 |
31 |
protein binding cytoplasm cytosol identical protein binding protein-containing complex binding protein-containing complex binding negative regulation of protein localization to cilium negative regulation of protein localization to cilium negative regulation of protein localization to ciliary membrane |
|
| TC0800001833.mm.2 |
Gm15056 |
predicted gene 15056 |
8 |
-20900605 |
NM_001177471 |
100504014 |
2 |
|
|
| TC0700001519.mm.2 |
Trim6 |
tripartite motif-containing 6 |
7 |
104218794 |
NM_001013616, BC138965 NM_001013616, BC138965 |
94088 |
25 |
protein polyubiquitination protein polyubiquitination positive regulation of defense response to virus by host positive regulation of cytokine production involved in immune response protein binding nucleus nucleoplasm cytoplasm cytoplasm cytoplasm cytosol cytosol transcription factor binding zinc ion binding regulation of gene expression positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation free ubiquitin chain polymerization protein ubiquitination transferase activity protein kinase binding protein kinase binding protein kinase binding protein-macromolecule adaptor activity response to lipopolysaccharide regulation of protein localization positive regulation of peptidyl-serine phosphorylation cellular response to interferon-beta identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of viral genome replication negative regulation of viral genome replication innate immune response negative regulation of transcription, DNA-templated regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity positive regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to virus protein tyrosine kinase binding positive regulation of transcription regulatory region DNA binding negative regulation of stem cell differentiation |
|
| TC1300000522.mm.2 |
Mylip |
myosin regulatory light chain interacting protein |
13 |
45389741 |
NM_153789, BC010206, NM_181043 NM_153789, BC010206, NM_181043 NM_153789, BC010206, NM_181043 |
218203 |
32 |
ubiquitin-protein transferase activity ubiquitin-protein transferase activity ubiquitin-protein transferase activity cytoplasm cytoskeleton plasma membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process nervous system development cytoskeletal protein binding negative regulation of neuron projection development negative regulation of low-density lipoprotein particle clearance membrane protein ubiquitination transferase activity protein destabilization regulation of low-density lipoprotein particle receptor catabolic process cholesterol homeostasis positive regulation of protein catabolic process metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to low-density lipoprotein particle stimulus |
|
| TC0100003882.mm.2 |
Chpf |
chondroitin polymerizing factor |
1 |
-75474568 |
NM_001001565, NM_001001566, BC071273 NM_001001565, NM_001001566, BC071273 NM_001001565, NM_001001566, BC071273 |
74241 |
29 |
protein binding cellular_component cytoplasm mitochondrion Golgi apparatus acetylgalactosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups chondroitin sulfate biosynthetic process chondroitin sulfate biosynthetic process chondroitin sulfate biosynthetic process chondroitin sulfate biosynthetic process Golgi cisterna membrane metal ion binding glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity |
00532 01100 |
| TC1600001479.mm.2 |
Apod |
apolipoprotein D |
16 |
-31296191 |
NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909 |
11815 |
59 |
response to reactive oxygen species response to reactive oxygen species response to reactive oxygen species extracellular region extracellular space intracellular anatomical structure cytoplasm cytoplasm endoplasmic reticulum glucose metabolic process lipid metabolic process lipid metabolic process lipid transport aging lipid binding negative regulation of platelet-derived growth factor receptor signaling pathway cholesterol binding cholesterol binding cytosolic ribosome dendrite negative regulation of protein import into nucleus neuronal cell body perinuclear region of cytoplasm negative regulation of smooth muscle cell proliferation negative regulation of focal adhesion assembly negative regulation of lipoprotein lipid oxidation negative regulation of lipoprotein lipid oxidation negative regulation of monocyte chemotactic protein-1 production negative regulation of cytokine production involved in inflammatory response negative regulation of smooth muscle cell-matrix adhesion negative regulation of T cell migration |
|
| TC0300002237.mm.2 |
Tmem131l |
transmembrane 131 like |
3 |
-83898286 |
NM_172681, BC062940 NM_172681, BC062940 |
229473 |
21 |
molecular_function cytoplasm endoplasmic reticulum plasma membrane plasma membrane membrane integral component of membrane Wnt signaling pathway negative regulation of immature T cell proliferation in thymus negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway |
|
| TC0500000170.mm.2 |
Gsap |
gamma-secretase activating protein |
5 |
21176278, 21186266, 21186266 |
NM_175437 |
212167 |
14 |
amyloid-beta binding Golgi apparatus trans-Golgi network trans-Golgi network regulation of proteolysis positive regulation of amyloid-beta formation positive regulation of amyloid-beta formation positive regulation of amyloid-beta formation |
|
| TC0500000602.mm.2 |
Fam114a1 |
family with sequence similarity 114, member A1 |
5 |
64970074 |
NM_026667, BC027235, BC110359 NM_026667, BC027235, BC110359 NM_026667, BC027235, BC110359 |
68303 |
17 |
molecular_function nucleoplasm cytoplasm Golgi apparatus cytosol biological_process |
|
| TC1900001118.mm.2 |
Ccdc86 |
coiled-coil domain containing 86 |
19 |
-10941480 |
NM_023731, BC043326 NM_023731, BC043326 |
108673 |
21 |
nucleus nucleoplasm chromosome nucleolus nucleolus |
|
| TC0200004204.mm.2 |
Prr5l |
proline rich 5 like |
2 |
-101714284, -101714284, -101714284 |
NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 |
72446 |
19 |
negative regulation of protein phosphorylation positive regulation of protein phosphorylation mitochondrion negative regulation of signal transduction regulation of fibroblast migration regulation of fibroblast migration positive regulation of phosphatidylinositol 3-kinase signaling ubiquitin protein ligase binding TORC2 complex TORC2 complex cellular response to oxidative stress TORC2 signaling TORC2 signaling TORC2 signaling positive regulation of mRNA catabolic process positive regulation of intracellular protein transport |
|
| TC0200003528.mm.2 |
Nmi |
N-myc (and STAT) interactor |
2 |
-51948498 |
NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 |
64685 |
23 |
macrophage activation involved in immune response transcription coregulator activity protein binding extracellular space extracellular space nucleus nucleoplasm cytoplasm cytoplasm cytosol transcription by RNA polymerase II negative regulation of cell population proliferation response to virus membrane negative regulation of type I interferon production negative regulation of interferon-alpha production negative regulation of interferon-beta production toll-like receptor 4 signaling pathway identical protein binding positive regulation of innate immune response negative regulation of innate immune response negative regulation of innate immune response positive regulation of inflammatory response interferon-gamma-mediated signaling pathway negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of protein K48-linked ubiquitination |
|
| TC1700000932.mm.2 |
Trem1 |
triggering receptor expressed on myeloid cells 1 |
17 |
48232738 |
NM_021406, BC148731 NM_021406, BC148731 |
58217 |
89 |
cytokine production cytokine production involved in immune response acute inflammatory response membrane integral component of membrane cell migration neutrophil chemotaxis chemokine production signaling receptor activity neutrophil-mediated killing of gram-negative bacterium neutrophil extravasation scaffold protein binding |
|
| TC0800000659.mm.2 |
Ddx60 |
DExD/H box helicase 60 |
8 |
61928086 |
NM_001081215 |
234311 |
16 |
double-stranded DNA binding RNA binding double-stranded RNA binding single-stranded RNA binding protein binding cytoplasm cytoplasm cytosol response to virus intermediate filament cytoskeleton defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway |
|
| TC1800001512.mm.2 |
Ptpn2 |
protein tyrosine phosphatase, non-receptor type 2 |
18 |
-67665500 |
NM_001127177, NM_008977, BC008269 NM_001127177, NM_008977, BC008269 NM_001127177, NM_008977, BC008269 |
19255 |
111 |
negative regulation of transcription by RNA polymerase II phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein tyrosine phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity integrin binding protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment cytosol plasma membrane protein dephosphorylation protein dephosphorylation protein dephosphorylation negative regulation of cell population proliferation insulin receptor signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage membrane dephosphorylation hydrolase activity phosphatase activity protein kinase binding syntaxin binding B cell differentiation T cell differentiation erythrocyte differentiation receptor tyrosine kinase binding peptidyl-tyrosine dephosphorylation peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis negative regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of protein tyrosine kinase activity negative regulation of interleukin-6-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade STAT family protein binding regulation of hepatocyte growth factor receptor signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway |
|
| TC1700002819.mm.2 |
H2-T23 |
histocompatibility 2, T region locus 23 |
17 |
-36029976 |
NM_010398, BC099472 NM_010398, BC099472 |
15040 |
74 |
positive regulation of antibody-dependent cellular cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity adaptive immune response immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent natural killer cell tolerance induction positive regulation of immunoglobulin production regulation of natural killer cell mediated immunity positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell cytokine production signaling receptor binding signaling receptor binding extracellular space plasma membrane immune response external side of plasma membrane cell surface membrane integral component of membrane antibacterial humoral response phagocytic vesicle membrane beta-2-microglobulin binding MHC class Ib protein complex positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of TRAIL production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation CD8-positive, alpha-beta T cell activation protection from natural killer cell mediated cytotoxicity MHC class I protein binding peptide antigen binding peptide antigen binding T cell receptor binding MHC class I protein complex negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity natural killer cell lectin-like receptor binding inner ear development defense response to Gram-positive bacterium integral component of lumenal side of endoplasmic reticulum membrane positive regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation |
04144 04145 04514 04612 04650 04940 05320 05330 05332 05416 |
| TC1500001729.mm.2 |
Ly6c1 |
lymphocyte antigen 6 complex, locus C1 |
15 |
-75045472, -75045014, -75045472, -75044017 |
NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 |
17067 |
61 |
plasma membrane external side of plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| TC0800002658.mm.2 |
Snx20 |
sorting nexin 20 |
8 |
-88626827 |
NM_027840, BC039809 NM_027840, BC039809 |
71607 |
10 |
phosphatidylinositol-4,5-bisphosphate binding nucleus nucleoplasm cytoplasm endosome plasma membrane lipid binding protein transport membrane early endosome membrane phosphatidylinositol-3-phosphate binding phosphatidylinositol binding |
|
| TC1300002697.mm.2 |
Snx18 |
sorting nexin 18 |
13 |
-113592178 |
NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 |
170625 |
21 |
mitotic cell cycle mitotic cytokinesis protein binding phosphatidylinositol-4,5-bisphosphate binding endosome plasma membrane endocytosis cell cycle lipid binding protein transport membrane endosomal transport clathrin-coated vesicle growth cone extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle phosphatidylinositol binding cleavage furrow formation neuronal cell body positive regulation of GTPase activity cell division extracellular exosome |
|
| TC0500001349.mm.2 |
Oas1b |
2'-5' oligoadenylate synthetase 1B |
5 |
120812634, 120812637 |
NM_001083925, NR_003507, BC012877 NM_001083925, NR_003507, BC012877 NM_001083925, NR_003507, BC012877 |
23961 |
46 |
2'-5'-oligoadenylate synthetase activity double-stranded RNA binding nucleoplasm cytosol membrane negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity |
05160 |
| TC0600002324.mm.2 |
Ggct |
gamma-glutamyl cyclotransferase |
6 |
-54985094 |
NM_026637, BC080818 NM_026637, BC080818 |
110175 |
34 |
release of cytochrome c from mitochondria gamma-glutamylcyclotransferase activity gamma-glutamylcyclotransferase activity cytosol lyase activity protein homodimerization activity |
00480 |
| TC0600001657.mm.2 |
Aebp2 |
AE binding protein 2 |
6 |
140622662, 140626884, 140623501, 140623501, 140624908 |
NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 |
11569 |
39 |
negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding DNA binding nucleus nucleoplasm chromatin organization regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II ESC/E(Z) complex ESC/E(Z) complex ESC/E(Z) complex metal ion binding |
|
| TC0800000800.mm.2 |
|
|
|
|
NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 |
|
|
nucleotide binding oocyte maturation G protein-coupled receptor binding G protein-coupled receptor binding in utero embryonic development protease binding adaptive immune response immune system process negative regulation of dendritic cell cytokine production protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity hormone activity protein binding ATP binding extracellular region extracellular space extracellular space cytoplasm cytosol cytoskeleton protein phosphorylation enzyme linked receptor protein signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tyrosine phosphorylation of STAT protein positive regulation of cell population proliferation negative regulation of cell population proliferation male gonad development male gonad development positive regulation of epithelial cell migration membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein phosphatase binding B cell differentiation B cell differentiation erythrocyte differentiation negative regulation of interleukin-10 production negative regulation of interleukin-12 production intracellular signal transduction interleukin-4-mediated signaling pathway positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of apoptotic process T cell homeostasis T cell homeostasis negative regulation of apoptotic process positive regulation of cAMP-mediated signaling innate immune response negative regulation of FasL production negative regulation of T-helper 1 cell differentiation positive regulation of transcription by RNA polymerase II perinuclear region of cytoplasm lymph node development negative regulation of T cell activation positive regulation of nitric-oxide synthase biosynthetic process positive regulation of calcium ion transport regulation of T cell apoptotic process negative regulation of thymocyte apoptotic process response to interleukin-2 response to interleukin-4 response to interleukin-4 response to interleukin-15 response to interleukin-9 cellular response to cytokine stimulus positive regulation of wound healing regulation of male gonad development positive regulation of dendritic cell apoptotic process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC1000001149.mm.2 |
Tmcc3 |
transmembrane and coiled coil domains 3 |
10 |
94575256, 94576262, 94550919, 94311948, 94550871, 94514856 |
NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 |
319880 |
20 |
endoplasmic reticulum biological_process endomembrane system membrane integral component of membrane identical protein binding 14-3-3 protein binding |
|
| TC1900000225.mm.2 |
Ms4a6b |
membrane-spanning 4-domains, subfamily A, member 6B |
19 |
11518558 |
NM_027209, BC027425 NM_027209, BC027425 |
69774 |
14 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC0700002414.mm.2 |
Selenow |
selenoprotein W |
7 |
-15917207 |
NM_009156, BC052719 NM_009156, BC052719 |
20364 |
32 |
cytoplasm cytosol plasma membrane response to selenium ion antioxidant activity oxidoreductase activity |
|
| TC0700002632.mm.2 |
Lipe |
lipase, hormone sensitive |
7 |
-25379526, -25379526 |
NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 |
16890 |
153 |
sterol esterase activity sterol esterase activity triglyceride lipase activity triglyceride lipase activity triglyceride lipase activity protein binding extracellular space nucleus cytoplasm cytoplasm mitochondrion lipid droplet cytosol cytosol plasma membrane caveola transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription lipid metabolic process steroid metabolic process cholesterol metabolic process membrane lipid catabolic process lipase activity hydrolase activity hydrolase activity, acting on ester bonds serine hydrolase activity triglyceride catabolic process triglyceride catabolic process triglyceride catabolic process protein kinase binding hormone-sensitive lipase activity rRNA primary transcript binding long-chain fatty acid catabolic process diacylglycerol catabolic process diacylglycerol catabolic process ether lipid metabolic process acylglycerol lipase activity acylglycerol lipase activity retinyl-palmitate esterase activity retinyl-palmitate esterase activity 1,3-diacylglycerol acylhydrolase activity 1,2-diacylglycerol acylhydrolase activity |
04910 |
| TC0500001597.mm.2 |
|
|
|
|
NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 |
|
|
GTPase activator activity phospholipid binding cytoplasm cytosol plasma membrane signal transduction membrane negative regulation of GTPase activity intracellular signal transduction regulation of GTPase activity negative regulation of Ras protein signal transduction metal ion binding cellular response to calcium ion |
|
| TC1700000362.mm.2 |
Clcn7 |
chloride channel, voltage-sensitive 7 |
17 |
25136630, 25133390 |
NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 |
26373 |
53 |
nucleotide binding voltage-gated chloride channel activity protein binding ATP binding nucleoplasm lysosome ion transport chloride transport response to pH chloride transmembrane transporter activity antiporter activity membrane integral component of membrane cytoplasmic vesicle intracellular membrane-bounded organelle transmembrane transport |
|
| TC0800002146.mm.2 |
Tlr3 |
toll-like receptor 3 |
8 |
-45395664, -45395664 |
NM_126166, BC099937 NM_126166, BC099937 |
142980 |
523 |
microglial cell activation positive regulation of cytokine production toll-like receptor signaling pathway toll-like receptor signaling pathway immune system process regulation of dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway RNA binding double-stranded RNA binding transmembrane signaling receptor activity protein binding cytoplasm endosome endoplasmic reticulum integral component of plasma membrane defense response inflammatory response signal transduction I-kappaB phosphorylation response to virus cell surface positive regulation of gene expression membrane integral component of membrane positive regulation of type I interferon production positive regulation of chemokine production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway positive regulation of type III interferon production signaling receptor activity identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to exogenous dsRNA response to dsRNA innate immune response positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus cellular response to exogenous dsRNA extrinsic apoptotic signaling pathway necroptotic signaling pathway positive regulation of NIK/NF-kappaB signaling |
04620 05160 |
| TC0600001422.mm.2 |
C1ra |
complement component 1, r subcomponent A |
6 |
124512620 |
NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 |
50909 |
19 |
immune system process serine-type endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular space extracellular space complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation identical protein binding innate immune response blood microparticle |
04145 04610 05150 05322 |
| TC0100002204.mm.2 |
Mgat4a |
mannoside acetylglucosaminyltransferase 4, isoenzyme A |
1 |
-37439339, -37439339 |
NM_173870, BC165942 NM_173870, BC165942 |
269181 |
19 |
extracellular region endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi stack protein N-linked glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups metal ion binding |
00510 01100 |
| TC1000003226.mm.2 |
Gstt3 |
glutathione S-transferase, theta 3 |
10 |
-75774121, -75774116 |
NM_133994, BC003903, BC057964, BC062201 NM_133994, BC003903, BC057964, BC062201 NM_133994, BC003903, BC057964, BC062201 NM_133994, BC003903, BC057964, BC062201 |
103140 |
15 |
glutathione transferase activity glutathione transferase activity cytoplasm glutathione metabolic process glutathione metabolic process transferase activity |
|
| TC0600000841.mm.2 |
St3gal5 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
6 |
72097607 |
NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 |
20454 |
59 |
Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups lactosylceramide alpha-2,3-sialyltransferase activity lactosylceramide alpha-2,3-sialyltransferase activity |
00604 01100 |
| TC0900002764.mm.2 |
Hmgn3 |
high mobility group nucleosomal binding domain 3 |
9 |
-83109941 |
NM_026122, NM_175074, BC005693 NM_026122, NM_175074, BC005693 NM_026122, NM_175074, BC005693 |
94353 |
32 |
chromatin DNA binding chromatin binding chromatin binding chromatin binding nucleus nucleus nucleus chromatin organization regulation of transcription by RNA polymerase II nucleosomal DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity regulation of insulin secretion involved in cellular response to glucose stimulus |
|
| TC0900002389.mm.2 |
Pml |
promyelocytic leukemia |
9 |
-58217179 |
NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990 |
18854 |
204 |
chromosome, telomeric region chromatin heterochromatin response to hypoxia response to hypoxia regulation of protein phosphorylation positive regulation of defense response to virus by host immune system process DNA binding transcription coactivator activity transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm endosome endoplasmic reticulum cytosol regulation of transcription, DNA-templated regulation of transcription, DNA-templated protein targeting protein import into nucleus apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell cycle arrest cell cycle arrest cell cycle arrest transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation cell aging zinc ion binding negative regulation of cell population proliferation negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress response to UV response to gamma radiation regulation of calcium ion transport into cytosol fibroblast migration membrane viral process nuclear matrix nuclear matrix negative regulation of angiogenesis negative regulation of angiogenesis PML body PML body PML body PML body myeloid cell differentiation regulation of cell adhesion negative regulation of cell growth PML body organization PML body organization PML body organization positive regulation of histone deacetylation ubiquitin protein ligase binding nuclear membrane SUMO binding positive regulation of telomere maintenance negative regulation of telomere maintenance via telomerase endoplasmic reticulum calcium ion homeostasis negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production circadian regulation of gene expression negative regulation of translation in response to oxidative stress response to cytokine extrinsic component of endoplasmic reticulum membrane regulation of circadian rhythm intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding protein homodimerization activity entrainment of circadian clock by photoperiod proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response innate immune response cell fate commitment regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription by RNA polymerase II SMAD binding metal ion binding protein heterodimerization activity positive regulation of fibroblast proliferation retinoic acid receptor signaling pathway rhythmic process protein stabilization cobalt ion binding maintenance of protein location in nucleus defense response to virus negative regulation of telomerase activity positive regulation of apoptotic process involved in mammary gland involution branching involved in mammary gland duct morphogenesis protein-containing complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to interleukin-4 intrinsic apoptotic signaling pathway by p53 class mediator cellular senescence extrinsic apoptotic signaling pathway sumo-dependent protein binding negative regulation of viral release from host cell negative regulation of viral release from host cell positive regulation of protein localization to chromosome, telomeric region cellular response to leukemia inhibitory factor negative regulation of ubiquitin-dependent protein catabolic process regulation of double-strand break repair positive regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway |
04120 04144 05200 05221 |
| TC1400002487.mm.2 |
Rgcc |
regulator of cell cycle |
14 |
-79288749 |
NM_025427, BC049580, BC050935 NM_025427, BC049580, BC050935 NM_025427, BC049580, BC050935 |
66214 |
37 |
G1/S transition of mitotic cell cycle negative regulation of exit from mitosis negative regulation of cytokine production positive regulation of cytokine production negative regulation of endothelial cell proliferation positive regulation of extracellular matrix constituent secretion protein binding nucleus nucleoplasm nucleolus cytoplasm cytoplasm centrosome cytoskeleton complement activation cell cycle negative regulation of cell population proliferation positive regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of angiogenesis protein kinase binding protein kinase binding protein kinase activator activity protein kinase activator activity positive regulation of collagen biosynthetic process negative regulation of blood vessel endothelial cell migration positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity positive regulation of stress fiber assembly regulation of cell cycle R-SMAD binding positive regulation of cell cycle arrest cellular response to hypoxia mitotic cell cycle arrest fibroblast activation negative regulation of fibroblast growth factor production positive regulation of G1/S transition of mitotic cell cycle positive regulation of extracellular matrix assembly negative regulation of mitotic cell cycle phase transition negative regulation of cell-cell adhesion mediated by cadherin positive regulation of endothelial cell apoptotic process |
|
| TC1100003664.mm.2 |
Cacnb1 |
calcium channel, voltage-dependent, beta 1 subunit |
11 |
-98004924, -98004924, -98001507 |
NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 |
12295 |
64 |
voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated calcium channel activity voltage-gated calcium channel activity calcium channel activity protein binding plasma membrane plasma membrane voltage-gated calcium channel complex voltage-gated calcium channel complex protein targeting to membrane ion transport calcium ion transport chemical synaptic transmission neuromuscular junction development high voltage-gated calcium channel activity high voltage-gated calcium channel activity membrane sarcoplasmic reticulum T-tubule regulation of ion transmembrane transport calcium ion transmembrane transport presynapse presynapse regulation of voltage-gated calcium channel activity regulation of calcium ion transmembrane transport via high voltage-gated calcium channel cellular response to amyloid-beta |
04010 04260 05410 05412 05414 |
| TC0700002503.mm.2 |
Bcl3 |
B cell leukemia/lymphoma 3 |
7 |
-19808461 |
NM_033601, BC156806 NM_033601, BC156806 |
12051 |
84 |
follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling transcription factor binding response to virus response to UV-C antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator midbody negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production protein-containing complex Bcl3-Bcl10 complex Bcl3/NF-kappaB2 complex T-helper 1 type immune response defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle T-helper 2 cell differentiation positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of receptor signaling pathway via JAK-STAT spleen development |
|
| TC0400003383.mm.2 |
St3gal3 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
4 |
-117932152 |
NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 |
20441 |
29 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Golgi apparatus protein glycosylation protein glycosylation N-acetyllactosaminide alpha-2,3-sialyltransferase activity sialyltransferase activity ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups |
00514 00533 00601 01100 |
| TC1200001768.mm.2 |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
12 |
-55489408 |
NM_010907, BC046754 NM_010907, BC046754 |
18035 |
242 |
protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytosol plasma membrane protein import into nucleus I-kappaB kinase/NF-kappaB signaling cytoplasmic sequestering of NF-kappaB nuclear localization sequence binding regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux negative regulation of lipid storage enzyme binding heat shock protein binding ubiquitin protein ligase binding lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to muramyl dipeptide response to lipopolysaccharide protein-containing complex tumor necrosis factor-mediated signaling pathway toll-like receptor 4 signaling pathway response to muscle stretch regulation of cell population proliferation identical protein binding cytoplasmic sequestering of transcription factor response to exogenous dsRNA protein-containing complex binding negative regulation of myeloid cell differentiation negative regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of inflammatory response NF-kappaB binding nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to biotic stimulus cellular response to cytokine stimulus cellular response to tumor necrosis factor cellular response to organic cyclic compound |
04062 04210 04380 04620 04621 04622 04623 04660 04662 04722 04920 05140 05142 05145 05160 05200 05215 05220 05222 |
| TC0100000916.mm.2 |
Gpc1 |
glypican 1 |
1 |
92831644 |
NM_016696, BC062902 NM_016696, BC062902 |
14733 |
55 |
copper ion binding nucleoplasm endosome Golgi lumen cytosol plasma membrane regulation of signal transduction cell surface Schwann cell differentiation membrane cell migration fibroblast growth factor binding fibroblast growth factor binding heparan sulfate proteoglycan catabolic process extracellular matrix anchored component of membrane myelin assembly negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway neuronal cell body laminin binding membrane raft membrane raft synapse synapse synapse anchored component of plasma membrane collagen-containing extracellular matrix collagen V binding regulation of protein localization to membrane positive regulation of skeletal muscle cell differentiation |
|
| TC0500001359.mm.2 |
Naa25 |
N(alpha)-acetyltransferase 25, NatB auxiliary subunit |
5 |
121397994 |
NM_172722, BC132172, BC138093 NM_172722, BC132172, BC138093 NM_172722, BC132172, BC138093 |
231713 |
22 |
peptide alpha-N-acetyltransferase activity cytoplasm cytoplasm Golgi apparatus cytosol N-terminal peptidyl-methionine acetylation NatB complex |
|
| TC1700001522.mm.2 |
Fpr1 |
formyl peptide receptor 1 |
17 |
-17876470 |
NM_013521, BC148696 NM_013521, BC148696 |
14293 |
76 |
G protein-coupled receptor binding complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane plasma membrane chemotaxis inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane RAGE receptor binding |
04080 05150 |
| TC1600000760.mm.2 |
Dcbld2 |
discoidin, CUB and LCCL domain containing 2 |
16 |
58408534 |
NM_028523, BC066097 NM_028523, BC066097 |
73379 |
21 |
integral component of plasma membrane cell surface membrane integral component of membrane negative regulation of cell growth wound healing |
|
| TC1600001203.mm.2 |
Prm1 |
protamine 1 |
16 |
-10796331 |
NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733 |
19118 |
110 |
nucleosome DNA binding nucleus nucleus nucleus chromosome nucleus organization multicellular organism development spermatogenesis spermatid development cell differentiation chromosome condensation |
|
| TC0300003067.mm.2 |
Lmo4 |
LIM domain only 4 |
3 |
-144188529, -144188529, -144188529 |
NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 |
16911 |
153 |
neural tube closure ventricular septum development protein binding nucleus regulation of transcription by RNA polymerase II transcription factor binding ventral spinal cord interneuron differentiation spinal cord motor neuron differentiation spinal cord association neuron differentiation regulation of cell migration cell leading edge negative regulation of protein-containing complex assembly positive regulation of kinase activity regulation of cell fate specification positive regulation of transcription by RNA polymerase II metal ion binding thymus development regulation of cell activation RNA polymerase II transcription regulator complex |
|
| TC0700002507.mm.2 |
Pvr |
poliovirus receptor |
7 |
-19903577 |
NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 |
52118 |
70 |
virus receptor activity protein binding plasma membrane adherens junction homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell surface cell migration dynein light chain binding cell-cell adhesion |
|
| TC1900001085.mm.2 |
Stxbp3-ps |
syntaxin-binding protein 3, pseudogene |
19 |
-9557605 |
NR_073559 |
619371 |
3 |
|
|
| TC0900003241.mm.2 |
Myd88 |
myeloid differentiation primary response gene 88 |
9 |
-119335933 |
NM_010851, BC005591, BC058787 NM_010851, BC005591, BC058787 NM_010851, BC005591, BC058787 |
17874 |
2155 |
response to molecule of fungal origin leukocyte activation involved in inflammatory response neutrophil activation involved in immune response immune system process MyD88-dependent toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway signaling receptor binding Toll binding interleukin-1 receptor binding interleukin-1 receptor binding protein binding nucleus cytoplasm cytoplasm cytosol plasma membrane plasma membrane phagocytosis phagocytosis apoptotic process inflammatory response immune response signal transduction cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway JNK cascade Toll signaling pathway Toll signaling pathway response to virus induced systemic resistance regulation of gene expression positive regulation of gene expression positive regulation of gene expression postsynaptic density immunoglobulin mediated immune response cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to peptidoglycan response to lipopolysaccharide response to lipopolysaccharide type I interferon production regulation of interleukin-6 production regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interleukin-17 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production protein-containing complex Toll-like receptor binding Toll-like receptor binding regulation of cell population proliferation defense response to bacterium identical protein binding defense response to protozoan positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling protein self-association innate immune response positive regulation of JNK cascade positive regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation regulation of inflammatory response defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity type I interferon signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 3'-UTR-mediated mRNA stabilization neutrophil-mediated killing of bacterium TIR domain binding cellular response to lipopolysaccharide establishment of endothelial intestinal barrier cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response regulation of neutrophil migration regulation of chemokine (C-X-C motif) ligand 1 production regulation of chemokine (C-X-C motif) ligand 2 production |
04210 04620 05140 05142 05143 05144 05145 |
| MG-1-pos-10338280_st |
|
|
|
|
|
|
|
|
|
| TC0100002707.mm.2 |
|
|
|
|
NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 |
|
|
DNA-binding transcription factor activity, RNA polymerase II-specific nucleus regulation of transcription by RNA polymerase II |
|
| TC0400001651.mm.2 |
Runx3 |
runt related transcription factor 3 |
4 |
135120644, 135152544 |
NM_019732, BC168396 NM_019732, BC168396 |
12399 |
229 |
negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific ossification chondrocyte differentiation chondrocyte differentiation DNA binding DNA-binding transcription factor activity protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein phosphorylation axon guidance core-binding factor complex hemopoiesis neuron differentiation hair follicle morphogenesis neuron projection development interferon-gamma production histone deacetylase binding intracellular membrane-bounded organelle negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation regulation of cell differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II SMAD binding cell maturation negative regulation of epithelial cell proliferation response to transforming growth factor beta sequence-specific double-stranded DNA binding positive regulation of extrinsic apoptotic signaling pathway |
|
| TC0800002842.mm.2 |
Psmb10 |
proteasome (prosome, macropain) subunit, beta type 10 |
8 |
-105935727 |
NM_013640, BC004730 NM_013640, BC004730 |
19171 |
66 |
proteasome complex cell morphogenesis immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteasome core complex proteolysis peptidase activity proteasomal ubiquitin-independent protein catabolic process hydrolase activity T cell proliferation proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process spermatoproteasome complex |
03050 |
| TC0900003011.mm.2 |
Parp3 |
poly (ADP-ribose) polymerase family, member 3 |
9 |
-106470321 |
NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754 |
235587 |
19 |
telomere maintenance NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity nucleus nucleoplasm nucleolus cytoplasm DNA repair double-strand break repair double-strand break repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus nuclear body transferase activity transferase activity, transferring glycosyl groups DNA ADP-ribosylation site of double-strand break site of double-strand break site of double-strand break intercellular bridge negative regulation of isotype switching positive regulation of DNA ligation regulation of mitotic spindle organization protein poly-ADP-ribosylation protein auto-ADP-ribosylation protein mono-ADP-ribosylation NAD DNA ADP-ribosyltransferase activity negative regulation of telomerase RNA reverse transcriptase activity protein localization to site of double-strand break protein ADP-ribosylase activity protein ADP-ribosylase activity positive regulation of double-strand break repair via nonhomologous end joining |
03410 |
| TC0700002696.mm.2 |
Zfp36 |
zinc finger protein 36 |
7 |
-28376783 |
NM_011756, BC021391 NM_011756, BC021391 |
22695 |
173 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II MAPK cascade MAPK cascade MAPK cascade exosome (RNase complex) nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA poly(A) tail shortening P-body DNA binding mRNA binding mRNA binding mRNA 3'-UTR binding protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytosol regulation of transcription by RNA polymerase II mRNA catabolic process multicellular organism development response to wounding response to wounding cytoplasmic stress granule regulation of keratinocyte proliferation enzyme binding protein kinase binding C-C chemokine binding CCR4-NOT complex heat shock protein binding nuclear-transcribed mRNA catabolic process, deadenylation-independent decay regulation of tumor necrosis factor production negative regulation of interleukin-2 production negative regulation of viral transcription miRNA mediated inhibition of translation intracellular signal transduction mRNA 3'-UTR AU-rich region binding mRNA 3'-UTR AU-rich region binding p38MAPK cascade response to starvation regulation of mRNA stability regulation of mRNA stability regulation of mRNA stability cellular response to fibroblast growth factor stimulus cellular response to fibroblast growth factor stimulus protein-containing complex binding positive regulation of fat cell differentiation regulation of keratinocyte differentiation negative regulation of myeloid cell differentiation negative regulation of erythrocyte differentiation metal ion binding negative regulation of inflammatory response RNA destabilization mRNA transport positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA destabilization RNA polymerase binding RISC-loading complex 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus 14-3-3 protein binding 14-3-3 protein binding cellular response to granulocyte macrophage colony-stimulating factor stimulus positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA regulation of keratinocyte apoptotic process negative regulation of polynucleotide adenylyltransferase activity positive regulation of intracellular mRNA localization ribonucleoprotein complex ribonucleoprotein complex positive regulation of gene silencing by miRNA |
|
| TC0900000113.mm.2 |
Gpr83 |
G protein-coupled receptor 83 |
9 |
14860209 |
NM_010287 |
14608 |
33 |
G protein-coupled receptor activity neuropeptide Y receptor activity plasma membrane cilium signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane response to glucocorticoid non-motile cilium |
04080 |
| TC0600001736.mm.2 |
Stk38l |
serine/threonine kinase 38 like |
6 |
146724929, 146724929 |
NM_172734, BC062170 NM_172734, BC062170 |
232533 |
22 |
nucleotide binding magnesium ion binding actin binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytoplasm cytosol cytoskeleton protein phosphorylation actin cytoskeleton membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction intracellular signal transduction metal ion binding regulation of cellular component organization |
|
| TC0100000923.mm.2 |
Gpr35 |
G protein-coupled receptor 35 |
1 |
92978902, 92973118, 92975346 |
NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 |
64095 |
27 |
G protein-coupled receptor activity G protein-coupled receptor activity chemokine receptor activity plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane integral component of plasma membrane cytoskeleton organization signal transduction G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane C-X-C chemokine receptor activity positive regulation of Rho protein signal transduction macrophage chemotaxis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway chemokine-mediated signaling pathway negative regulation of voltage-gated calcium channel activity negative regulation of neuronal action potential |
04080 |
| TC1100002772.mm.2 |
Anxa6 |
annexin A6 |
11 |
-54978952 |
NM_001110211, NM_013472, BC005595 NM_001110211, NM_013472, BC005595 NM_001110211, NM_013472, BC005595 |
11749 |
58 |
neural crest cell migration plasma membrane repair phosphatidylserine binding growth plate cartilage chondrocyte differentiation calcium channel activity calcium ion binding GTP binding GTP binding calcium-dependent phospholipid binding calcium-dependent phospholipid binding nucleus cytoplasm cytoplasm lysosomal membrane cytosol focal adhesion calcium ion transport regulation of muscle contraction regulation of muscle contraction lipid binding intercalated disc ligand-gated ion channel activity ligand-gated ion channel activity cholesterol binding cholesterol binding membrane apical plasma membrane late endosome membrane protein-containing complex ion transmembrane transport chondroitin sulfate binding sarcolemma identical protein binding protein-containing complex binding calcium-dependent protein binding perinuclear region of cytoplasm actin filament binding negative regulation of sequestering of calcium ion mitochondrial calcium ion homeostasis mitochondrial calcium ion homeostasis collagen-containing extracellular matrix apoptotic signaling pathway apoptotic signaling pathway |
|
| MG-1-pos-10342553_st |
|
|
|
|
|
|
|
|
|
| TC1400002091.mm.2 |
Psme2 |
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
14 |
-55587439, -55587439 |
NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 |
19188 |
43 |
protein binding nucleoplasm cytoplasm positive regulation of endopeptidase activity antigen processing and presentation of exogenous antigen identical protein binding endopeptidase activator activity regulation of proteasomal protein catabolic process regulation of G1/S transition of mitotic cell cycle |
03050 04612 |
| TC0200001765.mm.2 |
Spint1 |
serine protease inhibitor, Kunitz type 1 |
2 |
119237359 |
NM_016907, BC005769 NM_016907, BC005769 |
20732 |
48 |
neural tube closure embryonic placenta development serine-type endopeptidase inhibitor activity extracellular region plasma membrane plasma membrane negative regulation of peptidase activity extracellular matrix organization peptidase inhibitor activity positive regulation of glial cell differentiation viral entry into host cell branching involved in labyrinthine layer morphogenesis placenta blood vessel development negative regulation of neural precursor cell proliferation |
|
| TC0700001913.mm.2 |
Htra1 |
HtrA serine peptidase 1 |
7 |
130936202 |
NM_019564, BC013516 NM_019564, BC013516 |
56213 |
71 |
placenta development serine-type endopeptidase activity protein binding insulin-like growth factor binding extracellular region cytoplasm plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane hydrolase activity growth factor binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway identical protein binding positive regulation of epithelial cell proliferation negative regulation of defense response to virus chorionic trophoblast cell differentiation collagen-containing extracellular matrix collagen-containing extracellular matrix |
|
| TC1700002813.mm.2 |
Ppt2 |
palmitoyl-protein thioesterase 2 |
17 |
-34616661, -34616661, -34616661, -34616661, -34616661 |
NM_019441, BC013462 NM_019441, BC013462 |
54397 |
22 |
lysosome palmitoyl-(protein) hydrolase activity hydrolase activity thiolester hydrolase activity intracellular membrane-bounded organelle intracellular membrane-bounded organelle palmitoyl hydrolase activity |
00062 01100 04142 |
| TC0800002597.mm.2 |
Junb |
jun B proto-oncogene |
8 |
-84976908 |
NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302 |
16477 |
179 |
RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific vasculogenesis osteoblast differentiation in utero embryonic development trophectodermal cell differentiation trophectodermal cell differentiation DNA binding DNA binding double-stranded DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm transcription regulator complex regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription factor binding cellular process osteoclast differentiation osteoblast proliferation transcription factor AP-1 complex regulation of cell population proliferation sequence-specific DNA binding positive regulation of cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II decidualization regulation of cell cycle regulation of cell cycle embryonic process involved in female pregnancy labyrinthine layer blood vessel development cellular response to calcium ion sequence-specific double-stranded DNA binding |
04380 |
| TC0600000609.mm.2 |
Snx10 |
sorting nexin 10 |
6 |
51524259, 51545292, 51524083, 51544522, 51523902 |
NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 |
71982 |
30 |
gastric acid secretion 1-phosphatidylinositol binding nucleus nucleus cytoplasm endosome endoplasmic reticulum endoplasmic reticulum centrosome cytoskeleton endocytosis endosome organization lipid binding protein transport membrane cell projection organization secretory granule osteoclast differentiation extrinsic component of endosome membrane phosphatidylinositol binding bone mineralization involved in bone maturation tooth eruption bone resorption bone remodeling ATPase binding calcium ion homeostasis cilium assembly protein localization to cilium protein localization to centrosome apical cytoplasm ruffle assembly cellular response to leukemia inhibitory factor |
|
| TC1400001906.mm.2 |
|
|
|
|
NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 |
|
|
phospholipase activity cytoplasm lipid metabolic process lipid catabolic process hydrolase activity sperm mitochondrion organization metal ion binding positive regulation of mitochondrial fission |
|
| TC0500003186.mm.2 |
Trafd1 |
TRAF type zinc finger domain containing 1 |
5 |
-121371724, -121371724 |
NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396 |
231712 |
19 |
protein binding zinc ion binding negative regulation of innate immune response metal ion binding |
|
| TC0900002377.mm.2 |
Csk |
c-src tyrosine kinase |
9 |
-57626645, -57626645 |
NM_007783, BC018394, BC052006 NM_007783, BC018394, BC052006 NM_007783, BC018394, BC052006 |
12988 |
138 |
nucleotide binding adaptive immune response immune system process protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding cytoplasm plasma membrane plasma membrane cell-cell junction protein phosphorylation protein phosphorylation negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of low-density lipoprotein particle clearance membrane kinase activity phosphorylation transferase activity protein phosphatase binding negative regulation of interleukin-6 production negative regulation of kinase activity protein kinase A catalytic subunit binding adherens junction organization intracellular signal transduction identical protein binding negative regulation of Golgi to plasma membrane protein transport positive regulation of MAP kinase activity membrane raft negative regulation of bone resorption protein autophosphorylation metal ion binding negative regulation of phagocytosis regulation of T cell activation regulation of Fc receptor mediated stimulatory signaling pathway regulation of Fc receptor mediated stimulatory signaling pathway proline-rich region binding negative regulation of ERK1 and ERK2 cascade cellular response to peptide hormone stimulus |
04062 04722 04810 |
| TC0200004545.mm.2 |
Sppl2a |
signal peptide peptidase like 2A |
2 |
-126890394 |
NM_023220, BC026578 NM_023220, BC026578 |
66552 |
31 |
aspartic-type endopeptidase activity lysosome lysosomal membrane lysosomal membrane endosome late endosome plasma membrane proteolysis membrane protein ectodomain proteolysis peptidase activity membrane integral component of membrane hydrolase activity Golgi-associated vesicle membrane Golgi-associated vesicle membrane membrane protein intracellular domain proteolysis late endosome membrane membrane protein proteolysis membrane protein proteolysis aspartic endopeptidase activity, intramembrane cleaving aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity intracellular membrane-bounded organelle regulation of immune response integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane |
|
| TC1300002013.mm.2 |
Nfil3 |
nuclear factor, interleukin 3, regulated |
13 |
-52967208 |
NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384 |
18030 |
116 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II immune response circadian rhythm positive regulation of gene expression positive regulation of gene expression negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated rhythmic process cellular response to interleukin-4 |
|
| TC0900002806.mm.2 |
Bcl2a1d |
B cell leukemia/lymphoma 2 related protein A1d |
9 |
-88723287 |
NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240 |
12047 |
20 |
mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage T cell differentiation protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein-containing complex binding protein heterodimerization activity T cell receptor signaling pathway BH domain binding extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC0200001448.mm.2 |
Trp53i11 |
transformation related protein 53 inducible protein 11 |
2 |
93187547, 93187547 |
NM_001025246, BC048398, BC098206 NM_001025246, BC048398, BC098206 NM_001025246, BC048398, BC098206 |
277414 |
18 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC1500001491.mm.2 |
|
|
|
|
NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 |
|
|
negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific skeletal system development hair follicle development chondrocyte differentiation nucleic acid binding DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transmembrane receptor protein serine/threonine kinase signaling pathway zinc ion binding protein domain specific binding regulation of chondrocyte differentiation protein-containing complex sequence-specific DNA binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
|
| TC1000000571.mm.2 |
Ppa1 |
pyrophosphatase (inorganic) 1 |
10 |
61648620 |
NM_026438, BC010468 NM_026438, BC010468 |
67895 |
34 |
magnesium ion binding inorganic diphosphatase activity cytoplasm cytosol phosphate-containing compound metabolic process phosphate-containing compound metabolic process pyrophosphatase activity hydrolase activity metal ion binding |
00190 |
| TC0300002050.mm.2 |
Gpr171 |
G protein-coupled receptor 171 |
3 |
-59096447 |
NM_173398, BC024054 NM_173398, BC024054 |
229323 |
14 |
G protein-coupled receptor activity plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity negative regulation of myeloid cell differentiation negative regulation of myeloid cell differentiation |
|
| TC1500001623.mm.2 |
Cyrib |
CYFIP related Rac1 interactor B |
15 |
-63929093, -63929093, -63929093 |
NM_144846, BC011343 NM_144846, BC011343 |
223601 |
30 |
positive regulation of T cell mediated cytotoxicity protein binding mitochondrion cilium membrane MHC class Ib protein binding, via antigen binding groove regulation of cell migration negative regulation of actin filament polymerization small GTPase binding positive regulation of interferon-gamma production positive regulation of T cell activation positive regulation of T cell activation regulation of chemotaxis negative regulation of small GTPase mediated signal transduction negative regulation of small GTPase mediated signal transduction cellular response to molecule of bacterial origin cellular response to molecule of bacterial origin regulation of mitochondrial fission regulation of mitochondrial fission regulation of establishment of cell polarity positive regulation of memory T cell activation |
|
| TC0300000092.mm.2 |
Car13 |
carbonic anhydrase 13 |
3 |
14641726 |
NM_024495, BC064050 NM_024495, BC064050 |
71934 |
21 |
carbonate dehydratase activity carbonate dehydratase activity cytoplasm cytosol cytosol one-carbon metabolic process zinc ion binding lyase activity hydro-lyase activity myelin sheath intracellular membrane-bounded organelle metal ion binding |
00910 |
| TC0100002193.mm.2 |
Tmem131 |
transmembrane protein 131 |
1 |
-36792188 |
NM_018872 |
56030 |
27 |
molecular_function membrane integral component of membrane |
|
| TC0500001403.mm.2 |
Rnf34 |
ring finger protein 34 |
5 |
122850187 |
NM_030564, BC004042 NM_030564, BC004042 |
80751 |
23 |
p53 binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytoplasm plasma membrane plasma membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process apoptotic process membrane protein ubiquitination nuclear body transferase activity ubiquitin protein ligase binding nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to cold protein K48-linked ubiquitination protein K48-linked ubiquitination negative regulation of signal transduction by p53 class mediator phosphatidylinositol phosphate binding negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of oxygen metabolic process negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
|
| TC0500002315.mm.2 |
Fbxl5 |
F-box and leucine-rich repeat protein 5 |
5 |
-43757748, -43744617 |
NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 |
242960 |
30 |
iron ion binding cytoplasm protein ubiquitination SCF ubiquitin ligase complex SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process metal ion binding perinuclear region of cytoplasm iron ion homeostasis iron ion homeostasis iron ion homeostasis iron ion homeostasis positive regulation of cellular protein catabolic process |
|
| TC0800000679.mm.2 |
Marchf1 |
membrane associated ring-CH-type finger 1 |
8 |
65618039, 66386300, 65618524 |
NM_001166372, NM_001166375, NM_175188, BC066008 NM_001166372, NM_001166375, NM_175188, BC066008 NM_001166372, NM_001166375, NM_175188, BC066008 NM_001166372, NM_001166375, NM_175188, BC066008 |
72925 |
41 |
protein polyubiquitination protein polyubiquitination protein polyubiquitination immune system process antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II ubiquitin-protein transferase activity cytoplasm lysosome lysosome lysosomal membrane endosome endoplasmic reticulum membrane Golgi apparatus plasma membrane immune response immune response immune response zinc ion binding membrane integral component of membrane transferase activity cytoplasmic vesicle early endosome membrane early endosome membrane early endosome membrane late endosome membrane late endosome membrane late endosome membrane trans-Golgi network membrane MHC protein binding MHC protein binding metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity |
|
| TC1300002535.mm.2 |
Gtf2h2 |
general transcription factor II H, polypeptide 2 |
13 |
-100460229, -100468576, -100460229 |
NM_022011, BC016231, BC053382, XR_141179 NM_022011, BC016231, BC053382, XR_141179 NM_022011, BC016231, BC053382, XR_141179 NM_022011, BC016231, BC053382, XR_141179 |
23894 |
33 |
core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH core complex G protein-coupled receptor internalization nucleic acid binding nucleus transcription factor TFIID complex transcription factor TFIIH holo complex transcription factor TFIIH holo complex DNA repair nucleotide-excision repair transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter cellular response to DNA damage stimulus zinc ion binding RNA polymerase II general transcription initiation factor activity nuclear speck metal ion binding protein N-terminus binding positive regulation of DNA helicase activity |
03022 03420 |
| TC1200000959.mm.2 |
Gpr65 |
G-protein coupled receptor 65 |
12 |
98268634 |
NM_008152, BC011332 NM_008152, BC011332 |
14744 |
57 |
G protein-coupled receptor activity G protein-coupled receptor activity plasma membrane integral component of plasma membrane apoptotic process signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway response to acidic pH membrane integral component of membrane actin cytoskeleton reorganization positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of stress fiber assembly activation of GTPase activity |
|
| TC0600001964.mm.2 |
Zfp800 |
zinc finger protein 800 |
6 |
-28239930, -28239930 |
NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 |
627049 |
12 |
nucleic acid binding DNA binding nucleus biological_process metal ion binding |
|
| TC0600000135.mm.2 |
St7 |
suppression of tumorigenicity 7 |
6 |
17749169, 17743591, 17693993 |
NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 |
64213 |
21 |
membrane integral component of membrane |
|
| TC0400000458.mm.2 |
Glipr2 |
GLI pathogenesis-related 2 |
4 |
43957701 |
NM_027450, BC031750 NM_027450, BC031750 |
384009 |
25 |
Golgi membrane extracellular region extracellular space Golgi apparatus positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition membrane protein homodimerization activity positive regulation of ERK1 and ERK2 cascade |
|
| TC1200000530.mm.2 |
Wdr20rt |
WD repeat domain 20, retrogene |
12 |
65225516 |
NM_027614, BC050778 NM_027614, BC050778 |
70948 |
11 |
molecular_function cellular_component |
|
| TC1600002177.mm.2 |
Dexi |
dexamethasone-induced transcript |
16 |
-10530206 |
NM_021428, BC017551 NM_021428, BC017551 |
58239 |
17 |
molecular_function cellular_component biological_process |
|
| MG-1-neg-10341560_st |
|
|
|
|
|
|
|
|
|
| TC0700003778.mm.2 |
Tsku |
tsukushi, small leucine rich proteoglycan |
7 |
-98350667, -98350667 |
NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 NM_001024619, NM_001168539, NM_001168540, NM_001168541, BC116310, BC116311, BC129977, BC129978 |
244152 |
28 |
protein binding extracellular region extracellular space extracellular space plasma membrane cholesterol metabolic process regulation of gene expression negative regulation of neuron projection development corpus callosum morphogenesis lateral ventricle development hippocampus development anterior commissure morphogenesis negative regulation of Wnt signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway extracellular matrix negative regulation of transforming growth factor beta1 production cholesterol efflux wound healing cholesterol homeostasis positive regulation of hair cycle camera-type eye development transforming growth factor beta binding transforming growth factor beta binding inner ear receptor cell stereocilium organization ciliary body morphogenesis energy homeostasis negative regulation of myofibroblast differentiation |
|
| TC1200000652.mm.2 |
Hif1a |
hypoxia inducible factor 1, alpha subunit |
12 |
73907866, 73901323, 73907866 |
NM_010431, BC026139 NM_010431, BC026139 |
15251 |
1372 |
negative regulation of transcription by RNA polymerase II response to reactive oxygen species chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific angiogenesis blood vessel development response to hypoxia response to hypoxia response to hypoxia response to hypoxia neural crest cell migration epithelial to mesenchymal transition embryonic placenta development embryonic placenta development B-1 B cell homeostasis vasculature development heart looping p53 binding positive regulation of neuroblast proliferation connective tissue replacement involved in inflammatory response wound healing cytokine production involved in inflammatory response outflow tract morphogenesis cardiac ventricle morphogenesis DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm transcription regulator complex cytoplasm cytosol lactate metabolic process regulation of glycolytic process regulation of glycolytic process regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cellular iron ion homeostasis signal transduction lactation transcription factor binding positive regulation of cell population proliferation visual learning regulation of gene expression regulation of gene expression positive regulation of autophagy vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration response to muscle activity positive regulation of macroautophagy nuclear body nuclear speck axonal transport of mitochondrion enzyme binding protein kinase binding protein domain specific binding neural fold elevation formation cerebral cortex development cell differentiation cell differentiation negative regulation of ossification negative regulation of bone mineralization positive regulation of vascular endothelial growth factor receptor signaling pathway motile cilium ubiquitin protein ligase binding negative regulation of TOR signaling oxygen homeostasis oxygen homeostasis regulation of transforming growth factor beta2 production collagen metabolic process protein-containing complex histone acetyltransferase binding embryonic hemopoiesis nuclear hormone receptor binding positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell population proliferation hemoglobin biosynthetic process glucose homeostasis histone deacetylase binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration sequence-specific DNA binding sequence-specific DNA binding regulation of transcription from RNA polymerase II promoter in response to oxidative stress regulation of transcription from RNA polymerase II promoter in response to oxidative stress protein-containing complex binding positive regulation of erythrocyte differentiation positive regulation of gluconeogenesis positive regulation of angiogenesis positive regulation of transcription, DNA-templated negative regulation of vasoconstriction negative regulation of growth positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II muscle cell cellular homeostasis positive regulation of hormone biosynthetic process protein heterodimerization activity protein heterodimerization activity protein dimerization activity blood vessel morphogenesis digestive tract morphogenesis camera-type eye morphogenesis positive regulation of smooth muscle cell proliferation regulation of catalytic activity cartilage development elastin metabolic process Hsp90 protein binding intestinal epithelial cell maturation response to fungicide epithelial cell differentiation involved in mammary gland alveolus development iris morphogenesis retina vasculature development in camera-type eye positive regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of chemokine-mediated signaling pathway regulation of thymocyte apoptotic process negative regulation of thymocyte apoptotic process E-box binding cellular response to hypoxia cellular response to hypoxia cellular response to hypoxia dopaminergic neuron differentiation dopaminergic neuron differentiation RNA polymerase II transcription regulator complex hypoxia-inducible factor-1alpha signaling pathway cellular response to virus positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of autophagy of mitochondrion regulation of aerobic respiration positive regulation of signaling receptor activity negative regulation of reactive oxygen species metabolic process regulation of protein neddylation negative regulation of mesenchymal cell apoptotic process |
04150 05200 05211 |
| TC0900001802.mm.2 |
Zfp558 |
zinc finger protein 558 |
9 |
-18454053, -18454053 |
NM_028935 |
72230 |
13 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific regulation of transcription by RNA polymerase II |
|
| TC0900001142.mm.2 |
Bcl2a1a |
B cell leukemia/lymphoma 2 related protein A1a |
9 |
88956919 |
NM_009742 |
12044 |
56 |
B cell homeostasis negative regulation of B cell apoptotic process protein binding cytoplasm mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein-containing complex binding protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC1700002815.mm.2 |
C4a |
complement component 4A (Rodgers blood group) |
17 |
-34809091, -34809091 |
NM_011413, BC141050, BC172697 NM_011413, BC141050, BC172697 NM_011413, BC141050, BC172697 |
625018 |
62 |
complement binding complement component C1q complex binding extracellular region extracellular space extracellular space complement activation carbohydrate binding axon dendrite neuronal cell body other organism cell synapse |
|
| TC0200005181.mm.2 |
Znfx1 |
zinc finger, NFX1-type containing 1 |
2 |
-167035795, -167035796 |
NM_001033196 |
98999 |
24 |
DNA-binding transcription factor activity RNA binding nucleus regulation of transcription, DNA-templated zinc ion binding heterochromatin assembly by small RNA nuclear RNA-directed RNA polymerase complex metal ion binding |
|
| TC1100004060.mm.2 |
Cd300lf |
CD300 molecule like family member F |
11 |
-115116213 |
NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 |
246746 |
50 |
virus receptor activity phosphatidylserine binding immune system process transmembrane signaling receptor activity interleukin-4 receptor binding protein binding plasma membrane lipid binding membrane integral component of membrane osteoclast differentiation negative regulation of mast cell activation negative regulation of mast cell activation negative regulation of MyD88-dependent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway interleukin-13-mediated signaling pathway ceramide binding ceramide binding positive regulation of interleukin-4-mediated signaling pathway negative regulation of apoptotic cell clearance positive regulation of apoptotic cell clearance positive regulation of apoptotic cell clearance |
|
| TC0200000484.mm.2 |
Gbgt1 |
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 |
2 |
28496890 |
NM_139197, BC106831 NM_139197, BC106831 |
227671 |
6 |
Golgi apparatus carbohydrate metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation lipid glycosylation vesicle metal ion binding globoside alpha-N-acetylgalactosaminyltransferase activity globoside alpha-N-acetylgalactosaminyltransferase activity |
00603 01100 |
| TC0400001382.mm.2 |
Ppt1 |
palmitoyl-protein thioesterase 1 |
4 |
122836226 |
NM_008917, BC148714 NM_008917, BC148714 |
19063 |
82 |
protein depalmitoylation protein depalmitoylation protein depalmitoylation protein binding extracellular region extracellular space nucleus lysosome lysosome lysosome lysosome Golgi apparatus receptor-mediated endocytosis receptor-mediated endocytosis pinocytosis lysosome organization lysosomal lumen acidification neurotransmitter secretion nervous system development nervous system development brain development visual perception grooming behavior synaptic vesicle associative learning adult locomotory behavior palmitoyl-(protein) hydrolase activity palmitoyl-(protein) hydrolase activity palmitoyl-(protein) hydrolase activity palmitoyl-(protein) hydrolase activity protein transport lipid catabolic process palmitoyl-CoA hydrolase activity hydrolase activity thiolester hydrolase activity negative regulation of cell growth axon axon dendrite membrane raft organization regulation of phospholipase A2 activity lysophosphatidic acid binding neuron projection neuronal cell body neuronal cell body negative regulation of apoptotic process intracellular membrane-bounded organelle intracellular membrane-bounded organelle negative regulation of neuron apoptotic process cellular protein catabolic process cellular macromolecule catabolic process membrane raft synapse positive regulation of receptor-mediated endocytosis positive regulation of pinocytosis palmitoyl hydrolase activity sulfatide binding |
00062 01100 04142 |
| TC0900003121.mm.2 |
Tdgf1 |
teratocarcinoma-derived growth factor 1 |
9 |
-110939607 |
NM_011562, BC052646 NM_011562, BC052646 |
21667 |
158 |
activation of MAPK activity blood vessel development vasculogenesis in utero embryonic development morphogenesis of a branching structure positive regulation of cell-matrix adhesion cell migration involved in sprouting angiogenesis signaling receptor binding signaling receptor binding protein binding extracellular region extracellular region extracellular space extracellular space nucleus cytoplasm Golgi apparatus plasma membrane plasma membrane determination of left/right symmetry gastrulation heart development heart development heart development growth factor activity positive regulation of cell population proliferation anterior/posterior axis specification, embryo anterior/posterior axis specification anterior/posterior pattern specification regulation of signal transduction regulation of signal transduction cell surface cell surface cell surface positive regulation of endothelial cell migration coreceptor activity membrane apical plasma membrane Wnt-protein binding peptidyl-serine phosphorylation extrinsic component of plasma membrane cell differentiation regulation of cell migration positive regulation of cell migration positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway anchored component of membrane cellular response to hepatocyte growth factor stimulus nodal signaling pathway nodal signaling pathway nodal signaling pathway nodal binding nodal binding negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus membrane raft positive regulation of transcription by RNA polymerase II positive regulation of fibroblast proliferation perinuclear region of cytoplasm anatomical structure development positive regulation of peptidyl-tyrosine phosphorylation cardiac muscle cell differentiation activin receptor binding type I activin receptor binding cellular response to interferon-gamma cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus |
|
| TC1600000346.mm.2 |
Rtp4 |
receptor transporter protein 4 |
16 |
23609918 |
NM_023386, BC024872 NM_023386, BC024872 |
67775 |
15 |
detection of chemical stimulus involved in sensory perception of bitter taste detection of chemical stimulus involved in sensory perception of bitter taste protein binding cytoplasm cytoplasm protein targeting to membrane protein targeting to membrane membrane integral component of membrane olfactory receptor binding protein insertion into membrane defense response to virus |
|
| TC0600001421.mm.2 |
C1rl |
complement component 1, r subcomponent-like |
6 |
124493112 |
NM_181344, BC070472 NM_181344, BC070472 |
232371 |
14 |
immune system process serine-type endopeptidase activity extracellular region extracellular space extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation innate immune response blood microparticle |
|
| TC1100003790.mm.2 |
Stat3 |
signal transducer and activator of transcription 3 |
11 |
-100886805 |
NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 |
20848 |
1720 |
chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II repressing transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific temperature homeostasis eye photoreceptor cell differentiation DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex cytoplasm cytoplasm mitochondrion mitochondrial inner membrane cytosol cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II protein import into nucleus defense response acute-phase response inflammatory response signal transduction receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT transcription factor binding cell population proliferation positive regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of autophagy positive regulation of gene expression positive regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process postsynaptic density phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway stem cell population maintenance protein kinase binding protein phosphatase binding sexual reproduction positive regulation of cell migration intracellular receptor signaling pathway chromatin DNA binding CCR5 chemokine receptor binding response to estradiol positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production cellular response to hormone stimulus leptin-mediated signaling pathway leptin-mediated signaling pathway leptin-mediated signaling pathway leptin-mediated signaling pathway response to cytokine glucocorticoid receptor binding regulation of multicellular organism growth regulation of cell population proliferation glucose homeostasis eating behavior mRNA transcription by RNA polymerase II identical protein binding identical protein binding protein homodimerization activity response to peptide hormone sequence-specific DNA binding sequence-specific DNA binding cellular response to leptin stimulus response to leptin response to leptin response to leptin positive regulation of erythrocyte differentiation positive regulation of Notch signaling pathway positive regulation of angiogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of mitochondrial membrane permeability protein dimerization activity astrocyte differentiation modulation of chemical synaptic transmission positive regulation of NF-kappaB transcription factor activity regulation of cell cycle regulation of cell cycle radial glial cell differentiation regulation of feeding behavior growth hormone receptor signaling pathway growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT negative regulation of cell death interleukin-6-mediated signaling pathway primary miRNA binding cellular response to cytokine stimulus cellular response to organic cyclic compound T-helper 17 type immune response T-helper 17 cell lineage commitment RNA polymerase II transcription regulator complex energy homeostasis Schaffer collateral - CA1 synapse glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of neuron death positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of metalloendopeptidase activity positive regulation of vascular endothelial cell proliferation positive regulation of miRNA mediated inhibition of translation negative regulation of primary miRNA processing positive regulation of gene silencing by miRNA negative regulation of stem cell differentiation positive regulation of ATP biosynthetic process negative regulation of neuron migration |
04062 04630 04920 05145 05160 05200 05212 05221 |
| TC1000002642.mm.2 |
Dram1 |
DNA-damage regulated autophagy modulator 1 |
10 |
-88322803 |
NM_027878, BC021433 NM_027878, BC021433 |
71712 |
16 |
molecular_function cytoplasm lysosome lysosome autophagy apoptotic process regulation of autophagy regulation of autophagy membrane integral component of membrane |
|
| TC0300000258.mm.2 |
Atp11b |
ATPase, class VI, type 11B |
3 |
35754062 |
NM_029570, BC076603 NM_029570, BC076603 |
76295 |
19 |
endoplasmic reticulum endoplasmic reticulum trans-Golgi network plasma membrane phospholipid translocation recycling endosome recycling endosome ATPase-coupled intramembrane lipid transporter activity |
|
| TC0100000766.mm.2 |
Sp100 |
nuclear antigen Sp100 |
1 |
85649987, 85649987, 85649987, 85650013 |
NM_013673, BC069183 NM_013673, BC069183 |
20684 |
27 |
DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding protein binding nucleus nucleus cytoplasm regulation of transcription by RNA polymerase II PML body |
|
| TC0200002876.mm.2 |
Camk1d |
calcium/calmodulin-dependent protein kinase ID |
2 |
-5293456, -5293456 |
NM_177343, BC141413, BC141414 NM_177343, BC141413, BC141414 NM_177343, BC141413, BC141414 |
227541 |
27 |
nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin-dependent protein kinase activity calmodulin binding ATP binding intracellular anatomical structure nucleus cytoplasm cytoplasm protein phosphorylation inflammatory response nervous system development metabolic process positive regulation of neuron projection development kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation positive regulation of CREB transcription factor activity positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of phagocytosis regulation of dendrite development positive regulation of respiratory burst regulation of granulocyte chemotaxis positive regulation of neutrophil chemotaxis |
|
| TC0700003998.mm.2 |
|
|
|
|
NR_030719, NR_030720 NR_030719, NR_030720 |
|
|
|
|
| TC0700004007.mm.2 |
Gvin-ps5 |
GTPase, very large interferon inducible, pseudogene 5 |
7 |
-106322395, -106075731 |
NR_030720 |
668128 |
7 |
|
|
| TC0700002474.mm.2 |
Vasp |
vasodilator-stimulated phosphoprotein |
7 |
-19256929 |
NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 NM_001282021, NM_001282022, NM_009499, NR_104069, BC010223, BC015289 |
22323 |
113 |
neural tube closure neural tube closure actin binding protein binding profilin binding profilin binding cytoplasm cytosol cytosol cytoskeleton plasma membrane bicellular tight junction focal adhesion focal adhesion axon guidance axon guidance actin polymerization or depolymerization membrane SH3 domain binding lamellipodium actin cytoskeleton organization actin cytoskeleton organization cell junction filopodium positive regulation of actin filament polymerization positive regulation of actin filament polymerization cell projection protein homotetramerization |
04510 04666 04670 |
| TC0800002634.mm.2 |
N4bp1 |
NEDD4 binding protein 1 |
8 |
-86841138 |
NM_030563 |
80750 |
27 |
RNA binding protein binding nucleus nucleus nucleolus PML body PML body negative regulation of protein ubiquitination negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to UV cellular response to UV |
|
| TC0100003102.mm.2 |
Btg2 |
BTG anti-proliferation factor 2 |
1 |
-134074864 |
NM_007570, BC132259, BC138639 NM_007570, BC132259, BC138639 NM_007570, BC132259, BC138639 |
12227 |
113 |
negative regulation of transcription by RNA polymerase II transcription corepressor activity protein binding nucleus cytoplasm protein methylation cellular response to DNA damage stimulus negative regulation of cell population proliferation negative regulation of cell population proliferation associative learning anterior/posterior pattern specification negative regulation of translation dentate gyrus development central nervous system neuron development neuron differentiation neuron projection development skeletal muscle cell differentiation negative regulation of apoptotic process negative regulation of neuron apoptotic process negative regulation of mitotic cell cycle positive regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of neural precursor cell proliferation |
03018 |
| TC1400000945.mm.2 |
Trim35 |
tripartite motif-containing 35 |
14 |
66297024 |
NM_029979, BC049105, BC145783, BC145809 NM_029979, BC049105, BC145783, BC145809 NM_029979, BC049105, BC145783, BC145809 NM_029979, BC049105, BC145783, BC145809 |
66854 |
29 |
protein binding nucleus cytoplasm cytoplasm apoptotic process zinc ion binding negative regulation of cell population proliferation protein ubiquitination positive regulation of apoptotic process positive regulation of apoptotic process positive regulation of apoptotic process innate immune response innate immune response negative regulation of mitotic cell cycle metal ion binding ubiquitin protein ligase activity negative regulation of viral release from host cell |
|
| TC0400000092.mm.2 |
Gem |
GTP binding protein (gene overexpressed in skeletal muscle) |
4 |
11704446 |
NM_010276, BC029668 NM_010276, BC029668 |
14579 |
35 |
nucleotide binding mitotic cell cycle magnesium ion binding GTPase activity calcium channel regulator activity protein binding GTP binding GTP binding nucleus plasma membrane signal transduction cytoplasmic side of plasma membrane membrane GDP binding midbody spindle midzone chromosome organization metaphase plate congression mitotic spindle negative regulation of high voltage-gated calcium channel activity |
|
| TC0100002725.mm.2 |
Sp110 |
Sp110 nuclear body protein |
1 |
-85576898, -85576898 |
NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 |
109032 |
29 |
DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding nucleus nucleoplasm regulation of transcription by RNA polymerase II apoptotic process response to bacterium response to bacterium positive regulation of apoptotic process innate immune response |
|
| TC0400000529.mm.2 |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
4 |
48045304, 48045304 |
NM_015743, BC156736 NM_015743, BC156736 |
18124 |
115 |
negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific mesoderm formation DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity nucleus transcription regulator complex transcription regulator complex regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II gastrulation axon guidance zinc ion binding pyruvate oxidation positive regulation of cardiac muscle hypertrophy positive regulation of glucose transmembrane transport protein kinase binding hippocampus development adult behavior positive regulation of mast cell cytokine production histone acetyltransferase binding glucocorticoid receptor binding glucocorticoid receptor binding cAMP response element binding common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway inner ear morphogenesis response to hydrogen peroxide protein homodimerization activity negative regulation of apoptotic process mast cell degranulation negative regulation of neuron apoptotic process sequence-specific DNA binding cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation metal ion binding platelet-derived growth factor receptor signaling pathway regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation semicircular canal morphogenesis positive regulation of epithelial cell proliferation neuromuscular process controlling balance vestibular reflex regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation positive regulation of monocyte aggregation negative regulation of oxidative stress-induced neuron death negative regulation of hydrogen peroxide-induced neuron death positive regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of leukocyte apoptotic process positive regulation of feeding behavior |
|
| TC1000001183.mm.2 |
Btg1 |
BTG anti-proliferation factor 1 |
10 |
96617000 |
NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309 |
12226 |
44 |
protein binding nucleus nucleus cytoplasm cytoplasm protein methylation negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of cell population proliferation enzyme binding positive regulation of catalytic activity positive regulation of endothelial cell differentiation positive regulation of myoblast differentiation positive regulation of angiogenesis negative regulation of mitotic cell cycle positive regulation of fibroblast apoptotic process |
03018 |
| TC0200000525.mm.2 |
Tbc1d13 |
TBC1 domain family, member 13 |
2 |
30133745 |
NM_146252, BC025586 NM_146252, BC025586 |
70296 |
21 |
GTPase activator activity GTPase activator activity protein binding cytoplasm cytosol intracellular protein transport intracellular protein transport membrane small GTPase binding activation of GTPase activity |
|
| TC1100001657.mm.2 |
Ifi35 |
interferon-induced protein 35 |
11 |
101448411 |
NM_027320, BC008158 NM_027320, BC008158 |
70110 |
21 |
macrophage activation involved in immune response extracellular space extracellular space nucleus nucleus cytoplasm cytosol negative regulation of cell population proliferation membrane positive regulation of toll-like receptor 4 signaling pathway identical protein binding positive regulation of innate immune response positive regulation of innate immune response positive regulation of inflammatory response positive regulation of inflammatory response negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling |
|
| TC1900000689.mm.2 |
Nfkb2 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 |
19 |
46305694, 46304736, 46305929 |
NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 |
18034 |
204 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific follicular dendritic cell differentiation germinal center formation DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II signal transduction extracellular matrix organization Bcl3/NF-kappaB2 complex NIK/NF-kappaB signaling positive regulation of transcription by RNA polymerase II rhythmic process lymph node development spleen development sequence-specific double-stranded DNA binding |
04010 04380 05200 |
| TC0300000769.mm.2 |
Adar |
adenosine deaminase, RNA-specific |
3 |
89715021, 89730717, 89715237 |
NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 |
56417 |
115 |
osteoblast differentiation in utero embryonic development hematopoietic progenitor cell differentiation immune system process somatic diversification of immune receptors via somatic mutation DNA binding left-handed Z-DNA binding RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity double-stranded RNA adenosine deaminase activity double-stranded RNA adenosine deaminase activity adenosine deaminase activity protein binding nucleus nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytoplasm cytoplasm adenosine to inosine editing adenosine to inosine editing adenosine to inosine editing adenosine to inosine editing RNA processing mRNA processing protein import into nucleus protein export from nucleus tRNA-specific adenosine deaminase activity response to virus base conversion or substitution editing nuclear speck hydrolase activity erythrocyte differentiation gene silencing by RNA pre-miRNA processing production of miRNAs involved in gene silencing by miRNA miRNA loading onto RISC involved in gene silencing by miRNA response to interferon-alpha negative regulation of apoptotic process negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of protein kinase activity by regulation of protein phosphorylation supraspliceosomal complex positive regulation of viral genome replication positive regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus definitive hemopoiesis negative regulation of type I interferon-mediated signaling pathway hematopoietic stem cell homeostasis cellular response to virus negative regulation of RNA interference |
04623 |
| TC1600000500.mm.2 |
Parp9 |
poly (ADP-ribose) polymerase family, member 9 |
16 |
35938469 |
NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466 |
80285 |
21 |
negative regulation of transcription by RNA polymerase II positive regulation of defense response to virus by host immune system process transcription corepressor activity transcription corepressor activity NAD+ ADP-ribosyltransferase activity enzyme inhibitor activity nucleus nucleus nucleoplasm cytoplasm cytoplasm mitochondrion cytosol DNA repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus posttranscriptional regulation of gene expression negative regulation of gene expression negative regulation of gene expression transferase activity enzyme binding protein-containing complex positive regulation of chromatin binding histone binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of catalytic activity ubiquitin-like protein ligase binding ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated defense response to virus regulation of response to interferon-gamma positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma-mediated signaling pathway protein poly-ADP-ribosylation ADP-D-ribose binding site of DNA damage STAT family protein binding protein mono-ADP-ribosylation positive regulation of protein localization to nucleus protein ADP-ribosylase activity positive regulation of double-strand break repair via nonhomologous end joining |
|
| TC0100003590.mm.2 |
Ifi214 |
interferon activated gene 214 |
1 |
-173521310 |
NM_001024721, BC094916 NM_001024721, BC094916 |
545384 |
12 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding |
|
| TC0400000698.mm.2 |
Slc31a1 |
solute carrier family 31, member 1 |
4 |
62360700 |
NM_175090, BC034674, BC058227 NM_175090, BC034674, BC058227 NM_175090, BC034674, BC058227 |
20529 |
55 |
copper ion transmembrane transporter activity copper ion transmembrane transporter activity copper ion transmembrane transporter activity protein binding cytoplasm late endosome plasma membrane plasma membrane ion transport copper ion transport cellular copper ion homeostasis cellular copper ion homeostasis copper ion import copper ion import membrane integral component of membrane copper ion transmembrane transport identical protein binding neuronal cell body recycling endosome transmembrane transport cellular response to cisplatin copper ion import across plasma membrane |
|
| TC0500002993.mm.2 |
Noc4l |
NOC4 like |
5 |
-110648418 |
NM_153570, BC024616 NM_153570, BC024616 |
100608 |
20 |
nucleus nucleoplasm nucleolus nucleolus membrane integral component of membrane Noc4p-Nop14p complex small-subunit processome ribosome biogenesis |
|
| TC1600001177.mm.2 |
Carhsp1 |
calcium regulated heat stable protein 1 |
16 |
-8658586 |
NM_025821, BC011225, BC086754 NM_025821, BC011225, BC086754 NM_025821, BC011225, BC086754 |
52502 |
33 |
cytoplasmic exosome (RNase complex) nucleic acid binding RNA binding mRNA 3'-UTR binding mRNA 3'-UTR binding protein binding cytoplasm cytoplasm cytosol P granule regulation of mRNA stability regulation of mRNA stability |
|
| TC1700000117.mm.2 |
Agpat4 |
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) |
17 |
12119283 |
NM_026644, BC047281 NM_026644, BC047281 |
68262 |
28 |
1-acylglycerol-3-phosphate O-acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity mitochondrial outer membrane mitochondrial outer membrane endoplasmic reticulum lipid metabolic process phospholipid metabolic process phospholipid metabolic process phospholipid biosynthetic process endomembrane system membrane integral component of membrane transferase activity transferase activity, transferring acyl groups lysophosphatidic acid acyltransferase activity |
00561 00564 01100 |
| TC1900000221.mm.2 |
Ms4a6c |
membrane-spanning 4-domains, subfamily A, member 6C |
19 |
11469367, 11469367 |
NM_001166376, NM_028595, BC062247 NM_001166376, NM_028595, BC062247 NM_001166376, NM_028595, BC062247 |
73656 |
13 |
membrane integral component of membrane |
|
| TC1400001432.mm.2 |
Dnase1l3 |
deoxyribonuclease 1-like 3 |
14 |
-7965189 |
NM_007870, BC012671 NM_007870, BC012671 |
13421 |
25 |
DNA catabolic process, endonucleolytic DNA catabolic process, endonucleolytic neutrophil activation involved in immune response regulation of acute inflammatory response DNA binding DNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity deoxyribonuclease I activity deoxyribonuclease activity extracellular region nucleus nucleus nucleus endoplasmic reticulum DNA catabolic process apoptotic DNA fragmentation apoptotic DNA fragmentation apoptotic DNA fragmentation apoptotic process programmed cell death involved in cell development programmed cell death involved in cell development programmed cell death hydrolase activity regulation of neutrophil mediated cytotoxicity |
|
| TC1900001018.mm.2 |
Ccdc88b |
coiled-coil domain containing 88B |
19 |
-6844622 |
NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 |
78317 |
12 |
positive regulation of cytokine production cytoplasm endoplasmic reticulum Golgi apparatus centrosome cytoskeleton microtubule binding membrane cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization positive regulation of T cell proliferation defense response to protozoan positive regulation of T cell activation dynein light intermediate chain binding |
|
| TC0700001273.mm.2 |
E230029C05Rik |
RIKEN cDNA E230029C05 gene |
7 |
90029158 |
NR_110364, NR_110365, NR_015614 NR_110364, NR_110365, NR_015614 NR_110364, NR_110365, NR_015614 |
319711 |
11 |
|
|
| TC0500001338.mm.2 |
Slc8b1 |
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 |
5 |
120511191 |
NM_001177594, NM_001177595, NM_133221, BC043689 NM_001177594, NM_001177595, NM_133221, BC043689 NM_001177594, NM_001177595, NM_133221, BC043689 NM_001177594, NM_001177595, NM_133221, BC043689 |
170756 |
37 |
calcium:sodium antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity mitochondrion mitochondrion mitochondrial inner membrane plasma membrane ion transport cation transport sodium ion transport calcium ion transport mitochondrial calcium ion transmembrane transport mitochondrial calcium ion transmembrane transport mitochondrial calcium ion transmembrane transport cellular calcium ion homeostasis cation transmembrane transporter activity antiporter activity membrane integral component of membrane mitochondrial crista mitochondrial crista integral component of mitochondrial membrane sodium ion transmembrane transport sarcolemma glucose homeostasis identical protein binding protein homodimerization activity protein homodimerization activity regulation of insulin secretion response to stimulus regulation of cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration mitochondrial calcium ion homeostasis mitochondrial calcium ion homeostasis mitochondrial calcium ion homeostasis transmembrane transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential calcium export from the mitochondrion calcium export from the mitochondrion calcium export from the mitochondrion regulation of lymphocyte chemotaxis regulation of store-operated calcium entry |
|
| TC0800001106.mm.2 |
Herpud1 |
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
8 |
94386428 |
NM_022331, BC013523 NM_022331, BC013523 |
64209 |
48 |
protein binding endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process cellular calcium ion homeostasis response to unfolded protein membrane integral component of membrane ubiquitin-dependent ERAD pathway endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol regulation of protein ubiquitination endoplasmic reticulum calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress response to endoplasmic reticulum stress negative regulation of cysteine-type endopeptidase activity involved in apoptotic process endoplasmic reticulum quality control compartment ion channel binding ion channel binding protein targeting to ER regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of ER-associated ubiquitin-dependent protein catabolic process regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of ER-associated ubiquitin-dependent protein catabolic process Lewy body core ubiquitin ligase-substrate adaptor activity negative regulation of intrinsic apoptotic signaling pathway |
04141 |
| TC0400004170.mm.2 |
Agrn |
agrin |
4 |
-156165289, -156190167, -156165291 |
NM_021604, BC150703 NM_021604, BC150703 |
11603 |
172 |
regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of protein phosphorylation dystroglycan binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region basement membrane basement membrane extracellular space extracellular space extracellular space Golgi lumen plasma membrane plasma membrane organization chemical synaptic transmission chemical synaptic transmission multicellular organism development synapse assembly neuromuscular junction development neuromuscular junction development regulation of synaptic growth at neuromuscular junction animal organ morphogenesis tissue development cell surface membrane integral component of membrane cell junction cell differentiation acetylcholine receptor regulator activity positive regulation of protein binding chondroitin sulfate binding BMP binding ATPase inhibitor activity sarcolemma synaptic cleft regulation of GTPase activity receptor clustering receptor clustering receptor clustering receptor clustering receptor clustering heparan sulfate proteoglycan binding positive regulation of neuron apoptotic process positive regulation of GTPase activity axonal growth cone ion channel binding synapse synapse synapse neurotransmitter receptor metabolic process positive regulation of synaptic growth at neuromuscular junction positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II transforming growth factor beta binding positive regulation of peptidyl-tyrosine phosphorylation regulation of synapse organization positive regulation of filopodium assembly regulation of cardiac muscle contraction positive regulation of protein tyrosine kinase activity collagen-containing extracellular matrix collagen-containing extracellular matrix regulation of microtubule cytoskeleton organization skeletal muscle acetylcholine-gated channel clustering regulation of cardiac muscle cell membrane potential glutamatergic synapse regulation of axon guidance negative regulation of sodium ion export across plasma membrane negative regulation of sodium:potassium-exchanging ATPase activity positive regulation of protein geranylgeranylation |
04512 |
| TC0300003210.mm.2 |
Schip1 |
schwannomin interacting protein 1 |
3 |
68572367, 68064801, 68468182, 68494180 |
NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 NM_001113420, NM_001113421, NM_001282044, NM_001282045, NM_013928, BC094348, NR_036665 |
30953 |
28 |
luteinization kidney development protein binding cytoplasm plasma membrane nitrogen compound metabolic process estrogen metabolic process female gonad development post-embryonic development fibroblast migration cell junction positive regulation of hippo signaling identical protein binding protein homodimerization activity platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis smooth muscle tissue development roof of mouth development face morphogenesis |
|
| TC0800001132.mm.2 |
Usb1 |
U6 snRNA biogenesis 1 |
8 |
95332283 |
NM_133954, BC016418, U6 NM_133954, BC016418, U6 NM_133954, BC016418, U6 |
101985 |
15 |
3'-5'-exoribonuclease activity 3'-5'-exoribonuclease activity nuclease activity nucleus nucleus nucleoplasm RNA splicing hydrolase activity U6 snRNA 3'-end processing U6 snRNA 3'-end processing intercellular bridge |
|
| TC1700000625.mm.2 |
H2-Ob |
histocompatibility 2, O region beta locus |
17 |
34238904 |
NM_010389, BC127027, BC127028 NM_010389, BC127027, BC127028 NM_010389, BC127027, BC127028 |
15002 |
43 |
negative regulation of antigen processing and presentation of peptide antigen via MHC class II intracellular anatomical structure lysosome MHC class II protein complex binding MHC class II protein complex |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| MG-1-pos-10339750_st |
|
|
|
|
|
|
|
|
|
| TC0800002012.mm.2 |
Rbpms |
RNA binding protein gene with multiple splicing |
8 |
-33782643, -33803939 |
NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 |
19663 |
48 |
nucleic acid binding transcription coactivator activity RNA binding mRNA binding nucleus nucleoplasm cytoplasm cytosol response to oxidative stress poly(A) binding cytoplasmic stress granule positive regulation of pathway-restricted SMAD protein phosphorylation protein homodimerization activity positive regulation of SMAD protein signal transduction |
|
| TC1700002216.mm.2 |
Foxp4 |
forkhead box P4 |
17 |
-47867132 |
NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 |
74123 |
58 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II heart development identical protein binding sequence-specific DNA binding metal ion binding embryonic foregut morphogenesis lung secretory cell differentiation regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation |
|
| TC1100003379.mm.2 |
Slfn9 |
schlafen 9 |
11 |
-82980302 |
NM_172796 |
237886 |
12 |
tRNA binding nucleotide binding nuclease activity endonuclease activity endoribonuclease activity ATP binding nucleus cytoplasm zinc ion binding hydrolase activity metal ion binding defense response to virus |
|
| TC1700002814.mm.2 |
C4b |
complement component 4B (Chido blood group) |
17 |
-34728380 |
NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005 NM_009780, BC067394, BC067409, BC150743, BC158005 |
12268 |
187 |
complement binding complement component C1q complex binding extracellular region extracellular space extracellular space extracellular space extracellular space complement activation complement activation immunoglobulin mediated immune response carbohydrate binding axon dendrite neuronal cell body other organism cell synapse |
04610 05150 05322 |
| TC1100004124.mm.2 |
St6galnac2 |
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
11 |
-116676704 |
NM_009180 |
20446 |
19 |
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Golgi apparatus protein glycosylation protein O-linked glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups protein sialylation |
|
| TC0200003599.mm.2 |
Cd302 |
CD302 antigen |
2 |
-60251992 |
NM_025422, BC005501, CD302 NM_025422, BC005501, CD302 NM_025422, BC005501, CD302 |
66205 |
16 |
cytoplasm cell cortex phagocytosis external side of plasma membrane membrane integral component of membrane filopodium carbohydrate binding signaling receptor activity cell projection |
|
| TC0400002799.mm.2 |
Akna |
AT-hook transcription factor |
4 |
-63367122, -63367122 |
NM_001045514, BC092227 NM_001045514, BC092227 |
100182 |
21 |
fibrillar center epithelial to mesenchymal transition DNA binding protein binding nucleus nucleoplasm cytoplasm centrosome centrosome centriole cytosol cytoskeleton microtubule nervous system development neuroblast division in subventricular zone intracellular membrane-bounded organelle positive regulation of transcription by RNA polymerase II regulation of inflammatory response delamination neuroblast delamination |
|
| TC1300002534.mm.2 |
Naip1 |
NLR family, apoptosis inhibitory protein 1 |
13 |
-100407769 |
NM_008670, BC132413 NM_008670, BC132413 |
17940 |
46 |
nucleotide binding cysteine-type endopeptidase inhibitor activity ATP binding cytoplasm cytoplasm apoptotic process inflammatory response negative regulation of peptidase activity detection of bacterium basolateral plasma membrane peptidase inhibitor activity defense response to bacterium neuron projection neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process perikaryon metal ion binding pyroptosis cellular response to estrogen stimulus IPAF inflammasome complex |
04621 |
| TC1100000494.mm.2 |
Trim7 |
tripartite motif-containing 7 |
11 |
48826137, 48837470 |
NM_053166, BC138188 NM_053166, BC138188 |
94089 |
21 |
nucleus nucleus cytoplasm cytoplasm cytoplasm zinc ion binding protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity |
|
| TC1000002664.mm.2 |
Apaf1 |
apoptotic peptidase activating factor 1 |
10 |
-90989310 |
NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 |
11783 |
151 |
nucleotide binding neural tube closure ATP binding nucleus cytoplasm cytosol cytosol apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process multicellular organism development brain development activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c cysteine-type endopeptidase activator activity involved in apoptotic process cardiac muscle cell apoptotic process forebrain development heat shock protein binding protein-containing complex identical protein binding identical protein binding regulation of apoptotic process apoptosome ADP binding neuron apoptotic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to transforming growth factor beta stimulus apoptotic signaling pathway regulation of apoptotic DNA fragmentation positive regulation of apoptotic signaling pathway |
04115 04210 05010 05012 05014 05016 05222 |
| TC0700001876.mm.2 |
Itgax |
integrin alpha X |
7 |
128129549, 128129549 |
NM_021334, BC167225 NM_021334, BC167225 |
16411 |
159 |
cell adhesion integrin-mediated signaling pathway positive regulation of cell population proliferation integrin complex external side of plasma membrane cell surface positive regulation of gene expression positive regulation of gene expression membrane integral component of membrane positive regulation of cell migration receptor tyrosine kinase binding positive regulation of myelination heterotypic cell-cell adhesion positive regulation of angiogenesis metal ion binding defense response to virus positive regulation of endothelial tube morphogenesis |
04810 |
| TC1100000362.mm.2 |
Lcp2 |
lymphocyte cytosolic protein 2 |
11 |
34046927 |
NM_010696, BC006948 NM_010696, BC006948 |
16822 |
113 |
cytokine production protein binding cytoplasm cytosol cytosol cell-cell junction transmembrane receptor protein tyrosine kinase signaling pathway intracellular signal transduction TCR signalosome plasma membrane raft mast cell activation T cell receptor signaling pathway |
04380 04650 04660 04664 |
| TC1000000592.mm.2 |
Dna2 |
DNA replication helicase/nuclease 2 |
10 |
62947028, 62947028 |
NM_177372, BC115716 NM_177372, BC115716 |
327762 |
26 |
DNA replication checkpoint nucleotide binding telomere maintenance DNA double-strand break processing chromosome, telomeric region DNA binding RNA binding catalytic activity helicase activity nuclease activity endonuclease activity protein binding ATP binding nucleus nucleoplasm cytoplasm mitochondrion gamma DNA polymerase complex DNA replication mitochondrial DNA replication DNA repair base-excision repair cellular response to DNA damage stimulus metabolic process hydrolase activity site-specific endodeoxyribonuclease activity, specific for altered base 5'-flap endonuclease activity 5'-flap endonuclease activity 5'-flap endonuclease activity single-stranded DNA helicase activity DNA replication, Okazaki fragment processing mitochondrial nucleoid DNA replication, removal of RNA primer 5'-3' DNA helicase activity mitochondrial DNA repair positive regulation of DNA replication metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding replication fork reversal nucleic acid phosphodiester bond hydrolysis mitotic telomere maintenance via semi-conservative replication |
03030 |
| TC1400002406.mm.2 |
Lrch1 |
leucine-rich repeats and calponin homology (CH) domain containing 1 |
14 |
-74754672 |
NM_001033439, NM_001252132 NM_001033439, NM_001252132 |
380916 |
23 |
protein binding cytoplasm cytoplasm negative regulation of GTPase activity negative regulation of GTPase activity cellular response to chemokine cellular response to chemokine cellular response to chemokine negative regulation of T cell migration negative regulation of T cell migration negative regulation of T cell migration |
|
| TC0200004733.mm.2 |
Flrt3 |
fibronectin leucine rich transmembrane protein 3 |
2 |
-140658197 |
NM_001172160, NM_178382, BC052043 NM_001172160, NM_178382, BC052043 NM_001172160, NM_178382, BC052043 |
71436 |
39 |
proepicardium cell migration involved in pericardium morphogenesis fibroblast growth factor receptor binding protein binding extracellular region extracellular space extracellular space endoplasmic reticulum cytosol plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane cell-cell junction focal adhesion cell adhesion multicellular organism development axon guidance axon guidance synapse assembly heart development fibroblast growth factor receptor signaling pathway postsynaptic density membrane integral component of membrane cell junction neuron projection development neuron projection development protein homodimerization activity cell projection axon terminus axonal growth cone chemorepellent activity embryonic morphogenesis response to axon injury synapse organization positive regulation of synapse assembly head development synaptic membrane cell-cell adhesion via plasma-membrane adhesion molecules cell-cell adhesion via plasma-membrane adhesion molecules glutamatergic synapse glutamatergic synapse integral component of postsynaptic membrane integral component of postsynaptic membrane integral component of postsynaptic membrane synaptic membrane adhesion synaptic membrane adhesion neuron projection extension |
|
| TC0500003178.mm.2 |
Oas1c |
2'-5' oligoadenylate synthetase 1C |
5 |
-120800198 |
NM_033541, BC108955, BC126877 NM_033541, BC108955, BC126877 NM_033541, BC108955, BC126877 |
114643 |
18 |
RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytosol immune response membrane transferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity |
|
| TC1100002176.mm.2 |
Myo1g |
myosin IG |
11 |
-6506547 |
NM_178440, BC113755, BC113954 NM_178440, BC113755, BC113954 NM_178440, BC113755, BC113954 |
246177 |
23 |
microfilament motor activity nucleotide binding phagocytic cup adaptive immune response immune system process T cell mediated immunity motor activity actin binding calmodulin binding ATP binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding nucleoplasm cytoplasm plasma membrane plasma membrane plasma membrane microvillus microvillus exocytosis phagocytosis actin filament organization lipid binding actin cytoskeleton membrane myosin complex lamellipodium vesicle transport along actin filament filopodium actin-dependent ATPase activity leading edge membrane cell-substrate adhesion vesicle Fc-gamma receptor signaling pathway involved in phagocytosis cell projection phosphatidylinositol-3,4-bisphosphate binding actin filament binding cell gliding T cell meandering migration |
|
| TC0400003679.mm.2 |
Xkr8 |
X-linked Kx blood group related 8 |
4 |
-132724903 |
NM_201368, BC057035 NM_201368, BC057035 |
381560 |
18 |
tolerance induction to self antigen molecular_function plasma membrane plasma membrane apoptotic process membrane integral component of membrane engulfment of apoptotic cell engulfment of apoptotic cell establishment of localization in cell phosphatidylserine exposure on apoptotic cell surface phosphatidylserine exposure on apoptotic cell surface phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development |
|
| TC0600002423.mm.2 |
Il12rb2 |
interleukin 12 receptor, beta 2 |
6 |
-67292017, -67292017 |
NM_008354, BC137745 NM_008354, BC137745 |
16162 |
111 |
cytokine receptor activity protein binding plasma membrane plasma membrane external side of plasma membrane external side of plasma membrane membrane integral component of membrane peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway protein kinase binding cytokine binding response to lipopolysaccharide interferon-gamma production positive regulation of interferon-gamma production response to cytokine receptor complex |
04060 04630 |
| TC0900002604.mm.2 |
Aqp9 |
aquaporin 9 |
9 |
-71110658, -71110658 |
NM_001271843, NM_022026, NR_073483, BC024105 NM_001271843, NM_022026, NR_073483, BC024105 NM_001271843, NM_022026, NR_073483, BC024105 NM_001271843, NM_022026, NR_073483, BC024105 |
64008 |
62 |
purine nucleobase transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane water transport water transport purine nucleobase transport response to organic substance urea transmembrane transporter activity water channel activity water channel activity glycerol channel activity urea channel activity channel activity canalicular bile acid transport polyol transport glycerol transport amine transport pyrimidine nucleobase transport membrane integral component of membrane basolateral plasma membrane intracellular membrane-bounded organelle response to mercury ion transmembrane transport urea transmembrane transport |
04976 |
| TC1100001981.mm.2 |
Pgs1 |
phosphatidylglycerophosphate synthase 1 |
11 |
117986856 |
NM_133757, BC151089, BC151185 NM_133757, BC151089, BC151185 NM_133757, BC151089, BC151185 |
74451 |
21 |
nucleotide binding catalytic activity ATP binding mitochondrion mitochondrion endoplasmic reticulum lipid metabolic process CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity phospholipid biosynthetic process transferase activity cardiolipin biosynthetic process |
00564 01100 |
| TC1700002820.mm.2 |
H2-T-ps |
histocompatibility 2, T region locus, pseudogene |
17 |
-36109029 |
NM_001271005, XM_003688945 NM_001271005, XM_003688945 |
667803 |
13 |
|
|
| TC0300002994.mm.2 |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
3 |
-135584654 |
NM_008689, BC138535, BC138536 NM_008689, BC138535, BC138536 NM_008689, BC138535, BC138536 |
18033 |
1492 |
negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific negative regulation of cytokine production DNA binding DNA binding chromatin binding double-stranded DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm mitochondrion cytosol cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process response to oxidative stress signal transduction positive regulation of gene expression negative regulation of gene expression negative regulation of calcidiol 1-monooxygenase activity response to organic cyclic compound enzyme binding heat shock protein binding negative regulation of interleukin-12 production protein-containing complex response to muscle stretch identical protein binding identical protein binding actinin binding neuron projection negative regulation of apoptotic process sequence-specific DNA binding sequence-specific DNA binding protein-containing complex binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II lymph node development negative regulation of inflammatory response cellular response to lipopolysaccharide cellular response to nicotine cellular response to carbohydrate stimulus cellular response to cytokine stimulus cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to dsRNA cellular response to organic cyclic compound positive regulation of canonical Wnt signaling pathway positive regulation of hyaluronan biosynthetic process cellular response to peptide positive regulation of pri-miRNA transcription by RNA polymerase II cellular response to angiotensin cellular response to diterpene cellular response to glucoside cellular response to brain-derived neurotrophic factor stimulus positive regulation of miRNA metabolic process positive regulation of gene silencing by miRNA |
04010 04062 04210 04380 04620 04621 04622 04623 04660 04662 04722 04920 05140 05142 05145 05146 05160 05200 05212 05215 05220 05221 05222 |
| TC0400004047.mm.2 |
Pik3cd |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
4 |
-149649167, -149649167, -149649167, -149649167 |
NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840, BC035203 |
18707 |
187 |
nucleotide binding B cell homeostasis positive regulation of endothelial cell proliferation adaptive immune response immune system process protein binding ATP binding cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex chemotaxis inflammatory response cell surface receptor signaling pathway positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression phosphatidylinositol 3-kinase signaling phosphatidylinositol 3-kinase signaling membrane kinase activity 1-phosphatidylinositol-3-kinase activity phosphorylation cell migration transferase activity cell differentiation positive regulation of cell migration positive regulation of neutrophil apoptotic process phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process positive regulation of cell migration by vascular endothelial growth factor signaling pathway B cell activation innate immune response positive regulation of angiogenesis phosphatidylinositol phosphorylation phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol-mediated signaling homeostasis of number of cells defense response to fungus positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling phosphatidylinositol kinase activity positive regulation of epithelial tube formation |
00562 04012 04062 04070 04150 04210 04370 04380 04510 04620 04630 04650 04660 04662 04664 04666 04670 04722 04810 04910 04914 04930 04960 04973 05100 05142 05145 05146 05160 05200 05210 05211 05212 05213 05214 05215 05218 05220 05221 05222 05223 |
| TC0500003318.mm.2 |
Sbds |
SBDS ribosome maturation factor |
5 |
-130245731 |
NM_023248, BC003849 NM_023248, BC003849 |
66711 |
28 |
spindle pole inner cell mass cell proliferation hematopoietic progenitor cell differentiation nucleus nucleoplasm nucleolus cytoplasm cytosol cytoskeleton rRNA processing mitotic spindle organization microtubule binding rRNA binding bone mineralization leukocyte chemotaxis ribosome biogenesis mature ribosome assembly ribosome binding bone marrow development |
03008 |
| TC1400002454.mm.2 |
Lacc1 |
laccase domain containing 1 |
14 |
-77024200 |
NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140 |
210808 |
18 |
pattern recognition receptor signaling pathway cytokine production involved in immune response immune system process adenosine deaminase activity purine-nucleoside phosphorylase activity copper ion binding nucleus cytoplasm peroxisome endoplasmic reticulum inflammatory response transferase activity hydrolase activity S-methyl-5-thioadenosine phosphorylase activity regulation of cellular pH innate immune response metal ion binding guanosine phosphorylase activity regulation of inflammatory response nucleotide-binding oligomerization domain containing 2 signaling pathway regulation of purine nucleotide metabolic process |
|
| TC1000002490.mm.2 |
Sbno2 |
strawberry notch 2 |
10 |
-80062415, -80056991, -80056991, -80080409 |
NM_183426, BC056369 NM_183426, BC056369 |
216161 |
22 |
ossification macrophage activation involved in immune response macrophage activation involved in immune response macrophage activation involved in immune response protein binding nucleus regulation of transcription, DNA-templated cell differentiation bone mineralization osteoclast differentiation osteoclast differentiation chromatin DNA binding histone binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of inflammatory response regulation of inflammatory response regulation of inflammatory response bone trabecula morphogenesis cellular response to lipopolysaccharide cellular response to interleukin-11 cellular response to interleukin-6 cellular response to interleukin-6 cellular response to interleukin-6 multinuclear osteoclast differentiation osteoclast fusion cellular response to leukemia inhibitory factor |
|
| TC0300000765.mm.2 |
Pbxip1 |
pre B cell leukemia transcription factor interacting protein 1 |
3 |
89436703 |
NM_146131, BC026838, BC027771, BC034200 NM_146131, BC026838, BC027771, BC034200 NM_146131, BC026838, BC027771, BC034200 NM_146131, BC026838, BC027771, BC034200 |
229534 |
25 |
molecular_function transcription corepressor activity nucleus cytoplasm cytoskeleton microtubule membrane cell differentiation negative regulation of transcription, DNA-templated regulation of Rho guanyl-nucleotide exchange factor activity |
|
| TC1700002766.mm.2 |
|
|
|
|
NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264 |
|
|
transcription corepressor activity nucleus centriole biological_process |
|
| TC0700003938.mm.2 |
Trim12a |
tripartite motif-containing 12A |
7 |
-104299896, -104303594 |
NM_023835, BC094899 NM_023835, BC094899 |
76681 |
20 |
protein polyubiquitination ubiquitin-protein transferase activity nucleoplasm cytoplasm cytoplasm cytosol autophagy zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity |
|
| TC0700004316.mm.2 |
Tbc1d10b |
TBC1 domain family, member 10b |
7 |
-127197458 |
NM_144522, BC072576 NM_144522, BC072576 |
68449 |
24 |
GTPase activator activity GTPase activator activity cytoplasm plasma membrane intracellular protein transport retrograde transport, endosome to Golgi regulation of GTPase activity activation of GTPase activity |
|
| TC0400001525.mm.2 |
Marcksl1 |
MARCKS-like 1 |
4 |
129513580 |
NM_010807, BC006757 NM_010807, BC006757 |
17357 |
47 |
actin binding calmodulin binding cytoplasm cytoskeleton plasma membrane plasma membrane actin filament organization central nervous system development synaptic vesicle positive regulation of cell population proliferation membrane actin filament binding anchored component of presynaptic membrane presynaptic cytosol voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels |
04666 05140 |
| TC0100003264.mm.2 |
Rgl1 |
ral guanine nucleotide dissociation stimulator,-like 1 |
1 |
-152516762, -152516762 |
NM_016846, BC017678, XR_140453 NM_016846, BC017678, XR_140453 NM_016846, BC017678, XR_140453 |
19731 |
18 |
guanyl-nucleotide exchange factor activity intracellular anatomical structure signal transduction small GTPase mediated signal transduction |
|
| TC0300002860.mm.2 |
|
|
|
|
NM_001114665, NM_153118, NR_106117, BC034510 NM_001114665, NM_153118, NR_106117, BC034510 NM_001114665, NM_153118, NR_106117, BC034510 NM_001114665, NM_153118, NR_106117, BC034510 |
|
|
cytoplasm cytoskeleton plasma membrane endocytosis autophagy signal transduction lipid binding membrane cytoplasmic vesicle cilium assembly |
|
| TC1300001366.mm.2 |
BC147527 |
cDNA sequence BC147527 |
13 |
120300391 |
NM_001037925, BC147527, BC147545 NM_001037925, BC147527, BC147545 NM_001037925, BC147527, BC147545 |
625360 |
8 |
|
|
| TC0200005114.mm.2 |
Sdc4 |
syndecan 4 |
2 |
-164424246 |
NM_011521, BC005679 NM_011521, BC005679 |
20971 |
155 |
neural tube closure fibronectin binding protein kinase C binding protein binding extracellular region Golgi lumen focal adhesion cell surface cell surface cell surface regulation of fibroblast migration membrane integral component of membrane cell migration wound healing negative regulation of T cell proliferation identical protein binding costamere membrane raft positive regulation of protein kinase activity positive regulation of stress fiber assembly positive regulation of focal adhesion assembly inner ear receptor cell stereocilium organization thrombospondin receptor activity positive regulation of exosomal secretion positive regulation of extracellular exosome assembly |
04512 04514 05144 |
| TC1700002135.mm.2 |
Enpp4 |
ectonucleotide pyrophosphatase/phosphodiesterase 4 |
17 |
-44096309, -44096309 |
NM_199016, BC027749 NM_199016, BC027749 |
224794 |
17 |
catalytic activity plasma membrane blood coagulation hemostasis membrane integral component of membrane hydrolase activity positive regulation of blood coagulation purine ribonucleoside catabolic process metal ion binding bis(5'-adenosyl)-triphosphatase activity |
|
| TC0900001391.mm.2 |
Gmppb |
GDP-mannose pyrophosphorylase B |
9 |
108049263 |
NM_177910, BC061207 NM_177910, BC061207 |
331026 |
16 |
nucleotide binding mannose-1-phosphate guanylyltransferase activity GTP binding cytoplasm mitochondrion biosynthetic process transferase activity nucleotidyltransferase activity |
00051 00520 01100 |
| TC0900000533.mm.2 |
Jaml |
junction adhesion molecule like |
9 |
45079182 |
NM_001005421, BC050133 NM_001005421, BC050133 |
270152 |
14 |
immune system process integrin binding nucleoplasm plasma membrane plasma membrane bicellular tight junction cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane cell junction neutrophil chemotaxis monocyte extravasation protein homodimerization activity gamma-delta T cell activation cell adhesion molecule binding leukocyte migration positive regulation of epithelial cell proliferation involved in wound healing neutrophil extravasation |
|
| TC1700002774.mm.2 |
Cmtr1 |
cap methyltransferase 1 |
17 |
29660594 |
NM_028791, BC024691 NM_028791, BC024691 |
74157 |
25 |
nucleic acid binding mRNA (nucleoside-2'-O-)-methyltransferase activity mRNA (nucleoside-2'-O-)-methyltransferase activity nucleus nucleus nucleoplasm cytoplasm 7-methylguanosine mRNA capping 7-methylguanosine mRNA capping mRNA processing methyltransferase activity transferase activity methylation intracellular membrane-bounded organelle mRNA methylation cap1 mRNA methylation cap1 mRNA methylation |
|
| TC1700001033.mm.2 |
Vav1 |
vav 1 oncogene |
17 |
57279099 |
NM_001163815, NM_001163816, NM_011691, BC020487 NM_001163815, NM_001163816, NM_011691, BC020487 NM_001163815, NM_001163816, NM_011691, BC020487 NM_001163815, NM_001163816, NM_011691, BC020487 |
22324 |
225 |
phosphotyrosine residue binding guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity protein binding cytosol cell-cell junction phagocytosis immune response G protein-coupled receptor signaling pathway integrin-mediated signaling pathway small GTPase mediated signal transduction T cell differentiation T cell differentiation neutrophil chemotaxis regulation of Rho protein signal transduction intracellular signal transduction T cell activation regulation of GTPase activity regulation of GTPase activity positive regulation of GTPase activity positive regulation of cell adhesion positive regulation of natural killer cell mediated cytotoxicity metal ion binding reactive oxygen species metabolic process phosphorylation-dependent protein binding |
04062 04510 04650 04660 04662 04664 04666 04670 04810 |
| TC0600001877.mm.2 |
Gpr85 |
G protein-coupled receptor 85 |
6 |
-13834451 |
NM_145066, BC026975, BC065154 NM_145066, BC026975, BC065154 NM_145066, BC026975, BC065154 |
64450 |
25 |
G protein-coupled receptor activity endoplasmic reticulum plasma membrane plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane |
|
| TC0100001202.mm.2 |
Ppp1r15b |
protein phosphatase 1, regulatory subunit 15B |
1 |
133131165 |
NM_133819, BC156913 NM_133819, BC156913 |
108954 |
23 |
protein phosphatase type 1 complex protein phosphatase type 1 complex protein phosphatase type 1 complex negative regulation of protein phosphorylation endoplasmic reticulum regulation of translation regulation of translational initiation response to oxidative stress response to oxidative stress ER overload response ER overload response protein phosphatase regulator activity protein phosphatase regulator activity positive regulation of phosphoprotein phosphatase activity response to endoplasmic reticulum stress response to endoplasmic reticulum stress response to hydrogen peroxide peptidyl-serine dephosphorylation negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation |
|
| TC0100002177.mm.2 |
Neurl3 |
neuralized E3 ubiquitin protein ligase 3 |
1 |
-36264601 |
NM_153408, BC056622 NM_153408, BC056622 |
214854 |
15 |
protein ubiquitination transferase activity metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity |
|
| TC1900000442.mm.2 |
Pdcd1lg2 |
programmed cell death 1 ligand 2 |
19 |
29410918 |
NM_021396, BC104138, BC104139 NM_021396, BC104138, BC104139 NM_021396, BC104138, BC104139 |
58205 |
98 |
adaptive immune response immune system process protein binding plasma membrane immune response cell surface receptor signaling pathway external side of plasma membrane membrane integral component of membrane T cell costimulation negative regulation of interferon-gamma production negative regulation of interleukin-10 production positive regulation of T cell proliferation positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of activated T cell proliferation cellular response to lipopolysaccharide |
04514 |
| TC1800000689.mm.2 |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
18 |
66458603 |
NM_021451, BC050821 NM_021451, BC050821 |
58801 |
126 |
release of cytochrome c from mitochondria release of cytochrome c from mitochondria protein binding mitochondrion mitochondrion mitochondrion mitochondrion apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus intrinsic apoptotic signaling pathway in response to DNA damage response to UV response to X-ray negative regulation of mitochondrial membrane potential intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process T cell homeostasis positive regulation of apoptotic process positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of neuron apoptotic process negative regulation of fibroblast proliferation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
04115 |
| TC0200001849.mm.2 |
Slc28a2 |
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 |
2 |
122426434 |
NM_172980, BC055376 NM_172980, BC055376 |
269346 |
20 |
retina homeostasis retina homeostasis neurotransmitter transmembrane transporter activity nucleoside transmembrane transporter activity nucleoside transmembrane transporter activity purine nucleobase transmembrane transporter activity nucleoside:sodium symporter activity nucleoside:sodium symporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane neurotransmitter transport vesicle membrane purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transporter activity uridine transmembrane transporter activity symporter activity pyrimidine- and adenine-specific:sodium symporter activity purine nucleoside transmembrane transport purine nucleoside transmembrane transport uridine transport membrane integral component of membrane coated vesicle brush border membrane adenosine transport protein localization to cell surface inosine transport pyrimidine-containing compound transmembrane transport nucleoside transmembrane transport nucleoside transmembrane transport purine nucleobase transmembrane transport |
|
| TC1600000264.mm.2 |
B3gnt5 |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 |
16 |
19760233 |
NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 |
108105 |
22 |
Golgi apparatus protein glycosylation multicellular organism development central nervous system development brain development acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sphingolipid biosynthetic process lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity |
00601 01100 |
| TC0500003615.mm.2 |
Usp12 |
ubiquitin specific peptidase 12 |
5 |
-146734811 |
NM_011669, BC049274, BC068136 NM_011669, BC049274, BC068136 NM_011669, BC049274, BC068136 |
22217 |
25 |
cysteine-type endopeptidase activity cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity nucleus nucleus cytosol cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination protein deubiquitination protein deubiquitination hydrolase activity metal ion binding positive regulation of T cell receptor signaling pathway ubiquitinyl hydrolase activity ubiquitinyl hydrolase activity |
|
| TC1300001654.mm.2 |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
13 |
-24012483, -24012480, -24012480 |
NM_026825, BC167257 NM_026825, BC167257 |
68732 |
23 |
nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane membrane cell migration nuclear speck lamellipodium lamellipodium lamellipodium assembly positive regulation of cell migration positive regulation of cell migration positive regulation of actin filament polymerization cell leading edge ruffle organization filamentous actin cell projection macropinocytosis macropinosome protein-containing complex binding protein-containing complex binding urate metabolic process positive regulation of stress fiber assembly positive regulation of stress fiber assembly barbed-end actin filament uncapping actin filament network formation positive regulation of substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading positive regulation of lamellipodium organization positive regulation of lamellipodium organization negative regulation of barbed-end actin filament capping |
|
| TC0100001620.mm.2 |
Cfap45 |
cilia and flagella associated protein 45 |
1 |
172521129 |
NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 |
71870 |
13 |
molecular_function nucleoplasm biological_process |
|
| TC1700002558.mm.2 |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
17 |
-78852549 |
NM_011163, BC016422 NM_011163, BC016422 |
19106 |
219 |
nucleotide binding activation of MAPKK activity positive regulation of cytokine production immune system process RNA binding double-stranded RNA binding double-stranded RNA binding protein kinase activity protein kinase activity protein kinase activity protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol cytosol translation protein phosphorylation protein phosphorylation response to virus response to toxic substance kinase activity phosphorylation transferase activity negative regulation of translation endoplasmic reticulum unfolded protein response response to lipopolysaccharide positive regulation of chemokine production positive regulation of stress-activated MAPK cascade response to vitamin E negative regulation of osteoblast proliferation cellular response to amino acid starvation response to interferon-alpha identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of viral genome replication negative regulation of viral genome replication innate immune response protein autophosphorylation protein autophosphorylation perinuclear region of cytoplasm positive regulation of NF-kappaB transcription factor activity defense response to virus regulation of NLRP3 inflammasome complex assembly positive regulation of NIK/NF-kappaB signaling regulation of hematopoietic progenitor cell differentiation regulation of hematopoietic stem cell proliferation regulation of hematopoietic stem cell differentiation |
04141 05160 |
| TC0800000916.mm.2 |
Tbc1d9 |
TBC1 domain family, member 9 |
8 |
83165351 |
NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027 |
71310 |
17 |
GTPase activator activity calcium ion binding intracellular protein transport activation of GTPase activity |
|
| TC1100002770.mm.2 |
Tnip1 |
TNFAIP3 interacting protein 1 |
11 |
-54910786 |
NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 NM_001199275, NM_001199276, NM_001271455, NM_001271456, NM_021327, BC008186, BC008665 |
57783 |
44 |
MyD88-dependent toll-like receptor signaling pathway protein binding nucleus nucleoplasm cytoplasm cytosol inflammatory response leukocyte cell-cell adhesion glycoprotein biosynthetic process polyubiquitin modification-dependent protein binding polyubiquitin modification-dependent protein binding identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of inflammatory response positive regulation of inflammatory response mitogen-activated protein kinase binding mitogen-activated protein kinase binding negative regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade positive regulation of protein deubiquitination |
|
| TC1100002374.mm.2 |
Rel |
reticuloendotheliosis oncogene |
11 |
-23736849 |
NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 |
19696 |
241 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus transcription regulator complex cytoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II inflammatory response I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling negative regulation of gene expression negative regulation of interferon-beta production positive regulation of interleukin-12 production cellular response to stress response to cytokine NIK/NF-kappaB signaling sequence-specific DNA binding innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of neuron death |
|
| TC0500002945.mm.2 |
Mfsd7a |
major facilitator superfamily domain containing 7A |
5 |
-108441053 |
NM_172883, BC094512 NM_172883, BC094512 |
243197 |
13 |
cellular_component membrane integral component of membrane transmembrane transport |
|
| TC1900000224.mm.2 |
Gm8369 |
predicted gene 8369 |
19 |
11492037 |
NM_001164202 |
666926 |
8 |
molecular_function cellular_component biological_process |
|
| TC1800000909.mm.2 |
Cd226 |
CD226 antigen |
18 |
89197426 |
NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 |
225825 |
66 |
cytokine production cytokine production positive regulation of natural killer cell cytokine production positive regulation of natural killer cell cytokine production positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of immunoglobulin mediated immune response positive regulation of immunoglobulin mediated immune response integrin binding protein binding plasma membrane cell adhesion external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane protein kinase binding positive regulation of interferon-gamma production positive regulation of interferon-gamma production positive regulation of mast cell activation positive regulation of mast cell activation positive regulation of natural killer cell mediated cytotoxicity cell adhesion molecule binding positive regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway |
04514 |
| TC1900000219.mm.2 |
Ms4a4b |
membrane-spanning 4-domains, subfamily A, member 4B |
19 |
11443557 |
NM_021718, BC028433 NM_021718, BC028433 |
60361 |
19 |
integral component of plasma membrane |
|
| TC1000000011.mm.2 |
Plekhg1 |
pleckstrin homology domain containing, family G (with RhoGef domain) member 1 |
10 |
3872666, 3740376 |
NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 |
213783 |
22 |
nucleoplasm |
|
| TC1000000506.mm.2 |
Pkib |
protein kinase inhibitor beta, cAMP dependent, testis specific |
10 |
57650980, 57645868, 57631980 |
NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 NM_001039050, NM_001039051, NM_001039052, NM_001039053, NM_001190402, NM_008863, BC087894 |
18768 |
20 |
protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity nucleus cytoplasm negative regulation of protein kinase activity positive regulation of telomere maintenance via telomerase positive regulation of telomerase activity positive regulation of telomere capping negative regulation of cAMP-dependent protein kinase activity negative regulation of cAMP-dependent protein kinase activity |
|
| TC1800000124.mm.2 |
Taf4b |
TATA-box binding protein associated factor 4b |
18 |
14783244 |
NM_001100449 |
72504 |
40 |
fibrillar center DNA binding DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm transcription regulator complex transcription factor TFIID complex transcription factor TFIID complex cytoplasm DNA-templated transcription, initiation regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter spermatogenesis RNA polymerase II general transcription initiation factor activity cell differentiation protein heterodimerization activity oogenesis NF-kappaB binding positive regulation of stem cell proliferation |
03022 05016 |
| TC1500001658.mm.2 |
St3gal1 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
15 |
-67102874 |
NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 |
20442 |
35 |
memory B cell differentiation beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity extracellular region Golgi apparatus protein phosphorylation protein glycosylation protein glycosylation sialyltransferase activity ganglioside biosynthetic process via lactosylceramide ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups trans-Golgi network membrane negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process Golgi medial cisterna membrane Golgi trans cisterna membrane protein sialylation protein sialylation protein sialylation |
00512 00533 00603 00604 01100 |
| TC0600001696.mm.2 |
Etnk1 |
ethanolamine kinase 1 |
6 |
143167229 |
NM_029250 |
75320 |
33 |
nucleotide binding ethanolamine kinase activity ATP binding cytoplasm lipid metabolic process phosphatidylethanolamine biosynthetic process phospholipid biosynthetic process kinase activity phosphorylation transferase activity |
00564 01100 |
| MG-1-pos-10341395_st |
|
|
|
|
|
|
|
|
|
| TC1000001744.mm.2 |
Rab32 |
RAB32, member RAS oncogene family |
10 |
-10545038 |
NM_026405, BC016409, BC055945 NM_026405, BC016409, BC055945 NM_026405, BC016409, BC055945 |
67844 |
35 |
nucleotide binding GTPase activity GTPase activity protein binding GTP binding mitochondrion mitochondrion mitochondrion mitochondrial outer membrane early endosome endoplasmic reticulum Golgi apparatus trans-Golgi network intracellular protein transport mitochondrion organization endomembrane system membrane vesicle-mediated transport antigen processing and presentation GTP-dependent protein binding cytoplasmic vesicle vesicle melanosome organization melanosome membrane endosome to melanosome transport AP-1 adaptor complex binding AP-3 adaptor complex binding BLOC-2 complex binding melanosome melanosome melanosome mitochondria-associated endoplasmic reticulum membrane phagocytic vesicle protein localization to membrane phagosome maturation melanosome assembly |
|
| TC0500003464.mm.2 |
Pilrb1 |
paired immunoglobin-like type 2 receptor beta 1 |
5 |
-137852146 |
NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 |
170741 |
12 |
myeloid dendritic cell activation protein binding plasma membrane membrane integral component of membrane MHC class I protein binding MHC class I protein binding negative regulation of osteoclast differentiation |
|
| TC0300001578.mm.2 |
Ptger3 |
prostaglandin E receptor 3 (subtype EP3) |
3 |
157566875 |
NM_011196, BC058742 NM_011196, BC058742 |
19218 |
151 |
fever generation fever generation positive regulation of protein phosphorylation desensitization of G protein-coupled receptor signaling pathway G protein-coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity prostaglandin E receptor activity prostaglandin E receptor activity prostaglandin E receptor activity protein binding plasma membrane plasma membrane plasma membrane inflammatory response signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration cell surface positive regulation of gene expression negative regulation of norepinephrine secretion regulation of circadian sleep/wake cycle, wakefulness regulation of norepinephrine secretion intestine smooth muscle contraction intestine smooth muscle contraction urinary bladder smooth muscle contraction bicarbonate transport membrane integral component of membrane brush border membrane positive regulation of fever generation receptor internalization nuclear membrane response to lipopolysaccharide positive regulation of urine volume neuron projection neuronal cell body positive regulation of cAMP-mediated signaling positive regulation of vasoconstriction positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion negative regulation of gastric acid secretion negative regulation of gastric acid secretion negative regulation of platelet aggregation negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of potassium ion transmembrane transport negative regulation of calcium ion transmembrane transport negative regulation of gastrin-induced gastric acid secretion positive regulation of smooth muscle contraction involved in micturition cellular response to forskolin positive regulation of inhibitory G protein-coupled receptor phosphorylation negative regulation of circadian sleep/wake cycle, wakefulness positive regulation of myofibroblast contraction positive regulation of colon smooth muscle contraction positive regulation of gastric mucosal blood circulation prostaglandin receptor internalization proximal neuron projection positive regulation of neutrophil extravasation negative regulation of forebrain neuron differentiation |
04020 04080 |
| TC0500001098.mm.2 |
Dr1 |
down-regulator of transcription 1 |
5 |
108268896 |
NM_026106, BC013461 NM_026106, BC013461 |
13486 |
30 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II core promoter sequence-specific DNA binding DNA binding transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex Ada2/Gcn5/Ada3 transcription activator complex Ada2/Gcn5/Ada3 transcription activator complex chromatin remodeling RNA polymerase II general transcription initiation factor activity TBP-class protein binding TBP-class protein binding negative cofactor 2 complex histone H3 acetylation positive regulation of transcription by RNA polymerase II protein heterodimerization activity RNA polymerase II preinitiation complex assembly RNA polymerase II transcription regulator complex |
|
| TC1500002042.mm.2 |
Dennd6b |
DENN/MADD domain containing 6B |
15 |
-89182212 |
NM_027081, BC139003 NM_027081, BC139003 |
69440 |
13 |
guanyl-nucleotide exchange factor activity cytoplasm endosome recycling endosome |
|
| TC1500000897.mm.2 |
Lrrk2 |
leucine-rich repeat kinase 2 |
15 |
91673223 |
NM_025730 |
66725 |
231 |
SNARE binding SNARE binding MAPK cascade nucleotide binding activation of MAPKK activity activation of MAPK activity magnesium ion binding negative regulation of protein phosphorylation positive regulation of protein phosphorylation actin binding GTPase activity protein kinase activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine phosphatase activity GTPase activator activity protein binding ATP binding GTP binding cytoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix lysosome lysosome endosome endosome endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus Golgi apparatus Golgi-associated vesicle trans-Golgi network cytosol cytosol plasma membrane plasma membrane plasma membrane microvillus protein phosphorylation protein phosphorylation protein phosphorylation protein phosphorylation protein import into nucleus protein import into nucleus endocytosis autophagy response to oxidative stress mitochondrion organization mitochondrion organization endoplasmic reticulum organization endoplasmic reticulum organization endoplasmic reticulum organization Golgi organization Golgi organization Golgi organization lysosome organization signal transduction neuromuscular junction development synaptic vesicle determination of adult lifespan cellular response to starvation regulation of gene expression regulation of autophagy positive regulation of autophagy positive regulation of autophagy positive regulation of autophagy regulation of protein kinase A signaling negative regulation of protein processing negative regulation of neuron projection development regulation of neuron maturation tubulin binding membrane inclusion body negative regulation of macroautophagy kinase activity phosphorylation transferase activity hydrolase activity syntaxin-1 binding peptidyl-serine phosphorylation peptidyl-threonine phosphorylation calcium-mediated signaling calcium-mediated signaling olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb cell junction cell differentiation signaling receptor complex adaptor activity clathrin binding axon axon dendrite dendrite growth cone small GTPase binding small GTPase binding positive regulation of protein ubiquitination cytoplasmic vesicle regulation of protein stability mitochondrial membrane negative regulation of protein binding positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process cytoplasmic side of mitochondrial outer membrane positive regulation of tumor necrosis factor production dendrite cytoplasm GTP-dependent protein kinase activity negative regulation of GTPase activity cellular response to oxidative stress cellular protein localization intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior regulation of lysosomal lumen pH synaptic vesicle recycling peroxidase inhibitor activity regulation of locomotion regulation of membrane potential regulation of membrane potential identical protein binding identical protein binding protein homodimerization activity cell projection neuron projection neuronal cell body positive regulation of programmed cell death terminal bouton perikaryon perikaryon intracellular membrane-bounded organelle intracellular membrane-bounded organelle ion channel binding amphisome autolysosome protein-containing complex binding membrane raft membrane raft synapse synapse GTP metabolic process protein autophosphorylation intracellular distribution of mitochondria neuron projection morphogenesis neuron projection morphogenesis protein kinase A binding protein kinase A binding protein kinase A binding mitochondrion localization positive regulation of nitric-oxide synthase biosynthetic process regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dopamine receptor signaling pathway regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of ER to Golgi vesicle-mediated transport regulation of canonical Wnt signaling pathway regulation of canonical Wnt signaling pathway regulation of dendritic spine morphogenesis regulation of dendritic spine morphogenesis regulation of dendritic spine morphogenesis endoplasmic reticulum exit site endoplasmic reticulum exit site endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site protein localization to endoplasmic reticulum exit site neuron death cellular response to manganese ion cellular response to organic cyclic compound reactive oxygen species metabolic process positive regulation of canonical Wnt signaling pathway negative regulation of excitatory postsynaptic potential multivesicular body, internal vesicle glutamatergic synapse glutamatergic synapse caveola neck presynaptic cytosol neuron projection arborization regulation of synaptic vesicle endocytosis regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis regulation of neuron death negative regulation of neuron death positive regulation of histone deacetylase activity negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of neuroblast proliferation regulation of synaptic vesicle transport regulation of synaptic vesicle transport negative regulation of autophagosome assembly negative regulation of autophagosome assembly negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of hydrogen peroxide-induced cell death negative regulation of protein targeting to mitochondrion cellular response to dopamine positive regulation of microglial cell activation beta-catenin destruction complex binding Wnt signalosome assembly Wnt signalosome assembly regulation of retrograde transport, endosome to Golgi regulation of retrograde transport, endosome to Golgi regulation of CAMKK-AMPK signaling cascade ribonucleoprotein complex Wnt signalosome Wnt signalosome regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis |
05012 |
| TC0X00000204.mm.2 |
Rp2 |
retinitis pigmentosa 2 homolog |
X |
20364480, 20364480 |
NM_133669, BC049698 NM_133669, BC049698 |
19889 |
26 |
nucleotide binding magnesium ion binding cell morphogenesis GTPase activator activity GTPase activator activity GTP binding nucleoplasm cytoplasm Golgi apparatus centriole plasma membrane plasma membrane cilium post-Golgi vesicle-mediated transport post-Golgi vesicle-mediated transport protein transport membrane nuclear body cytoplasmic vesicle ciliary basal body ciliary basal body cell projection periciliary membrane compartment periciliary membrane compartment |
|
| TC0200002594.mm.2 |
Cebpb |
CCAAT/enhancer binding protein (C/EBP), beta |
2 |
167688914 |
NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 |
12608 |
535 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II condensed chromosome, centromeric region chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific ovarian follicle development embryonic placenta development granuloma formation DNA binding DNA binding chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription factor binding positive regulation of gene expression nuclear matrix nuclear matrix kinase binding cell differentiation neuron differentiation response to lipopolysaccharide regulation of interleukin-6 production positive regulation of interleukin-4 production mammary gland epithelial cell proliferation response to endoplasmic reticulum stress histone acetyltransferase binding glucocorticoid receptor binding T-helper 1 cell activation CHOP-C/EBP complex negative regulation of T cell proliferation defense response to bacterium identical protein binding protein homodimerization activity histone deacetylase binding negative regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding ubiquitin-like protein ligase binding fat cell differentiation fat cell differentiation regulation of cell differentiation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein heterodimerization activity positive regulation of inflammatory response brown fat cell differentiation mammary gland epithelial cell differentiation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of biomineral tissue development cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to interleukin-1 hepatocyte proliferation hepatocyte proliferation RNA polymerase II transcription regulator complex liver regeneration positive regulation of cold-induced thermogenesis regulation of odontoblast differentiation regulation of odontoblast differentiation positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress sequence-specific double-stranded DNA binding positive regulation of sodium-dependent phosphate transport regulation of dendritic cell differentiation |
|
| TC1000002320.mm.2 |
Arid5b |
AT rich interactive domain 5B (MRF1-like) |
10 |
-68095592 |
NM_023598, BC165988 NM_023598, BC165988 |
71371 |
46 |
negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding kidney development DNA binding transcription coactivator activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II nitrogen compound metabolic process male gonad development female gonad development post-embryonic development fibroblast migration adrenal gland development multicellular organism growth fat cell differentiation platelet-derived growth factor receptor signaling pathway cell development muscle organ morphogenesis skeletal system morphogenesis positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity roof of mouth development face morphogenesis adipose tissue development fat pad development cellular response to leukemia inhibitory factor |
|
| TC0200000740.mm.2 |
Kynu |
kynureninase |
2 |
43555324, 43555324, 43555324 |
NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 |
70789 |
13 |
catalytic activity nucleoplasm cytoplasm mitochondrion mitochondrion cytosol tryptophan catabolic process NAD biosynthetic process hydrolase activity pyridine nucleotide biosynthetic process tryptophan catabolic process to kynurenine tryptophan catabolic process to acetyl-CoA quinolinate biosynthetic process pyridoxal phosphate binding kynureninase activity kynureninase activity response to interferon-gamma response to vitamin B6 protein homodimerization activity anthranilate metabolic process anthranilate metabolic process 3-hydroxykynureninase activity |
00380 01100 |
| TC1100002310.mm.2 |
Aftph |
aftiphilin |
11 |
-20685084 |
NM_001252503, NM_181411, BC052036 NM_001252503, NM_181411, BC052036 NM_001252503, NM_181411, BC052036 |
216549 |
21 |
nucleoplasm cytoplasm Golgi apparatus cytosol protein transport AP-1 adaptor complex AP-1 adaptor complex clathrin binding clathrin binding trans-Golgi network membrane intracellular membrane-bounded organelle intracellular transport |
|
| TC1100003069.mm.2 |
Nlgn2 |
neuroligin 2 |
11 |
-69823122, -69823122 |
NM_198862, BC156963 NM_198862, BC156963 |
216856 |
99 |
thigmotaxis regulation of respiratory gaseous exchange by nervous system process protein binding cytoplasm plasma membrane integral component of plasma membrane cell adhesion neuron cell-cell adhesion neuron cell-cell adhesion chemical synaptic transmission synapse assembly jump response positive regulation of cell population proliferation cell surface cell surface membrane integral component of membrane sensory perception of pain cell junction positive regulation of insulin secretion positive regulation of synaptic transmission, GABAergic social behavior protein localization to synapse locomotory exploration behavior signaling receptor activity neurexin family protein binding neurexin family protein binding identical protein binding cell projection dendritic shaft synapse synapse postsynaptic membrane synaptic vesicle endocytosis modulation of chemical synaptic transmission modulation of chemical synaptic transmission synapse organization cell adhesion molecule binding neuromuscular process controlling balance positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic excitatory synapse excitatory synapse inhibitory synapse inhibitory synapse positive regulation of dendritic spine development terminal button organization postsynaptic membrane assembly postsynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering positive regulation of inhibitory postsynaptic potential positive regulation of inhibitory postsynaptic potential ribbon synapse glycinergic synapse glycinergic synapse glycinergic synapse dopaminergic synapse postsynaptic specialization assembly postsynaptic specialization assembly postsynaptic specialization assembly GABA-ergic synapse GABA-ergic synapse GABA-ergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane integral component of postsynaptic specialization membrane insulin metabolic process positive regulation of protein localization to synapse positive regulation of t-SNARE clustering inhibitory synapse assembly regulation of presynapse assembly regulation of AMPA receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering |
04514 |
| TC0700003594.mm.2 |
Furin |
furin (paired basic amino acid cleaving enzyme) |
7 |
-80389193, -80389193 |
NM_001081454, NM_011046, BC048234 NM_001081454, NM_011046, BC048234 NM_001081454, NM_011046, BC048234 |
18550 |
114 |
Golgi membrane blastocyst formation protease binding endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase inhibitor activity protein binding extracellular region extracellular region endosome early endosome endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane Golgi apparatus trans-Golgi network trans-Golgi network plasma membrane signal peptide processing proteolysis peptidase activity serine-type peptidase activity regulation of signal transduction cell surface trans-Golgi network transport vesicle membrane membrane integral component of membrane protein processing protein processing protein processing protein processing peptide hormone processing peptide hormone processing hydrolase activity trans-Golgi network transport vesicle integral component of Golgi membrane positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway zymogen activation Golgi cisterna regulation of cholesterol transport negative regulation of low-density lipoprotein particle receptor catabolic process nerve growth factor production negative regulation of transforming growth factor beta1 production secretion by cell regulation of protein catabolic process peptide binding peptide biosynthetic process membrane raft metal ion binding nerve growth factor binding regulation of endopeptidase activity dibasic protein processing zymogen inhibition positive regulation of transforming growth factor beta1 activation |
|
| TC0200001371.mm.2 |
Acp2 |
acid phosphatase 2, lysosomal |
2 |
91202911 |
NM_007387, BC023343 NM_007387, BC023343 |
11432 |
37 |
skeletal system development phosphotyrosine residue binding acid phosphatase activity acid phosphatase activity acid phosphatase activity acid phosphatase activity phosphoprotein phosphatase activity lysosome lysosome lysosome lysosome lysosome organization lysosome organization response to organic substance membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity cytoplasmic vesicle neuron projection autophagic cell death |
00740 04142 |
| TC1200000359.mm.2 |
Dock4 |
dedicator of cytokinesis 4 |
12 |
40446052 |
NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663 |
238130 |
25 |
guanyl-nucleotide exchange factor activity GTPase activator activity nucleolus cytoplasm Golgi apparatus cytosol plasma membrane small GTPase mediated signal transduction membrane SH3 domain binding PDZ domain binding receptor tyrosine kinase binding small GTPase binding stereocilium stereocilium bundle cell chemotaxis negative regulation of vascular associated smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration |
|
| TC1600000558.mm.2 |
Tmem39a |
transmembrane protein 39a |
16 |
38562813, 38558697 |
NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 |
67846 |
17 |
molecular_function endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane autophagy membrane integral component of membrane positive regulation of viral genome replication negative regulation of autophagosome maturation negative regulation of autophagosome maturation negative regulation of autophagosome assembly negative regulation of autophagosome assembly |
|
| MG-1-neg-10341772_st |
|
|
|
|
|
|
|
|
|
| TC0600001424.mm.2 |
C1rb |
complement component 1, r subcomponent B |
6 |
124570429 |
NM_001113356 |
667277 |
4 |
immune system process serine-type endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular space extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation identical protein binding innate immune response blood microparticle |
|
| MG-1-neg-10341658_st |
|
|
|
|
|
|
|
|
|
| TC0900000824.mm.2 |
Dennd4a |
DENN/MADD domain containing 4A |
9 |
64811010 |
NM_001162917, BC172087 NM_001162917, BC172087 |
102442 |
13 |
guanyl-nucleotide exchange factor activity cytoplasmic vesicle regulation of Rab protein signal transduction |
|
| TC0600000250.mm.2 |
Strip2 |
striatin interacting protein 2 |
6 |
29917012 |
NM_001037740, NM_177204, NR_104576, BC147502 NM_001037740, NM_177204, NR_104576, BC147502 NM_001037740, NM_177204, NR_104576, BC147502 NM_001037740, NM_177204, NR_104576, BC147502 |
320609 |
16 |
molecular_function cytoplasm cytosol cytosol cytoskeleton organization cytoskeleton organization regulation of cell shape cell migration |
|
| TC1000001947.mm.2 |
Ncoa7 |
nuclear receptor coactivator 7 |
10 |
-30645581, -30645581 |
NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 |
211329 |
27 |
nucleus regulation of transcription by RNA polymerase II response to oxidative stress nuclear receptor coactivator activity nuclear receptor coactivator activity nuclear hormone receptor binding positive regulation of transcription by RNA polymerase II negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death |
|
| TC0700003936.mm.2 |
|
|
|
|
XM_003688838, XM_992714 XM_003688838, XM_992714 |
|
|
|
|
| TC1100003314.mm.2 |
Lgals9 |
lectin, galactose binding, soluble 9 |
11 |
-78962978 |
NM_001159301, NM_010708, BC003754 NM_001159301, NM_010708, BC003754 NM_001159301, NM_010708, BC003754 |
16859 |
104 |
positive regulation of cytokine production immune system process signaling receptor binding protein binding extracellular region extracellular region nucleus nucleus cytoplasm cytosol cytosol chemotaxis heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules female pregnancy positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation galactoside binding galactoside binding galactoside binding enzyme binding carbohydrate binding carbohydrate binding carbohydrate binding response to lipopolysaccharide negative regulation of interferon-gamma production negative regulation of interferon-gamma production negative regulation of interferon-gamma production positive regulation of chemokine production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of natural killer cell activation regulation of natural killer cell differentiation toll-like receptor 3 signaling pathway positive regulation of macrophage activation negative regulation of natural killer cell degranulation protein serine/threonine kinase activator activity positive regulation of innate immune response maintenance of protein location positive regulation of regulatory T cell differentiation negative regulation of inflammatory response positive regulation of oxidoreductase activity collagen-containing extracellular matrix cellular response to virus positive regulation of defense response to bacterium positive regulation of T cell migration negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of transcription regulatory region DNA binding |
|
| TC0200002580.mm.2 |
|
|
|
|
NM_001081005, NR_028540 NM_001081005, NR_028540 |
|
|
molecular_function cellular_component biological_process negative regulation of mammary gland epithelial cell proliferation mammary gland epithelial cell differentiation |
|
| TC0200003532.mm.2 |
Arl5a |
ADP-ribosylation factor-like 5A |
2 |
-52397950 |
NM_182994, BC048170, BC100307 NM_182994, BC048170, BC100307 NM_182994, BC048170, BC100307 |
75423 |
16 |
nucleotide binding GTP binding cytoplasm trans-Golgi network intracellular protein transport vesicle-mediated transport protein localization to Golgi membrane protein localization to Golgi membrane |
|
| TC0200000220.mm.2 |
Il2ra |
interleukin 2 receptor, alpha chain |
2 |
11642791 |
NM_008367, BC114437 NM_008367, BC114437 |
16184 |
301 |
immune system process inflammatory response to antigenic stimulus regulation of T cell tolerance induction interleukin-2 receptor activity interleukin-2 receptor activity interleukin-2 receptor activity protein binding activation-induced cell death of T cells inflammatory response Notch signaling pathway external side of plasma membrane cell surface membrane integral component of membrane interleukin-2 binding interleukin-2 binding positive regulation of T cell proliferation positive regulation of activated T cell proliferation negative regulation of T cell proliferation T cell homeostasis positive regulation of T cell differentiation regulation of T cell homeostatic proliferation negative regulation of lymphocyte proliferation negative regulation of inflammatory response |
04060 04144 04630 04640 |
| TC0500000710.mm.2 |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
5 |
75574990, 75574986 |
NM_001122733, NM_021099, BC052457, BC075716 NM_001122733, NM_021099, BC052457, BC075716 NM_001122733, NM_021099, BC052457, BC075716 NM_001122733, NM_021099, BC052457, BC075716 |
16590 |
1574 |
nucleotide binding activation of MAPK activity ovarian follicle development fibrillar center acrosomal vesicle protease binding hematopoietic progenitor cell differentiation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation immature B cell differentiation dendritic cell cytokine production mast cell chemotaxis myeloid leukocyte differentiation protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity stem cell factor receptor activity protein binding ATP binding extracellular space cytoplasm plasma membrane plasma membrane integral component of plasma membrane cell-cell junction protein phosphorylation glycosphingolipid metabolic process chemotaxis inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development germ cell development spermatogenesis spermatogenesis spermatid development positive regulation of cell population proliferation positive regulation of cell population proliferation germ cell migration regulation of cell shape visual learning response to radiation external side of plasma membrane external side of plasma membrane cytoplasmic side of plasma membrane cell surface positive regulation of gene expression membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine binding lamellipodium assembly hemopoiesis cell differentiation B cell differentiation T cell differentiation erythrocyte differentiation erythrocyte differentiation melanocyte differentiation positive regulation of cell migration positive regulation of cell migration positive regulation of pseudopodium assembly actin cytoskeleton reorganization mast cell cytokine production positive regulation of kinase activity somatic stem cell population maintenance embryonic hemopoiesis ectopic germ cell programmed cell death intracellular signal transduction hematopoietic stem cell migration megakaryocyte development Fc receptor signaling pathway Kit signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway SH2 domain binding positive regulation of tyrosine phosphorylation of STAT protein protein homodimerization activity negative regulation of programmed cell death negative regulation of programmed cell death receptor complex mast cell degranulation positive regulation of MAP kinase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade pigmentation pigmentation positive regulation of Notch signaling pathway positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via JAK-STAT protein autophosphorylation protein autophosphorylation metal ion binding developmental pigmentation developmental pigmentation somatic stem cell division positive regulation of long-term neuronal synaptic plasticity digestive tract development stem cell differentiation epithelial cell proliferation detection of mechanical stimulus involved in sensory perception of sound positive regulation of DNA-binding transcription factor activity cell chemotaxis mast cell differentiation cellular response to thyroid hormone stimulus melanocyte migration melanocyte adhesion positive regulation of pyloric antrum smooth muscle contraction regulation of bile acid metabolic process positive regulation of colon smooth muscle contraction positive regulation of small intestine smooth muscle contraction positive regulation of vascular associated smooth muscle cell differentiation |
04060 04144 04640 04916 05200 05221 |
| TC1600001048.mm.2 |
Morc3 |
microrchidia 3 |
16 |
93832120 |
NM_001045529, BC098072, BC145705 NM_001045529, BC098072, BC145705 NM_001045529, BC098072, BC145705 |
338467 |
28 |
RNA binding nucleus nucleus nucleoplasm nucleoplasm protein phosphorylation cell aging zinc ion binding post-embryonic development PML body PML body peptidyl-serine phosphorylation methylated histone binding metal ion binding negative regulation of fibroblast proliferation protein stabilization maintenance of protein location in nucleus |
|
| TC1400001930.mm.2 |
Gch1 |
GTP cyclohydrolase 1 |
14 |
-47153894 |
NM_008102, BC005643, BC069921 NM_008102, BC005643, BC069921 NM_008102, BC005643, BC069921 |
14528 |
72 |
nucleotide binding catalytic activity GTPase activity GTP cyclohydrolase I activity GTP cyclohydrolase I activity GTP cyclohydrolase I activity calcium ion binding GTP binding GTP binding nucleus nucleoplasm cytoplasm cytoplasm cytosol tetrahydrobiopterin biosynthetic process tetrahydrobiopterin biosynthetic process tetrahydrobiopterin biosynthetic process metabolic process regulation of blood pressure regulation of blood pressure zinc ion binding zinc ion binding positive regulation of heart rate regulation of lung blood pressure hydrolase activity GTP-dependent protein binding translation initiation factor binding cytoplasmic vesicle nuclear membrane protein-containing complex response to interferon-gamma response to tumor necrosis factor vasodilation dopamine biosynthetic process pteridine-containing compound biosynthetic process identical protein binding protein homodimerization activity protein-containing complex binding negative regulation of blood pressure tetrahydrofolate biosynthetic process metal ion binding response to pain neuromuscular process controlling posture positive regulation of nitric-oxide synthase activity mitogen-activated protein kinase binding dihydrobiopterin metabolic process protein-containing complex assembly cellular response to lipopolysaccharide regulation of serotonin biosynthetic process regulation of removal of superoxide radicals |
00790 01100 |
| TC0300002752.mm.2 |
Stxbp3 |
syntaxin binding protein 3 |
3 |
-108793179 |
NM_011504, BC062901 NM_011504, BC062901 |
20912 |
48 |
cellular glucose homeostasis cellular glucose homeostasis protein binding cytoplasm cytosol cytosol plasma membrane plasma membrane plasma membrane plasma membrane intracellular protein transport exocytosis vesicle docking involved in exocytosis neurotransmitter secretion brain development protein transport membrane vesicle-mediated transport basolateral plasma membrane apical plasma membrane apical plasma membrane syntaxin-1 binding syntaxin-1 binding syntaxin binding syntaxin binding syntaxin binding syntaxin binding protein to membrane docking insulin secretion secretory granule platelet alpha granule response to insulin response to insulin specific granule protein-containing complex binding phagocytic vesicle negative regulation of calcium ion-dependent exocytosis negative regulation of glucose import negative regulation of glucose import platelet aggregation tertiary granule cellular response to interferon-gamma presynapse |
|
| TC1100002746.mm.2 |
|
|
|
|
|
|
|
|
|
| TC1800000092.mm.2 |
Rbbp8 |
retinoblastoma binding protein 8, endonuclease |
18 |
11657348, 11633275 |
NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 |
225182 |
36 |
single-stranded DNA endodeoxyribonuclease activity single-stranded DNA endodeoxyribonuclease activity G1/S transition of mitotic cell cycle Y-form DNA binding double-strand/single-strand DNA junction binding double-strand break repair via homologous recombination RNA polymerase II repressing transcription factor binding blastocyst hatching DNA binding damaged DNA binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding transcription corepressor activity nuclease activity endonuclease activity nucleus nucleoplasm chromosome DNA repair cellular response to DNA damage stimulus cell cycle DNA double-strand break processing involved in repair via single-strand annealing DNA double-strand break processing involved in repair via single-strand annealing hydrolase activity transcription repressor complex site of double-strand break identical protein binding intracellular membrane-bounded organelle cell division meiotic cell cycle flap-structured DNA binding |
|
| TC0800000297.mm.2 |
Sfrp1 |
secreted frizzled-related protein 1 |
8 |
23411501 |
NM_013834, BC024495, BC094662 NM_013834, BC024495, BC094662 NM_013834, BC024495, BC094662 |
20377 |
175 |
ureteric bud development somitogenesis somitogenesis neural tube closure hematopoietic progenitor cell differentiation cysteine-type endopeptidase activity frizzled binding protein binding extracellular region extracellular space extracellular space extracellular space cytosol plasma membrane multicellular organism development heparin binding positive regulation of cell population proliferation negative regulation of cell population proliferation male gonad development female gonad development dorsal/ventral axis specification anterior/posterior pattern specification cell surface regulation of cell cycle process negative regulation of gene expression negative regulation of gene expression negative regulation of epithelial to mesenchymal transition regulation of neuron projection development neural crest cell fate commitment response to organic cyclic compound Wnt signaling pathway Wnt-protein binding Wnt-protein binding neural tube development actin cytoskeleton organization hemopoiesis cell differentiation positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of ossification negative regulation of ossification negative regulation of ossification positive regulation of cell growth negative regulation of cell growth negative regulation of cell migration negative regulation of BMP signaling pathway negative regulation of osteoblast proliferation negative regulation of osteoblast proliferation substrate adhesion-dependent cell spreading somatic stem cell population maintenance non-canonical Wnt signaling pathway response to drug identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity cellular response to fibroblast growth factor stimulus stromal-epithelial cell signaling involved in prostate gland development negative regulation of B cell differentiation negative regulation of B cell differentiation positive regulation of fat cell differentiation negative regulation of osteoblast differentiation negative regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated development of primary male sexual characteristics negative regulation of insulin secretion negative regulation of bone remodeling negative regulation of fibroblast proliferation digestive tract morphogenesis positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of peptidyl-tyrosine phosphorylation canonical Wnt signaling pathway canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway hematopoietic stem cell differentiation bone trabecula formation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of branching involved in prostate gland morphogenesis negative regulation of androgen receptor signaling pathway collagen-containing extracellular matrix cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to estrogen stimulus cellular response to estrogen stimulus cellular response to X-ray cellular response to heparin dopaminergic neuron differentiation negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway regulation of establishment of planar polarity planar cell polarity pathway involved in neural tube closure Wnt signaling pathway involved in somitogenesis convergent extension involved in somitogenesis positive regulation of canonical Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of midbrain dopaminergic neuron differentiation negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of non-canonical Wnt signaling pathway negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation negative regulation of fibroblast apoptotic process positive regulation of fibroblast apoptotic process positive regulation of extrinsic apoptotic signaling pathway |
04310 |
| TC0300001292.mm.2 |
Tifa |
TRAF-interacting protein with forkhead-associated domain |
3 |
127790656, 127789871 |
NM_145133, BC065775 NM_145133, BC065775 |
211550 |
20 |
immune system process cytoplasmic pattern recognition receptor signaling pathway cytoplasmic pattern recognition receptor signaling pathway protein binding cytoplasm cytoplasm I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response innate immune response protein homooligomerization |
|
| TC1000000123.mm.2 |
Txlnb |
taxilin beta |
10 |
17796218 |
NM_138628, BC141023 NM_138628, BC141023 |
378431 |
12 |
molecular_function cytoplasm biological_process syntaxin binding |
|
| TC1100003128.mm.2 |
Nlrp1c-ps |
NLR family, pyrin domain containing 1C, pseudogene |
11 |
-71242429 |
NR_027858, BC141384 NR_027858, BC141384 |
627984 |
2 |
|
|
| TC1300002011.mm.2 |
Auh |
AU RNA binding protein/enoyl-coenzyme A hydratase |
13 |
-52835109 |
NM_016709, BC049597 NM_016709, BC049597 |
11992 |
22 |
RNA binding mRNA 3'-UTR binding catalytic activity enoyl-CoA hydratase activity enoyl-CoA hydratase activity enoyl-CoA hydratase activity methylglutaconyl-CoA hydratase activity mitochondrion mitochondrion mitochondrion fatty acid beta-oxidation branched-chain amino acid catabolic process lyase activity itaconyl-CoA hydratase activity |
00280 01100 |
| TC0500000738.mm.2 |
Rest |
RE1-silencing transcription factor |
5 |
77265493 |
NM_011263, BC127065 NM_011263, BC127065 |
19712 |
200 |
negative regulation of transcription by RNA polymerase II regulation of alternative mRNA splicing, via spliceosome chromatin transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific response to hypoxia hematopoietic progenitor cell differentiation response to ischemia nucleic acid binding DNA binding DNA binding chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytosol cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription factor binding negative regulation of cell population proliferation regulation of gene expression regulation of gene expression positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of gene expression negative regulation of gene expression transcription repressor complex transcription repressor complex transcription repressor complex negative regulation of aldosterone biosynthetic process protein-containing complex cellular response to stress somatic stem cell population maintenance cellular response to drug identical protein binding positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process sequence-specific DNA binding sequence-specific DNA binding negative regulation by host of viral transcription protein-containing complex binding negative regulation of neuron differentiation negative regulation of neuron differentiation negative regulation of neuron differentiation negative regulation of neuron differentiation positive regulation of neuron differentiation regulation of osteoblast differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion metal ion binding negative regulation of neurogenesis neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound auditory receptor cell stereocilium organization cardiac muscle cell myoblast differentiation histone H4 deacetylation cellular response to electrical stimulus cellular response to glucocorticoid stimulus neuronal stem cell population maintenance modification of synaptic structure positive regulation of stem cell population maintenance regulation of oxidative stress-induced neuron death negative regulation of oxidative stress-induced neuron death positive regulation of oxidative stress-induced neuron death negative regulation of cortisol biosynthetic process negative regulation of transcription regulatory region DNA binding negative regulation of dense core granule biogenesis negative regulation of mesenchymal stem cell differentiation negative regulation of amniotic stem cell differentiation |
05016 |
| TC1700000765.mm.2 |
H2-M3 |
histocompatibility 2, M region locus 3 |
17 |
37270233 |
NM_013819, BC031984 NM_013819, BC031984 |
14991 |
41 |
negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin alpha-beta T cell activation involved in immune response peripheral B cell tolerance induction antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent positive regulation of tolerance induction positive regulation of T cell tolerance induction positive regulation of natural killer cell cytokine production immune response-inhibiting cell surface receptor signaling pathway signaling receptor binding signaling receptor binding extracellular space early endosome plasma membrane immune response external side of plasma membrane external side of plasma membrane negative regulation of angiogenesis MHC class Ib protein complex positive regulation of interferon-gamma production positive regulation of interleukin-12 production cis-Golgi network membrane negative regulation of T cell proliferation protection from natural killer cell mediated cytotoxicity peptide antigen binding peptide antigen binding peptide antigen binding peptide antigen binding CD8 receptor binding defense response to bacterium defense response to bacterium identical protein binding protein homodimerization activity positive regulation of nitric oxide biosynthetic process positive regulation of regulatory T cell differentiation negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity negative regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein homotrimerization negative regulation of G0 to G1 transition positive regulation of endothelial cell apoptotic process positive regulation of cellular senescence negative regulation of dendritic cell differentiation |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC1100002397.mm.2 |
Vrk2 |
vaccinia related kinase 2 |
11 |
-26471401 |
NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520 |
69922 |
27 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleus nuclear envelope cytoplasm cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane protein phosphorylation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding protein domain specific binding mitochondrial membrane protein-containing complex cellular response to oxidative stress regulation of MAPK cascade protein autophosphorylation protein autophosphorylation regulation of interleukin-1-mediated signaling pathway |
|
| TC1600000861.mm.2 |
Usp25 |
ubiquitin specific peptidase 25 |
16 |
77014068 |
NM_013918, BC048171, BC063059 NM_013918, BC048171, BC063059 NM_013918, BC048171, BC063059 |
30940 |
28 |
proteasome complex cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm endoplasmic reticulum cytosol cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination protein deubiquitination hydrolase activity ubiquitin protein ligase binding SUMO binding SUMO binding ATPase binding protein K63-linked deubiquitination protein K48-linked deubiquitination negative regulation of ERAD pathway |
|
| TC1600001106.mm.2 |
Mefv |
Mediterranean fever |
16 |
-3707214 |
NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 NM_001161790, NM_001161791, NM_019453, BC108993, BC108994 |
54483 |
28 |
immune system process actin binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytosol cytosol cytoskeleton microtubule microtubule associated complex inflammatory response zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination cytoplasmic vesicle negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production response to interferon-gamma identical protein binding cell projection innate immune response metal ion binding negative regulation of inflammatory response ubiquitin protein ligase activity negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of cytokine production involved in inflammatory response negative regulation of NLRP3 inflammasome complex assembly positive regulation of cysteine-type endopeptidase activity |
04621 |
| TC0100000292.mm.2 |
Il1r2 |
interleukin 1 receptor, type II |
1 |
40084713, 40086092 |
NM_010555, BC032962 NM_010555, BC032962 |
16178 |
52 |
interleukin-1 receptor activity interleukin-1 receptor activity interleukin-1, type II, blocking receptor activity extracellular region cytoplasm plasma membrane negative regulation of protein processing membrane integral component of membrane interleukin-1 binding interleukin-1 binding negative regulation of interleukin-1 alpha production negative regulation of cytokine production involved in inflammatory response negative regulation of interleukin-1-mediated signaling pathway |
04010 04060 04640 05146 |
| TC1900001435.mm.2 |
Htr7 |
5-hydroxytryptamine (serotonin) receptor 7 |
19 |
-35958417, -35958417 |
NM_008315, BC116986 NM_008315, BC116986 |
15566 |
71 |
G protein-coupled receptor activity G protein-coupled serotonin receptor activity G protein-coupled serotonin receptor activity rough endoplasmic reticulum plasma membrane integral component of plasma membrane smooth muscle contraction signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission memory circadian rhythm synaptic vesicle positive regulation of neuron projection development negative regulation of serotonin secretion urinary bladder smooth muscle contraction membrane integral component of membrane dendrite dendrite neurotransmitter receptor activity neurotransmitter receptor activity vasoconstriction negative regulation of circadian sleep/wake cycle, REM sleep neuronal cell body axon terminus behavioral response to pain detection of mechanical stimulus involved in sensory perception of pain response to corticosterone micturition long-term synaptic potentiation regulation of vein smooth muscle contraction dopaminergic neuron differentiation integral component of postsynaptic membrane integral component of presynaptic membrane regulation of synaptic vesicle exocytosis |
04020 04080 |
| TC1200002526.mm.2 |
Serpina3h |
serine (or cysteine) peptidase inhibitor, clade A, member 3H |
12 |
104247895 |
NR_033450 |
546546 |
13 |
|
|
| TC0100001031.mm.2 |
Serpinb8 |
serine (or cysteine) peptidase inhibitor, clade B, member 8 |
1 |
107590005, 107590005 |
NM_001159748, NM_011459, BC025121 NM_001159748, NM_011459, BC025121 NM_001159748, NM_011459, BC025121 |
20725 |
14 |
serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular space cytoplasm cytosol negative regulation of peptidase activity negative regulation of endopeptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity epithelial cell-cell adhesion |
|
| MG-1-neg-10340371_st |
|
|
|
|
|
|
|
|
|
| TC1000000711.mm.2 |
Adora2a |
adenosine A2a receptor |
10 |
75316876, 75324857, 75317599 |
NM_009630, BC110692 NM_009630, BC110692 |
11540 |
432 |
G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor activity synaptic transmission, dopaminergic G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway response to amphetamine G protein-coupled receptor activity protein binding intermediate filament plasma membrane plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated negative regulation of protein kinase activity signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway protein kinase C-activating G protein-coupled receptor signaling pathway synaptic transmission, cholinergic locomotory behavior locomotory behavior negative regulation of cell population proliferation endomembrane system positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion postsynaptic density membrane membrane integral component of membrane enzyme binding axon dendrite axolemma response to caffeine type 5 metabotropic glutamate receptor binding positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission, GABAergic asymmetric synapse synaptic transmission, glutamatergic positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of locomotion vasodilation presynaptic membrane eating behavior eating behavior identical protein binding neuronal cell body negative regulation of vascular permeability negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to alkaloid negative regulation of neuron apoptotic process protein-containing complex binding postsynaptic membrane positive regulation of circadian sleep/wake cycle, sleep negative regulation of alpha-beta T cell activation astrocyte activation presynaptic active zone neuron projection morphogenesis positive regulation of protein secretion negative regulation of inflammatory response alpha-actinin binding regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential prepulse inhibition glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of long-term synaptic potentiation regulation of synaptic vesicle exocytosis positive regulation of apoptotic signaling pathway |
04020 04080 04270 |
| TC1400001504.mm.2 |
Ube2e2 |
ubiquitin-conjugating enzyme E2E 2 |
14 |
-18573565, -18573565, -18573565 |
NM_144839, BC016265 NM_144839, BC016265 |
218793 |
19 |
nucleotide binding protein polyubiquitination ubiquitin-protein transferase activity ATP binding nucleus cellular response to DNA damage stimulus transferase activity ISG15-protein conjugation ISG15-protein conjugation ISG15 transferase activity ISG15 transferase activity ubiquitin conjugating enzyme activity ubiquitin conjugating enzyme activity protein K63-linked ubiquitination protein K63-linked ubiquitination protein K48-linked ubiquitination protein K48-linked ubiquitination protein K11-linked ubiquitination protein K11-linked ubiquitination positive regulation of G1/S transition of mitotic cell cycle |
04120 04141 |
| TC0200003880.mm.2 |
Serping1 |
serine (or cysteine) peptidase inhibitor, clade G, member 1 |
2 |
-84765359 |
NM_009776, BC002026 NM_009776, BC002026 |
12258 |
38 |
complement binding negative regulation of complement activation, lectin pathway immune system process serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular region extracellular space extracellular space extracellular space extracellular space complement activation, classical pathway blood coagulation hemostasis negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of blood coagulation peptidase inhibitor activity fibrinolysis innate immune response negative regulation of complement activation collagen-containing extracellular matrix |
04610 |
| TC1000001743.mm.2 |
Adgb |
androglobin |
10 |
-10335702 |
NM_001127353, BC153036 NM_001127353, BC153036 |
215772 |
11 |
calcium-dependent cysteine-type endopeptidase activity intracellular anatomical structure proteolysis oxygen binding heme binding |
|
| TC0700000756.mm.2 |
Siglecf |
sialic acid binding Ig-like lectin F |
7 |
43351340 |
NM_001271019, NM_145581, BC145038, BC145987 NM_001271019, NM_145581, BC145038, BC145987 NM_001271019, NM_145581, BC145038, BC145987 NM_001271019, NM_145581, BC145038, BC145987 |
233186 |
34 |
lysosome plasma membrane cell adhesion membrane integral component of membrane regulation of endocytosis carbohydrate binding sialic acid binding sialic acid binding monosaccharide binding |
|
| TC1_GL456211_random00000010.mm.2 |
|
|
|
|
|
|
|
|
|
| TC0700004019.mm.2 |
Olfr700 |
olfactory receptor 700 |
7 |
-106805509 |
NM_146600, BC104091, BC106812 NM_146600, BC104091, BC106812 NM_146600, BC104091, BC106812 |
258593 |
6 |
olfactory receptor activity G protein-coupled receptor signaling pathway sensory perception of smell integral component of membrane |
04740 |
| TC1300000476.mm.2 |
Hivep1 |
human immunodeficiency virus type I enhancer binding protein 1 |
13 |
42052020 |
NM_007772, BC156925 NM_007772, BC156925 |
110521 |
28 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding DNA binding DNA binding protein binding nucleus nucleus nucleus nucleoplasm mitochondrion cytosol regulation of transcription by RNA polymerase II zinc ion binding nuclear body BMP signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II metal ion binding HMG box domain binding sequence-specific double-stranded DNA binding |
|
| TC0200003801.mm.2 |
Pde11a |
phosphodiesterase 11A |
2 |
-75985807 |
NM_001081033, BC158125 NM_001081033, BC158125 |
241489 |
25 |
catalytic activity cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cytoplasm signal transduction phosphoric diester hydrolase activity metabolic process negative regulation of cGMP-mediated signaling negative regulation of cGMP-mediated signaling hydrolase activity cGMP binding perikaryon negative regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity |
00230 |
| TC0700003648.mm.2 |
Cemip |
cell migration inducing protein, hyaluronan binding |
7 |
-83932856 |
NM_030728, BC115873, BC116643 NM_030728, BC115873, BC116643 NM_030728, BC115873, BC116643 |
80982 |
33 |
hyalurononglucosaminidase activity hyalurononglucosaminidase activity hyaluronic acid binding hyaluronic acid binding extracellular region nucleus cytoplasm cytoplasm endoplasmic reticulum plasma membrane clathrin-coated pit sensory perception of sound metabolic process positive regulation of peptidyl-threonine phosphorylation membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hyaluronan catabolic process hyaluronan catabolic process positive regulation of cell migration clathrin-coated vesicle membrane clathrin heavy chain binding clathrin-coated endocytic vesicle ER retention sequence binding positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein targeting to membrane positive regulation of protein kinase C activity |
|
| TC1100000952.mm.2 |
Zmynd15 |
zinc finger, MYND-type containing 15 |
11 |
70459432 |
NM_001029929, BC151086 NM_001029929, BC151086 |
574428 |
12 |
nucleus cytoplasm spermatogenesis spermatid development spermatid development cell differentiation histone deacetylase binding histone deacetylase binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding |
|
| TC1700001027.mm.2 |
Tnfsf9 |
tumor necrosis factor (ligand) superfamily, member 9 |
17 |
57105384 |
NM_009404, BC138767, BC138770 NM_009404, BC138767, BC138770 NM_009404, BC138767, BC138770 |
21950 |
102 |
signaling receptor binding cytokine activity tumor necrosis factor receptor binding extracellular space plasma membrane plasma membrane immune response membrane integral component of membrane positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding positive regulation of activated T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation myeloid dendritic cell differentiation positive regulation of cytotoxic T cell differentiation positive regulation of cytotoxic T cell differentiation |
04060 |
| TC1100001242.mm.2 |
Slfn3 |
schlafen 3 |
11 |
83191329 |
NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 |
20557 |
17 |
negative regulation of cell population proliferation |
|
| TC1000002383.mm.2 |
Gstt1 |
glutathione S-transferase, theta 1 |
10 |
-75783812, -75783812 |
NM_008185, BC012254, BC055020 NM_008185, BC012254, BC055020 NM_008185, BC012254, BC055020 |
14871 |
32 |
glutathione transferase activity glutathione transferase activity glutathione transferase activity glutathione peroxidase activity nucleus cytoplasm cytosol DNA modification glutathione metabolic process glutathione metabolic process glutathione metabolic process glutathione metabolic process transferase activity dichloromethane metabolic process alkylhalidase activity |
00480 00980 00982 |
| TC1700002597.mm.2 |
Slc8a1 |
solute carrier family 8 (sodium/calcium exchanger), member 1 |
17 |
-81373104 |
NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 NM_001112798, NM_001286684, NM_011406, NR_104580, BC079673 |
20541 |
175 |
response to hypoxia embryonic placenta development regulation of the force of heart contraction regulation of heart rate regulation of sodium ion transport heart morphogenesis calcium:sodium antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity protein binding calmodulin binding nucleoplasm mitochondrion microtubule plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane ion transport sodium ion transport sodium ion transport calcium ion transport calcium ion transport cellular calcium ion homeostasis cellular sodium ion homeostasis cell communication positive regulation of cytosolic calcium ion concentration cytoskeletal protein binding post-embryonic development regulation of gene expression positive regulation of fibroblast migration regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion postsynaptic density intercalated disc vascular associated smooth muscle contraction antiporter activity cation:cation antiporter activity membrane membrane integral component of membrane basolateral plasma membrane metal ion transport Z disc T-tubule T-tubule axon axon dendrite positive regulation of bone mineralization ankyrin binding ankyrin binding response to ATP cellular response to reactive oxygen species embryonic heart tube development sodium ion transmembrane transport sodium ion transmembrane transport response to muscle stretch sodium ion export across plasma membrane sodium ion export across plasma membrane sarcolemma sarcolemma sarcolemma cell projection neuronal cell body dendritic spine dendritic shaft axon terminus ion channel binding relaxation of smooth muscle synapse synapse postsynaptic membrane metal ion binding muscle fiber development negative regulation of cytosolic calcium ion concentration regulation of calcium ion transport cardiac muscle cell development calcium ion homeostasis transmembrane transport cardiac muscle contraction calcium ion transport into cytosol calcium ion transport into cytosol calcium ion import calcium ion import calcium ion transmembrane transport calcium ion transmembrane transport cellular response to caffeine cellular response to cAMP negative regulation of protein serine/threonine kinase activity cell periphery regulation of cardiac muscle cell membrane potential calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential cell communication by electrical coupling involved in cardiac conduction calcium ion import across plasma membrane sodium ion import across plasma membrane sodium ion import across plasma membrane positive regulation of the force of heart contraction postsynapse integral component of postsynaptic membrane ion antiporter activity involved in regulation of postsynaptic membrane potential calcium ion export calcium ion export calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
04020 04260 04974 05410 05412 05414 |
| MG-1-neg-10343761_st |
|
|
|
|
|
|
|
|
|
| TC0500003465.mm.2 |
Pilrb2 |
paired immunoglobin-like type 2 receptor beta 2 |
5 |
-137865828, -137865820 |
NM_001024932, BC147405, BC147406 NM_001024932, BC147405, BC147406 NM_001024932, BC147405, BC147406 |
545812 |
10 |
membrane integral component of membrane MHC class I protein binding |
|
| TC1400002293.mm.2 |
Dock5 |
dedicator of cytokinesis 5 |
14 |
-67751927 |
NM_177780, BC158046, BC158135, BC158138 NM_177780, BC158046, BC158135, BC158138 NM_177780, BC158046, BC158135, BC158138 NM_177780, BC158046, BC158135, BC158138 |
68813 |
38 |
guanyl-nucleotide exchange factor activity GTPase activator activity cytoplasm cytosol plasma membrane cytoskeleton organization small GTPase mediated signal transduction positive regulation of epithelial cell migration membrane cell migration positive regulation of substrate adhesion-dependent cell spreading negative regulation of vascular associated smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration |
|
| TC0100001468.mm.2 |
Tnfsf4 |
tumor necrosis factor (ligand) superfamily, member 4 |
1 |
161395437 |
NM_009452, BC153120 NM_009452, BC153120 |
22164 |
112 |
blood vessel development negative regulation of cytokine production positive regulation of cytokine production defense response to nematode acute inflammatory response positive regulation of immunoglobulin production positive regulation of immune effector process positive regulation of T cell cytokine production regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of type 2 immune response positive regulation of immunoglobulin mediated immune response cytokine activity tumor necrosis factor receptor binding protein binding extracellular space extracellular space inflammatory response inflammatory response immune response cholesterol metabolic process response to virus cell surface membrane integral component of membrane negative regulation of interferon-gamma production negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of interleukin-4 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding memory T cell activation T-helper 2 cell activation response to nitrogen dioxide cellular response to nitrogen dioxide CD4-positive, alpha-beta T cell costimulation T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of memory T cell differentiation negative regulation of DNA-binding transcription factor activity innate immune response negative regulation of regulatory T cell differentiation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation negative regulation of transcription, DNA-templated positive regulation of alpha-beta T cell proliferation regulation of inflammatory response positive regulation of inflammatory response positive regulation of B cell activation negative regulation of T cell apoptotic process negative regulation of activation-induced cell death of T cells cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus chemokine (C-C motif) ligand 11 production positive regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of T cell migration positive regulation of T cell costimulation positive regulation of memory T cell activation positive regulation of T-helper 2 cell activation positive regulation of interleukin-4-dependent isotype switching to IgE isotypes negative regulation of extrinsic apoptotic signaling pathway |
04060 |
| TC0900001720.mm.2 |
Birc2 |
baculoviral IAP repeat-containing 2 |
9 |
-7818225, -7818225 |
NM_007465, BC145985 NM_007465, BC145985 |
11797 |
90 |
protein polyubiquitination response to hypoxia XY body placenta development transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus nucleus cytoplasm cytoplasm apoptotic process zinc ion binding cytoplasmic side of plasma membrane transferase activity positive regulation of protein ubiquitination protein-containing complex CD40 receptor complex identical protein binding regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process protein-containing complex binding membrane raft metal ion binding protein N-terminus binding chaperone binding regulation of cell cycle regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity necroptotic process cellular response to tumor necrosis factor FBXO family protein binding regulation of NIK/NF-kappaB signaling negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination positive regulation of protein polyubiquitination regulation of reactive oxygen species metabolic process |
04120 04210 04510 04621 05145 05200 05222 |
| TC0600000240.mm.2 |
Tspan33 |
tetraspanin 33 |
6 |
29694213 |
NM_146173, BC024685 NM_146173, BC024685 |
232670 |
18 |
cytoplasm plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane enzyme binding enzyme binding cell junction pore complex pore complex pore complex assembly pore complex assembly protein maturation protein maturation protein maturation protein localization to plasma membrane protein localization to plasma membrane protein localization to plasma membrane tetraspanin-enriched microdomain |
|
| MG-1-neg-10339929_st |
|
|
|
|
|
|
|
|
|
| MG-1-pos-10343399_st |
|
|
|
|
|
|
|
|
|
| TC1100001543.mm.2 |
Mllt6 |
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 |
11 |
97663411 |
NM_139311, BC152980 NM_139311, BC152980 |
246198 |
27 |
renal system process nucleus excretion positive regulation of sodium ion transport nucleosome binding nucleosome binding negative regulation of urine volume renal sodium excretion renal potassium excretion histone binding histone binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of histone H3-K79 methylation |
|
| TC1700000934.mm.2 |
Treml4 |
triggering receptor expressed on myeloid cells-like 4 |
17 |
48264294 |
NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 |
224840 |
15 |
positive regulation of defense response to virus by host immune system process T cell antigen processing and presentation protein binding lysosomal membrane endoplasmic reticulum plasma membrane phagocytosis, engulfment protein localization cell surface endosome membrane membrane integral component of membrane positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 13 signaling pathway signaling receptor activity innate immune response defense response to virus |
|
| TC1500001730.mm.2 |
Ly6c2 |
lymphocyte antigen 6 complex, locus C2 |
15 |
-75108160, -75108160 |
NM_001099217, BC092082 NM_001099217, BC092082 |
100041546 |
8 |
plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| MG-1-neg-10339892_st |
|
|
|
|
|
|
|
|
|
| TC1000000021.mm.2 |
Akap12 |
A kinase (PRKA) anchor protein (gravin) 12 |
10 |
4266328 |
NM_031185, BC138364, BC138365 NM_031185, BC138364, BC138365 NM_031185, BC138364, BC138365 |
83397 |
66 |
calmodulin binding cytoplasm cytosol cytoskeleton plasma membrane protein targeting signal transduction signal transduction adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase binding regulation of protein kinase A signaling positive regulation of protein kinase A signaling membrane signaling receptor complex adaptor activity positive regulation of tumor necrosis factor production neuronal cell body negative regulation of vascular permeability modulation of chemical synaptic transmission modulation of chemical synaptic transmission modulation of chemical synaptic transmission protein kinase A binding positive regulation of nitric-oxide synthase biosynthetic process positive regulation of hepatic stellate cell migration positive regulation of ERK1 and ERK2 cascade regulation of protein kinase C signaling Schaffer collateral - CA1 synapse Schaffer collateral - CA1 synapse positive regulation of oligodendrocyte apoptotic process |
|
| TC0600000182.mm.2 |
Cped1 |
cadherin-like and PC-esterase domain containing 1 |
6 |
21985909 |
NM_001081351, BC151018 NM_001081351, BC151018 |
214642 |
12 |
molecular_function endoplasmic reticulum biological_process |
|
| TC0900001392.mm.2 |
Amigo3 |
adhesion molecule with Ig like domain 3 |
9 |
108053158 |
NM_177275, BC157008 NM_177275, BC157008 |
320844 |
20 |
molecular_function cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nervous system development brain development negative regulation of neuron projection development membrane integral component of membrane integral component of membrane protein-containing complex binding positive regulation of synapse assembly |
|
| TC1300002774.mm.2 |
Zfp456 |
zinc finger protein 456 |
13 |
-67363583 |
NM_001001186, BC141197 NM_001001186, BC141197 |
408065 |
10 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific nucleus regulation of transcription by RNA polymerase II |
|
| TC0200003512.mm.2 |
Rnd3 |
Rho family GTPase 3 |
2 |
-51130438 |
NM_028810, BC009002 NM_028810, BC009002 |
74194 |
48 |
nucleotide binding GTPase activity protein binding GTP binding intracellular anatomical structure Golgi apparatus cytoskeleton plasma membrane cell cortex actin filament organization establishment or maintenance of cell polarity small GTPase mediated signal transduction regulation of cell shape membrane cell migration protein kinase binding cortical cytoskeleton organization cytoplasmic vesicle regulation of actin cytoskeleton organization cell projection intracellular membrane-bounded organelle |
|
| TC0200000485.mm.2 |
|
|
|
|
|
|
|
|
|
| TC0200001913.mm.2 |
Dusp2 |
dual specificity phosphatase 2 |
2 |
127336158 |
NM_010090, BC048696 NM_010090, BC048696 |
13537 |
24 |
inactivation of MAPK activity endoderm formation phosphoprotein phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding nucleus nucleoplasm cytoplasm protein dephosphorylation protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity nuclear membrane peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation mitogen-activated protein kinase binding mitogen-activated protein kinase binding |
04010 |
| MG-1-neg-10339282_st |
|
|
|
|
|
|
|
|
|
| TC0300000881.mm.2 |
Rfx5 |
regulatory factor X, 5 (influences HLA class II expression) |
3 |
94954107, 94954515 |
NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 |
53970 |
32 |
negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II |
04612 05340 |
| TC1000002725.mm.2 |
Socs2 |
suppressor of cytokine signaling 2 |
10 |
-95411489, -95411489, -95411489, -95411489 |
NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 |
216233 |
137 |
regulation of cell growth growth hormone receptor binding insulin-like growth factor receptor binding protein binding cytoplasm phosphatidylinositol 3-kinase complex lactation lactation JAK pathway signal transduction adaptor activity negative regulation of signal transduction response to estradiol cellular response to hormone stimulus intracellular signal transduction regulation of growth regulation of multicellular organism growth negative regulation of multicellular organism growth negative regulation of multicellular organism growth positive regulation of neuron differentiation negative regulation of receptor signaling pathway via JAK-STAT phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity growth hormone receptor signaling pathway mammary gland alveolus development mammary gland alveolus development |
04630 04910 04930 |
| TC0X00001682.mm.2 |
Gpm6b |
glycoprotein m6b |
X |
166344552, 166238942 |
NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 NM_001177955, NM_001177956, NM_001177957, NM_001177958, NM_001177959, NM_001177960, NM_001177961, NM_001177962, NM_023122, BC025165 |
14758 |
39 |
ossification plasma membrane plasma membrane protein transport membrane integral component of membrane positive regulation of bone mineralization neuron projection development regulation of actin cytoskeleton organization membrane raft membrane raft negative regulation of serotonin uptake negative regulation of serotonin uptake regulation of focal adhesion assembly extracellular matrix assembly negative regulation of protein localization to cell surface |
|
| TC0900002770.mm.2 |
Tent5a |
terminal nucleotidyltransferase 5A |
9 |
-85320438, -85320438 |
NM_001160378, NM_001160379 NM_001160378, NM_001160379 |
212943 |
17 |
cellular_component response to bacterium mRNA stabilization RNA adenylyltransferase activity |
|
| TC0100000129.mm.2 |
Paqr8 |
progestin and adipoQ receptor family member VIII |
1 |
20917839, 20890547 |
NM_028829, BC059813 NM_028829, BC059813 |
74229 |
23 |
steroid hormone receptor activity steroid binding Golgi apparatus plasma membrane plasma membrane multicellular organism development lipid binding membrane integral component of membrane cell differentiation signaling receptor activity oogenesis response to steroid hormone |
|
| TC1500001144.mm.2 |
Fbxo4 |
F-box protein 4 |
15 |
-3963563 |
NM_134099, BC040086 NM_134099, BC040086 |
106052 |
24 |
ubiquitin ligase complex protein polyubiquitination telomere maintenance ubiquitin-protein transferase activity protein binding cytoplasm ubiquitin-dependent protein catabolic process aging posttranscriptional regulation of gene expression protein ubiquitination SCF ubiquitin ligase complex SCF ubiquitin ligase complex cellular homeostasis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination regulation of protein stability protein destabilization positive regulation of telomere maintenance via telomerase common myeloid progenitor cell proliferation protein homodimerization activity negative regulation of fibroblast proliferation ubiquitin protein ligase activity cellular response to ionizing radiation negative regulation of protein localization to nucleus positive regulation of protein polyubiquitination regulation of DNA damage checkpoint |
04120 |
| TC1000000100.mm.2 |
Hivep2 |
human immunodeficiency virus type I enhancer binding protein 2 |
10 |
13966378, 13966074 |
NM_010437, BC150704, XR_105340 NM_010437, BC150704, XR_105340 NM_010437, BC150704, XR_105340 |
15273 |
44 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific nucleic acid binding DNA binding DNA-binding transcription factor activity nucleus nucleoplasm transcription regulator complex transcription, DNA-templated regulation of transcription by RNA polymerase II signal transduction positive regulation of transcription by RNA polymerase II metal ion binding |
|
| TC0X00001288.mm.2 |
Armcx3 |
armadillo repeat containing, X-linked 3 |
X |
134756551, 134756750 |
NM_027870, BC051113, BC011101 NM_027870, BC051113, BC011101 NM_027870, BC051113, BC011101 |
71703 |
22 |
protein binding nucleus cytoplasm mitochondrion mitochondrion mitochondrial outer membrane cytosol mitochondrion organization membrane integral component of membrane axonal transport of mitochondrion integral component of mitochondrial outer membrane cellular protein localization cellular protein localization positive regulation of transcription by RNA polymerase II |
|
| TC0100003361.mm.2 |
Gpr52 |
G protein-coupled receptor 52 |
1 |
-160574716 |
NM_001146330 |
620246 |
5 |
G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway phototransduction locomotory behavior G protein-coupled photoreceptor activity membrane integral component of membrane response to drug cellular response to light stimulus |
|
| TC0600003613.mm.2 |
Klra3 |
killer cell lectin-like receptor, subfamily A, member 3 |
6 |
-130323288 |
NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 NM_001289604, NM_001289605, NM_010648, BC099867, BC099878, BC099879, BC099880, BC101952, BC103543, BC103544, BC103545, BC132524, BC132526, BC145192, BC145193 |
16634 |
50 |
plasma membrane |
04650 05332 |